Synthesis Problems

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2022

  1. (+)-Ingenol & (+)-Phorbol (Baran, 2013 & 2016)
  2. Amycolamicin & Kibdelomycin (Li, 2021)
  3. Ladderane Phospholipid (Burns, 2016)
  4. Pulvomycin D (Bach, 2021)
  5. (-)-10-Hydroxyacutuminine (Reisman, 2022)
  6. Shearinines A & G (Carreira, 2022)
  7. Corymine & Rubriflordilactone B (Li, 2017Li, 2017)
  8. Weisaconitine D & Liljestrandine (Sarpong, 2015)
  9. (-)-Cajanusine (Brown, 2020)
  10. (-)-Rhodomollanol A (Ding, 2020)
  11. Flueggeacosine B (Han, 2022)
  12. Retrosynthesis
  13. 10-Hydroxyacutuminine (Reisman, 2022)
  14. (+)-Dictyoxetane (Magauer, 2016)
  15. Spirochensilide A (Yang, 2020)
  16. Isoadenolin I & Isorosthin L (Liang, 2021)
  17. Aspidodasycarpine, Lonicerine and Lanciferine (Li, 2016)

2021

  1. (-)-Vinigrol (Li, 2019 & Baran, 2009)
  2. (+)-Pleuromutilin (Reisman, 2018 )
  3. (-)-Misramine (Zhou, 2020 )
  4. Review on the synthesis of eight-membered carbocycles (Li, 2020 )
  5. Avenaol (Tsukano, 2017 )
  6. (±)-Phomoidride D (Wood, 2018)
  7. (-)-Haliclonin A (Huang, 2016 )
  8. Reaction Mechanisms Exercise
  9. Industrial Synthesis 12.05.2021
  10. Brasilicardin (Tanino, 2018)
  11. Prostaglandins (Chen & Zhang, 2021 – Aggarwal, 2012)
  12. Bryostatin 3 (Trost, 2020)
  13. Industrial Synthesis – Asunaprevir & Entecavir (BMS)
  14. Perseanol (Reisman, 2019)
  15. Canataxpropellane (Gaish, 2020)
  16. (+)-Euphorikanin A (Carreira, 2021)
  17. Batrachotoxin (Du Bois, 2016)
  18. Pateamine A (Fürstner, 2018)
  19. Industrial Synthesis – ELQ-300 & Pyrethroids
  20. Clionastatins A and B (Gui, 2021)
  21. Cryptotrione (Wong & Peng, 2020)
  22. Jerome’s mechanism exercise
  23. Shagenes A & B (Tsukano & Takemoto, 2021)
  24. Total syntheses starting from Carvone (Lindel, Nicolaou, Tang, Inoue)
  25. Bilobalide (Shenvi, 2019)
  26. Harziane Diterpenoid (Carreira, 2020)
  27. BMS-986251 (BMS, 2021)
  28. Xishacorene B (Sarpong, 2021)

2020

  1. Curcumalactone (Romo, 2012)
  2. Ophioboline (Maimone, 2020)
  3. Bryostatine 1 (Wender, 2017)
  4. Scabrolide A (Stoltz, 2020)
  5. Dichrocephones A and B (Christman, 2018)
  6. Tagetitoxin (Baran, 2020)
  7. Leustroducsin B (Trost, 2015)
  8. (-)-Tetrapetalone A (Wood, 2017)
  9. Spirofungin A (Kozmin, 2007)
  10. (-)-Acutumine (Herzon, 2013)
  11. (-)-Picrotoxinin (Shenvi, 2020, Corey, Yoshikoshi, Trost) Solution
  12. (-)-Mitrephorone (Carreira, 2018, Carreira, 2020)
  13. Cephanolide A (Gao, 2020)
  14. (+)-Waihoensene (Gaich, 2020)
  15. Macfarlandin C (Overman, 2020)
  16. Mollebenzylanol A (Ito, 2020)

2019

  1. (±)-Hippolachnin-A (Trauner, 2017)
  2. (-)-Doliculide P (Zhou, 2019)
  3. (-)-Ambiguine P (Rawal, 2019)
  4. Pleocarpenone & Pleocarpenene (Snapper, 2007)
  5. (±)-Erysotramidine (Padwa, 1988).
  6. (+)-Psiguadial B (Reisman, 2016).
  7. (±)-Limonin (Yamashita, 2015).
  8. Aspeverin (Levinson, 2014).

2018

  1. (-)-Calyciphylline (Smith, 2014)
  2. Communesin F (Movassaghi, 2016)
  3. (+)-Psiguadial (Reisman, 2016)
  4. Arboridinine (Kam, 2015)
  5. Peroranoid (Shen, Yang, Hao, 2016)
  6. Nahuoic Acid Ci (Bii) (Smith, 2017)
  7. (-)-Isokopsine (Yong Qin, 2017)
  8. Guignarderemophilanes C and D (Gademann, 2018).
  9. (-)-Acutumine (Herzon, 2013).
  10. Neoxaline (Sunazaka, 2018).
  11. (±)-Dehaloperophoramidine (Somfai, 2017).
  12. Plumisclerin-A (Yao, 2018)

2017

  1. Notoamide & Sclerotamide (Li, 2016)
  2. Spinosin A (Dai, 2016)
  3. Rubriflordilactone B (Li, 2016)
  4. Cycloclavine (Wipf, 2017)
  5. Eupalinilide E (Siegel, 2016)
  6. (+)-Citrinadin B (Wood, 2013)
  7. Hyperforin (Shair, 2013)
  8. Ovarectaene (Fürstner, 2017)
  9. Lancifodilactone G acetate (Yang, 2017)
  10. Gelsemoxonine (Fukuyama, 2011)
  11. Vigulariol (Clark, 2007)
  12. Lycopalhine A (Fukuyama, 2016)
  13. (-)-Thiobinupharidine (Zakarian, 2017)
  14. Photoredox catalysis as key step in total synthesis of natural products
  15. Longeracinphyllin A (Li, 2017)
  16. Disciformycin A & B (Fürstner, 2017)

2016

  1. Celastrol (Camelio, 2015)
  2. Cyperolone (Kirsch, 2012)
  3. Epoxyeujindole A (Li, 2015)
  4. (+)-Nakadomarin A (Kerr, 2007)
  5. (+)-CP-263 (Shair, 2000)

2015

  1. Nominine (Gin, 2006)
  2. Gracilamine (Gao, 2014)
  3. Englerin A (Nicolaou, 2010)
  4. Oridamycin (Li, 2014)
  5. Ginkolide (Crimmins, 2000)
  6. Jiadifenolide (Sorensen, 2014)
  7. Roseophilin (Furstner, 1998)
  8. Maoecrystal V (Thomson, 2014)
  9. Key steps in Total Synthesis I ( )
  10. Key steps in Total Synthesis II ( )
  11. (-)-hapalindole U & (+)-ambiguine H ( )
  12. Welwitindolinone A isonitrile (Wood, 2006)

2014

  1. Nakiterpiosin (Chen, 2009)
  2. Harringtonolide (Mander, 1998)
  3. Daphnilactone (Heathcock, 1989)
  4. 7-DeacetoxyalcyoninAcetate (Overman, 1995)
  5. Pactamycin (Johnson, 2013)
  6. Resiniferatoxin (Wender, 1997)
  7. Sieboldine A (Overman, 2010)

2013

  1. Flinderoles (Toste, 2011)
  2. Gelsemoxonine (Fukuyama, 2011)
  3. Echinopine A and B (Mulzer, 2009)
  4. Neurymenolide A (Fürstner, 2012)

2012

  1. (-)-N-Methylwelwitindolinone C Isothiocyanate (Garg, 2011)
  2. Seragakinone A (Suzuki, 2011)
  3. Tulearin C (Fürstner, 2011)
  4. Hirsutellone B (Nicolaou, 2009)
  5. Hopeanol (Snyder, 2012)
  6. Pentacycloanammoxic Acid Methylester (Corey, 2004)
  7. Guanacastepenes (Carreira, 2011)
  8. (-)-FR901483 (Tu, 2012)

2011

  1. Streptazolin (Kibayashi, 1996)
  2. Cyanthiwigin U (Phillips, 2005)
  3. (+)-Laurenyne (Boeckman, 2002)
  4. Chlorosulpholipid Cytotoxin (Carreira, 2009)
  5. (+)-Liphagal (Stoltz, 2011)
  6. Meloscine (Curran, 2011)
  7. Hapalindole K (Johnston, 2011)
  8. (+)-Omphadiol (Romo, 2011)