Preprints
The most recent research results from LCSO, not yet peer-reviewed. Do not hesitate to contact us for suggestions, collaborations or to coordinate publications if you work on a similar topic!
Accessing CF3-Cyclopropenes — A Platform for the Synthesis of Trifluoromethylated Building Blocks
Wei Wu, Tobias M. Milzarek, Matthew D. Wodrich and Jerome Waser
ChemRxiv 2025, DOI: 10.26434/chemrxiv-2025-zpkgt
Practical synthesis of Csp3 Chlorinated Compounds from Cyclopropanes, Olefins and C-H Bonds via photolysis of Willgerodt-type reagents
Tin V. T. Nguyen, Trinh T. H. Tran, Thanh V. Q. Nguyen and Jerome Waser
ChemRxiv 2024, DOI: 10.26434/chemrxiv-2024-bjx6t
Journal Articles
2025
Peptide-Carbazolyl Cyanobenzene Conjugates: Enabling Biomolecule Functionalization via Photoredox and Energy Transfer Catalysis
Xing-Yu Liu, Wei Cai, Anne-Sophie Chauvin, Beat Fierz and Jerome Waser
Angew. Chem., Int. Ed. 2025, 64, e202507602. (10.1002/anie.202507602) Open Access! Green Access Raw data
Synthesis of Bicyclo[1.1.1]pentane Z-Substituted Enamides, Enol Ethers, and Vinyl Sulfides Using Iodine (III) Reagents
Najung Lee, Jonas Dechent, Elija Grinhagena, and Jerome Waser
Angew. Chem., Int. Ed. 2025, 64, e202508404. (10.1002/anie.202508404) Open Access! Green Access Raw data
Enantioselective Synthesis of 1,2-Disubstituted Thiocyclobutanes via Michael Addition
Emma G. L. Robert and Jerome Waser
Chem. Sci. 2025, 16, 12115-12121. (10.1039/D5SC01727K) Open Access! Raw data
Photocatalyzed Azidofunctionalization of Alkenes via Radical-Polar Crossover
Pierre Palamini, Alexandre A. Schoepfer and Jerome Waser
Angew. Chem., Int. Ed. 2025, 64, e202420455. (10.1002/anie.202420455) Green Access Raw data
2024
Diastereoselective Synthesis of N-Heterocycle Substituted Cyclobutanes via Michael Addition onto Cyclobutenes
Emma G. L. Robert and Jerome Waser
Chem. Eur. J. 2024, 30, e202403986. (10.1002/chem.202403986) Green Access Raw data
Homologation of Alkenyl Carbonyls via a Cyclopropanation/Light-Mediated Selective C-C Cleavage Strategy
Tin V. T. Nguyen, Duncan K. Brownsey, André Bossonnet, Matthew D. Wodrich and Jerome Waser
Angew. Chem., Int. Ed. 2024, 63, e202417719. (10.1002/anie.202417719) Open Access! Raw data
Cost-informed Bayesian reaction optimization
Alexandre A Schoepfer, Jan Weinreich, Ruben Laplaza, Jerome Waser and Clemence Corminboeuf
Digital Discovery 2024, 3, 2289-2297. (10.1039/D4DD00225C) Open Access! Joined publication with LCMD.
Forging 1,1′-Bicyclopropenyls by Synergistic Au/Ag Dual-Catalyzed Cyclopropenyl Cross-Coupling
Xiangdong Li and Jerome Waser
J. Am. Chem. Soc. 2024, 146, 29712-29719. (10.1021/jacs.4c10996) Open Access! Raw data
Enamine Synthesis via Regiocontrolled 6-endo-dig and 5-exo-dig Tethered Carboamination of Propargylic Alcohols
Helena Solé-Àvila, Mikus Puriņš, Lucas Eichenberger and Jerome Waser
Angew. Chem. Int. Ed. 2024, 63, e202411383. (10.1002/anie.202411383) Open Access! Raw data
Platinum-Catalyzed Isomerization of Cyclopropenes to 1,3-Dienes
Vladyslav Smyrnov, Antonin Homassel, Leander Choudhury, Jerome Waser
Helv. Chim. Acta 2024, 107, e2024000105. (10.1002/hlca.202400105) Open Access! Raw data
Ficini Reaction with Acrylates for the Stereoselective Synthesis of Aminocyclobutanes
Emma G. L. Robert and Jerome Waser
Chem. Eur. J. 2024, 30, e202401810. (10.1002/chem.202401810) Open Access! Raw data
Reaction-Agnostic Featurization of Bidentate Ligands for Bayesian Ridge Regression of Enantioselectivity
Alexandre A. Schoepfer, Ruben Laplaza, Matthew D. Wodrich, Jerome Waser, and Clemence Corminboeuf
ACS Catal. 2024, 14, 9302-9312. (10.1021/acscatal.4c02452) Open Access! Code, Visualizations, Joined publication with LCMD.
Hypervalent Iodine Amino Acid Building Blocks for Bioorthogonal Peptide Macrocyclization
Xing-Yu Liu, Olha Mykhailenko, Adriana Faraone and Jerome Waser
Angew. Chem. Int. Ed. 2024, 63, e202404747. (10.1002/anie.202404747) Open Access! Raw data
Photocatalytic Decarboxylative Functionalization of Cyclopropenes via Cyclopropenium Cation Intermediates
Vladyslav Smyrnov and Jerome Waser
Angew. Chem. Int. Ed. 2024, 63, e202404265. (10.1002/anie.202404265) Open Access! Raw data
Lewis Acid Catalyzed [4+2] Annulation of Bicyclobutanes with Dienol Ethers for the Synthesis of Bicyclo[4.1.1]octanes
Stefano Nicolai and Jerome Waser
Chem. Sci. 2024, 15, 10823-10829. (10.1039/D4SC02767A) Open Access! Raw data
Accessing elusive σ-type cyclopropenium cation equivalents through redox gold catalysis
Xiangdong Li, Matthew D. Wodrich and Jerome Waser
Nat. Chem. 2024, 16, 901-912. (10.1038/s41557-024-01535-8) Open Access! Raw data
Organic Dye Photocatalyzed Synthesis of Functionalized Lactones and Lactams via a Cyclization–Alkynylation Cascade
Diana Cavalli and Jerome Waser
Org. Lett. 2024, 26, 4235–4239. (10.1021/acs.orglett.4c01078) Open Access! Raw data
SOMOphilic alkyne vs radical-polar crossover approaches: The full story of the azido-alkynylation of alkenes
Julien Borrel and Jerome Waser
Beilstein J. Org. Chem. 2024, 20, 701-713. (10.3762/bjoc.20.64) Open Access!
Benzylic C(sp3)−H Azidation: Copper vs Iron Catalysis
Angel Rentería-Gómez, Rubén O. Torres-Ochoa, Pierre Palamini, Raphaël Simonet-Davin, Qian Wang, Jérôme Waser, Jieping Zhu
Helv. Chim. Acta 2024, 107, e202400004. (10.1002/hlca.202400004) Open Access! Joined publication with LSPN.
Interrupted Polonovski Strategy for the Synthesis of Functionalized Amino Acids and Peptides
Christine Marty, Emmanuelle M. D. Allouche, and Jerome Waser
Org. Lett. 2024, 26, 456-460. (10.1021/acs.orglett.3c03603) Green Access Raw data
2023
Synthesis of Fluorescent Cyclic Peptides via Gold(I)-Catalyzed Macrocyclization
Xing-Yu Liu, Wei Cai, Nathan Ronceray, Aleksandra Radenovic, Beat Fierz and Jerome Waser
J. Am. Chem. Soc. 2023, 145, 26525-26531. (10.1021/jacs.3c09261) Open Access! Raw data
Photocatalyzed [2σ + 2σ] and [2σ + 2π] Cycloadditions for the Synthesis of Bicyclo[3.1.1]heptanes and 5- or 6-Membered Carbocycles
Tin V. T. Nguyen, André Bossonnet, Matthew D. Wodrich and Jerome Waser
J. Am. Chem. Soc. 2023, 145, 25411-25421. (10.1021/jacs.3c09789) Green Access Raw data
Acyl-Ethynylbenziodoxolone (acyl-EBX): Access to Ketene Dithioarylacetals
Pierre Palamini, Julien Borrel, Maël Djaïd, Morgane Delattre and Jerome Waser
Org. Lett. 2023, 25, 7535-7539. (10.1021/acs.orglett.3c02869) Green Access Raw data
One-pot synthesis of functionalized bis(trifluoromethylated)benziodoxoles from iodine(i) precursors
Tobias M. Milzarek, Nieves P. Ramirez, Xing-Yu Liu and Jerome Waser
Chem. Commun. 2023, 59, 12637-12640. (10.1039/D3CC04525K) Green Access Raw data
Cysteine-Cysteine Cross-Conjugation of both Peptides and Proteins with a Bifunctional Hypervalent Iodine-Electrophilic Reagent
Ilias Koutsopetras, Abhaya Kumar Mishra, Rania Benazza, Oscar Hernandez-Alba, Sarah Cianférani, Guilhem Chaubet, Stefano Nicolai and Jerome Waser
Chem. Eur. J. 2023, 29, e202302689. (10.1002/chem.202302689) Open Access!
Semipinacol Rearrangement of Cyclopropenylcarbinols for the Synthesis of Highly Substituted Cyclopropanes
Vladyslav Smyrnov and Jerome Waser
Org. Lett. 2023, 25, 6999-7003. (10.1021/acs.orglett.3c02543) Green Access Raw data
Iron-Catalyzed Synthesis of α-Azido α-Amino Esters via the Alkylazidation of Alkenes
Pierre Palamini, Emmanuelle M. D. Allouche, and Jerome Waser
Org. Lett. 2023, 25, 6791-6795. (DOI: 10.1021/acs.orglett.3c02153) Open Access! Raw data
Azido-alkynylation of alkenes through radical-polar crossover
Julien Borrel and Jerome Waser
Chem. Sci. 2023, 14, 9452-9460. (DOI: 10.1039/D3SC03309K) Open Access! Raw data
Photochemical [2+2] Cycloaddition of Alkynyl Boronates
Oleksandr S. Liashuk, Oleksandr O. Grygorenko, Yulian M. Volovenko and Jerome Waser
Chem. Eur. J. 2023, 29, e202301650. (DOI: 10.1002/chem.202301650) Open Access! Raw data
Synthesis of Trifluoromethylated Alkenes: Hypervalent Iodine Meets High-Valent Copper
Tobias Michael Milzarek and Jerome Waser
Angew. Chem., Int. Ed. 2023, 62, e202306128. (DOI: 10.1002/anie.202306128) Open Access! Raw data
Peptide-Hypervalent Iodine Reagent Chimeras: Enabling Peptide Functionalization and Macrocyclization
Xing-Yu Liu, Xinjian Ji, Christian Heinis and Jerome Waser
Angew. Chem., Int. Ed. 2023, 62, e202306036. (DOI: 10.1002/anie.202306036) Open Access! Raw data
Copper (I)-BOX Catalyzed Asymmetric 3-Component Reaction for the Synthesis of Trifluoromethylated Propargylic Ethers and Anilines
Nieves P. Ramirez and Jerome Waser
Angew. Chem., Int. Ed. 2023, 62, e202305776. (DOI: 10.1002/anie.202305776) Open Access! Raw data
Synthesis of propargyl silanes from terminal alkynes via a migratory Sonogashira reaction
Mikus Purins, Lucas Eichenberger, and Jerome Waser
Chem. Commun. 2023, 59, 7931-7934. (DOI: 10.1039/D3CC01847D ) Open Access! Raw data
Donor-Acceptor Aminocyclobutane Monoesters: Synthesis and Silylium-Catalyzed (4+2) Annulation with Indoles
Emma G. L. Robert, Vincent Pirenne, Matthew D. Wodrich and Jerome Waser
Angew. Chem., Int. Ed. 2023, 62, e202302420. (DOI: 10.1002/anie.202302420 ) Open Access! Raw data
X-Ray and NMR Structural Data of Ethynylbenziodoxolones (EBXs) Reagents and Their Analogues
Eliott Le Du, Nieves P. Ramirez, Stefano Nicolai, Rosario Scopelliti, Farzaneh Fadaei-Tirani, Matthew D. Wodrich, Durga Prasad Hari and Jerome Waser
Helv. Chim. Acta 2023, e202200175. (DOI: 10.1002/hlca.202200175 ) Open Access!
Review Articles
2025
Cycloaddition and Annulation Reactions with Donor-Acceptor Cyclobutanes
Emma G. L. Robert and Jerome Waser
Helv. Chim. Acta. 2025, 108, e202500140. (DOI: 10.1002/hlca.202500140). Open Access!
Peptide/Protein Functionalization and Macrocyclization via Alkyne Umpolung with Hypervalent Iodine Reagents
Xing-Yu Liu and Jerome Waser
Acc. Chem. Res. 2025, 58, 2852-2861. (DOI: 10.1021/acs.accounts.5c00451). Open Access!
Synthesis and Applications of Alkynylbenziodoxol(on)es in Science of Synthesis: Hypervalent Halogens in Organic Synthesis
Stefano Nicolai and Jerome Waser
Thieme 2025. (DOI: 10.1055/sos-SD-246-00076).
The Azidofunctionalization of Alkenes
Pierre Palamini and Jerome Waser
ChemistryEurope 2025, e2500140. (DOI: 10.1002/ceur.202500140). Open Access!
Unlocking σ-Type Cyclopropenium Cation Transfer Reactions by an Iodine(III)-Based Umpolung Strategy
Xiangdong Li and Jerome Waser
Synlett 2025, 36, 1945-1949. (DOI: 10.1055/a-2535-0332).
Photomediated aliphatic C–H functionalization
Tin V. T. Nguyen and Jerome Waser
Nat. Chem. 2025, 17, 314-315. (DOI: 10.1038/s41557-025-01755-6). Green Access
2024
Merging the Reactivity of (Pseudo)cyclic Hypervalent Iodine Reagents and Carbenes or Carbenoids
Nieves P. Ramirez* and Jerome Waser
Synthesis 2024, 56, 3815-3828. (DOI: 10.1055/a-2418-8285 ). Green Access
Silylium-Catalyzed Activation of Donor-Acceptor Strained Rings and Annulation with Indoles
Emma G. L. Robert and Jerome Waser
Chimia, 2024,78, 234. (10.2533/chimia.2024.234)
2023
Recent progress in alkynylation with hypervalent iodine reagents
Eliott Le Du and Jerome Waser
Chem. Commun. 2023, 59, 1589-1604. (DOI: 10.1039/D2CC06168F ) Open Access!
Publications prior to 2023
Publications 2020-2022
Publications 2017-2019
Publications 2013-2016
Publications 2009-2012