Chemical Biology Seminars (CH-629)

The Chemical Biology Seminars Series is Organized by Prof. Christian Heinis, Prof. Beat Fierz, Prof. Yimon Aye and Prof. Pablo Rivera-Fuentes. It takes place every Tuesday at 16:15 unless otherwise indicated.

Upcoming Seminars


Past seminars

2021

Prof. Herbert Waldmann

Chemical Evolution of Natural Product Structure

21-09-202121-09-2021

With: Prof. Herbert Waldmann, Max Planck Insitute of Molecular Physiology
Online: https://epfl.zoom.us/j/62430541332
Category: Conferences – Seminars

Sliding, Pushing, Crashing: the Treacherous Pathways of Chromosome Replication in a Crowded World

11-05-202111-05-2021

With: Karl Duderstadt (MPI Biochemistry, München)
Online: https://epfl.zoom.us/j/88089196947
Category: Conferences – Seminars

Synthetic biology approaches to study and exploit RNA regulation

13-04-202113-04-2021

With: Prof Bryan Dickinson earned his B.S. in Biochemistry from the University of Maryland, College Park and his Ph.D. in Chemistry from the University of California at Berkeley for work performed with Professor Christopher Chang. His graduate work focused on the synthesis and application of small molecule fluorescent probes for the detection of hydrogen peroxide in living systems. Then, as a Jane Coffin Childs Memorial postdoctoral fellow with Professor David Liu at Harvard University, he developed new methods to rapidly evolve proteins to perform novel functions. Bryan joined the faculty at the University of Chicago in the Department of Chemistry in the Summer of 2014 and is a member of the University of Chicago Comprehensive Cancer Center. He was promoted to Associate Professor in 2019. The Dickinson Group employs synthetic organic chemistry, molecular evolution, and protein design to develop molecular technologies to study chemistry in living systems. The group’s current primary research interests include: 1) how lipid modifications on proteins are controlled and regulate cell signaling, 2) developing new evolution technologies to reprogram and control biomolecular interactions, and 3) engineering systems to understand and exploit epitranscriptomic, RNA regulation. The motivating principle of the Dickinson Group is that our ability as chemists to create functional molecules through both rational and evolutionary approaches will lead to new breakthroughs in biology and biotechnology.
Online: https://epfl.zoom.us/j/82539880760
Category: Conferences – Seminars

NLRP1 inflammasome Activation

23-03-202123-03-2021

With: Dr. Daniel Bachovchin is an Assistant Professor in the Chemical Biology Program at the Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center. His lab uses chemical and cell biology approaches to study proteins and pathways involved in innate immunity, in particular inflammasomes. Dr. Bachovchin received his Ph.D. in 2011 from The Scripps Research Institute under the guidance of Dr. Benjamin F. Cravatt.  From 2011-2015, Dr. Bachovchin was a postdoctoral fellow in Dr. Todd Golub’s laboratory at The Broad Institute.       
Online: https://epfl.zoom.us/j/85636008530
Category: Conferences – Seminars

Understand the anti-cancer STING pathway and harness it to treat metastatic cancers

09-03-202109-03-2021

With:  Dr. Lingyin Li is an assistant professor in the Biochemistry Department at Stanford School of Medicine. She is also a fellow at the Stanford ChEM-H institute. She was born in 1981 in Xi’an, the ancient capital city of China for many of the most important dynasties in the Chinese history and also where the terracotta warriors were uncovered. As a teenager, she was fascinated by Chinese history and literature until her sixth-grade math teacher one day remarked: literature is for girls and math is for boys. At a rebellious age, she shifted her focus to math, physics, and chemistry, and eventually attended University of Science and Technology of China. There she majored in Polymer Physics in the Chemistry and Chemical Engineering Institute and earned a bachelor of engineering degree in 2003.
Category: Conferences – Seminars

Using Chemistry to Understand the O-GlcNAc Posttranslational Modification

16-02-202116-02-2021

With: Prof. Matthew Pratt (USC)
Online: https://epfl.zoom.us/j/81548074478
Category: Conferences – Seminars


2020

Unravelling the poly(ADP-ribose) code: How the structural diversity of the post-translational modification poly(ADP-ribose) affects biochemical and biological processes

15-12-202015-12-2020

With: Prof. Aswin Mangerich (Universität Konstanz)
Online: https://epfl.zoom.us/j/83488461124
Category: Conferences – Seminars

Integrative dynamic structural biology of biomolecular assemblies resolved by multi-scale super-resolution FRET spectroscopy and imaging

24-11-202024-11-2020

With: Claus A.M. Seidel (Heinrich Heine University, Germany)
Online: https://epfl.zoom.us/j/81648589177
Category: Conferences – Seminars

Thiol-based Redox Signaling

13-10-202013-10-2020

With: Prof. Tobias P. Dick (DKFZ, Heidelberg)
Place and room: ZOOM- Reg. Mandatory
Category: Conferences – Seminars

Harnessing massive peptide libraries to explore the inhibition of epigenetic drug targets

30-06-202030-06-2020

With: Prof. Louise Walport
Category: Conferences – Seminars

Enabling Technologies for the Green Synthesis of Pharmaceutical Agents

09-06-202009-06-2020

With: Dr. Rebecca Ruck Dr. Rebecca T. Ruck joined Merck Research Laboratories, Process Research & Development in 2005 and is currently Executive Director of Enabling Technologies, PR&D in Rahway, NJ. Her team is tasked with leveraging its expertise in areas such as Catalysis, Biotechnology and Flow Chemistry to enable processes for APIs in the MSD pipeline and developing new capabilities that will allow us to continue to do so into the future. Becky previously served as Director of three different teams: Process Chemistry, Catalysis & Automation and Discovery Process Chemistry. Over the course of her career, Becky and her team have impacted projects across a range of therapeutic areas, including beta-lactamase inhibitors, hepatitis C and diabetes.   Becky earned her A.B. summa cum laude from Princeton University in 1998. She received a Ph.D. from Harvard University in 2003, where she was an NSF Fellow in the research group of Professor Eric Jacobsen. Following graduate studies, Becky served as an NIH post-doctoral fellow in the lab of Professor Robert Bergman at the University of California, Berkeley. She has a real passion for driving Women in Chemistry activities and was named the 2018 winner of the ACS Award for Encouraging Women into Careers in the Chemical Sciences.  
Place and room: Zoom
Category: Conferences – Seminars

The power of chemoselectivity : Functional protein-conjugates for extra- and intracellular targeting

09-03-202009-03-2020

With: Prof. Christian Hackenberger, (FMP Berlin)
Place and room: CH G1 495
Category: Conferences – Seminars


2019

Reprogramming the reactivity of iron in cancer

15-10-201915-10-2019

With: Raphaël Rodriguez
Place and room: BCH 2201
Category: Conferences – Seminars

Redox signaling mechanisms under infection conditions and antibiotics in the major pathogen Staphylococcus aureus

01-10-201901-10-2019

With: Prof. Haike Antelmann
Place and room: BCH 2201
Category: Conferences – Seminars

NMR-based tools for structural biology in gels and cells

20-09-201920-09-2019

With: Prof. Galia Debelouchina, UCSD – University of California San Diego
Place and room: BCH 3303
Category: Conferences – Seminars

A cyclic peptide toolkit to modulate PADI4 activity

03-07-201903-07-2019

With: Dr. Louise Walport
Place and room: BCH 5310
Category: Conferences – Seminars

Dr. Daniel Obrecht

Protein Epitope Mimetics: from Discovery to the Clinic

02-07-201902-07-2019

With: Dr. Daniel Obrecht, CSO Polyphor
Place and room: CH G1 495
Category: Conferences – Seminars

Roles of ZRANB3 in replication stress response

07-05-201907-05-2019

With: Professor Dragana Ahel  (University of Oxford)
Place and room: SV 1717
Category: Conferences – Seminars

Adventures in Targeting Protein Lipdation: Breaking Drug Resistance Using Chemical Biology

09-04-201909-04-2019

With: Prof. Edward Tate (Imperial College London)
Place and room: CH G1 495
Category: Conferences – Seminars

Dynamic chaperone–client-interactions characterized at atomic resolution

09-04-201909-04-2019

With: Prof. Sebastian Hiller (University of Basel)
Place and room: CH G1 495
Category: Conferences – Seminars

dNTPs and maintenance of genome stability

26-02-201926-02-2019

With: Professor Andrei Chabes Dept. of Medical Biochemistry and Biophysics Umeå University SE 901 87 Umeå Sweden Phone: +46 73 620 5446 
Place and room: BCH 2218
Category: Conferences – Seminars

Developing small molecule catalysts for chemical protein degradation

19-02-201919-02-2019

With: Prof. Dennis Gillingham
Place and room: BCH 3118
Category: Conferences – Seminars


2018

Prof. Patrick Barth

Inaugural lecture // Membrane Proteins: from Structure Prediction to Designing Novel Functions

06-12-201806-12-2018

With: Prof. Patrick Barth, Institute of Bioengineering, EPFL
Place and room: SV 1717
Category: Inaugural lectures – Honorary Lecture

Activation of transcription factor Nrf2 as a strategy to restore the cellular redox and protein homeostasis

04-12-201804-12-2018

With: Albena T. Dinkova-Kostova
Place and room: BCH 2201
Category: Conferences – Seminars

The CRL4 ubiquitin ligase: at the intersection of genome stability and drug discover

23-10-201823-10-2018

With: Prof. Nicolas Thomä, FMI Basel, Switzerland
Place and room: BCH 2201
Category: Conferences – Seminars

Ubiquitin E3 ligase activity-based profiling: from Parkin to the impalpable

16-10-201816-10-2018

With: Prof. Satpal Virdee (University of Dundee)
Place and room: BCH 2218
Category: Conferences – Seminars

Peptides and Peptidomimetics for Selective Anion Recognition in Aqueous Solution

02-10-201802-10-2018

With: Prof. Kate Jolliffe, (The University of Sydney, Australia)
Place and room: BCH 3118
Category: Conferences – Seminars

Genetic code expansion for temporal controlled labeling of endogenous expressed proteins

05-09-201805-09-2018

With: Prof. Matthias Meier, Helmholtz Zentrum, Muenchen
Place and room: BCH 4310
Category: Conferences – Seminars

Transcriptional control in time and space

10-07-201810-07-2018

With: Nadine L. Vastenhouw (MPI Molecular Cell Biology and Genetics – Germany)
Place and room: SV 1717
Category: Conferences – Seminars

PROTAC-mediated Protein Degradation: The chemical equivalent of siRNA

21-06-201821-06-2018

With: Prof. Craig Crews, Yale University
Place and room: BCH 2218
Category: Conferences – Seminars

"Protein Self-Assembly by Chemical Design"

20-06-201820-06-2018

With: Akif Tezcan, UCSD
Place and room: BCH 3118
Category: Conferences – Seminars

Expanding the Genetic Code – Chemistry in Living Systems

15-05-201815-05-2018

With: Prof. Kathrin Lang (TU Munich)
Place and room: BCH 2218
Category: Conferences – Seminars

Engineering Chromatin States Towards Understanding Epigenetic Regulation

16-03-201816-03-2018

With: Prof.Yael David MSKCC, New York
Place and room: BCH 2218
Category: Conferences – Seminars


2017

Decoding chromatin modification states using chemical biology and proteomic approaches

12-12-201712-12-2017

With: Prof. Till Bartke,   Institute of Functional Epigenetics Helmholtz Zentrum München
Place and room: BCH 5310
Category: Conferences – Seminars

Selective chemical intervention on protein-protein interactions: from inhibitors to degraders

17-10-201717-10-2017

With: Prof. Alessio Ciulli, University of Dundee
Place and room: BCH 2218
Category: Conferences – Seminars

Peptide‐based probes for lysine deacetylases

20-09-201720-09-2017

With: Prof. Dirk Schwarzer, Universität Tübingen
Place and room: BCH 2218
Category: Conferences – Seminars

Molecular mechanisms of epigenetic regulation

11-09-201711-09-2017

With: Prof. Tatiana Kutateladze Department of Pharmacology University of Colorado School of Medicine, Aurora, Colorado, USA
Place and room: SV1717.A
Category: Conferences – Seminars

X-Ray Crystal Structure of a Chromatosome—the Fundamental Nucleosome-Linker Histone Assembly of Chromatin

22-06-201722-06-2017

With: Prof. Curtis Davey (NTU – Singapore)
Place and room: CH G1 495
Category: Conferences – Seminars

An iron hand over cancer stem cells

27-04-201727-04-2017

With: Prof. Raphael Rodriguez, Institut Curie, Paris
Place and room: BCH 2218
Category: Conferences – Seminars

Probing unfolded and intrinsically disordered proteins with single-molecule spectroscopy

06-04-201706-04-2017

With: Prof. Ben Schuler, University of Zurich
Place and room: BCH 2218
Category: Conferences – Seminars

EPIGENETIC REGULATION OF CHROMATIN DYNAMICS

20-01-201720-01-2017

With: Prof. Michael Poirier, Ohio Stat University
Place and room: CH G1 495
Category: Conferences – Seminars

The power of chemoselectivity: Functional protein-conjugates for proteomic and pharmaceutical research

19-01-201719-01-2017

With: Prof. Christian Hackenberger, Humboldt Universität zu Berlin and Leibniz-Institut für Molekulare Pharmakologie (FMP) –  Berlin
Place and room: CH G1 495
Category: Conferences – Seminars