MS Equipment

List of Mass Spectrometers

LTQ Orbitrap ELITE ETD (Thermo fisher)

The Orbitrap Elite combines the high-field OrbitrapTM mass analyzer with the dual pressure linear ion trap and achieves routinely high resolution (>100,000) and high mass accuracy (∼2 ppm). It enables multiple fragmentation techniques such as CID, HCD and ETD. It is equipped with the standard ESI (H-ESI II) and the nanoESI (nanoSpray Flex Ion) sources, as well as the nanochiped-based ESI system Advion TriVera Nanomate®.  It is interfaced with a nanoUPLC Ultimate 3000 system (Dionex) for LC-MS and LC-MSn experiments.

Orbitrap Q Exactive HF (Thermo Fisher)

orbitrap

The Q Exactive HF system combines a segmented quadrupole for high-performance precursor ion selection with a high-resolution, accurate-mass (HR/AM) ultra-high-field Orbitrap mass analyzer. This instrument achieves routinely high resolution (>100,000) and high mass accuracy (∼2 ppm) with HCD fragmentation capabilities. It is equipped with the standard ESI (H-ESI II) source and interfaced with a UPLC Ultimate 3000 system (Dionex) for LC-MS and LC-MSn experiments. In addition, with the Protein Mode and BioPharma options as well as extended quadrupole mass range, this instrument is ideal for Native MS and Top-Down Proteomics experiments.

MALDI-TOF/TOF AutoFlex Speed (Bruker)

Maldi-tof autoflex

The MALDI-TOF AutoFlex speed has advanced performances for a broad range of applications. The instrument can be operated in reflector and linear modes (up to 100 kDa for intact proteins and large molecules such as polymers), as well as TOF/TOF tandem mass spectrometry. Its SmartbeamTM-II 2 kHtz laser and system electronics allow intensive and high throughput applications. This is an open-access instrument (training required) well suited for analysis of peptides and proteins, as well as small organic components, organometallics, nucleic acids, sugars and polymers.

Xevo G2-S QTOF (Waters)

The Xevo® G2-S QTof is equipped with the StepWave™ ion optics to achieve high sensitivity levels and the QuanTof™ technology for high mass resolution, matrix-tolerant high dynamic range, quantitative performance, mass accuracy and speed of analysis. The mass analyzer is interfaced with Acquity UPLCpumps and sample manager systems. UPLC-MS and MS/MS can be acquired using the UPLC/MSE data acquisition or Fast Data Directed Analysis (FastDDA) modes, depending on the application. The instrument is equipped with the multi-ionization ESI-APCI source, as well as the APPI source.

6530 Accurate-Mass Q-TOF LC/MS (Agilent Technologies)

The 6530 Q-TOF incorporates the Agilent Jet Stream thermal gradient focusing technology, which dramatically improves the sensitivity. Its TOF technology delivers high mass accuracy (< 5ppm), resolution (20,000 not dependent on spectral acquisition rate) and dynamic range. It can be operated in a broad mass range mode (m/z 25 to 20,000). The instrument is interfaced with Agilent 1290 Infinite UHPLC modules and equipped with the Dual Jetstream ESI source.

LCQFleet (Thermo fisher)

LCQFleet

The LCQFleet Ion Trap mass spectrometer provides high sensitivity MS at fast cycle time measurements, and a fast positive/negative switching ionization mode. The instrument can be operated in Full-scan MS/MS mode, in Selected Reaction Monitoring (SRM) for quantitative experiments and MSn for multi-stage MS experiments to probe the structure of ions. The LCQFleet is equipped with the Ion Max-S API source and interfaced with a Dionex Ultimate 3000 UPLC system. This is an open-access instrument (training required).

TSQ8000 Triple Quadrupole GC-MS/MS (Thermo Fisher)

TSQ8000

The TSQ8000 Triple Quadrupole GC-MS/MS instrument is paired with the Thermo scientific TRACE 1300 GC and the autosampler AI1310. The Triple quadrupole can work in Full scan, SIM, SRM and product ion-scan modes. It offers an extractable EI ion source with a vacuum probe interlock to remove entire source without venting. The mass range is 1.2-1200 m/z, and Electron Energy of the source is adjustable from 0 to 150 eV. Data are processed using XCalibur and TraceFinder Software for GC-MS quantification, as well as the NIST and MassFinder libraries for compound identification.

The TRACE 1300 GC is routinely equipped with a Capillary column VF-5ms suitable for a wide range of applications. The instrument is interfaced with the TriPlus RSH Autosampler for both liquid and Head-space injections.

ICP-MS NexIon 350 (Perkin Elmer)

icp-ms

The NexION® 350D inductively coupled plasma mass spectrometer features a dual-channel Universal Cell and the Dynamic Reaction Cell™ technology, giving the flexibility to choose Kinetic Energy Discrimination (KED) and/or use a scanning quadrupole in the Dynamic Reaction Cell. The instrument provides enhanced sensitivity (down to low ppt level for certain metals) and allows both precise quantitative and semiquantitative (screening mode) analysis of various metals.