Laboratory of Proteostasis and Molecular Therapeutics (LPMT)
Prof. Zuzanna KOZICKA
We study how cells control protein fate – and how these mechanisms can be rewired for therapeutic benefit. Working at the interface of chemistry and biology, we use chemical perturbations alongside biochemistry, structural biology, cell-based approaches, and genetic screens to dissect proteostasis pathways. A central focus of the lab is understanding how small molecules modulate protein–protein interactions, including through strategies such as targeted protein degradation
Laboratory of Biomolecular Engineering and Nanomedicine (LIBN)
Prof. Angela STEINAUER
We harness protein design and directed evolution to engineer minimal mRNA nanocarriers for precise and efficient delivery. We start with candidate proteins that naturally assemble into capsids, then refine and evolve their properties to package and protect RNA, enable cell-specific targeting, drive endosomal escape, and support robust cytosolic translation. By integrating fundamental insights with advanced chemical biology methods, we aim to develop next-generation protein-based solutions for RNA therapeutics.
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Laboratory of Organometallic and Medicinal Chemistry (LCOM),
Prof. Paul J. DYSON
Biphasic catalysis in water and ionic liquids. Design of ruthenium anticancer compounds. Transition metal clusters in novel synthesis and catalysis.
Laboratory of Biophysical Chemistry of Macromolecules (LCBM),
Prof. Beat FIERZ
Investigation of the structure, dynamics and function of chromatin in vitro and in vivo. Development of spectroscopic methods to investigate the dynamics of large macromolecular assemblies. Biophysical chemistry of protein-protein and protein-DNA interactions. Synthetic protein chemistry and protein engineering.
Group for Functionalized Biomaterials (GBF)
Prof. Sandrine GERBER
Organic synthesis, Targeting ligands for cancer cell biomarkers, Chemical functionalization of bioceramics, Coating and post-functionalization of metal oxide imaging nanoparticles, Polymer modification and characterization, Hydrogel microspheres for cell immobilization.
Laboratory of Therapeutic Proteins and Peptides (LPPT)
Prof. Christian HEINIS
Generation of new molecule designs for the use in therapy. Testing the therapeutic potential of the newly developed chemical structures.
Laboratory of Stem Cell Bioengineering (LSCB)
Prof. Matthias LUTOLF
Our work is at the interface of stem cell biology, soft matter engineering and micro-engineering to elucidate how stem cells take decisions and how their decision-making process is influenced by signals from the microenvironment.