Polina Shichkova

Molecular Systems, Simulation Neuroscience

Polina Shichkova is a PhD student in the Molecular Systems group within the Simulation Neuroscience division.

She focuses on detailed data driven reconstruction and simulation of the neuron-glia-vasculature metabolism coupled to electrical activity of the neurons.

Polina has a BSc and MSc in Applied Mathematics and Physics from Moscow Institute of Physics and Technology, Moscow, Russia. In addition, she has an MSc in Biotechnology from the Skolkovo Institute of Science and Technology, Moscow, Russia.

Polina’s projects during her studies were related to bioinformatics, systems biology and rational drug design. She also worked on molecular modeling for biological visualization of CRISPR-Cas systems in a joint project between Skolkovo Institute of Science and Technology and Visual Science company.

In 2017, at the Hackathon LauzHack Lausanne she was part of the team that won the SGS challenge; in 2019, at Swiss Blockchain Hackathon Zurich she was part of the team that won Finance challenge.

In her spare time, she enjoys dance (especially ballet), drawing, piano, rock climbing, yoga and snowboarding.

Publications

A Standardized Brain Molecular Atlas: A Resource for Systems Modeling and Simulation. Shichkova P, Coggan JS, Markram H, Keller D. Front Mol Neurosci. 2021 Nov 10;14:604559. doi: 10.3389/fnmol.2021.604559. eCollection 2021. PMID: 34858137  https://www.frontiersin.org/articles/10.3389/fnmol.2021.604559/full

Metabolome signature of autism in the human prefrontal cortex. Kurochkin I, Khrameeva E, Tkachev A, Stepanova V, Vanyushkina A, Stekolshchikova E, Li Q, Zubkov D, Shichkova P, Halene T, Willmitzer L, Giavalisco P, Akbarian S, Khaitovich P. Commun Biol. 2019 Jun 21;2:234. doi: 10.1038/s42003-019-0485-4. eCollection 2019. PMID: 31263778  https://www.nature.com/articles/s42003-019-0485-4

Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex. Colangelo C, Shichkova P, Keller D, Markram H, Ramaswamy S. Front Neural Circuits. 2019 Apr 12;13:24. doi: 10.3389/fncir.2019.00024. eCollection 2019. PMID: 31031601 Review. https://www.frontiersin.org/articles/10.3389/fncir.2019.00024/full

Anti-leprosy drug clofazimine inhibits growth of triple-negative breast cancer cells via inhibition of canonical Wnt signaling. Koval AV, Vlasov P, Shichkova P, Khunderyakova S, Markov Y, Panchenko J, Volodina A, Kondrashov FA, Katanaev VL. Biochem Pharmacol. 2014 Feb 15;87(4):571-8. doi: 10.1016/j.bcp.2013.12.007. PMID: 24355563 https://www.sciencedirect.com/science/article/pii/S0006295213007600?via%3Dihub

Biorxiv: Genomic analysis of human polymorphisms affecting drug-protein interactions. O Pich i Rosello, AV Vlasova, PA Shichkova, Y Markov, PK Vlasov, FA Kondrashov 2017 Biorxiv https://www.biorxiv.org/content/10.1101/119933v1