Our group is driven by the passion of discovering new reactivity in organic chemistry, especially using catalysis. Basing on high energy molecules, such as strained rings or cyclic hypervalent iodine reagents for electrophilic alkynylation and other transformations, we develop non-conventional bond disconnections for the synthesis of important building blocks and bioactive molecules, as well as the modification of biomolecules . We also control the regioselective functionalization of alkenes and alkynes using in situ tethering approaches. Regular group meetings and seminars allow us to share and enhance our knowledge and love of organic chemistry.
(Only complete applications following the guidelines will be considered!)
December 31: The last work of Julien and Guillaume on the copper-catalyzed oxyalkynylation of thiiranes is now accepted in Organic Letters (DOI: 10.1021/acs.orglett.9b04157)!
December 24: Our ultimate synthesis of TIPS-EBX with process and product safety studies performed by Merck has now been published in Organic Process Research and Development (DOI: 10.1021/acs.oprd.9b00498)!
December 19: Good bye party for Javier who is leaving the group after more than 2.5 years of postdoc: Good luck for your future outside LCSO.
December 16: The Swiss State has awarded 17 million Swiss Francs to the project suchcat (Sustainable Processes Through Catalysis) with Jerome as co-director!
December 13: The LCSO Christmas party has taken place at the Royal Savoy: 30 current and past LCSO members to celebrate also Jerome’s promotion to full professor.
December 13: Elija has successfully passed her first year candidacy exam. Congrat!
December 10: Raphael has received a teaching excellence award for his contribution to a new service course in organic chemistry. Congratulation!
December 4: Franck Le Vaillant has received the special “top 8%” distinction for his PhD thesis. Congratulation!
November 21: The work of Franck and Marion in collaboration with the Corminboeuf lab on fragmentation-alkynylation cascades has been included in the personal choice of associate editor Paolo Melchiorre at Chemical Science .
October 18: The last work of Bastian and Alec on the synthesis of bicyclo[3.1.0]hexanes has been included in the hot article collection in Chemical Science (DOI: 10.1039/C9SC03790J ).
October 10: The artwork of Franck and Paola for the review of Franck on “somophilic” alkynylation has been selected for the back cover in Chemical Science (DOI: 10.1039/C9SC90218J).
October 8: The last work of Bastian and Alec on the synthesis of bicyclo[3.1.0]hexanes by (3+2) annulation of cyclopropenes with aminocyclopropanes is now accepted in Chemical Science (DOI: 10.1039/C9SC03790J )!
September 24: Nina and Eliott
have successfully passed their first year candidacy exam. Congrat!
September 21: The work on doubly orthogonal cysteine labelling by Romain, Javier and Raphael together with Nora in Fierz group has been highlighted in Synfacts (DOI: 10.1055/s-0039-1690936).
September 17: The group is growing! This month Mikus and Julien joined LCSO as PhD students and Seongmin as visiting master student. Welcome!
September 14-15: Active participation of the LCSO members to the Open Days of EPFL.
September 7: Raphael has received the runner-up poster award in the chemical biology section at the SCS Fall meeting: Congrat!
September 5: Our preview on the great work of the Powers group on the mechanism of aerobic oxidation of organic iodines is now online in CHEM (DOI: 10.1016/j.chempr.2019.08.005 ).
August 28: Traditional Summer Group Outing! We visited the Vallorbe Caves, Jurapark and the Lac de Joux. Here some pictures: Group Outings
August 13: The review of Franck on the the “Third Way” to transfer triple bonds has been published in Chemical Science(DOI: 10.1039/C9SC03033F ).
July 18: Bastian has won one of the the Royal Society of Chemistry Poster Prizes at the ESOC conference. Congratulations!
July 18: Small rings strike again! The work of Mingming on the 1,3-Difunctionalization of aminocyclopropanes has been accepted in Angew. Chem. Int. Ed. (DOI: 10.1002/anie.201907060 ).
July 11: Jerome has been promoted to full professor by the ETH board!
July 5: Start of the move of the LCSO labs to the temporary laboratories at the first floor for renovation.
July 2: The work of Romain, Javier and Raphael, in collaboration with Prof. Fierz on the use of EBX reagents for the labeling of peptides and proteins has been accepted in Chem . Congratulations! (DOI: 10.1016/j.chempr.2019.06.022 ).
July 2: The work of Marion on photoredox-catalyzed decarboxylative alkynylation of peptides has been highlighted as Synfacts of the month by Yamamoto and Wu in the category peptide chemistry! (DOI: 10.1055/s-0039-1689776 ).