Welcome to LCSO!

Synthesis of metal complexes, ligands, and organocatalysts. New catalytic reactions for C-C bond formation. Investigation of reactions mechanism. Synthesis of complex bioactive compounds.

Our group is driven by the passion of discovering new reactivity in organic chemistry, especially using catalysis. Basing on high energy molecules, such as strained rings or cyclic hypervalent iodine reagents for electrophilic alkynylation and other transformations, we develop non-conventional bond disconnections for the synthesis of important building blocks and bioactive molecules, as well as the modification of biomolecules . We also control the regioselective functionalization of alkenes and alkynes using in situ tethering approaches. Regular group meetings and seminars allow us to share and enhance our knowledge and love of organic chemistry.


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Latest News

October 18: The last work of Bastian and Alec on the synthesis of bicyclo[3.1.0]hexanes has been included in the hot article collection in Chemical Science (DOI: 10.1039/C9SC03790J ).

October 10: The artwork of Franck and Paola for the review of Franck on “somophilic” alkynylation has been selected for the back cover in Chemical Science (DOI: 10.1039/C9SC90218J).

October 8: The last work of Bastian and Alec on the synthesis of bicyclo[3.1.0]hexanes by (3+2) annulation of cyclopropenes with aminocyclopropanes is now accepted in Chemical Science (DOI: 10.1039/C9SC03790J )!

September 24: Nina and Eliott have successfully passed their first year candidacy exam. Congrat!

September 21: The work on doubly orthogonal cysteine labelling by Romain, Javier and Raphael together with Nora in Fierz group has been highlighted in Synfacts (DOI: 10.1055/s-0039-1690936).

September 17: The group is growing! This month Mikus and Julien joined LCSO as PhD students and Seongmin as visiting master student. Welcome!

September 14-15: Active participation of the LCSO members to the Open Days of EPFL.

September 7: Raphael has received the runner-up poster award in the chemical biology section at the SCS Fall meeting: Congrat!

September 5: Our preview on the great work of the Powers group on the mechanism of aerobic oxidation of organic iodines is now online in CHEM (DOI: 10.1016/j.chempr.2019.08.005 ).

August 28: Traditional Summer Group Outing! We visited the Vallorbe Caves, Jurapark and the Lac de Joux. Here some pictures: Group Outings

August 13: The review of Franck on the the “Third Way” to transfer triple bonds has been published in Chemical Science(DOI: 10.1039/C9SC03033F ).

July 18: Bastian has won one of the the Royal Society of Chemistry Poster Prizes at the ESOC conference. Congratulations!

July 18: Small rings strike again! The work of Mingming on the 1,3-Difunctionalization of aminocyclopropanes has been accepted in Angew. Chem. Int. Ed. (DOI: 10.1002/anie.201907060 ).

July 11: Jerome has been promoted to full professor by the ETH board!

July 5: Start of the move of the LCSO labs to the temporary laboratories at the first floor for renovation.

July 2: The work of Romain, Javier and Raphael, in collaboration with Prof. Fierz on the use of EBX reagents for the labeling of peptides and proteins has been accepted in Chem . Congratulations! (DOI: 10.1016/j.chempr.2019.06.022 ).

July 2: The work of Marion on photoredox-catalyzed decarboxylative alkynylation of peptides has been highlighted as Synfacts of the month by Yamamoto and Wu in the category peptide chemistry! (DOI: 10.1055/s-0039-1689776 ).

June 13: Waser Group @LcsoLab has now 1000 followers. Thanks for following us!

May 17: Paola Caramenti successfully defended her PhD thesis. She is the thirteenth PhD student to obtain her degree at LCSO. Congratulations! She will now join the group of Prof. Alois Fürstner at MPI Mülheim as a SNF postdoctoral fellow.

May 5: The work of Phill on the use of carbonate salts as CO2 source in the palladium-catalyzed carboxy alkynylation of propargyl amines has been accepted in Eur. JOC . Congratulations! (DOI: 10.1002/ejoc.201900500 ).

April 18: The paper by Marion and Franck on the C-Terminal Bioconjugation of Peptides through Photoredox Decarboxylative Alkynyation has been accepted in Angew. Chem.  Congratulations! (DOI: 10.1002/anie.201901922 ).

March 27: The preprint of the work of Guillaume of on the copper-catalyzed vinylation of diazo compounds with vinylbenziodoxolones (VBX) reagents is now available on ChemRxiv (DOI: 10.26434/chemrxiv.7892513.v1 ).

March 18: The new traditional (Spring group photo ) of LCSO members is now available.

March 1: Dr. Vincent Pirenne from the group of Yannick Landais at the University of Bordeaux joins LCSO for his postdoc. Welcome!

February 22: Franck Le Vaillant successfully defended his PhD thesis. He is the twelvth PhD student to obtain his degree at LCSO. Congratulations!

February 12: Paola and Nina’s publication has been chosen as a hot article by Chemical Science!

February 8: The work of Stephanie on the synthesis of alkynyl sulfoxides with EBX reagents is now accepted in J. Org. Chem. (DOI: 10.1021/acs.joc.9b00050 ).

February 8: Julien Borrel from CPE Lyon has now started his master work at LCSO with an ISIC master grant.

February 4: The work of Paola and Nina on new reagents for the Umpolung of enamides is now accepted in Chem. Sci. (DOI: 10.1039/C8SC05573D ).

January 25: Romain Tessier successfully defended his PhD thesis. He is the eleventh PhD student to obtain his degree at LCSO. Congratulations!

January 15: LCSO has now two new members! Warm welcome to Elija who is starting her PhD, and to Luca who is starting a postdoctoral fellow.

January 8: The work of Phill and Erwann on the tethered functionalization of propargylic amines is now accepted in Chem. Eur. J. (DOI: 10.1002/chem.201900020).

January 7: The work of Nina and Franck on the synthesis of hydantoins with hypervalent iodine reagents has been published in Org. Lett. (DOI: 10.1021/acs.orglett.8b03843). This is publication number 100 for Jerome!