Welcome to LCSO!

Synthesis of metal complexes, ligands, and organocatalysts. New catalytic reactions for C-C bond formation. Investigation of reactions mechanism. Synthesis of complex bioactive compounds.

Our group is driven by the passion of discovering new reactivity in organic chemistry, especially using catalysis. Basing on high energy molecules, such as strained rings or cyclic hypervalent iodine reagents for electrophilic alkynylation and other transformations, we develop non-conventional bond disconnections for the synthesis of important building blocks and bioactive molecules, as well as the modification of biomolecules . We also control the regioselective functionalization of alkenes and alkynes using in situ tethering approaches. Regular group meetings and seminars allow us to share and enhance our knowledge and love of organic chemistry.



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LCSO Synthesis Problems

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Latest News

October 14: The Organic chemistry seminars start again after a long COVID interruption.

October 6: Mael Djaid from EPFL and Jonas Dechent from LMU joined LCSO for their master internship and thesis respectively. Welcome!

September 24: Guillaume Pisella successfully defended his PhD thesis. He is the seventeenth PhD student to obtain their degree at LCSO. Congratulations!

September 22: Helena Sole joins the group for her master internship. Welcome!

September 15: New PhD students at LCSO: Emma Robert is back for her PhD and Yuji Kamei starts his PhD as a shared student with the Fierz group. Welcome!

September 10: The most successful SCS fall meeting ever for LCSO: Stephanie wins the award for the best oral presentation and Nina the runner-up poster prize!

September 5: Six LCSO members participated to the Swiss Summer School in catalysis and sustainable chemistry chaired by Jerome and Bill Morandi with the support of the SCS and NCCR catalysis .

August 26: It is now already the one year anniversary of the @LCSOJournalClub!

August 18: The work of Stephanie, Diana and Franck on photomediated deoxyalkynylation is now accepted in Angewandte Chemie (DOI: 10.1002/anie.202110257 ).

August 17: Alumni news: Dr. Luca Buzzetti former postdoc at LCSO has started to work as a R&D Lead Chemist at F.I.S. (Fabbrica Italiana Syntetici S.p.A). Congratulations!

August 3: The work of Ming-Ming and Tin on diamine synthesis via the diazidation of alkenes and strained ring has been published in the Journal of the American Chemical Society (DOI: 10.1021/jacs.1c06700).

August 2: Dr. Xiangdong Li joined LCSO for his postdoc after a postdoc in the Alcarazo Group. Welcome!

August 1: Alumni news: Dr. Romain Tessier former PhD at LCSO has started to work as a Scientist Discovery Chemist for Janssen. Congratulations!

July 16: Najung Lee from Cambridge University joined LCSO for her summer internship. Welcome!

July 15: The work of Nieves and Guillaume on copper-catalyzed multi-component reactions of EBX, diazo compounds and anilines is now accepted in the Journal of Organic Chemistry (DOI: 10.1021/acs.joc.1c01423).

July 9: The work of Stephanie, Diana and Franck on photomediated deoxyalkynylation is now available as a preprint on ChemRxiv (DOI: 10.33774/chemrxiv-2021-56f12 ).

July 7: Our collaborative work with the (Matile group) at the university of Geneva on EBX and EBZ reagents as inhibitors of thiol-mediated uptake has been accepted in Helvetica Chimica Acta (DOI: 110.1002/hlca.202100085).

June 25: The work of Vladyslav and Bastian on quinoline synthesis from cyclopropenes has been accepted in Organic Letters (DOI: 10.1021/acs.orglett.1c01775).

June 17: Our traditional MOM synthesis competition could finally take place together with the Cramer and the Zhu group. Congrats Cédric Fung (Cramer) and Stephanie for the best synthesis!

June 1: Dr. Thomas Rossolini joins LCSO for his postdoc after a PhD in the Dixon group. Welcome!

May 31: Dr. Luca Buzzetti leaves LCSO after 2.5 years: Good luck for your future Luca!

May 28: Bastian Muriel successfully defended his PhD thesis. He is the sixteenth PhD student to obtain their degree at LCSO. Congratulations!

May 27: The work of Abhaya, Romain and Durga on the first amphiphilic EBX reagents has been accepted in Angewandte Chemie (DOI: 10.1002/anie.202106458).

May 26: The work of Vincent and Emma on the activation of DA aminocyclopropanes has been chosen as “pick of the week” by Chemical Science (DOI: 10.1039/D1SC01127H).

May 12: The last results of Eliott and Matt in collaboration with the Magnier group on new N‐Heterocyclic Alkynyl hypervalent iodine reagents have appeared in Chemistry A European Journal (DOI: 10.1002/chem.202101475).

May 5: The last results of Vincent and Emma on the activation of DA aminocyclopropanes bearing a single ester group for annulation with indoles have appeared in Chemical Science (DOI: 10.1039/D1SC01127H).

April 8: Thanks to COVID we have the largest ever LCSO delegation participating to the online ACS Spring meeting with 5 group members giving an oral presentation!

March 28: Our Journal Club has now an independent twitter account: @LCSOJournalClub.

March 18: Alumni news: Former group postdoc Dr. Durga Hari has started his independent carrier as assistant professor at IISC Bangalore: Congratulations!

March 3: Alumni news: Former group member Dr. Florian de Nanteuil has now come back to EPFL to work as scientific collaborator at SwissCat+ Florian will certainly contribute greatly to this initiative!

March 3: The website and logo of the NCCR Catalysis have been launched today. Eight LCSO members participate to this major effort in catalysis in Switzerland supported by the Swiss National Science Foundation.

February 8: Welcome to Tin Nguyen, our new PhD student from the Ecole Polytechnique and Paris Sarclay University and Emma Robert, our new master student from Ecole Supérieure CPE Lyon.

January 15: The last results of Elija and Javier in collaboration with the Heinis group on new hypervalent iodine reagents for cys-cys and cys-lys peptide stapling have appeared in Angewandte Chemie (DOI: 10.1002/anie.202014511).

January 11: Welcome to Pierre Palamini, our new PhD student from the Ecole Normale Supérieure de Chime de Montpelier.

January 7: The last results of Eliott and Marion on the photoredox-catalyzed oxidative functionalization of small peptides have appeared in Chemical Science (DOI: 10.1039/D0SC06180H).

December 10: The first online LCSO Alumni meeting has taken place in replacement of the traditional Christmas dinner canceled due to COVID reasons.

December 3: Bastian Muriel has successfully passed his PhD exam. Congratulations!

November 21: The last results of Durga, Guillaume, Matt and Artem on a [4+2] annulation reaction with benzene proceeding at room temperature have appeared in Angewandte Chemie (DOI: 10.1002/anie.202012299).

November 18: The last results of Bastian on the reaction of azide radicals with cyclopropenes have appeared in Angewandte Chemie (DOI: 10.1002/anie.202013516).

November 12: Marion Garreau successfully defended her PhD thesis. She is the fifteenth PhD student to obtain their degree at LCSO. Congratulations!

November 12: Welcome to Diana Cavalli, our new PhD student from the University of Basel.

November 10: The personal account of Stefano, Ugo, Bastian, Phill, Luca and Mikus on palladium-catalyzed alkenes and alkynes functionalization has appeared in Synlett in the special issue dedicated to Prof. Trost (DOI: 10.1055/a-1308-0021).

November 10: The last results of Ming-Ming and Seongmin on annulation reaction of aminocyclopropanes have appeared in Organic Letters (DOI: 110.1021/acs.orglett.0c03528).

October 30: Luca has won a poster award at the online Industrial Chemistry Symposium. Congratulations!

October 30: The review of Nina and Guillaume on vinylbenziodoxolone (VBX) reagents has now appeared in Helvetica Chimica Acta in the special issue dedicated to Prof. Togni (DOI: 10.1002/hlca.202000191).

October 14: Marion Garreau has successfully passed her PhD exam. Congratulations!

October 3: The last results of Luca, Mikus and Phill on catalytically formed chiral auxiliaries for amino alcohol synthesis have now appeared in the Journal of the American Chemical Society (DOI: 10.1021/jacs.0c09177).