Welcome to LCSO!

Synthesis of metal complexes, ligands, and organocatalysts. New catalytic reactions for C-C bond formation. Investigation of reactions mechanism. Synthesis of complex bioactive compounds.

Our group is driven by the passion of discovering new reactivity in organic chemistry, especially using catalysis. Basing on high energy molecules, such as strained rings or cyclic hypervalent iodine reagents for electrophilic alkynylation and other transformations, we develop non-conventional bond disconnections for the synthesis of important building blocks and bioactive molecules, as well as the modification of biomolecules . We also control the regioselective functionalization of alkenes and alkynes using in situ tethering approaches. Regular group meetings and seminars allow us to share and enhance our knowledge and love of organic chemistry.


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Latest News

April 1: The first bilateral online group meeting of LCSO vith the Noel Group at TU Eindhoven has taken place.

April 1: The last work of Romain, Raj and Javier on ethynylation of cysteine is now accepted in Angewandte Chemie (DOI: 10.1002/anie.202002626). This was a highly successful collaboration with the Biofunctional Chemistry group at the University of Strasbourg and the Adibekian group at Scripps Florida.

March 31: The traditional LCSO Spring Group Photo this year unfortunately via Zoom due to COVID.

March 25: The first organic seminar online has taken place with Prof. Song Lin from Cornell University.

March 19: The last work of Guillaume and Alec on the three component reaction of alcohols, diazo compounds and EBX reagents is now accepted in Chemistry a European Journal (DOI: 10.1002/chem.202001317)!

March 16: Due to the expanding COVID-19 pandemics, LCSO labs are closed for an unknown time.

March 2: Congratulation to Dr. Franck Le Vaillant, former LCSO PhD, who has been selected to participate to the (Lindau Nobel Laureate meeting)!

February 7: Welcome to Dr. Emmanuelle Allouche our new postdoc joining from the (Charette group)!

January 22: Phill Greenwood has successfully passed his PhD exam: Congratulations!

January 13: Welcome to Dr. Abahya Mishra our new postdoc joining from the (Szpilman group)!

December 31: The last work of Julien and Guillaume on the copper-catalyzed oxyalkynylation of thiiranes is now accepted in Organic Letters (DOI: 10.1021/acs.orglett.9b04157)!

December 24: Our ultimate synthesis of TIPS-EBX with process and product safety studies performed by Merck has now been published in Organic Process Research and Development (DOI: 10.1021/acs.oprd.9b00498)!

December 19: Good bye party for Javier who is leaving the group after more than 2.5 years of postdoc: Good luck for your future outside LCSO.

December 16: The Swiss State has awarded 17 million Swiss Francs to the project suchcat (Sustainable Processes Through Catalysis) with Jerome as co-director!

December 13: The LCSO Christmas party has taken place at the Royal Savoy: 30 current and past LCSO members to celebrate also Jerome’s promotion to full professor.

December 13: Elija has successfully passed her first year candidacy exam. Congrat!

December 10: Raphael has received a teaching excellence award for his contribution to a new service course in organic chemistry. Congratulation!

December 4: Franck Le Vaillant has received the special “top 8%” distinction for his PhD thesis. Congratulation!

November 21: The work of Franck and Marion in collaboration with the Corminboeuf lab on fragmentation-alkynylation cascades has been included in the personal choice of associate editor Paolo Melchiorre at Chemical Science .

October 18: The last work of Bastian and Alec on the synthesis of bicyclo[3.1.0]hexanes has been included in the hot article collection in Chemical Science (DOI: 10.1039/C9SC03790J ).

October 10: The artwork of Franck and Paola for the review of Franck on “somophilic” alkynylation has been selected for the back cover in Chemical Science (DOI: 10.1039/C9SC90218J).

October 8: The last work of Bastian and Alec on the synthesis of bicyclo[3.1.0]hexanes by (3+2) annulation of cyclopropenes with aminocyclopropanes is now accepted in Chemical Science (DOI: 10.1039/C9SC03790J )!

September 24: Nina and Eliott have successfully passed their first year candidacy exam. Congrat!

September 21: The work on doubly orthogonal cysteine labelling by Romain, Javier and Raphael together with Nora in Fierz group has been highlighted in Synfacts (DOI: 10.1055/s-0039-1690936).

September 17: The group is growing! This month Mikus and Julien joined LCSO as PhD students and Seongmin as visiting master student. Welcome!

September 14-15: Active participation of the LCSO members to the Open Days of EPFL.

September 7: Raphael has received the runner-up poster award in the chemical biology section at the SCS Fall meeting: Congrat!

September 5: Our preview on the great work of the Powers group on the mechanism of aerobic oxidation of organic iodines is now online in CHEM (DOI: 10.1016/j.chempr.2019.08.005 ).

August 28: Traditional Summer Group Outing! We visited the Vallorbe Caves, Jurapark and the Lac de Joux. Here some pictures: Group Outings