Our group is driven by the passion of discovering new reactivity in organic chemistry, especially using catalysis. Basing on high energy molecules, such as strained rings or cyclic hypervalent iodine reagents for electrophilic alkynylation and other transformations, we develop non-conventional bond disconnections for the synthesis of important building blocks and bioactive molecules, as well as the modification of biomolecules . We also control the regioselective functionalization of alkenes and alkynes using in situ tethering approaches. Regular group meetings and seminars allow us to share and enhance our knowledge and love of organic chemistry.
(Only complete applications following the guidelines will be considered!)
May 12: The last results of Eliott and Matt in collaboration with the Magnier group on new N‐Heterocyclic Alkynyl hypervalent iodine reagents have appeared in Chemistry A European Journal (DOI: 10.1002/chem.202101475).
May 5: The last results of Vincent and Emma on the activation of DA aminocyclopropanes bearing a single ester group for annulation with indoles have appeared in Chemical Science (DOI: 10.1039/D1SC01127H).
April 8: Thanks to COVID we have the largest ever LCSO delegation participating to the online ACS Spring meeting with 5 group members giving an oral presentation!
March 28: Our Journal Club has now an independent twitter account: @LCSOJournalClub.
March 18: Alumni news: Former group postdoc Dr. Durga Hari has started his independent carrier as assistant professor at IISC Bangalore: Congratulations!
March 3: Alumni news: Former group member Dr. Florian de Nanteuil has now come back to EPFL to work as scientific collaborator at SwissCat+ Florian will certainly contribute greatly to this initiative!
March 3: The website and logo of the NCCR Catalysis have been launched today. Eight LCSO members participate to this major effort in catalysis in Switzerland supported by the Swiss National Science Foundation.
February 8: Welcome to Tin Nguyen, our new PhD student from the Ecole Polytechnique and Paris Sarclay University and Emma Robert, our new master student from Ecole Supérieure CPE Lyon.
January 15: The last results of Elija and Javier in collaboration with the Heinis group on new hypervalent iodine reagents for cys-cys and cys-lys peptide stapling have appeared in Angewandte Chemie (DOI: 10.1002/anie.202014511).
January 11: Welcome to Pierre Palamini, our new PhD student from the Ecole Normale Supérieure de Chime de Montpelier.
January 7: The last results of Eliott and Marion on the photoredox-catalyzed oxidative functionalization of small peptides have appeared in Chemical Science (DOI: 10.1039/D0SC06180H).
December 10: The first online LCSO Alumni meeting has taken place in replacement of the traditional Christmas dinner canceled due to COVID reasons.
December 3: Bastian Muriel has successfully passed his PhD exam. Congratulations!
November 21: The last results of Durga, Guillaume, Matt and Artem on a [4+2] annulation reaction with benzene proceeding at room temperature have appeared in Angewandte Chemie (DOI: 10.1002/anie.202012299).
November 18: The last results of Bastian on the reaction of azide radicals with cyclopropenes have appeared in Angewandte Chemie (DOI: 10.1002/anie.202013516).
November 12: Marion Garreau successfully defended her PhD thesis. She is the fifteenth PhD student to obtain their degree at LCSO. Congratulations!
November 12: Welcome to Diana Cavalli, our new PhD student from the University of Basel.
November 10: The personal account of Stefano, Ugo, Bastian, Phill, Luca and Mikus on palladium-catalyzed alkenes and alkynes functionalization has appeared in Synlett in the special issue dedicated to Prof. Trost (DOI: 10.1055/a-1308-0021).
November 10: The last results of Ming-Ming and Seongmin on annulation reaction of aminocyclopropanes have appeared in Organic Letters (DOI: 110.1021/acs.orglett.0c03528).
October 30: Luca has won a poster award at the online Industrial Chemistry Symposium. Congratulations!
October 30: The review of Nina and Guillaume on vinylbenziodoxolone (VBX) reagents has now appeared in Helvetica Chimica Acta in the special issue dedicated to Prof. Togni (DOI: 10.1002/hlca.202000191).
October 14: Marion Garreau has successfully passed her PhD exam. Congratulations!
October 3: The last results of Luca, Mikus and Phill on catalytically formed chiral auxiliaries for amino alcohol synthesis have now appeared in the Journal of the American Chemical Society (DOI: 10.1021/jacs.0c09177).