Our group is driven by the passion of discovering new reactivity in organic chemistry, especially using catalysis. Basing on high energy molecules, such as strained rings or cyclic hypervalent iodine reagents for electrophilic alkynylation and other transformations, we develop non-conventional bond disconnections for the synthesis of important building blocks and bioactive molecules, as well as the modification of biomolecules . We also control the regioselective functionalization of alkenes and alkynes using in situ tethering approaches. Regular group meetings and seminars allow us to share and enhance our knowledge and love of organic chemistry.
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Latest News
June 2: Elija Grinhagena successfully defended her PhD thesis. She is the twenty-fourth PhD student to obtain their degree at LCSO. Congratulations!
June 2: The last work of Nieves on enantioselective 3-component reactions of diazo compounds, EBx reagents and nucleophiles is now accepted in Angewandte Chemie (DOI: 10.1002/anie.202305776).
May 31: The last work of Mikus and Lucas on the synthesis of propargyl silane using a migratory Sonogashira reaction is now accepted in Chemical Communications (DOI: 10.1039/D3CC01847D).
May 3: Mikus and Julien won a ChemistryTravelAward 2023 from SCS and SCNAT. Congratulations!
April 30: @LcsoLab has now more than 10’000 followers on twitter!
April 29: LCSO participated to the EPFL Open Days: we hosted interested visitors from all generations.
April 19: The last work of Emma, Vincent and Matt on the annulation of aminocyclobutanes and indoles is now accepted in Angewandte Chemie (DOI: 10.1002/anie.202302420).
April 14: Nina Declas successfully defended her PhD thesis. She is the twenty-third PhD student to obtain their degree at LCSO. Congratulations!
April 13: A preprint of the work of Xingyu in collaboration with the Heinis group on the synthesis and use of the first Peptide-EBX reagents is now available on ChemRxiv (DOI: 10.26434/chemrxiv-2023-jskfd).
April 1: Elodie Delavictoire joins the group to do her master thesis with the support of an ISIC master grant. Welcome!
March 29: Nieves has won a runner up prize for her poster presentation at the NCCR Catalysis retreat. Congrats!
March 17: Tin has won a runner up prize for his poster presentation at the RSC Twitter conference. Congrats!
March 7: The LCSO winter group outing has taken place with hiking, Fondue and Tobogganing in Leysin.
February 14: The compilation of X-ray, MEP and NMR data on EBX reagents of our group is now available at Helvetica Chimica Acta (DOI: 10.1002/hlca.202200175).
February 9: Christine has passed her first year candidacy exam. Congrats!
January 30: A preprint of the work of Nieves on enantioselective three component reactions with diazo compounds and EBx reagents is now available on ChemRxiv (DOI: 10.26434/chemrxiv-2023-78fk0).
January 27: A preprint of the work of Tin and Andre on the photocatalyzed cycloaddition of cyclpropanes with alkynes, alkenes and bicyclobutanes is now available on ChemRxiv (DOI: 10.26434/chemrxiv-2023-s8j30).
January 24: Elija has passed her final PhD exam. Congrats!
January 20: Eliott Le Du successfully defended his PhD thesis. He is the twenty-second PhD student to obtain their degree at LCSO. Congratulations!
January 19: The review of Eliott on alkynylation with hypervalent iodine reagents is now accepted in Chemical Communications (DOI: 10.1039/D2CC06168F).
January 9: Prof. Mark Lautens has joined us for six weeks during his sabbatical!