Our group is driven by the passion of discovering new reactivity in organic chemistry, especially using catalysis. Basing on high energy molecules, such as strained rings or cyclic hypervalent iodine reagents for electrophilic alkynylation and other transformations, we develop non-conventional bond disconnections for the synthesis of important building blocks and bioactive molecules, as well as the modification of biomolecules . We also control the regioselective functionalization of alkenes and alkynes using in situ tethering approaches. Regular group meetings and seminars allow us to share and enhance our knowledge and love of organic chemistry.
(Only complete applications following the guidelines will be considered!)
October 11: Nieves is leaving the group after three years postdoc. Good luck for the future!
October 7: The last work of Pierre, Julien, Mael and Morgane on in situ generated Acyl-EBX reagents is now accepted in Organic Letters (DOI: 10.1021/acs.orglett.3c02869).
October 6: The yearly LCSO Alumni meeting has taken place in BCH 2201.
September 30: The last work of Nieves, Tobias and Xingyu on the improved synthesis of Bis(trifluoromethylated) EBx reagents is now accepted in Chem. Commun. (DOI: 10.1039/D3CC04525K).
September 26: Helena has successfully passed her candidacy exam. Congratulations!
September 25: Mikus has successfully passed his final PhD exam. Congratulations!
September 15: Josh Wu has started his PhD at LCSO. Welcome!
September 15: The last work of Abhaya and Stefano in collaboration with Ilias Koutsopetras in the Chaubet group at the University of Strasbourg on bioconjugation wiht EBZ reagents is now accepted in Chem. Eur. J. (DOI: 10.1002/chem.202302689).
September 14: The last work of Vladyslav on the synthesis of highly substituted cyclopropanes via a semipinacol rearrangement is now accepted in Organic Letters (DOI: 10.1021/acs.orglett.3c02543).
September 9: The last work of Pierre and Emmanuelle on the carboazidation of dehydroalanines using a iron catalyst is now accepted in Organic Letters (DOI: 10.1021/acs.orglett.3c02153).
September 7: Daphne Lucidarme has won a NCCR Catalysis Young Talents Fellowship to join LCSO for her master thesis. Congratulations!
August 25: Emma has won the award for the best poster presentation in organic chemistry at the SCS Fall meeting. Congratulations!
August 11: The last work of Julien on the azido-alkynylation of styrenes is now accepted in Chemical Science (DOI: 10.1039/D3SC03309K).
August 9: The LCSO Summer group outing has taken place at Stockhorn with several culinary stops.
August 8: A preprint of the work of Alexandre jointly with the Corminboeuf group on the use of linear models for bayesian optimization of bidentate ligands is now available on ChemRxiv (DOI: 10.26434/chemrxiv-2023-pknnt).
July 15: Welcome to our new group members: Najung Lee starting her PhD and Duncan Brownsey starting his postdoc!
July 3: The last work of Oleksandr on the photochemical [2+2] cycloaddition of alkynyl boronates is now accepted in Chem. Eur. J. (DOI: 10.1002/chem.202301650).
June 25: A strong LCSO delegation attended the ICHIC7 conference in Stockholm.
June 15: The last work of Xingyu on the development of peptide-EBX reagents and their use in thiol functionalization, photocatalyzed macrocyclization and binding studies with the Heinis group is now accepted in Angewandte Chemie (DOI: 10.1002/anie.202306036).
June 15: The last work of Tobias on the synthesis of heteroatom-substituted trifluoromethylated alkenes from VBXs is now accepted in Angewandte Chemie (DOI: 10.1002/anie.202306128).
June 2: Elija Grinhagena successfully defended her PhD thesis. She is the twenty-fourth PhD student to obtain their degree at LCSO. Congratulations!
June 2: The last work of Nieves on enantioselective 3-component reactions of diazo compounds, EBx reagents and nucleophiles is now accepted in Angewandte Chemie (DOI: 10.1002/anie.202305776).
May 31: The last work of Mikus and Lucas on the synthesis of propargyl silane using a migratory Sonogashira reaction is now accepted in Chemical Communications (DOI: 10.1039/D3CC01847D).
May 3: Mikus and Julien won a ChemistryTravelAward 2023 from SCS and SCNAT. Congratulations!
April 30: @LcsoLab has now more than 10’000 followers on twitter!
April 29: LCSO participated to the EPFL Open Days: we hosted interested visitors from all generations.
April 19: The last work of Emma, Vincent and Matt on the annulation of aminocyclobutanes and indoles is now accepted in Angewandte Chemie (DOI: 10.1002/anie.202302420).
April 14: Nina Declas successfully defended her PhD thesis. She is the twenty-third PhD student to obtain their degree at LCSO. Congratulations!
April 13: A preprint of the work of Xingyu in collaboration with the Heinis group on the synthesis and use of the first Peptide-EBX reagents is now available on ChemRxiv (DOI: 10.26434/chemrxiv-2023-jskfd).
April 1: Elodie Delavictoire joins the group to do her master thesis with the support of an ISIC master grant. Welcome!