Welcome to LCSO!

Synthesis of metal complexes, ligands, and organocatalysts. New catalytic reactions for C-C bond formation. Investigation of reactions mechanism. Synthesis of complex bioactive compounds.

Our group is driven by the passion of discovering new reactivity in organic chemistry, especially using catalysis. Basing on high energy molecules, such as strained rings or cyclic hypervalent iodine reagents for electrophilic alkynylation and other transformations, we develop non-conventional bond disconnections for the synthesis of important building blocks and bioactive molecules, as well as the modification of biomolecules . We also control the regioselective functionalization of alkenes and alkynes using in situ tethering approaches. Regular group meetings and seminars allow us to share and enhance our knowledge and love of organic chemistry.



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LCSO Synthesis Problems

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Latest News

January 3: Dr. Tobias Milzarek joins the group as Postdoc. Welcome!

November 26: Bastian Muriel has been awarded the top 8% PhD thesis distinction for EDCH in 2021. Congratulations!

October 21: The review of Emmanuelle and Elija onthe use of hypervalent iodine reagents for the modification of peptides and proteins is now accepted in Angewandte Chemie (DOI: 10.1002/anie.202112287 ).

October 21: Our Full LCSO Brain Storming Session has taken place again after cancellation last year due to COVID.

October 14: The Organic chemistry seminars start again after a long COVID interruption.

October 6: Mael Djaid from EPFL and Jonas Dechent from LMU joined LCSO for their master internship and thesis respectively. Welcome!

September 24: Guillaume Pisella successfully defended his PhD thesis. He is the seventeenth PhD student to obtain their degree at LCSO. Congratulations!

September 22: Helena Sole joins the group for her master internship. Welcome!

September 15: New PhD students at LCSO: Emma Robert is back for her PhD and Yuji Kamei starts his PhD as a shared student with the Fierz group. Welcome!

September 10: The most successful SCS fall meeting ever for LCSO: Stephanie wins the award for the best oral presentation and Nina the runner-up poster prize!

September 5: Six LCSO members participated to the Swiss Summer School in catalysis and sustainable chemistry chaired by Jerome and Bill Morandi with the support of the SCS and NCCR catalysis .

August 26: It is now already the one year anniversary of the @LCSOJournalClub!

August 18: The work of Stephanie, Diana and Franck on photomediated deoxyalkynylation is now accepted in Angewandte Chemie (DOI: 10.1002/anie.202110257 ).

August 17: Alumni news: Dr. Luca Buzzetti former postdoc at LCSO has started to work as a R&D Lead Chemist at F.I.S. (Fabbrica Italiana Syntetici S.p.A). Congratulations!

August 3: The work of Ming-Ming and Tin on diamine synthesis via the diazidation of alkenes and strained ring has been published in the Journal of the American Chemical Society (DOI: 10.1021/jacs.1c06700).

August 2: Dr. Xiangdong Li joined LCSO for his postdoc after a postdoc in the Alcarazo Group. Welcome!

August 1: Alumni news: Dr. Romain Tessier former PhD at LCSO has started to work as a Scientist Discovery Chemist for Janssen. Congratulations!

July 16: Najung Lee from Cambridge University joined LCSO for her summer internship. Welcome!

July 15: The work of Nieves and Guillaume on copper-catalyzed multi-component reactions of EBX, diazo compounds and anilines is now accepted in the Journal of Organic Chemistry (DOI: 10.1021/acs.joc.1c01423).

July 9: The work of Stephanie, Diana and Franck on photomediated deoxyalkynylation is now available as a preprint on ChemRxiv (DOI: 10.33774/chemrxiv-2021-56f12 ).

July 7: Our collaborative work with the (Matile group) at the university of Geneva on EBX and EBZ reagents as inhibitors of thiol-mediated uptake has been accepted in Helvetica Chimica Acta (DOI: 110.1002/hlca.202100085).

June 25: The work of Vladyslav and Bastian on quinoline synthesis from cyclopropenes has been accepted in Organic Letters (DOI: 10.1021/acs.orglett.1c01775).

June 17: Our traditional MOM synthesis competition could finally take place together with the Cramer and the Zhu group. Congrats Cédric Fung (Cramer) and Stephanie for the best synthesis!

June 1: Dr. Thomas Rossolini joins LCSO for his postdoc after a PhD in the Dixon group. Welcome!

May 31: Dr. Luca Buzzetti leaves LCSO after 2.5 years: Good luck for your future Luca!

May 28: Bastian Muriel successfully defended his PhD thesis. He is the sixteenth PhD student to obtain their degree at LCSO. Congratulations!

May 27: The work of Abhaya, Romain and Durga on the first amphiphilic EBX reagents has been accepted in Angewandte Chemie (DOI: 10.1002/anie.202106458).

May 26: The work of Vincent and Emma on the activation of DA aminocyclopropanes has been chosen as “pick of the week” by Chemical Science (DOI: 10.1039/D1SC01127H).

May 12: The last results of Eliott and Matt in collaboration with the Magnier group on new N‐Heterocyclic Alkynyl hypervalent iodine reagents have appeared in Chemistry A European Journal (DOI: 10.1002/chem.202101475).

May 5: The last results of Vincent and Emma on the activation of DA aminocyclopropanes bearing a single ester group for annulation with indoles have appeared in Chemical Science (DOI: 10.1039/D1SC01127H).