Author: Yimon Aye
The Ring Master is born
Training of natural electrophiles to target a single protein leads to improved target specificity and drug activity, but retains the electrophile’s privileged properties. The first step to translation of T-REX, by Xuyu et al., is set to appear in ACS Central Science: Precision targeting of pten-null triple-negative breast tumors guided by electrophilic metabolite sensing We (…)
2020 ACS Award in Biological Chemistry
We thank the American Chemical Society (ACS) and the award sponsor, Eli Lilly & Co., for recognizing our lab with the prestigious ACS Eli Lilly Award. Previous awardees since 1935
Jinmin pockets Master Thesis Prize in Chemical Biology!
We are excited to congratulate Jinmin for snatching the best master thesis prize award in NCCR Chemical Biology! For more information about this one-of-a-kind interface training program for master students, please check out: NCCR master program in chemical biology We are now accepting program applications from aspiring chemical biologists worldwide: the upcoming deadline is end (…)
The role of the ZRANB3/RNR signaling axis in cancer comes into focus
Our new paper detailing how ZRANB3 is a poignant example of non-oncogene addiction in H-RasG12V-induced transformation and how nuclear RNR-alpha can inhibit this function is set to appear in Cell Chemical Biology. Critically, some approved anti-cancer drugs targeting RNR-alpha such as clofarabine also taps into this pathway: Clofarabine commandeers the RNR-α—ZRANB3 nuclear signaling axis We (…)
A SPARK of inspiration gave us the chance to JUMP forward
We thank the Swiss National Science Foundation (SNSF)’s pilot funding scheme SPARK, that is designed to promote unconventional projects and uses a new double-blind reviewing process, for supporting our proposed idea, JUMP, among >700 submissions.