Welcome to the Laboratory of Electrophile And Genome Operation (LEAGO). Our business is understanding cellular communication processes. We are most well-known for our studies into electrophile signalling, but we also study nucleotide signalling pathways. Our work is slowly bringing both eclectic forms of cellular communication into focus. Critically, we have proven that electrophile signalling impinges on all aspects of cellular processes, and we have uncovered hidden aspects of nucleotide signalling pathways that serve to guard the genome. We pioneered the use of photocaged electrophiles (REX technologies) to bypass many of the limitations associated with the use of reactive electrophiles in cells/whole organisms. These technologies that can trigger protein specific electrophile-mediated signalling or can profile the best electrophile sensors are proving to be uniquely useful. We have also used biochemistry/cell biology/genetics to uncover novel roles of one of the most ancient enzymes, ribonucleotide reductase. Unsurprisingly, we are a multidisciplinary lab that uses chemistry, biochemistry, cell biology, genetics and a number of model organisms to solve complex problems. Our work is of significant relevance to human health. Through our united team effort, we strive to develop novel interventions, and to better understanding of current drugs through active collaborations with industrial scientists.
- T-REX™ Electrophile Delivery & G-REX™ Profiling of Privileged Sensors Responsive to Native Signaling Electrophiles & Covalent Drugs
- Novel Functions of Protein Multimers in Nucleotide Signaling, DNA Biogenesis, and Genome Maintenance
- Synthetic Methodology
- Chemical Biology
- Molecular and Cell Biology
- Beyond in vitro and cell-based mechanistic studies, we use more complex and biologically-relevant systems, namely, C. elegans, zebrafish, and mice as our in vivo models