The role of the ZRANB3/RNR signaling axis in cancer comes into focus

— Yimon Aye

Our new paper detailing how ZRANB3 is a poignant example of non-oncogene addiction in H-RasG12V-induced transformation and how nuclear RNR-alpha can inhibit this function is set to appear in Cell Chemical Biology. Critically, some approved anti-cancer drugs targeting RNR-alpha such as clofarabine also taps into this pathway: Clofarabine commandeers the RNR-α—ZRANB3 nuclear signaling axis We (...)

Three is not a crowd!

— Yimon Aye

(W)Hu ‘R’ you? A key transcription factor in a druggable pathway is regulated by two mRNA-binding proteins in a mechanism conserved from humans to zebrafish: Post-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1 Poganik et al. Just Accepted FASEB Journal Gotta get with my friends!: in this invited opinion piece (in Current (...)

2020 ACS award in biological chemistry

— Yimon Aye

We thank the ACS and the award sponsor, Eli Lilly & Co., for recognizing our lab with the prestigious ACS Eli Lilly Award. Previous awardees since 1935

Team snatched honours

— Yimon Aye

Jan 2019: At the 2nd PSL International Chemical Biology Symposium at the Curie Institute in Paris, Dr. Xuyu Liu won the poster prize dedicated to Organic and Biological Chemistry Jan 2019: We thank the Novartis Foundation for supporting our ZRANB3-RNR signaling research project March 2019: We thank the Swiss National Science Foundation for Project Funding supporting (...)

Six contributions in a row

— Yimon Aye

March 2019 Our original-research and review contributions to: (1) the inaugural Technological Corner in Trends in Biochemical Sciences, (2) an opinion piece, “Genie in a bottle“, in Current Opinion in Chemical Biology (Chemical Genetics), and (3) ChemBioTalents special issue in ChemBioChem, appear. (4) Our chemical biology primer for the Rising Stars in Chemistry special issue (...)