Six contributions in a row

— Yimon Aye

March 2019 Our original-research and review contributions to: (1) the inaugural Technological Corner in Trends in Biochemical Sciences, (2) an opinion piece, “Genie in a bottle“, in Current Opinion in Chemical Biology (Chemical Genetics), and (3) ChemBioTalents special issue in ChemBioChem, appear. (4) Our chemical biology primer for the Rising Stars in Chemistry special issue (...)

Our lab snatched three honours

— Yimon Aye

January 2019: At the 2nd PSL International Chemical Biology Symposium at the Curie Institute in Paris, Dr. Xuyu Liu won the poster prize dedicated to Organic and Biological Chemistry January 2019: Our lab was recognised by the Novartis Foundation in support of our genome regulation research program March 2019: Our electrophile signaling research program received support from (...)

A preview on ‘sec-rets’ and an interview on ‘crossing borders with chemical biology’

— Yimon Aye

Lab contributes to a preview and an interview in Cell Chemical Biology and Trends in Biochemical Sciences (for the Trends Talk section), respectively: — “Weighing up the selenocysteome uncovers new sec-rets” – for the paper by Guo et al. 2018 Cell Chem Biol (in press) Jesse Poganik & Yimon Aye — “Crossing borders with chemical (...)

Delve deeper into electrophile signaling through “proteomics and beyond” in Trends in Biochemical Sciences

— Yimon Aye

To proteomics and beyond: Cell decision making shaped by reactive electrophiles Trends in Biochemical Sciences (Elsevier) — just accepted (September 2018) Link to paper Revolutionary proteomics strategies have enabled rapid profiling of the cellular targets of electrophilic small molecules. However, precise means to directly interrogate how these individual electrophilic modifications at low occupancy functionally reshape signaling (...)

Double agent exposed in Nature Chemical Biology

— admin

The large subunit of ribonucleotide reductase—the harbinger of the DNA world—downregulates replication when inside the nucleus: it plays a tug-of-war with IRBIT/importin-α1 in the cytosol and PCNA/ZRANB3 in the nucleus Springer SharedIt Link Nuclear RNR-α Antagonizes Cell Proliferation by Directly Inhibiting ZRANB3 Yuan Fu#, Marcus J. C. Long#, Somsinee Wisitpitthaya, Huma Inayet, Timothy M. Pierpont, (...)