The role of the ZRANB3/RNR signaling axis in cancer comes into focus

Our new paper detailing how ZRANB3 is a poignant example of non-oncogene addiction in H-RasG12V-induced transformation and how nuclear RNR-alpha can inhibit this function is set to appear in Cell Chemical Biology. Critically, some approved anti-cancer drugs targeting RNR-alpha such as clofarabine also taps into this pathway:

Clofarabine commandeers the RNR-α—ZRANB3 nuclear signaling axis

We thank our funders (in particular, the Norvartis Foundation, for supporting this specific project) and our past and present team member contributors who made this discovery possible.

Related recent work: Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3  (2018 Nature Chemical Biology)

Related recent perspective: The more the merrier: How homo-oligomerization alters the interactome and function of ribonucleotide reductase (2019 Current Opinion in Chemical Biology)