Our new paper detailing how ZRANB3 is a poignant example of non-oncogene addiction in H-RasG12V-induced transformation and how nuclear RNR-alpha can inhibit this function is set to appear in Cell Chemical Biology. Critically, some approved anti-cancer drugs targeting RNR-alpha such as clofarabine also taps into this pathway:
We thank our funders (in particular, the Norvartis Foundation, for supporting this specific project) and our past and present team member contributors who made this discovery possible.
Related recent work: Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3 (2018 Nature Chemical Biology)
Related recent perspective: The more the merrier: How homo-oligomerization alters the interactome and function of ribonucleotide reductase (2019 Current Opinion in Chemical Biology, In Press)