The main interest of our laboratory is to develop new fundamental organic chemistry. Of course, it is exciting then to use this new reactivity for applications. We love then to collaborate with other scientists, especially in the fields of chemical biology, computational/digital chemistry and catalysis/synthesis. You will find below current ongoing collaborations of LCSO, as well as past collaborations that resulted in joined publications. Of course, we are always eager to start new collaborations!
Chemical Biology
Ongoing Collaborations
Prof. Tom N. Grossmann, Georg-August-Universität Göttingen
Peptide-Carbazolyl Cyanobenzene Conjugates: Enabling Biomolecule Functionalization via Photoredox and Energy Transfer Catalysis
Xing-Yu Liu, Wei Cai, Anne-Sophie Chauvin, Beat Fierz and Jerome Waser
Angew. Chem., Int. Ed. 2025, 64, e202507602. (10.1002/anie.202507602) Open Access! Green Access Raw data
Synthesis of Fluorescent Cyclic Peptides via Gold(I)-Catalyzed Macrocyclization
Xing-Yu Liu, Wei Cai, Nathan Ronceray, Aleksandra Radenovic, Beat Fierz and Jerome Waser
J. Am. Chem. Soc. 2023, 145, 26525-26531. (10.1021/jacs.3c09261) Open Access! Raw data
”Doubly Orthogonal” Labeling of Peptides and Proteins
Romain Tessier, Javier Ceballos, Nora Guidotti, Raphael Simonet-Davin, Beat Fierz and Jerome Waser
Chem 2019, 5, 2243-2263. (DOI:10.1016/j.chempr.2019.06.022 ) Green Access
Peptide-Hypervalent Iodine Reagent Chimeras: Enabling Peptide Functionalization and Macrocyclization
Xing-Yu Liu, Xinjian Ji, Christian Heinis and Jerome Waser
Angew. Chem., Int. Ed. 2023, 62, e202306036. (DOI: 10.1002/anie.202306036) Open Access! Raw data
Cys‐Cys and Cys‐Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents
Javier Ceballos, Elija Grinhagena, Gontran Sangouard, Christian Heinis and Jerome Waser
Angew. Chem., Int. Ed. 2021, 60, 9022-9031. (10.1002/anie.202014511) Open Access!
Dr. Guilhem Chaubet, University of Strasbourg
Cysteine-Cysteine Cross-Conjugation of both Peptides and Proteins with a Bifunctional Hypervalent Iodine-Electrophilic Reagent
Ilias Koutsopetras, Abhaya Kumar Mishra, Rania Benazza, Oscar Hernandez-Alba, Sarah Cianférani, Guilhem Chaubet, Stefano Nicolai and Jerome Waser
Chem. Eur. J. 2023, 29, e202302689. (10.1002/chem.202302689) Open Access!
Ethynylation of Cysteines from Peptides to Proteins in Living Cells
Romain Tessier, Raj Kumar Nandi, Brendan G. Dwyer, Daniel Abegg, Charlotte Sornay, Javier Ceballos, Stephane Erb, Sarah Cianferani, Alain Wagner, Guilhem Chaubet, Alexander Adibekian and Jerome Waser
Angew. Chem., Int. Ed. 2020, 59, 10961-10970. (10.1002/anie.202002626 ) Green Access
Past Collaborations
Prof. Aleksandra Radenovic, EPFL
Synthesis of Fluorescent Cyclic Peptides via Gold(I)-Catalyzed Macrocyclization
Xing-Yu Liu, Wei Cai, Nathan Ronceray, Aleksandra Radenovic, Beat Fierz and Jerome Waser
J. Am. Chem. Soc. 2023, 145, 26525-26531. (10.1021/jacs.3c09261) Open Access! Raw data
Prof. Alexander Adibekian, University of Illinois Chicago
Ethynylation of Cysteines from Peptides to Proteins in Living Cells
Romain Tessier, Raj Kumar Nandi, Brendan G. Dwyer, Daniel Abegg, Charlotte Sornay, Javier Ceballos, Stephane Erb, Sarah Cianferani, Alain Wagner, Guilhem Chaubet, Alexander Adibekian and Jerome Waser
Angew. Chem., Int. Ed. 2020, 59, 10961-10970. (10.1002/anie.202002626 ) Green Access
Proteome-Wide Profiling of Targets of Cysteine-reactive Small Molecules by using Ethynyl Benziodoxolone Reagents
Daniel Abegg, Reto Frei, Luca Cerato, Durga Prasad Hari, Chao Wang, Jerome Waser and Alexander Adibekian
Angew. Chem., Int. Ed. 2015, 54, 10852–10857. (DOI: 10.1002/anie.201505641)
Prof. Stefan Matile, University of Geneva
Tyrosine bioconjugation with hypervalent iodine
Nina Declas, John R. J. Maynard, Laure Menin, Natalia Gasilova, Sebastian Götze, Jakob L. Sprague, Pierre Stallforth, Stefan Matile and Jerome Waser
Chem. Sci. 2022, 13, 12808-12817. (10.1039/D2SC04558C) Open Access! Raw data
Inhibition of Thiol-Mediated Uptake with Irreversible Covalent Inhibitors
Bumhee Lim, Yangyang Cheng, Takehiro Kato, Anh-Tuan Pham, Eliott Le Du, Abhaya Kumar Mishra, Elija Grinhagena, Dimitri Moreau, Naomi Sakai, Jerome Waser and Stefan Matile
Helv. Chim. Acta 2021, 104, e2100085. (10.1002/hlca.202100085) Open Access!
Prof. Pierre Stallforth,HKI Jena
Tyrosine bioconjugation with hypervalent iodine
Nina Declas, John R. J. Maynard, Laure Menin, Natalia Gasilova, Sebastian Götze, Jakob L. Sprague, Pierre Stallforth, Stefan Matile and Jerome Waser
Chem. Sci. 2022, 13, 12808-12817. (10.1039/D2SC04558C) Open Access! Raw data
Prof. Sandrine Gerber, EPFL and Dr. Florenz Sasse, Helmholtz Centre for Infection Research
Total Synthesis and Biological Evaluation of Jerantinine E
Reto Frei, Davide Staedler, Aruna Raja, Raimo Franke, Florenz Sasse, Sandrine Gerber-Lemaire and Jerome Waser
Angew. Chem., Int. Ed. 2013, 52, 13373-13376. (DOI: 10.1002/anie.201305533) Green Access
Computational/Digital Chemistry
Ongoing Collaborations
Prof. Philippe Schwaller, EPFL
Prof. Clemence Corminboeuf, EPFL
Cost-informed Bayesian reaction optimization
Alexandre A Schoepfer, Jan Weinreich, Ruben Laplaza, Jerome Waser and Clemence Corminboeuf
Digital Discovery 2024, 3, 2289-2297. (10.1039/D4DD00225C) Open Access! Joined publication with LCMD.
Reaction-Agnostic Featurization of Bidentate Ligands for Bayesian Ridge Regression of Enantioselectivity
Alexandre A. Schoepfer, Ruben Laplaza, Matthew D. Wodrich, Jerome Waser, and Clemence Corminboeuf
ACS Catal. 2024, 14, 9302-9312. (10.1021/acscatal.4c02452) Open Access! Code, Visualizations, Joined publication with LCMD.
Fine-Tuned Organic Photoredox Catalysts for Fragmentation-Alkynylation Cascades of Cyclic Oxime Ethers
Franck Le Vaillant, Marion Garreau, Stefano Nicolai, Ganna Gryn’ova, Clemence Corminboeuf and Jerome Waser
Chem. Sci. 2018, 9, 5883-5889. (DOI:10.1039/C8SC01818A ) Open access!
Heterotetracenes: Flexible Synthesis and in Silico Assessment of the Hole Transport Properties
Yifan Li, Ganna Gryn’ova, Felipe Saenz, Xavier Jeanbourquin, Kevin Sivula, Clemence Corminboeuf and Jerome Waser
Chem. Eur. J. 2017, 23, 8058-8065. (DOI: 10.1002/chem.201701139 ) Green Access
Prof. Alireza Ariafard, University of Tasmania
Gold-catalyzed domino cyclization–alkynylation reactions with EBX reagents: new insights into the reaction mechanism
Hossein Ghari, Yifan Li, Roohollah Roohzadeh, Paola Caramenti, Jerome Waser and Alireza Ariafard
Dalton Trans. 2017, 46, 12257-12262. (DOI: 10.1039/C7DT03154H) Green Access
Catalysis/Synthesis
Ongoing Collaborations
Prof. Javier Perez-Ramirez, ETHZ
Prof. Raffaella Buonsanti, EPFL
Dr. Thanh V. Q. Nguyen, AstraZeneca
Practical synthesis of Csp3 Chlorinated Compounds from Cyclopropanes, Olefins and C-H Bonds via photolysis of Willgerodt-type reagents
Tin V. T. Nguyen, Trinh T. H. Tran, Thanh V. Q. Nguyen and Jerome Waser
ChemRxiv 2024, DOI: 10.26434/chemrxiv-2024-bjx6t
Benzylic C(sp3)−H Azidation: Copper vs Iron Catalysis
Angel Rentería-Gómez, Rubén O. Torres-Ochoa, Pierre Palamini, Raphaël Simonet-Davin, Qian Wang, Jérôme Waser, Jieping Zhu
Helv. Chim. Acta 2024, 107, e202400004. (10.1002/hlca.202400004) Open Access! Joined publication with LSPN.
Past Collaborations
Prof. Oleksandr Grygorenko, Taras Shevchenko National University of Kyiv
Photochemical [2+2] Cycloaddition of Alkynyl Boronates
Oleksandr S. Liashuk, Oleksandr O. Grygorenko, Yulian M. Volovenko and Jerome Waser
Chem. Eur. J. 2023, 29, e202301650. (DOI: 10.1002/chem.202301650) Open Access! Raw data
Prof. Emmanuel Magnier, Institut Lavoisier de Versailles
Structure and Reactivity of N-Heterocyclic Alkynyl Hypervalent Iodine Reagents
Eliott Le Du, Thibaut Duhail, Matthew D. Wodrich, Rosario Scopelliti, Farzaneh Fadaei-Tirani, Elsa Anselmi, Emmanuel Magnier and Jerome Waser
Chem. Eur. J. 2021, 27, 10979-10986. (10.1002/chem.202101475) Raw data Open Access!
Prof. Christoforos G. Kokotos, National and Kapodistrian University of Athens
Photochemical Functionalization of Heterocycles with EBX Reagents; C‐H Alkynylation versus Deconstructive Ring Cleavage
Errika Voutyritsa, Marion Garreau, Maroula G. Kokotou, Ierasia Triandafillidi, Jérôme Waser and Christoforos G. Kokotos
Chem. Eur. J. 2020, 26, 14453-14460. (10.1002/chem.202002868 ) Green Access
Triazene-Activated Donor–Acceptor Cyclopropanes: Ring-Opening and (3 + 2) Annulation Reactions
Abdusalom A. Suleymanov, Eliott Le Du, Zhaowen Dong, Bastian Muriel, Rosario Scopelliti, Farzaneh Fadaei-Tirani, Jérôme Waser and Kay Severin
Org. Lett. 2020, 22, 10, 4517-4522. (10.1021/acs.orglett.0c01527 ) Raw data Green Access
One-Pot Synthesis of 1-[(Triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one (TIPS-EBX): Process Safety Assessment and Impact of Impurities on Product Stability
Durga Prasad Hari, Paola Caramenti, Lionel Schouwey, Miyeon Chang, Stefano Nicolai, Donald Bachert, Timothy Wright, Chuck Orella and Jerome Waser
Org. Process Res. Dev. 2020, 24, 106-110. (DOI:10.1021/acs.oprd.9b00498) Green Access
Prof. Thierry Meyer, EPFL and Dr. Annik Nanchen, TUV SUD Schweiz AG
Cyclic Hypervalent Iodine Reagents for Azidation: Safer Reagents and Photoredox-Catalyzed Ring Expansion
Sebastian Alazet, Johannes Preindl, Raphael Simonet-Davin, Stefano Nicolai, Annik Nanchen, Thierry Meyer and Jerome Waser
J. Org. Chem. 2018, 83, 12334-12356. (DOI:10.1021/acs.joc.8b02068 ) Open access!
Heterotetracenes: Flexible Synthesis and in Silico Assessment of the Hole Transport Properties
Yifan Li, Ganna Gryn’ova, Felipe Saenz, Xavier Jeanbourquin, Kevin Sivula, Clemence Corminboeuf and Jerome Waser
Chem. Eur. J. 2017, 23, 8058-8065. (DOI: 10.1002/chem.201701139 ) Green Access
Ethynylbenziodoxolones (EBX) as Reagents for the Ethynylation of Stabilized Enolates
Davinia Fernández González, Jonathan P. Brand, Régis Mondière and Jerome Waser
Adv. Synth. Catal. 2013, 355, 1631-1639. (DOI: 10.1002/adsc.201300266) Green Access
