Laboratory of Therapeutic Proteins and Peptides
Currently we focus on the following three projects:
The ultimate goal of our laboratory is the development of therapeutics for addressing unmet medical needs. We work with cyclic peptides because they can engage with difficult protein targets to which classical small molecules can hardly bind.
Phage display technology allows for the genetic encoding of billions of different peptide sequences. We combine phage display and chemical reactions to generate and screen large combinatorial libraries of bicyclic peptides.
A major goal of our laboratory is the development of orally available or even cell permeable macrocycles that bind to targets of interest. Towards this end, we develop methods for the combinatorial synthesis of large libraries of sub-kDa macrocycles.
Selected recent publications
Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
Wilbs, J., Kong, X.-D., Middendorp, S.J., Prince, R., Cooke, A., Demarest, C.T., Abdelhafez, M.M., Roberts, K., Umei, N., Gonschorek, P., Lamers, C., Deyle, K., Rieben, R., Cook, K.E., Angelillo-Scherrer, A. and Heinis, C.
Kong, X.-D., Moriya, J., Carle, V., Pojer, F., Abriata, L.A., Deyle, K. and Heinis, C.
Kale, S.S., Villequey, C., Kong, X.D., Zorzi, A., Deyle, K. and Heinis, C.
Post-doc position: Synthesis and high-throughput screening of (peptide) macrocycle libraries (collaborative project with Roche)
PhD position: Phage display selection of cyclic peptides and development of peptide-based therapeutics
Master projects: We are looking for enthusiastic master students. Candidates are invited to send their CV via email to Prof. Christian Heinis