Laboratory of Therapeutic Proteins and Peptides
Open Positions:
PhD projects: We expect to soon open new PhD positions in cyclic peptide drug development (combinatorial chemistry, HTS, drug development). For interested students, please send a CV and cover letter to Prof. Christian Heinis.
Master projects: We are looking for enthusiastic master students. Candidates are invited to send their CV via email to Prof. Christian Heinis.
Currently we focus on the following three projects:
Development of drugs based on cyclic peptides
The ultimate goal of our laboratory is the development of therapeutics for addressing unmet medical needs. We work with cyclic peptides because they can engage with difficult protein targets to which classical small molecules can hardly bind.
Phage display selection of bicyclic peptides
Phage display technology allows for the genetic encoding of billions of different peptide sequences. We combine phage display and chemical reactions to generate and screen large combinatorial libraries of bicyclic peptides.
High-throughput synthesis of macrocycles
A major goal of our laboratory is the development of cell permeable or even orally available macrocycles that bind to targets of interest. Towards this end, we develop methods for the combinatorial synthesis of large libraries of sub-kDa macrocycles.
Selected recent publications
Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale
Habeshian, S., Merz, M.L., Sangouard, G., Mothukuri, G.K., Schüttel, M., Bognár; Z., Díaz-Perlas, C., Vesin, J., Bortoli Chapalay, J., Turcatti, G., Cendron, L., Angelini, A. and Heinis, C.
De novo development of proteolytically resistant therapeutic peptides for oral administration
Kong, X.-D., Moriya, J., Carle, V., Pojer, F., Abriata, L.A., Deyle, K. and Heinis, C.
Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
Wilbs, J., Kong, X.-D., Middendorp, S.J., Prince, R., Cooke, A., Demarest, C.T., Abdelhafez, M.M., Roberts, K., Umei, N., Gonschorek, P., Lamers, C., Deyle, K., Rieben, R., Cook, K.E., Angelillo-Scherrer, A. and Heinis, C.
We are grateful for support by the Swiss National Science Foundation and the European Research Council.
