Laboratory of Therapeutic Proteins and Peptides

Our laboratory aims at developing new therapeutics based on cyclic peptides. A major focus is the in vitro evolution of bicyclic peptides by phage display.

We conduct research in three major areas:

Development of drugs based on cyclic peptides

The ultimate goal of our laboratory is the development of therapeutics for addressing unmet medical needs. We work with cyclic peptides because they can engage with difficult protein targets to which classical small molecules can hardly bind.

Phage display selection of bicyclic peptides

Phage display technology allows for the genetic encoding of billions of different peptide sequences. We combine phage display and chemical reactions to generate and screen large combinatorial libraries of bicyclic peptides.

High-throughput screening of macrocycles

A major goal of our laboratory is the development of orally available or even cell permeable macrocycles that bind to targets of interest. Towards this end, we develop methods for the combinatorial synthesis of large libraries of sub-kDa macrocycles.

Selected recent publications

Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands

Kale, S. S., Bergeron-Brlek, M., Wu, Y., Kumar, M.G., Pham, M.V., Bortoli, J., Vesin, J., Kong, X.-D., Franco Machado, J., Deyle, K., Gonschorek, P., Turcatti, G., Cendron, L., Angelini, A. and Heinis, C.

Cyclization of peptides with two chemical bridges affords large scaffold diversities

Kale, S.S., Villequey, C., Kong, X.D., Zorzi, A., Deyle, K. and Heinis, C.

Open Positions:

Post-doc position: Synthesis and high-throughput screening of (peptide) macrocycle libraries for the development of inhibitors of protein-protein interactions

PhD position: Phage display selection of cyclic peptides

Master projects: We are looking for enthusiastic master students. Candidates are invited to send their CV via email to Prof. Christian Heinis