Laboratory of Therapeutic Proteins and Peptides

Our laboratory aims at developing new therapeutics based on cyclic peptides. A major focus is the in vitro evolution of bicyclic peptides by phage display.

Open Positions:

Post-doc position in peptide engineering and diagnostic assay development: A collaborative project of our lab with BÜHLMANN Laboratories to develop a new diagnostic assay.

PDF post-doc

Master projects: We are looking for enthusiastic master students. Candidates are invited to send their CV via email to Prof. Christian Heinis

Currently we focus on the following three projects:

Development of drugs based on cyclic peptides

The ultimate goal of our laboratory is the development of therapeutics for addressing unmet medical needs. We work with cyclic peptides because they can engage with difficult protein targets to which classical small molecules can hardly bind.

Phage display selection of bicyclic peptides

Phage display technology allows for the genetic encoding of billions of different peptide sequences. We combine phage display and chemical reactions to generate and screen large combinatorial libraries of bicyclic peptides.

High-throughput screening of macrocycles

A major goal of our laboratory is the development of orally available or even cell permeable macrocycles that bind to targets of interest. Towards this end, we develop methods for the combinatorial synthesis of large libraries of sub-kDa macrocycles.

Selected recent publications

Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs

Wilbs, J., Kong, X.-D., Middendorp, S.J., Prince, R., Cooke, A., Demarest, C.T., Abdelhafez, M.M., Roberts, K., Umei, N., Gonschorek, P., Lamers, C., Deyle, K., Rieben, R., Cook, K.E., Angelillo-Scherrer, A. and Heinis, C.

De novo development of proteolytically resistant therapeutic peptides for oral administration

Kong, X.-D., Moriya, J., Carle, V., Pojer, F., Abriata, L.A., Deyle, K. and Heinis, C.

Cyclization of peptides with two chemical bridges affords large scaffold diversities

Kale, S.S., Villequey, C., Kong, X.D., Zorzi, A., Deyle, K. and Heinis, C.

We are grateful for support by the Swiss National Science Foundation and the European Research Council.