2024
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Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation
Angewandte Chemie-International Edition. 2024-05-24. DOI : 10.1002/anie.202400350.Solid-phase peptide synthesis in 384-well plates
Journal Of Peptide Science. 2024-01-14. DOI : 10.1002/psc.3555.2023
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Development of cyclic peptides that can be administered orally to inhibit disease targets
Nature Chemical Biology. 2023-12-28. DOI : 10.1038/s41589-023-01505-0.De novo development of small cyclic peptides that are orally bioavailable
Nature Chemical Biology. 2023-12-28. DOI : 10.1038/s41589-023-01496-y.High-Density Immobilization of TCEP on Silica Beads for Efficient Disulfide Reduction and Thiol Alkylation in Peptides
Chembiochem. 2023-12-04. Vol. 25, num. 3. DOI : 10.1002/cbic.202300592.Peptide-Hypervalent Iodine Reagent Chimeras: Enabling Peptide Functionalization and Macrocyclization
Angewandte Chemie-International Edition. 2023-07-07. Vol. 62, num. 33, p. e202306036. DOI : 10.1002/anie.202306036.High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays
Nature Communications. 2023-05-17. Vol. 14, num. 1, p. 2774. DOI : 10.1038/s41467-023-38075-7.Motifs for making tricycles
Nature Chemical Biology. 2023-05-08. DOI : 10.1038/s41589-023-01329-y.2022
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Solid-phase peptide synthesis on disulfide-linker resin followed by reductive release affords pure thiol-functionalized peptides
Organic & Biomolecular Chemistry. 2022-07-09. Vol. 20, num. 29, p. 5699-5703. DOI : 10.1039/d2ob00910b.Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale
Nature Communications. 2022-07-02. Vol. 13, num. 1, p. 3823. DOI : 10.1038/s41467-022-31428-8.Phage Display Selected Cyclic Peptide Inhibitors of Kallikrein-Related Peptidases 5 and 7 and Their In Vivo Delivery to the Skin
Journal Of Medicinal Chemistry. 2022-06-02. Vol. 65, num. 14, p. 9735-9749. DOI : 10.1021/acs.jmedchem.2c00306.Cyclative Release Strategy to Obtain Pure Cyclic Peptides Directly from the Solid Phase
Acs Chemical Biology. 2022-01-11. Vol. 17, num. 1, p. 181–186. DOI : 10.1021/acschembio.1c00843.2021
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Picomole-Scale Synthesis and Screening of Macrocyclic Compound Libraries by Acoustic Liquid Transfer
Angewandte Chemie-International Edition. 2021-08-25. Vol. 60, num. 40, p. 21702-21707. DOI : 10.1002/anie.202107815.Generation of a 100-billion cyclic peptide phage display library having a high skeletal diversity
Protein Engineering Design & Selection. 2021-08-02. Vol. 34, p. gzab018. DOI : 10.1093/protein/gzab018.Combining biological and chemical diversity
Nature Chemistry. 2021-06-01. Vol. 13, num. 6, p. 512-513. DOI : 10.1038/s41557-021-00722-1.Development of Selective FXIa Inhibitors Based on Cyclic Peptides and Their Application for Safe Anticoagulation
Journal Of Medicinal Chemistry. 2021-05-27. Vol. 64, num. 10, p. 6802-6813. DOI : 10.1021/acs.jmedchem.1c00056.In Vitro-Evolved Peptides Bind Monomeric Actin and Mimic Actin-Binding Protein Thymosin-β4
ACS Chemical Biology. 2021-05-21. Vol. 16, num. 5, p. 820-828. DOI : 10.1021/acschembio.0c00825.Combination of polycarboxybetaine coating and factor XII inhibitor reduces clot formation while preserving normal tissue coagulation during extracorporeal life support
Biomaterials. 2021-05-01. Vol. 272, p. 120778. DOI : 10.1016/j.biomaterials.2021.120778.Chemical Biology and Drug Discovery Symposium at the LS2 Annual Meeting 2021
Chimia. 2021-04-01. Vol. 75, num. 4, p. 342-342. DOI : 10.2533/chimia.2021.342.Cys-Cys and Cys-Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents
Angewandte Chemie-International Edition. 2021-01-15. Vol. 60, num. 16, p. 9022-9031. DOI : 10.1002/anie.202014511.2020
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Generation of a Large Peptide Phage Display Library by Self-Ligation of Whole-Plasmid PCR Product
ACS Chemical Biology. 2020-10-30. Vol. 15, num. 11, p. 2907-2915. DOI : 10.1021/acschembio.0c00497.Tissue Factor-Independent Coagulation Correlates with Clinical Phenotype in Factor XI Deficiency and Replacement Therapy
Thrombosis And Haemostasis. 2020-09-13. Vol. 121, num. 02, p. 150-163. DOI : 10.1055/s-0040-1715899.Macrocycle synthesis strategy based on step-wise “adding and reacting” three components enables screening of large combinatorial libraries
Chemical Science. 2020-06-26. Vol. 11, num. 30, p. 7858-7863. DOI : 10.1039/D0SC01944E.De novo development of proteolytically resistant therapeutic peptides for oral administration
Nature Biomedical Engineering. 2020-05-11. Vol. 4, p. 560–571. DOI : 10.1038/s41551-020-0556-3.A releasable disulfide-linked peptide tag facilitates the synthesis and purification of short peptides
Chemical Communications. 2020-03-07. Vol. 56, num. 19, p. 2917-2920. DOI : 10.1039/c9cc09247a.Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
Nature Communications. 2020-08-04. Vol. 11, num. 1, p. 3890. DOI : 10.1038/s41467-020-17648-w.Synthesis of DNA‐encoded disulfide‐ and thioether‐cyclized peptides
ChemBioChem. 2020. Vol. 21, num. 4, p. 543-549. DOI : 10.1002/cbic.201900390.2019
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Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands
Science Advances. 2019-08-21. Vol. 5, num. 8, p. eaaw2851. DOI : 10.1126/sciadv.aaw2851.Engineered peptide macrocycles can inhibit matrix metalloproteinases with high selectivity
Angewandte Chemie. 2019-06-28. Vol. 131, num. 34, p. 11927-11931. DOI : 10.1002/ange.201906791.2018
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The Partnership of DMCCB and LS2
Chimia. 2018-11-01. Vol. 72, num. 11, p. 817-818. DOI : 10.2533/chimia.2018.817.Drugs Based on de novo-developed Peptides are Coming of Age
Chimia. 2018-06-01. Vol. 72, num. 6, p. 426-427. DOI : 10.2533/chimia.2018.426.Cyclization of peptides with two chemical bridges affords large scaffold diversities
Nature Chemistry. 2018. Vol. 10, num. 7, p. 715-723. DOI : 10.1038/s41557-018-0042-7.2017
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Bypassing bacterial infection in phage display by sequencing DNA released from phage particles
Protein Engineering, Design and Selection. 2017-11-29. Vol. 30, num. 11, p. 761-768. DOI : 10.1093/protein/gzx057.Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides
Nature Communications. 2017. Vol. 8, p. 16092. DOI : 10.1038/ncomms16092.Polar Hinges as Functionalized Conformational Constraints in (Bi) cyclic Peptides
Chembiochem. 2017. Vol. 18, num. 4, p. 387-395. DOI : 10.1002/cbic.201600612.Precisely Regulated and Efficient Locking of Linear Peptides into Stable Multicyclic Topologies through a One-Pot Reaction
Angewandte Chemie-International Edition. 2017. Vol. 56, num. 16, p. 4458-4463. DOI : 10.1002/anie.201610942.Peptide macrocycle inhibitor of coagulation factor XII with subnanomolar affinity and high target selectivity
Journal Of Medicinal Chemistry. 2017. Vol. 60, num. 3, p. 1151-1158. DOI : 10.1021/acs.jmedchem.6b01548.2016
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Improving the binding affinity of in-vitro-evolved cyclic peptides by inserting atoms into the macrocycle backbone
Chembiochem. 2016. Vol. 17, num. 24, p. 2299-2303. DOI : 10.1002/cbic.201600336.Phage selection of chemically stabilized alpha-helical peptide ligands
ACS Chemical Biology. 2016. Vol. 11, num. 5, p. 1422-1427. DOI : 10.1021/acschembio.5b00963.Development of potent and selective S. aureus sortase A inhibitors Based on Peptide Macrocycles
ACS Medicinal Chemistry Letters. 2016. Vol. 7, num. 6, p. 606-611. DOI : 10.1021/acsmedchemlett.6b00045.Phage selection of peptide macrocycles against b-catenin to interfere with Wnt signaling
ChemMedChem. 2016. Vol. 11, num. 8, p. 834-839. DOI : 10.1002/cmdc.201500557.2015
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Phage Selection of Bicyclic Peptide Ligands of the Notch1 Receptor
Chemmedchem. 2015. Vol. 10, num. 10, p. 1754-1761. DOI : 10.1002/cmdc.201500261.A Synthetic Factor XIIa Inhibitor Blocks Selectively Intrinsic Coagulation Initiation
Acs Chemical Biology. 2015. Vol. 10, num. 8, p. 1861-1870. DOI : 10.1021/acschembio.5b00103.Bicyclic Peptides Conjugated to an Albumin-Binding Tag Diffuse Efficiently into Solid Tumors
Molecular Cancer Therapeutics. 2015. Vol. 14, num. 1, p. 151-161. DOI : 10.1158/1535-7163.Mct-14-0534.2014
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Identification of target-binding peptide motifs by high-throughput sequencing of phage-selected peptides
Nucleic Acids Research. 2014. Vol. 42, num. 22, p. e169. DOI : 10.1093/nar/gku940.Chemical biology & drug discovery
European Journal Of Medicinal Chemistry. 2014. Vol. 88, p. 1-2. DOI : 10.1016/j.ejmech.2014.10.017.Phage selection of bicyclic peptides binding Her2
Tetrahedron. 2014. Vol. 70, num. 42, p. 7733-7739. DOI : 10.1016/j.tet.2014.05.106.Drug discovery: tools and rules for macrocycles
Nature chemical biology. 2014. Vol. 10, num. 9, p. 696-8. DOI : 10.1038/nchembio.1605.Phage Selection of Photoswitchable Peptide Ligands
Journal Of The American Chemical Society. 2014. Vol. 136, num. 16, p. 5880-5883. DOI : 10.1021/ja501861m.Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides
Nature Chemistry. 2014. Vol. 6, p. 1009-1016. DOI : 10.1038/nchem.2043.Peptide ligands stabilized by small molecules
Angewandte Chemie (International ed. in English). 2014. Vol. 53, num. 6, p. 1602-6. DOI : 10.1002/anie.201309459.2013
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Tracking chemical reactions on the surface of filamentous phage using mass spectrometry
Chemical communications (Cambridge, England). 2013. Vol. 50, num. 40, p. 5267-5269. DOI : 10.1039/c3cc47496h.Directed Evolution of Bicyclic Peptides for Therapeutic Application
Chimia. 2013. Vol. 67, num. 12, p. 910-915. DOI : 10.2533/chimia.2013.910.Improving binding affinity and stability of peptide ligands by substituting glycines with D-amino acids
Chembiochem : a European journal of chemical biology. 2013. Vol. 14, num. 11, p. 1316-1322. DOI : 10.1002/cbic.201300228.Development of a selective peptide macrocycle inhibitor of coagulation factor XII toward the generation of a safe antithrombotic therapy
Journal of medicinal chemistry. 2013. Vol. 56, num. 9, p. 3742-3746. DOI : 10.1021/jm400236j.Pattern-Based Sensing of Peptides and Aminoglycosides with a Single Molecular Probe
Organic Letters. 2013. Vol. 15, p. 3456-3459. DOI : 10.1021/ol401495c.Bicyclic peptide ligands pulled out of cysteine-rich peptide libraries
Journal of the American Chemical Society. 2013. Vol. 135, num. 17, p. 6562-6569. DOI : 10.1021/ja400461h.Phage display libraries of differently sized bicyclic peptides
Medchemcomm. 2013. Vol. 4, num. 1, p. 145-150. DOI : 10.1039/c2md20171b.Polycyclic Peptide Therapeutics
Chemmedchem. 2013. Vol. 8, num. 3, p. 377-384. DOI : 10.1002/cmdc.201200513.Phage selection of cyclic peptide antagonists with increased stability toward intestinal proteases
Protein engineering, design & selection : PEDS. 2013. Vol. 26, num. 1, p. 81-89. DOI : 10.1093/protein/gzs085.