Our main focus is to understand the molecular organization and function of chromatin, the DNA-protein complex which organizes the eukaryotic genome and regulates gene expression, using a combination of chemistry and biophysics.


There are open positions for PhD students! If you are interested to perform a PhD thesis on the chemical biology and biophysics of chromatin, directly contact: [email protected] We have also openings for Postdoctoral fellows!


Monday – Friday 09:00-18:00

Head of the laboratory
Prof. Beat FIERZ
Office: CH B3 485
T:  41 (0)21 693 71 53
F: 41 (0)21 693 61 90

E-mail: [email protected]

Office: CH B3 495
T: 41 (0)21 693 5293
F: 41 (0)21 693 6190

Email : [email protected]

Mailing Address
Ecole polytechnique fédérale de Lausanne
Institut des sciences et ingénierie chimiques
CH B3 485 (Bât. CH)
Station 6
CH-1015 Lausanne

Recent publications:

New paper!

See the mechanism how the pioneer transcription factor Rap1 invades chromatin fibers!

New paper

Check out the new paper in CHEM with LCSO! novel methods for doubly orthogonal labeling of proteins (and nucleosomes)! A great handle to modify your proteins.

New review

Check out the new review with Michael Poirier on chromatin dynamics in Annual Review of Biophysics!

New paper

A new synthesis for nucleosomes asymetrically modified at H3K36..

New review

Check our our new review on the chemical biology and biophysics of chromatin silencing in Curr. Opin. Chem. Biol.

New paper

Congrats to Sinan, Iuliia and Carolin for having their paper on the effect of uH2A.X on chromatin structure accepted in Chemical Science!

Recent news:

January 2021:

Welcome to Inna Brakti, a new PhD student.

December 2020:

Congrats to Alexandra, Pauline and Sim for all passing their first year exams!

September 2020:

Congrats to Nora, for passing her PhD exam.

October 2019:

Congrats Maxime, Anne, Iuliia and Ruud for having their manuscript accepted in Molecular Cell!

Welcome to Pauline Franz and Sim Sakong, two new PhD students.

September 2019:

Congrats to Kristina, for passing her first year exam!

August 2019:

Welcome to Alexandra Teslenko, a new PhD student.

March 2019:

Congrats to Ninad, for passing his PhD exam.

December 2018: 

We thank the Novartis Foundation for Biomedical Research for funding our project investigating molecular mechanisms of DNA repair regulation.

November 2018:

We are excited to have been awarded an SV-iPhD grant, together with the Suter lab (UPSUTER) on pioneer TF mechanisms.

September 2018:

The LCBM welcomes Kristina Makasheva, a new PhD student.

August 2018:

It was a great summer school in Chemical Biology! Thanks to all the great speakers and participants for this inspiring event.

July 2018:

Congratulations to Rebeca for successfully defending her Master thesis.

Congratulations to Louise for successfully defending her PhD thesis.

Congratulations to Jade for finishing her apprenticeship in the LCBM and for receiving two prizes by the Labo Ecole.

June 2018:

Congratulations to Andreas for successfully defending his PhD.

Congratulations to Mathilde for successfully defending her Master Thesis.

January 2018:

The LCBM welcomes a new scientific collaborator, Ruud Hovius.