Revealing chromatin-specific functions of histone deacylases

C. Moreno-Yruela; B. Fierz 

CENP-A and CENP-B collaborate to create an open centromeric chromatin state

H. Nagpal; A. Ali-Ahmad; Y. Hirano; W. Cai; M. Halic et al. 

Synthesis of Fluorescent Cyclic Peptides via Gold(I)-Catalyzed Macrocyclization

X-Y. Liu; W. Cai; N. Ronceray; A. Radenovic; B. Fierz et al. 

Short talk Single-molecule enzymology of chromatin ubiquitination

A. Teslenko; B. Fierz 

Cooperation between bHLH transcription factors and histones for DNA access

A. K. Michael; L. Stoos; P. Crosby; N. Eggers; X. Y. Nie et al. 

Tubulin engineering by semi-synthesis reveals that polyglutamylation directs detyrosination

E. Ebberink; S. Fernandes; G. Hatzopoulos; N. Agashe; P-H. Chang et al. 

Target search dynamics of Sox transcription factors

S. Sakong; D. Suter; B. Fierz 

De novo design of protein interactions with learned surface fingerprints

P. Gainza Cirauqui; S. Wehrle; A. K. Van Hall-Beauvais; A. Marchand; A. Scheck et al. 

Development of multiplexed single-molecule imaging techniques to study chromatin invasion dynamics of chromatin effector proteins

Multivalent Peptide Ligands To Probe the Chromocenter Microenvironment in Living Cells

N. Guidotti; Á. Eördögh; M. Mivelaz; P. Rivera-Fuentes; B. Fierz 

Multiplexed single-molecule experiments reveal Cas9 nucleosome invasion dynamics

K. Makasheva; L. Bryan; M. Jinek; B. Fierz 

Development of a single-molecule approach to observe ubiquitination dynamics in defined chromatin states

A. Teslenko; B. Fierz 

Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein

P. O. Heidarsson; D. Mercadante; A. Sottini; D. Nettels; M. B. Borgia et al. 

Dynamic Chromatin Invasion and Remodeling by the Transcription Factor Rap1

Multiplexed Single-Molecule Experiments Reveal Nucleosome Invasion Dynamics of the Cas9 Genome Editor

K. Makasheva; L. C. Bryan; C. Anders; S. Panikulam; M. Jinek et al. 

O-GlcNAcylation of High Mobility Group Box 1 (HMGB1) Alters Its DNA Binding and DNA Damage Processing Activities

A. T. Balana; A. Mukherjee; H. Nagpal; S. P. Moon; B. Fierz et al. 

SUV39 SET domains mediate crosstalk of heterochromatic histone marks

A. Stirpe; N. Guidotti; S. J. Northall; S. Kilic; A. Hainard et al. 

Applying Peptide and Protein Synthesis to Study Post-translational Modifications in Epigenetics and Beyond

B. Fierz 

A single-molecule multiplexed approach to study Cas9 nucleosomes invasion

K. Makasheva; L. Bryan; B. Fierz 

Development of a single-molecule approach to observe ubiquitination dynamics in defined chromatin states

A. Teslenko; B. Fierz 

Torsin ATPases influence chromatin interaction of the Torsin regulator LAP1

N. Luithle; J. u. de Bos; R. Hovius; D. Maslennikova; R. T. M. Lewis et al. 

Observing protein interaction dynamics to chemically defined chromatin fibers by colocalization single-molecule fluorescence microscopy

M. Mivelaz; B. Fierz 

The Elusive Structure of Centro-Chromatin: Molecular Order or Dynamic Heterogenetity?

H. Nagpal; B. Fierz 

Modeling biochemical reaction networks in complex intracellular environments

Structural mechanism of cGAS inhibition by the nucleosome

G. R. Pathare; A. Decout; S. Glück; S. Cavadini; K. Makasheva et al. 

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

B. Guey; M. Wischnewski; A. Decout; K. Makasheva; M. Kaynak et al. 

Development of chemical biology tools to reveal the function and organization of the silenced chromatin state

Nucleosome Binding by the Lysine Specific Demethylase 1 (LSD1) Enzyme Enables Histone H3 Demethylation

A. Dhall; P. M. M. Shelton; A. Delachat; C. J. A. Leonen; B. Fierz et al. 

Chromatin Fiber Invasion and Nucleosome Displacement by the Rap1 Transcription Factor

M. Mivelaz; A-M. Cao; S. Kubik; S. Zencir; R. Hovius et al. 

KAP1 is an antiparallel dimer with a functional asymmetry

G. Fonti; M. J. Marcaida; L. C. Bryan; S. Traeger; A. S. Kalantzi et al. 

Chemical and biophysical methods to explore dynamic mechanisms of chromatin silencing

I. Boichenko; B. Fierz 

“Doubly Orthogonal” Labeling of Peptides and Proteins

R. Tessier; J. Ceballos; N. Guidotti; R. Simonet-Davin; B. Fierz et al. 

Revealing dynamic chromatin invasion by pioneer transcription factors on the single-molecule scale

B. Fierz 

Biophysics of Chromatin Dynamics

B. Fierz; M. G. Poirier 

Gene control with a “twist”: Exploring the dynamic chromatin landscape Gene control with a “twist”: Exploring the dynamic chromatin landscape

B. Fierz 

A Modular Ligation Strategy for Asymmetric Bivalent Nucleosomes Trimethylated at K36 and K27

N. Guidotti; C. C. Lechner; A. L. Bachmann; B. Fierz 

Chromatin Remodeling Induced by the Invasion of Yeast Pioneer Transcription Factor Rap1 Revealed by Single-Molecule FRET

A-M. Cao; M. Mivelaz; I. Boichenko; L. Bryan; S. Kubik et al. 

Revealing chromatin organization in metaphase chromosomes

B. Fierz 

Protein Engineering Tools to Explore the Function of Protein Post-Translational Modifications for Chromatin and Microtubule Cytoskeletal Biology

Single-molecule dynamics and genome-wide transcriptomics reveal that NF-kB (p65)-DNA binding times can be decoupled from transcriptional activation

A. Callegari; C. Sieben; A. Benke; D. M. Suter; B. Fierz et al. 

ESM-SnowMIP: assessing snow models and quantifying snow-related climate feedbacks

G. Krinner; C. Derksen; R. Essery; M. Flanner; S. Hagemann et al. 

Investigation of a wind-packing event in Queen Maud Land, Antarctica

C. G. Sommer; N. Wever; C. Fierz; M. Lehning 

Representation of Horizontal Transport Processes in Snowmelt Modeling by Applying a Footprint Approach

S. Schlogl; M. Lehning; C. Fierz; R. Mott 

Wind Tunnel Experiments: Influence of Erosion and Depositionon Wind-Packing of New Snow

C. Sommer; M. Lehning; C. Fierz 

Wind-packing of snow: How do wind crusts form?

Deciphering the chromatin binding mechanisms of human HP1 variants at the single-molecule level

Dynamic protein-chromatin interactions in heterochromatin and during the DNA damage response on the single molecule level

A bi-terminal protein ligation strategy to probe chromatin structure during DNA damage

S. Kilic; I. Boichenko; C. C. Lechner; B. Fierz 

Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α

S. Kilic; S. Felekyan; O. Doroshenko; I. Boichenko; M. Dimura et al. 

Engineered Multivalent Sensors to Detect Coexisting Histone Modifications in Living Stem Cells

A. M-F. Delachat; N. Guidotti; A. L. Bachmann; A. C. Meireles-Filho; H. Pick et al. 

Wind tunnel experiments: saltation is necessary for wind-packing

C. G. Sommer; M. Lehning; C. Fierz 

Genetically encoded multivalent sensors to detect bivalent epigenetic modifications in living stem cells

DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation

J. Choi; A. L. Bachmann; K. Tauscher; C. Benda; B. Fierz et al. 

Single-molecule kinetic analysis of HP1-chromatin binding reveals a dynamic network of histone modification and DNA interactions

L. C. Bryan; D. R. Weilandt; A. L. Bachmann; S. Kilic; C. C. Lechner et al. 

Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells

O. Cuvier; B. Fierz 

Impact of climate change in Switzerland on socioeconomic snow indices

E. Schmucki; C. Marty; C. Fierz; R. Weingartner; M. Lehning 

Heterochromatin protein 1 recruitment and chromatin conformational dynamics at the single-molecule level

A new ring‐shaped wind tunnel facility to study wind‐packing of snow.

C. Sommer; M. Lehning; C. Fierz 

Wind slab formation in snow: experimental setup and first results.

C. Sommer; M. Lehning; C. Fierz 

Simulating ice layer formation under the presence of preferential flow in layered snowpacks

N. Wever; S. Würzer; C. Fierz; M. Lehning 

Assessing wet snow avalanche activity using detailed physics based snowpack simulations

N. Wever; C. Vera Valero; C. Fierz 

Recent advances in liquid water flow modelling in the physics based SNOWPACK model

N. Wever; S. Würzer; C. Fierz; M. Lehning 

2016 International Symposium on Chemical Biology of the NCCR Chemical Biology Campus Biotech, Geneva 13-15.1.2016

O. Hantschel; B. Fierz 

Traceless Synthesis of Asymmetrically Modified Bivalent Nucleosomes

C. C. Lechner; N. D. Agashe; B. Fierz 

A two-state activation mechanism controls the histone methyltransferase Suv39h1

M. M. Mueller; B. Fierz; L. Bittova; G. Liszczak; T. W. Muir 

Dynamic Chromatin Regulation from a Single Molecule Perspective

B. Fierz 

Heterochromatin Assembly and Dynamics on the Single Molecule Level

S. Kilic; B. Andreas; L. Bryan; B. Fierz 

Verification of the multi-layer SNOWPACK model with different water transport schemes

N. Wever; L. Schmid; A. Heilig; O. Eisen; C. Fierz et al. 

Simulations of 21st century snow response to climate change in Switzerland from a set of RCMs

E. Schmucki; C. Marty; C. Fierz; M. Lehning 

Molecular and Chemical Mechanism in Epigenetics – Swiss Summer School 2015 July 12–17, 2015, Hotel Kurhaus, Arolla, Switzerland

L. C. Bryan; A. L. Bachmann; B. Fierz 

Multivalency governs HP1α association dynamics with the silent chromatin state

S. Kilic; A. L. Bachmann; L. C. Bryan; B. Fierz 

Development and in vitro characterization of a genetically encoded split fluorescent probe targeting bivalent chromatin

N. Guidotti 

Investigating G-quadruplex dynamics in nucleosomes

M. Meystre 

Model simulations of the modulating effect of the snow cover in a rain-on-snow event

N. Wever; T. Jonas; C. Fierz; M. Lehning 

Sumoylated Human Histone H4 Prevents Chromatin Compaction by Inhibiting Long-range Internucleosomal Interactions

A. Dhall; S. Wei; B. Fierz; C. L. Woodcock; T-H. Lee et al. 

Chromatin as a Dynamic Platform for Protein-Protein Interactions

B. Fierz 

Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries

U. T. T. Nguyen; L. Bittova; M. M. Müller; B. Fierz; Y. David et al. 

Engineering chromatin states: Chemical and synthetic biology approaches to investigate histone modification function

H. Pick; S. Kilic; B. Fierz 

Solving Richards Equation for snow improves snowpack meltwater runoff estimations in detailed multi-layer snowpack model

N. Wever; C. Fierz; C. Mitterer; H. Hirashima; M. Lehning 

Evaluation of modelled snow depth and snow water equivalent at three contrasting sites in Switzerland using SNOWPACK simulations driven by different meteorological data input

E. Schmucki; C. Marty; C. Fierz; M. Lehning 

Synthetic Chromatin Approaches To Probe the Writing and Erasing of Histone Modifications

B. Fierz 

The Uncertainty of Seasonal Snow Energy- and Mass Balance Simulations as a Function of Typical Input Uncertainty

M. Lehning; M. Bavay; R. Dadic; R. Mott; C. G. Fierz 

Simulating melt crust and ice lens formation in a physically based snowpack model

N. Wever; C. Fierz; M. Lehning 

SNOWPACK: where do we stand today?

C. Fierz; M. Bavay; N. Wever; M. Lehning 

Snow cover runoff and stream discharge modelling during snow melt in Alpine terrain

N. Wever; C. Fierz; M. Bavay; M. Lehning 

Improving stream flow discharge modelling during snow melt

N. Wever; C. Fierz; C. Mitterer; M. Lehning 

Histone H3 K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexes

D-H. Kim; Z. Tang; M. Shimada; B. Fierz; B. Houck-Loomis et al. 

Testing the diffusing boundary model for the helix-coil transition in peptides

S. Neumaier; A. Reiner; M. Büttner; B. Fierz; T. Kiefhaber 

Event-driven deposition of snow on the Antarctic Plateau: analyzing field measurements with SNOWPACK

C. D. G. Zwaaftink; A. Cagnati; A. Crepaz; C. Fierz; G. Macelloni et al. 

Stability of Nucleosomes Containing Homogenously Ubiquitylated H2A and H2B Prepared Using Semisynthesis

B. Fierz; S. Kilic; A. R. Hieb; K. Luger; T. W. Muir 

Chromatin as an expansive canvas for chemical biology

B. Fierz; T. W. Muir 

Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2

S. J. Whitcomb; B. Fierz; R. K. McGinty; M. Holt; T. Ito et al. 

Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction

B. Fierz; C. Chatterjee; R. K. McGinty; M. Bar-Dagan; D. P. Raleigh et al. 

Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation

C. Chatterjee; R. K. McGinty; B. Fierz; T. W. Muir 

Micrometeorological and morphological observations of surface hoar dynamics on a mountain snow cover

F. Stössel; M. Guala; C. Fierz; C. Manes; M. Lehning 

Local conformational dynamics in alpha-helices measured by fast triplet transfer

B. Fierz; A. Reiner; T. Kiefhaber 

Assessment of snow transport in avalanche terrain

M. Lehning; C. Fierz 

Slow fluorescence and fast intersystem crossing – The xanthone anomaly

B. Heinz; B. Schmidt; C. Root; F. Milota; B. Fierz et al. 

End-to-end vs interior loop formation kinetics in unfolded polypeptide chains

B. Fierz; T. Kiefhaber 

Loop formation in unfolded polypeptide chains on the picoseconds to microseconds time scale

B. Fierz; H. Satzger; C. Root; P. Gilch; W. Zinth et al.