Our group is interested in:
- developing synthetic methodologies, strategies and their applications in natural product total synthesis;
- devising novel multicomponent reactions (MCRs) and metal-catalyzed domino processes for the rapid construction of medicinally relevant heterocycles and macrocycles;
- searching for new catalytic enantioselective transformations, particularly enantioselective MCRs;
- Designing and synthesizing small molecules with specific biological activities.
Latest News
October 2019 : Warm welcome to our new visiting scholar, Dr. Weisi Guo. Enjoy your stay in Switzerland !
October 2019 : Raphael successfully defended his thesis in front of a committee of experts. Congratulations ! Many thanks to Prof. Andreas Kirschning and Bastien Nay for being part of the Jury.
September 2019 : Tonight we celebrate Cyril’s and Omar’s departure ! We wish you all the best for your future careers, and thank you for the pizzas 😉
September 2019 : Welcome to Rémi Laverne, our new PhD student ! Best of luck for your research !
August 2019 : Balazs Budai is the recipient of the Swiss Chemical Society Best Poster Award at the occasion of Villars’ SCS Summer School. Congratulations !
July 2019 : Xu’s most recent work was published in Chem. Eur. J. : “Remote C(sp3)−H Arylation and Vinylation of N‐Alkoxypyridinium Salts to δ‐Aryl and δ‐Vinyl Alcohols“. Xu accepted an academic position in China ; Best of luck for your future career !
July 2019 : Hua’s paper is now online in JACS : “Catalytic Enantioselective Pinacol and Meinwald Rearrangements for the Construction of Quaternary Stereocenters“. Congratulations !
July 2019 : Cyril is the recipient of the 2019 EPFL Doctorate Award ! Congratulations !
May 2019 : Congratulations to Scheng-Cai for his recent paper in Angewandte “Catalytic Kinetic Resolution by Enantioselective Aromatization: Conversion of Racemic Intermediates of the Barton–Zard Reaction into Enantioenriched 3‐Arylpyrroles“.
Latest Publications
Dr. Hua Wu, Dr. Qian Wang and Prof. Jieping Zhu
in JACS, ASAP (DOI : 10.1021/jacs.9b04551)
Catalytic Kinetic Resolution by Enantioselective Aromatization: Conversion of Racemic Intermediates of the Barton–Zard Reaction into Enantioenriched 3‐Arylpyrroles
Dr. Sheng-Cai Zheng, Dr. Qian Wang and Prof. Jieping Zhu
in Angewandte, ASAP (DOI : 10.1002/anie.201903589)
Copper‐Catalyzed 1,2‐Methoxy Methoxycarbonylation of Alkenes with Methyl Formate
Balazs Budai, Alexandre Leclair, Dr. Qian Wang & Prof. Jieping Zhu
in Angewandte, 2019, ASAP (DOI: 10.1002/anie.201904263)
Iron‐Catalyzed Remote C(sp3)‐H Azidation of O‐Acyl Oximes and N‐Acyloxy Imidates Enabled by 1,5‐Hydrogen Atom Transfer of Iminyl and Imidate Radicals: Synthesis of γ‐Azido Ketones and β‐Azido Alcohols
Dr. Ruben Torres Ochoa, Alexandre Leclair, Dr. Qian Wang & Prof. Jieping Zhu
in Chem. Eur. J., 2019, ASAP (DOI : 10.1002/chem.201901079)
Copper-catalyzed remote C(sp3)–H azidation and oxidative trifluoromethylation of benzohydrazides
Dr. Xu Bao, Dr. Qian Wang & Prof. Jieping Zhu
in Nature Communications, 2019, ASAP (DOI : 10.1038/s41467-019-08741-w)
Recent Advances in Catalytic Enantioselective Rearrangement
Dr. Hua Wu, Dr. Qian Wang and Prof. Jieping Zhu
in Eur. J. Org. Chem, 2019, ASAP (DOI : 10.1002/ejoc.201801799)
Dual Photoredox/Copper Catalysis for the Remote C(sp3)−H Functionalization of Alcohols and Alkyl Halides by N‐Alkoxypyridinium Salts
Dr. Xu Bao, Dr. Qian Wang & Prof. Jieping Zhu
in Angewandte, 2019, ASAP (DOI: 10.1002/anie.201813356)
Formal[4+1] Cycloaddition of o-Aminobenzyl Chlorideswith Isocyanides: Synthesis of 2-Amino-3-Substituted Indoles
Jacobus A. W. Jong, Dr. Xu Bao, Dr. Qian Wang & Prof. Jieping Zhu
in Helv. Chim. Acta, 2019, ASAP (DOI : 10.1002/hlca.201900002)
Stereoselective Total Synthesis of Eburnane-type Alkaloids Enabled byConformation-Directed Cyclization and Rearrangement
Dr. Guang Li, Dr. Cyril Piemontesi, Dr. Qian Wang & Prof. Jieping Zhu
in Angewandte, 2018, ASAP (DOI: doi.org/10.1002/anie.201813920)
From isonitrile to nitrile via ketenimine intermediate: Palladium-catalyzed 1,1-carbocyanation of allyl carbonate by α-isocyanoacetate
Dr. Guanyinsheng Qiu, Charlotte Sornay, David Savary, Dr. Sheng-Cai Zheng, Dr. Qian Wang and Prof. Jieping Zhu
in Tetrahedron, 2018, 74 (49), 6966-6971 (DOI : doi.org/10.1016/j.tet.2018.10.032)
Catalytic Atropenantioselective Heteroannulation between Isocyanoacetates and Alkynyl Ketones: Synthesis of Enantioenriched Axially Chiral 3‐Arylpyrroles
Dr. Sheng-Cai Zheng, Dr. Qian Wang and Prof. Jieping Zhu
in Angewandte, ASAP (DOI : doi.org/10.1002/anie.201812654 )
Catalytic Enantioselective α‐Ketol Rearrangement
Dr. Hua Wu, Rémi Andres, Dr. Qian Wang and Prof. Jieping Zhu
in Angewandte, ASAP (DOI : 10.1002/anie.201812244 )