LSPN

Total Synthesis – Multicomponent Reactions – Domino Process  Catalytic Enantioselective Transformations

Latest News

August 2020 : Jia-Chen’s radical cation cascade has just been published in Angewandte : “Radical Cation Cascade to Aryltetralin Cyclic Ether Lignans Enabled by Visible Light Photoredox Catalysis” Good job !

July 2020 : Rémi’s 5-steps Enantioselective Total Synthesis of Arborisidine has just been published in JACS ! Congratulations !

June 2020 : Bo’s paper was published in Helv. Chim. Acta in a special issue dedicated to EPFL professor Michael Graetzel : “Synthesis of Benzo[a]carbazoles via Visible Light‐Induced Cycloaromatization

May 2020 : Congratulations to Balazs for successfully defending his Ph.D. Thesis !

May 2020 : Our total synthesis of (+)-1,2-Dehydroaspidospermidine, (+)-Condyfoline and (-)-Tubifoline is now online in Angewandte. These syntheses take advantage of the TiCl3-mediated reductive cyclization of o-nitrostyrenes.

May 2020 : Congratulations to Tu & Weisi for their communication in Advanced Synthesis & Catalysis : “Copper‐Catalyzed Cyanoalkylative Aziridination of N‐Sulfonyl Allylamines“. This paper is part of a special issue dedicated to Prof. Bernd Giese at the occasion of his 80th birthday. 

May 2020 : The lab is gradually re-opening.

April 2020 : Lab lockdown is not a fatality for LSPN Seminars ! Today on Zoom, Dina gave a talk about “1,4-palladium shifts” – Thank you !

February 2020 : Hua’s investigations on Catalytic Enantioselective Benzilic Ester Rearrangement has been accepted in ACIE. Congratulations !

February 2020 : Dylan’s work towards Sarpagine has been published in Chem. Eur. J : “Towards Sarpagine‐Ajmaline‐Macroline Family Indole Alkaloids: Enantioselective Synthesis of N‐Demethyl Alstolactone Diastereomer” Good Job !

Monthly Seminars & Exercice Sessions

About Jieping

Latest Publications

Radical Cation Cascade to Aryltetralin Cyclic Ether Lignans Enabled by Visible Light Photoredox Catalysis

Dr. Jia-Chen, Dr. Qian Wang and Prof. Jieping Zhu

in Angewandte, ASAP (DOI : doi.org/10.1002/anie.202007548)

Asymmetric Total Synthesis of (-)-Arborisidine and (-)-19-epi-Arborisidine Enabled by a Catalytic Enantioselective Pictet-Spengler Reaction

Rémi Andres, Dr. Qian Wang and Prof. Jieping Zhu

in JACS, Just accepted (DOI : doi.org/10.1021/jacs.0c05804)

Synthesis of Benzo[a]carbazoles via Visible Light‐Induced Cycloaromatization

Dr. Bo Yao, Dr. Qian Wang and Prof. Jieping Zhu

in Helv. Chim. Acta, ASAP (DOI : doi.org/10.1002/hlca.202000106)

TiCl3‐Mediated Synthesis of 2,3,3‐Trisubstituted Indolenines: Total Synthesis of (+)‐1,2‐Dehydroaspidospermidine, (+)‐Condyfoline and (‐)‐Tubifoline

Bastien Delayre, Dr. Cyril Piemontesi, Dr. Qian Wang and Prof. Jieping Zhu

in Angewandte, ASAP (DOI : doi.org/10.1002/anie.202005380)

Enantioselective Benzilic Ester Rearrangement

Dr. Hua Wu, Dr. Qian Wang and Prof. Jieping Zhu

in Angewandte, ASAP (DOI : doi.org/10.1002/anie.202001258)

Towards Sarpagine‐Ajmaline‐Macroline Family Indole Alkaloids: Enantioselective Synthesis of N‐Demethyl Alstolactone Diastereomer

Dr. Dylan Dagoneau, Dr. Qian Wang and Prof. Jieping Zhu

in Chem. Eur. J., ASAP (DOI : doi.org/10.1002/chem.202000415)

Functionalization of remote C(sp3)-H bonds enabled by copper-catalyzed coupling of O-acyloximes with terminal alkynes

Dr. Zhaodong Li, Dr. Rubén O. Torres-Ochoa, Dr. Qian Wang and Prof. Jieping Zhu

in Nat. Comm., ASAP (DOI : doi.org/10.1038/s41467-020-14292-2)

Palladium‐catalyzed Enantioselective Cacchi Reaction: Asymmetric Synthesis of Axially Chiral 2,3‐Disubstituted Indoles

Dr. Yu-Ping He, Dr. Hua Wu, Dr. Qian Wang and Prof. Jieping Zhu

in Angewandte, ASAP (DOI : 10.1002/anie.201914049)

Catalytic Kinetic Resolution by Enantioselective Aromatization: Conversion of Racemic Intermediates of the Barton–Zard Reaction into Enantioenriched 3‐Arylpyrroles

Dr. Sheng-Cai Zheng, Dr. Qian Wang and Prof. Jieping Zhu

in Angewandte, ASAP (DOI : 10.1002/anie.201903589)

Copper‐Catalyzed 1,2‐Methoxy Methoxycarbonylation of Alkenes with Methyl Formate

Balazs Budai, Alexandre Leclair, Dr. Qian Wang & Prof. Jieping Zhu

in Angewandte, 2019, ASAP (DOI: 10.1002/anie.201904263)

Group Pictures 2010 – 2020

Fumehoods and  lab equipment @ LSPN

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