LSPN

Total synthesis of natural products Multicomponent reactions – Metal-catalyzed domino process – Catalytic enantioselective transformations

Our group is interested in:

  1. developing synthetic methodologies, strategies and their applications in natural product total synthesis;
  2. devising novel multicomponent reactions (MCRs) and metal-catalyzed domino processes for the rapid construction of medicinally relevant heterocycles and macrocycles;
  3. searching for new catalytic enantioselective transformations, particularly enantioselective MCRs;
  4. Designing and synthesizing small molecules with specific biological activities.

Latest News

October 2019 : Warm welcome to our new visiting scholar, Dr. Weisi Guo. Enjoy your stay in Switzerland !

October 2019 : Raphael successfully defended his thesis in front of a committee of experts. Congratulations ! Many thanks to Prof. Andreas Kirschning and Bastien Nay for being part of the Jury.

September 2019 : Tonight we celebrate Cyril’s and Omar’s departure ! We wish you all the best for your future careers, and thank you for the pizzas 😉

September 2019 : Welcome to Rémi Laverne, our new PhD student ! Best of luck for your research !

August 2019 : Balazs Budai is the recipient of the Swiss Chemical Society Best Poster Award at the occasion of Villars’ SCS Summer School. Congratulations !

July 2019 : Xu’s most recent work was published in Chem. Eur. J. : “Remote C(sp3)−H Arylation and Vinylation of N‐Alkoxypyridinium Salts to δ‐Aryl and δ‐Vinyl Alcohols“. Xu accepted an academic position in China ; Best of luck for your future career !

July 2019 : Hua’s paper is now online in JACS : “Catalytic Enantioselective Pinacol and Meinwald Rearrangements for the Construction of Quaternary Stereocenters“. Congratulations !

July 2019 : Cyril is the recipient of the 2019 EPFL Doctorate Award ! Congratulations !

May 2019 : Congratulations to Scheng-Cai for his recent paper in Angewandte “Catalytic Kinetic Resolution by Enantioselective Aromatization: Conversion of Racemic Intermediates of the Barton–Zard Reaction into Enantioenriched 3‐Arylpyrroles“.


Latest Publications

Catalytic Enantioselective Pinacol and Meinwald Rearrangements for the Construction of Quaternary Stereocenters

Dr. Hua Wu, Dr. Qian Wang and Prof. Jieping Zhu

in JACS, ASAP (DOI : 10.1021/jacs.9b04551)

Catalytic Kinetic Resolution by Enantioselective Aromatization: Conversion of Racemic Intermediates of the Barton–Zard Reaction into Enantioenriched 3‐Arylpyrroles

Dr. Sheng-Cai Zheng, Dr. Qian Wang and Prof. Jieping Zhu

in Angewandte, ASAP (DOI : 10.1002/anie.201903589)

Copper‐Catalyzed 1,2‐Methoxy Methoxycarbonylation of Alkenes with Methyl Formate

Balazs Budai, Alexandre Leclair, Dr. Qian Wang & Prof. Jieping Zhu

in Angewandte, 2019, ASAP (DOI: 10.1002/anie.201904263)

Iron‐Catalyzed Remote C(sp3)‐H Azidation of O‐Acyl Oximes and N‐Acyloxy Imidates Enabled by 1,5‐Hydrogen Atom Transfer of Iminyl and Imidate Radicals: Synthesis of γ‐Azido Ketones and β‐Azido Alcohols

Dr. Ruben Torres Ochoa, Alexandre Leclair, Dr. Qian Wang & Prof. Jieping Zhu

in Chem. Eur. J., 2019, ASAP (DOI : 10.1002/chem.201901079)

Copper-catalyzed remote C(sp3)–H azidation and oxidative trifluoromethylation of benzohydrazides

Dr. Xu Bao, Dr. Qian Wang & Prof. Jieping Zhu

in Nature Communications, 2019, ASAP (DOI : 10.1038/s41467-019-08741-w)

Recent Advances in Catalytic Enantioselective Rearrangement

Dr. Hua Wu, Dr. Qian Wang and Prof. Jieping Zhu

in Eur. J. Org. Chem, 2019, ASAP (DOI :  10.1002/ejoc.201801799)

Dual Photoredox/Copper Catalysis for the Remote C(sp3)−H Functionalization of Alcohols and Alkyl Halides by N‐Alkoxypyridinium Salts

Dr. Xu Bao, Dr. Qian Wang & Prof. Jieping Zhu

in Angewandte, 2019, ASAP (DOI: 10.1002/anie.201813356)

Formal[4+1] Cycloaddition of o-Aminobenzyl Chlorideswith Isocyanides: Synthesis of 2-Amino-3-Substituted Indoles

Jacobus A. W. Jong, Dr. Xu Bao, Dr. Qian Wang & Prof. Jieping Zhu

in Helv. Chim. Acta, 2019, ASAP (DOI : 10.1002/hlca.201900002)

Stereoselective Total Synthesis of Eburnane-type Alkaloids Enabled byConformation-Directed Cyclization and Rearrangement

Dr. Guang Li, Dr. Cyril Piemontesi, Dr. Qian Wang & Prof. Jieping Zhu

in Angewandte, 2018, ASAP (DOI: doi.org/10.1002/anie.201813920)

From isonitrile to nitrile via ketenimine intermediate: Palladium-catalyzed 1,1-carbocyanation of allyl carbonate by α-isocyanoacetate

Dr. Guanyinsheng Qiu, Charlotte Sornay, David Savary, Dr. Sheng-Cai Zheng, Dr. Qian Wang and Prof. Jieping Zhu

in Tetrahedron, 2018, 74 (49), 6966-6971 (DOI : doi.org/10.1016/j.tet.2018.10.032)

Catalytic Atropenantioselective Heteroannulation between Isocyanoacetates and Alkynyl Ketones: Synthesis of Enantioenriched Axially Chiral 3‐Arylpyrroles

Dr. Sheng-Cai Zheng, Dr. Qian Wang and Prof. Jieping Zhu

in Angewandte, ASAP (DOI : doi.org/10.1002/anie.201812654 )

Catalytic Enantioselective α‐Ketol Rearrangement

Dr. Hua Wu, Rémi Andres, Dr. Qian Wang and Prof. Jieping Zhu

in Angewandte, ASAP (DOI : 10.1002/anie.201812244 )