LSPN

Total Synthesis – Multicomponent Reactions – Domino Process  Catalytic Enantioselective Transformations

Latest News

November 2020 : Congratulations to Weisi for his recent publication in ACIE  “Selective 1,2‐Aminoisothiocyanation of 1,3‐Dienes Under Visible Light Photoredox Catalysis” Great Job !

November 2020 : Congratulations to Dr. Balazs Budai for his recent PhD defense ! Best of luck for your future research in the Hartwig group !

November 2020 : Warm welcome to Dan & Jing, the two new members of the lab.

October 2020 : Congratulations to Takujii and Rémi for winning the MOM (EPFL’s retrosynthesis competition) !

October 2020 : Welcome to Alberto and Guoqiang to the lab! Best of luck with your research !

September 2020 : Our Total Synthesis of (+)-1,2-Dehydroaspidospermidine, (+)-Condyfoline, and (–)-Tubifoline has been highlighted in Synfact as Synfact of the Month !

September 2020 : A warm welcome to Takuji and Cédric, two new PhD candidates in the group !

August 2020 : Alexandre won the organic chemistry poster prize at the SCS Fall Meeting ! Congratulations !

August 2020 : Angel and Omar’s paper has just been published in OL ! Palladium-Catalyzed Multicomponent Synthesis of Fully Substituted Alkylidene Furanones – Congratulations !

August 2020 : Great group outing with all the team ! More pictures here

August 2020 : Jia-Chen’s radical cation cascade has just been published in Angewandte : “Radical Cation Cascade to Aryltetralin Cyclic Ether Lignans Enabled by Visible Light Photoredox Catalysis” Good job !

July 2020 : Rémi’s 5-steps Enantioselective Total Synthesis of Arborisidine has just been published in JACS ! Congratulations !

May 2020 : Our total synthesis of (+)-1,2-Dehydroaspidospermidine, (+)-Condyfoline and (-)-Tubifoline is now online in Angewandte. These syntheses take advantage of the TiCl3-mediated reductive cyclization of o-nitrostyrenes.

 

Monthly Seminars & Exercice Sessions

About Jieping

Latest Publications

Selective 1,2‐Aminoisothiocyanation of 1,3‐Dienes Under Visible Light Photoredox Catalysis

Dr. Weisi Guo, Dr. Qian Wang, and Prof. Jieping Zhu

in Angewandte, ASAP (DOI: doi.org/10.1002/anie.202014518)

Palladium-Catalyzed Multicomponent Synthesis of Fully Substituted Alkylidene Furanones

Dr. Ángel Rentería-Gómez, Dr. Rubén O. Torres-Ochoa, Dr. Rocío Gámez-Montaño, Dr. Qian Wang, and Prof. Jieping Zhu

in Organic Letters, ASAP (DOI : doi.org/10.1021/acs.orglett.0c02578)

Radical Cation Cascade to Aryltetralin Cyclic Ether Lignans Enabled by Visible Light Photoredox Catalysis

Dr. Jia-Chen, Dr. Qian Wang and Prof. Jieping Zhu

in Angewandte, ASAP (DOI : doi.org/10.1002/anie.202007548)

Asymmetric Total Synthesis of (-)-Arborisidine and (-)-19-epi-Arborisidine Enabled by a Catalytic Enantioselective Pictet-Spengler Reaction

Rémi Andres, Dr. Qian Wang and Prof. Jieping Zhu

in JACS, Just accepted (DOI : doi.org/10.1021/jacs.0c05804)

Synthesis of Benzo[a]carbazoles via Visible Light‐Induced Cycloaromatization

Dr. Bo Yao, Dr. Qian Wang and Prof. Jieping Zhu

in Helv. Chim. Acta, ASAP (DOI : doi.org/10.1002/hlca.202000106)

TiCl3‐Mediated Synthesis of 2,3,3‐Trisubstituted Indolenines: Total Synthesis of (+)‐1,2‐Dehydroaspidospermidine, (+)‐Condyfoline and (‐)‐Tubifoline

Bastien Delayre, Dr. Cyril Piemontesi, Dr. Qian Wang and Prof. Jieping Zhu

in Angewandte, ASAP (DOI : doi.org/10.1002/anie.202005380)

Enantioselective Benzilic Ester Rearrangement

Dr. Hua Wu, Dr. Qian Wang and Prof. Jieping Zhu

in Angewandte, ASAP (DOI : doi.org/10.1002/anie.202001258)

Towards Sarpagine‐Ajmaline‐Macroline Family Indole Alkaloids: Enantioselective Synthesis of N‐Demethyl Alstolactone Diastereomer

Dr. Dylan Dagoneau, Dr. Qian Wang and Prof. Jieping Zhu

in Chem. Eur. J., ASAP (DOI : doi.org/10.1002/chem.202000415)

Functionalization of remote C(sp3)-H bonds enabled by copper-catalyzed coupling of O-acyloximes with terminal alkynes

Dr. Zhaodong Li, Dr. Rubén O. Torres-Ochoa, Dr. Qian Wang and Prof. Jieping Zhu

in Nat. Comm., ASAP (DOI : doi.org/10.1038/s41467-020-14292-2)

Palladium‐catalyzed Enantioselective Cacchi Reaction: Asymmetric Synthesis of Axially Chiral 2,3‐Disubstituted Indoles

Dr. Yu-Ping He, Dr. Hua Wu, Dr. Qian Wang and Prof. Jieping Zhu

in Angewandte, ASAP (DOI : 10.1002/anie.201914049)

Group Pictures 2010 – 2020

Fumehoods and  lab equipment @ LSPN

Social Events & Group Outings