Benzylic C(sp3)-H Azidation: Copper vs Iron Catalysis

A. Renteria-Gomez; R. O. Torres-Ochoa; P. Palamini; R. Simonet-Davin; Q. Wang et al. 

Catalytic Enantioselective Synthesis of Inherently Chiral Macrocycles by Dynamic Kinetic Resolution

Q-L. Lu; X-D. Wang; S. Tong; J. Zhu; M-X. Wang 

Chalcogen bonding catalysis

G. Sekar; V. V. Nair; J. Zhu 

Palladium‐Based Dyotropic Rearrangement Enables A Triple Functionalization of Gem‐Disubstituted Alkenes: An Unusual Fluorolactonization Reaction

Q. Feng; C. Liu; Q. Wang; J. Zhu 

Enantioselective Total Synthesis of (-)-Artatrovirenol A

R. Lavernhe; P. Domke; Q. Wang; J. Zhu 

Asymmetric Construction of α,α‐Disubstituted Piperazinones Enabled by Benzilic Amide Rearrangement

Y. He; R. Quan; X. Li; J. Zhu; H. Wu 

Terminal Alkynes as One-Carbon Donors in [5+1] Heteroannulation: Synthesis of Pyridines via Ynimine Intermediates and Application in the Total Synthesis of Anibamine B

R. Lavernhe; Q. Wang; J. Zhu 

Divergent Asymmetric Total Synthesis of (−)‐Voacafricines A and B

R. Andres; Q. Wang; J. Zhu 

Highly Strained Oxygen‐Doped Chiral Molecular Belts of the Zigzag‐Type with Strong Circularly Polarized Luminescence

J. Chen; Z. Jiang; H. Xiao; S. Tong; T. Shi et al. 

Oxidative rearrangement of 1,1-disubstituted alkenes to ketones

Q. Feng; Q. Wang; J. Zhu 

Enantioselective Total Synthesis of (+)-Stephadiamine

B. Yang; G. Li; Q. Wang; J. Zhu 

Inherently chiral calixarenes by a catalytic enantioselective desymmetrizing cross-dehydrogenative coupling

X. Zhang; S. Tong; J. Zhu; M-X. Wang 

Organocatalytic Enantioselective Pictet–Spengler Reaction of α‐Ketoesters: Development and Application to the Total Synthesis of (+)‐Alstratine A

R. Andres; F. Sun; Q. Wang; J. Zhu 

Synthesis and Applications of Ynimines and Enantioselective Total Synthesis of Artatrovirenol A

Diverting the 5-exo-Trig Oxypalladation to Formally 6-endo-Trig Fluorocycloetherification Product through 1,2-O/Pd(IV) Dyotropic Rearrangement

J. Gong; Q. Wang; J. Zhu 

Asymmetric Synthesis of Enantioenriched Zigzag-Type Molecular Belts by Kinetic Resolution and Subsequent Transformations

Y-Q. Mao; Y. Zhang; S. Tong; J. Zhu; M-X. Wang 

Dual Photoredox and Copper Catalysis: Enantioselective 1,2-Amidocyanation of 1,3-Dienes

D. Forster; W. Guo; Q. Wang; J. Zhu 

TiCl3-Mediated Reductive Cyclization of Tetrasubstituted Alkenes and Enol Esters Bearing a 2-Nitrophenyl Substituent

Organocatalytic Enantioselective Diels-Alder Reaction of 2-Trifluoroacetamido-1,3-dienes with alpha,beta-Unsaturated Ketones

X-Q. Zhu; Q. Wang; J. Zhu 

Apparent 6-endo-trig Carbofluorination of Alkenes Enabled by Palladium-Based Dyotropic Rearrangement

J. Gong; Q. Wang; J. Zhu 

Synthesis of 3-Acyloxyindolenines by TiCl3-Mediated Reductive Cyclization of 2-(ortho-Nitroaryl)-Substituted Enol Esters

D. V. Boyarskaya; A. Ongaro; C. Piemontesi; Q. Wang; J. Zhu 

Thiazole Boron Difluoride Dyes with Large Stokes Shift, Solid State Emission and Room-Temperature Phosphorescence

W. Wang; S. Tong; Q-Q. Wang; Y-F. Ao; D-X. Wang et al. 

Migrative Carbofluorination of Saturated Amides Enabled by Pd-Based Dyotropic Rearrangement

G. Yang; H. Wu; S. Gallarati; C. Corminboeuf; Q. Wang et al. 

Two-Carbon Ring Expansion of Cyclobutanols to Cyclohexenones Enabled by Indole Radical Cation Intermediate: Development and Application to a Total Synthesis of Uleine

A. Leclair; Q. Wang; J. Zhu 

Catalytic enantioselective Pictet-Spengler reaction of carbonyl compounds: Development and application to the asymmetric total synthesis of indole alkaloids

Taming the radical cation intermediate enabled one-step access to structurally diverse lignans

J-C. Xiang; C. Fung; Q. Wang; J. Zhu 

Catalytic Enantioselective Pictet–Spengler Reaction of α‐Ketoamides Catalyzed by a Single H‐Bond Donor Organocatalyst

R. Andres; Q. Wang; J. Zhu 

Modular Synthesis of Benzocyclobutenes via Pd(II)-Catalyzed Oxidative [2+2] Annulation of Arylboronic Acids with Alkenes

T. Fujii; S. Gallarati; C. Corminboeuf; Q. Wang; J. Zhu 

Asymmetric Total Synthesis of Indole Alkaloids (+)-Condyfoline, (-)-Tubifoline, (+)-Dasycarpidone and (+)-Uleine

Photoredox Catalytic Three-Component Amidoazidation of 1,3-Dienes

D. Forster; W. Guo; Q. Wang; J. Zhu 

Copper‐Catalyzed Aza‐Sonogashira Cross‐Coupling to Ynimines: Development and Application to the Synthesis of Heterocycles

R. Lavernhe; R. O. Torres-Ochoa; Q. Wang; J. Zhu 

Enantioselective Total Synthesis of (+)-Nordasycarpidone, (+)-Dasycarpidone, and (+)-Uleine

B. Delayre; C. Fung; Q. Wang; J. Zhu 

C-C bond activation enabled by dyotropic rearrangement of Pd(iv) species

J. Cao; H. Wu; Q. Wang; J. Zhu 

Visible light photoredox-catalysed remote C-H functionalisation enabled by 1,5-hydrogen atom transfer (1,5-HAT)

W. Guo; Q. Wang; J. Zhu 

Enantioselective Total Synthesis of (+)-Alstilobanine C, (+)-Undulifoline, and (-)-Alpneumine H

G. Li; N. Gaeng; C. Piemontesi; Q. Wang; J. Zhu 

Selective 1,2-Aminoisothiocyanation of 1,3-Dienes Under Visible-Light Photoredox Catalysis

W. Guo; Q. Wang; J. Zhu 

Development of remote C-H bond functionalization of redox-active alcohol derivatives and oxidative transformations under photoredox catalysis

Macrocyclization of omega-Isocyanoaldehydes and Towards the Total Synthesis of Jamaicensamide A

Catalytic Enantioselective Synthesis of Morpholinones Enabled by Aza-Benzilic Ester Rearrangement

Y-P. He; H. Wu; Q. Wang; J. Zhu 

Iron-Catalysed Remote C(sp3)-H Azidation of O-Acyl Oximes and N -Acyloxy Imidates

A. Leclair; R. O. Torres-Ochoa; Q. Wang; J. Zhu 

Natural Product Synthesis Enabled by Domino Processes Incorporating a 1,2-Rearrangement Step

B. Delayre; Q. Wang; J. Zhu 

Catalytic Enantioselective Aminopalladation–Heck Cascade

Y. He; J. Cao; H. Wu; Q. Wang; J. Zhu 

Unified divergent strategy towards the total synthesis of the three sub-classes of hasubanan alkaloids

G. Li; Q. Wang; J. Zhu 

Radical-Cation Cascade to Aryltetralin Cyclic Ether Lignans Under Visible-Light Photoredox Catalysis

J-C. Xiang; Q. Wang; J. Zhu 

Palladium-Catalyzed Multicomponent Synthesis of Fully Substituted Alkylidene Furanones

A. Renteria-Gomez; R. O. Torres-Ochoa; R. Gamez-Montano; Q. Wang; J. Zhu 

Asymmetric Total Synthesis of (-)-Arborisidine and (-)-19-epi-Arborisidine Enabled by a Catalytic Enantioselective Pictet-Spengler Reaction

R. Andres; Q. Wang; J. Zhu 

Synthesis of Benzo[a]carbazoles through Visible Light-Induced Cycloaromatization

B. Yao; Q. Wang; J. Zhu 

TiCl3-Mediated Synthesis of 2,3,3-Trisubstituted Indolenines: Total Synthesis of (+)-1,2-Dehydroaspidospermidine, (+)-Condyfoline, and (-)-Tubifoline

B. Delayre; C. Piemontesi; Q. Wang; J. Zhu 

Copper-Catalyzed Cyanoalkylative Aziridination of N-Sulfonyl Allylamines

T. M. Ha; W. Guo; Q. Wang; J. Zhu 

Catalytic Enantioselective Benzilic Ester Rearrangement

H. Wu; Q. Wang; J. Zhu 

Towards the Sarpagine-Ajmaline-Macroline Family of Indole Alkaloids: Enantioselective Synthesis of an N-Demethyl Alstolactone Diastereomer

D. Dagoneau; Q. Wang; J. Zhu 

Construction of the Erythrinane Core Skeleton via Asymmetric Catalytic Cascade Reaction of Tertiary Enamides

L. Zhen; S. Tong; J. Zhu; M-X. Wang 

Copper-Catalyzed 1,2-Methoxy Methoxycarbonylation of Alkenes with Methyl Formate and Synthetic Studies Towards the Total Synthesis of Koumine, Voacafricine A and Voacafricine B

Catalytic Enantioselective Synthesis and Switchable Chiroptical Property of Inherently Chiral Macrocycles

S. Tong; J-T. Li; D-D. Liang; Y-Zhang; Q-Y. Feng et al. 

Palladium-Catalyzed Enantioselective Cacchi Reaction: Asymmetric Synthesis of Axially Chiral 2,3-Disubstituted Indoles

Y-P. He; H. Wu; Q. Wang; J. Zhu 

Functionalization of remote C(sp3)-H bonds enabled by copper-catalyzed coupling of O-acyloximes with terminal alkynes

Z. Li; R. O. Torres-Ochoa; Q. Wang; J. Zhu 

Fused N‐Heterocycles with Contiguous Stereogenic Centers Accessed by an Asymmetric Catalytic Cascade Reaction of Tertiary Enamides

L. Zhen; S. Tong; J. Zhu; M. Wang 

Organocatalytic Double Ugi Reaction with Statistical Amplification of Product Enantiopurity: A Linker Cleavage Approach To Access Highly Enantiopure Ugi Products

Q-Y. Feng; J. Zhu; M-X. Wang; S. Tong 

Desymmetrization of Prochiral Cyclopentenes Enabled by Enantioselective Palladium-Catalyzed Oxidative Heck Reaction

G. Chen; J. Cao; Q. Wang; J. Zhu 

Remote C(sp(3))-H Arylation and Vinylation of N-Alkoxypyridinium Salts to delta-Aryl and delta-Vinyl Alcohols

X. Bao; Q. Wang; J. Zhu 

Total Synthesis of Alstolactine A & Synthetic Studies Towards Members of Akuammiline Alkaloids

Catalytic Enantioselective Pinacol and Meinwald Rearrangements for the Construction of Quaternary Stereocenters

H. Wu; Q. Wang; J. Zhu 

Copper-Catalyzed 1,2-Methoxy Methoxycarbonylation of Alkenes with Methyl Formate

B. Budai; A. Leclair; Q. Wang; J. Zhu 

Catalytic Kinetic Resolution by Enantioselective Aromatization: Conversion of Racemic Intermediates of the Barton-Zard Reaction into Enantioenriched 3-Arylpyrroles

S-C. Zheng; Q. Wang; J. Zhu 

Iron‐Catalysed Remote C(sp 3 )−H Azidation of O ‐Acyl Oximes and N ‐Acyloxy Imidates Enabled by 1,5‐Hydrogen Atom Transfer of Iminyl and Imidate Radicals: Synthesis of γ‐Azido Ketones and β‐Azido Alcohols

R. O. Torres‐Ochoa; A. Leclair; Q. Wang; J. Zhu 

Formal [4+1] Cycloaddition of o ‐Aminobenzyl Chlorides with Isocyanides: Synthesis of 2‐Amino‐3‐Substituted Indoles

J. A. W. Jong; X. Bao; Q. Wang; J. Zhu 

Palladium-Catalyzed Synthesis of Ketenimines from Isocyanides and Synthetic Studies Towards the Total Synthesis of Mersilongine

Recent Advances in Catalytic Enantioselective Rearrangement

H. Wu; Q. Wang; J. Zhu 

Intramolecular Arylation of Tertiary Enamides through Pd(OAc)2-Catalyzed Dehydrogenative Cross-Coupling Reaction: Construction of Fused N-Heterocyclic Scaffolds and Synthesis of Isoindolobenzazepine Alkaloids

W. Zhu; S. Tong; J. Zhu; M-X. Wang 

Copper-catalyzed remote C(sp3)–H azidation and oxidative trifluoromethylation of benzohydrazides

X. Bao; Q. Wang; J. Zhu 

Stereoselective Total Synthesis of Eburnane-Type Alkaloids Enabled by Conformation-Directed Cyclization and Rearrangement

G. Li; C. Piemontesi; Q. Wang; J. Zhu 

Dual Photoredox/Copper Catalysis for the Remote C(sp3 )−H Functionalization of Alcohols and Alkyl Halides by N -Alkoxypyridinium Salts

X. Bao; Q. Wang; J. Zhu 

Construction of Quaternary Stereocenters by Palladium-Catalyzed Carbopalladation-Initiated Cascade Reactions

Y. Ping; Y. Li; J. Zhu; W. Kong 

Catalytic Atropenantioselective Heteroannulation between Isocyanoacetates and Alkynyl Ketones: Synthesis of Enantioenriched Axially Chiral 3-Arylpyrroles

S-C. Zheng; Q. Wang; J. Zhu 

Catalytic Enantioselective α-Ketol Rearrangement

H. Wu; R. Andres; Q. Wang; J. Zhu 

From isonitrile to nitrile via ketenimine intermediate: Palladium-catalyzed 1,1-carbocyanation of ally carbonate by alpha-isocyanoacetate

G. Qiu; C. Sornay; D. Savary; S-C. Zheng; Q. Wang et al. 

Lewis acid catalyst-steered divergent synthesis of functionalized vicinal amino alcohols and pyrroles from tertiary enamides

X-M. Xu; C-H. Lei; S. Tong; J. Zhu; M-X. Wang 

Enantioselective total synthesis of (+)-Peganumine A

C. Piemontesi; Q. Wang; J. Zhu 

Total Synthesis of Alstilobanine C, Undulifoline and Alstilobanine B

Metamorphosis of cycloalkenes for the divergent total synthesis of polycyclic indole alkaloids

Z. Xu; Q. Wang; J. Zhu 

Copper-catalyzed methylative difunctionalization of alkenes

X. Bao; T. Yokoe; T. M. Ha; Q. Wang; J. Zhu 

Chiral phosphoric acid-catalyzed enantioselective three-component Mannich reaction of acyclic ketones, aldehydes and anilines

S. Tong; Q. Wang; M-X. Wang; J. Zhu 

Copper-Catalyzed Arylation of Remote C(sp3 )−H Bonds in Carboxamides and Sulfonamides

Z. Li; Q. Wang; J. Zhu 

Still Unconquered: Enantioselective Passerini and Ugi Multicomponent Reactions

Q. Wang; D-X. Wang; M-X. Wang; J. Zhu 

Heteroannulation of Arynes with α-Amino Imides: Synthesis of 2,2-Disubstituted Indolin-3-ones and Application to the Enantioselective Total Synthesis of (+)-Hinckdentine A

R. O. Torres-Ochoa; T. Buyck; Q. Wang; J. Zhu 

Indole Alkaloids, Macrocycles and Heterocycles

Copper-Catalyzed Enantioselective Arylative Desymmetrization of Prochiral Cyclopentenes with Diaryliodonium Salts

H. Wu; Q. Wang; J. Zhu 

Palladium-Catalyzed Enantioselective Desymmetrizing Aza-Wacker Reaction: Development and Application to the Total Synthesis of (−)-Mesembrane and (+)-Crinane

X. Bao; Q. Wang; J. Zhu 

Cooperative Pd/Cu Catalysis: Multicomponent Synthesis of Tetrasubstituted Imidazolones from Methyl α-Isocyanoacetates, Primary Amines, and Aryl(vinyl) Iodides

A. Clemenceau; Q. Wang; J. Zhu 

“Divergent Total Synthesis of (-)-Rhazinilam, (-)-Leucomidine B and (+)-Leuconodine F” and “Synthetic Studies Towards Sarpagine-Related Indoles”

Catalytic Enantioselective Double Carbopalladation/C−H Functionalization with Statistical Amplification of Product Enantiopurity: A Convertible Linker Approach

S. Tong; A. Limouni; Q. Wang; M-X. Wang; J. Zhu 

Copper-Catalyzed Enantioselective Domino Arylation/Semipinacol Rearrangement of Allylic Alcohols with Diaryliodonium Salts

H. Wu; Q. Wang; J. Zhu 

Around isocyanide reactivity

Silver Nitrate-Catalyzed Isocyanide Insertion/Lactamization Sequence to Imidazolones and Quinazolin-4-ones: Development and Application in Natural Product Synthesis

A. Clemenceau; Q. Wang; J. Zhu 

α-Oxo-Ketenimines from Isocyanides and α-Haloketones: Synthesis and Divergent Reactivity

M. Mamboury; Q. Wang; J. Zhu 

Copper-Catalyzed Three-Component Carboazidation of Alkenes with Acetonitrile and Sodium Azide

A. Bunescu; T. M. Ha; Q. Wang; J. Zhu 

Palladium-Catalyzed Enantioselective Narasaka-Heck Reaction/Direct C−H Alkylation of Arenes: Iminoarylation of Alkenes

X. Bao; Q. Wang; J. Zhu 

Silver-Catalyzed Three-Component 1,1-Aminoacylation of Homopropargylamines: α-Additions for Both Terminal Alkynes and Isocyanides

S. Tong; C. Piemontesi; Q. Wang; M-X. Wang; J. Zhu 

Fluorophores for Excited-State Intramolecular Proton Transfer by an Yttrium Triflate Catalyzed Reaction of Isocyanides with Thiocarboxylic Acids

S. Tong; S. Zhao; Q. He; Q. Wang; M-X. Wang et al. 

Organocatalytic Enantioselective Acyloin Rearrangement of α-Hydroxy Acetals to α-Alkoxy Ketones

H. Wu; Q. Wang; J. Zhu 

Organocatalytic Nucleophilic Addition of Hydrazones to Imines: Synthesis of Enantioenriched Vicinal Diamines

Y. Wang; Q. Wang; J. Zhu 

Water as a Hydride Source in Palladium-Catalyzed Enantioselective Reductive Heck Reactions

W. Kong; Q. Wang; J. Zhu 

To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis

M. Giustiniano; A. Basso; V. Mercalli; A. Massarotti; E. Novellino et al. 

“Palladium-Catalyzed Diamination of Alkynes in Synthesis of Tetracycles” and “Copper-Catalyzed Cyanoalkylation of Unactivated Alkenes”

Palladium-Catalyzed Three-Component Reaction of Propargyl Carbonates, Isocyanides, and Alcohols or Water: Switchable Synthesis of Pyrroles and Its Bicyclic Analogues

G. Qiu; Q. Wang; J. Zhu 

Enantioselective Synthesis of Quaternary α-Amino Acids Enabled by the Versatility of the Phenylselenonyl Group

A. Clemenceau; Q. Wang; J. Zhu 

Organocatalytic Enantioselective Vinylogous Pinacol Rearrangement Enabled by Chiral Ion Pairing

H. Wu; Q. Wang; J. Zhu 

Ketenimines from Isocyanides and Allyl Carbonates: Palladium-Catalyzed Synthesis of β,γ-Unsaturated Amides and Tetrazoles

G. Qiu; M. Mamboury; Q. Wang; J. Zhu 

Enantioselective Synthesis of (+)-Peganumine A

C. Piemontesi; Q. Wang; J. Zhu 

Copper-catalysed cyanoalkylative cycloetherification of alkenes to 1,3-dihydroisobenzofurans: development and application to the synthesis of citalopram

T. M. Ha; Q. Wang; J. Zhu 

Synthesis of Diversely Functionalized Oxindoles Enabled by Migratory Insertion of Isocyanide to a Transient σ-Alkylpalladium(II) Complex

W. Kong; Q. Wang; J. Zhu 

Copper-Catalyzed Formal [2+2+1] Heteroannulation of Alkenes, Alkylnitriles, and Water: Method Development and Application to a Total Synthesis of (±)-Sacidumlignan D

T. M. Ha; C. Chatalova-Sazepin; Q. Wang; J. Zhu 

Switchable [3+2] and [4+2] Heteroannulation of Primary Propargylamines with Isonitriles to Imidazoles and 1,6-Dihydropyrimidines: Catalyst Loading Enabled Reaction Divergence

S. Tong; Q. Wang; M-X. Wang; J. Zhu 

Chiral Phosphoric Acid-Catalyzed Enantioselective Formal [3+2] Cycloaddition of Azomethine Imines with Enecarbamates

Y. Wang; Q. Wang; J. Zhu 

Enantioselective Total Synthesis of (−)-Terengganensine A

C. Piemontesi; Q. Wang; J. Zhu 

Chiral Phosphoric Acid Catalyzed Asymmetric Ugi Reaction by Dynamic Kinetic Resolution of the Primary Multicomponent Adduct

Y. Zhang; Y-F. Ao; Z-T. Huang; D-X. Wang; M-X. Wang et al. 

Synthesis of Vinyl Isocyanides and Development of a Convertible Isonitrile

M. Spallarossa; Q. Wang; R. Riva; J. Zhu 

Catalytic Asymmetric Tandem Reaction of Tertiary Enamides: Expeditious Synthesis of Pyrrolo[2,1-a]isoquinoline Alkaloid Derivatives

X-M. Xu; L. Zhao; J. Zhu; M-X. Wang 

Total Synthesis of (±)-Strictamine

W. Ren; Q. Wang; J. Zhu 

Synthesis of Oxazolidin-2-ones by Oxidative Coupling of Isonitriles, Phenyl Vinyl Selenone, and Water

T. Buyck; D. Pasche; Q. Wang; J. Zhu 

Enantioselective Total Syntheses of (−)-Rhazinilam, (−)-Leucomidine B, and (+)-Leuconodine F

D. Dagoneau; Z. Xu; Q. Wang; J. Zhu 

Palladium-Catalyzed Enantioselective Domino Heck/Intermolecular C–H Bond Functionalization: Development and Application to the Synthesis of (+)-Esermethole

W. Kong; Q. Wang; J. Zhu 

An Enantioselective Total Synthesis of (−)-Isoschizogamine

Z. Xu; X. Bao; Q. Wang; J. Zhu 

Sulfonamide and Tertiary Amine as Nucleophiles in Pd(II)-Catalyzed Diamination of Alkynes: Synthesis of Tetracyclic Indolobenzothiazine S,S‑Dioxides

T. M. Ha; B. Yao; Q. Wang; J. Zhu 

Aqueous Titanium Trichloride Promoted Reductive Cyclization of o-Nitrostyrenes to Indoles: Development and Application to the Synthesis of Rizatriptan and Aspidospermidine

S. Tong; Z. Xu; M. Mamboury; Q. Wang; J. Zhu 

Synthesis of diverse di- to penta-substituted 1,2-dihydropyridine derivatives from gold(I)-catalyzed intramolecular addition of tertiary enamides to alkynes

X. Zhang; X-M. Xu; L. Zhao; J. You; J. Zhu et al. 

Total Synthesis of Aspidosperma Family Indole Alkaloids through the iORC Domino Process

Total Syntheses of (−)-Mersicarpine, (−)-Scholarisine G, (+)-Melodinine E, (−)-Leuconoxine, (−)-Leuconolam, (−)-Leuconodine A, (+)-Leuconodine F, and (−)-Leuconodine C: Self-Induced Diastereomeric Anisochronism (SIDA) Phenomenon for Scholarisine G and Leuconodines A and C

Z. Xu; Q. Wang; J. Zhu 

Synthesis of Functionalized Epoxides by Copper-Catalyzed Alkylative Epoxidation of Allylic Alcohols with Alkyl Nitriles

A. Bunescu; Q. Wang; J. Zhu 

Pd/C-Catalyzed Cyclizative Cross-Coupling of Two ortho-Alkynylanilines under Aerobic Conditions: Synthesis of 2,3’-Bisindoles

B. Yao; Q. Wang; J. Zhu 

Integrated One-Pot Synthesis of 1,3-Oxazinan-2-ones from Isocyanoacetates and Phenyl Vinyl Selenones

T. Buyck; Q. Wang; J. Zhu 

Copper-Catalyzed Intermolecular Carboetherification of Unactivated Alkenes by Alkyl Nitriles and Alcohols

C. Chatalova-Sazepin; Q. Wang; G. M. Sammis; J. Zhu 

2-(Methoxycarbonyl)ethyl as a Removable N-Protecting Group: Synthesis of Indoloisoquinolinones by Pd(II)-Catalyzed Intramolecular Diamination of Alkynes

T. M. Ha; B. Yao; Q. Wang; J. Zhu 

Copper-Catalyzed Cyanomethylation of Allylic Alcohols with Concomitant 1,2-Aryl Migration: Efficient Synthesis of Functionalized Ketones Containing an α-Quaternary Center

A. Bunescu; Q. Wang; J. Zhu 

Enantioselective Synthesis of Putative Lipiarmycin Aglycon Related to Fidaxomicin/Tiacumicin B

W. Erb; J-M. Grassot; D. Linder; L. Neuville; J. Zhu 

Multicomponent Reactions in Organic Synthesis

Tuning the Reactivity of Isocyano Group: Synthesis of Imidazoles and Imidazoliums from Propargylamines and Isonitriles in the Presence of Multiple Catalysts

S. Tong; Q. Wang; M-X. Wang; J. Zhu 

Chiral Calcium–BINOL Phosphate Catalyzed Diastereo- and Enantioselective Synthesis of syn-1,2-Disubstituted 1,2-Diamines: Scope and Mechanistic Studies

C. Lalli; A. Dumoulin; C. Lebée; F. Drouet; V. Guérineau et al. 

Pd-Catalyzed Dehydrogenative Aryl−Aryl Bond Formation via Double C(sp2)−H Bond Activation: Efficient Synthesis of [3,4]-Fused Oxindoles

A. Bunescu; T. Piou; Q. Wang; J. Zhu 

Protecting-group-free enantioselective total synthesis of terengganensine A and towards the total synthesis of peganumine A

R. de Matos 

Studies towards the total synthesis of strictamine

C. Piemontesi 

Thiazoles enabled by discovering new reactivity of isonitriles: synthesis and fluorescence properties

S. Zhao 

On the Formation and Transformation of alpha-Iminonitriles, the Desymmetrization of Bicyclic Bislactones and Total Synthesis of (-)-Leucomidine B and (-)-Rhazinilam

Plastidic type I signal peptidase 1 is a redox-dependent thylakoidal processing peptidase

T. Midorikawa; J. K. Endow; J. Dufour; J. Zhu; K. Inoue 

Isocyanoacetates as Synthetic Platform Towards Natural Products and Biologically Relevant Scaffolds

“New methods for indoles and [3,4]-fused oxindoles syntheses” and “Copper-catalyzed/mediated difunctionalization of alkenes with alkylnitriles”

Copper-Mediated/Catalyzed Oxyalkylation of Alkenes with Alkylnitriles

A. Bunescu; Q. Wang; J. Zhu 

Unified Strategy to Monoterpene Indole Alkaloids: Total Syntheses of (±)-Goniomitine, (±)-1,2-Dehydroaspidospermidine, (±)-Aspidospermidine, (±)-Vincadifformine, and (±)-Kopsihainanine A

O. Wagnières; Z. Xu; Q. Wang; J. Zhu 

Functionalized imidazoliniums from the three-component domino reaction of N-formylmethylcarboxamides with amines and isocyanides

C-H. Lei; L. Zhao; D-X. Wang; J. Zhu; M-X. Wang 

Mechanistic Study on the Palladium(II)-Catalyzed Synthesis of 2,3-Disubstituted Indoles Under Aerobic Conditions: Anion Effects and the Development of a Low-Catalyst-Loading Process

B. Yao; Q. Wang; J. Zhu 

Phosphoric Acid Catalyzed Desymmetrization of Bicyclic Bislactones Bearing an All-Carbon Stereogenic Center: Total Syntheses of (−)-Rhazinilam and (−)-Leucomidine B

J-B. Gualtierotti; D. Pasche; Q. Wang; J. Zhu 

Triple Role of Phenylselenonyl Group Enabled a One-Pot Synthesis of 1,3-Oxazinan-2-ones From α-Isocyanoacetates, Phenyl Vinyl Selenones, and Water

T. Buyck; Q. Wang; J. Zhu 

Chiral Phosphoric Acid-Catalyzed Enantioselective Three- Component Aza-Diels-Alder Reactions of Aminopyrroles and Aminopyrazoles

J. Brioche; T. Courant; L. Alcaraz; M. Stocks; M. Furber et al. 

From Racemic to Enantioselective Total Synthesis of Trigonoliimines via Development of an Organocatalytic Enantioselective Michael Addition of α-Aryl-α-isocyanoacetate to Vinyl Phenyl Selenone

T. Buyck; Q. Wang; J. Zhu 

Phosphoric Acid Catalyzed Diastereo- and Enantioselective Synthesis of Substituted 1,3-Diaminotetralins

G. Dagousset; W. Erb; J. Zhu; G. Masson 

Copper-catalyzed three-component synthesis of 5-acetamidoimidazoles from carbodiimides, acyl chlorides and isocyanides

G. Sapuppo; Q. Wang; D. Swinnen; J. Zhu 

Three-Component Povarov Reaction–Heteroannulation with Arynes: Synthesis of 5,6-Dihydroindolo[1,2‑a]quinolines

A. Bunescu; Q. Wang; J. Zhu 

Multicomponent Domino Process: Rational Design and Serendipity

NIS-Assisted Aza-Friedel-Crafts Reaction with α-Carbamoysulfides as Precursors of

N. George; M. Bekkaye; A. Alix; J. Zhu; G. Masson 

Total Synthesis of (±)-Aspidophylline A

W. Ren; Q. Wang; J. Zhu 

Design and Synthesis of 16-Membered Cyclopeptides Active Against Vancomycin-resistant Enterococci (VRE)

J. Zhu 

Enantioselective Total Syntheses of Leuconolam–Leuconoxine–Mersicarpine Group Monoterpene Indole Alkaloids

Z. Xu; Q. Wang; J. Zhu 

Iron Chloride-Catalyzed Three-Component Domino Sequences: Syntheses of Functionalized α-Oxy-N-acylhemiaminals and α-Oxyimides

F. Drouet; J. Zhu; G. Masson 

Palladium(II)-Catalyzed Cyclizative Cross-Coupling of ortho-Alkynylanilines with ortho-Alkynylbenzamides under Aerobic Conditions

B. Yao; Q. Wang; J. Zhu 

Synthesis of Multifunctionalized 1,2,3,4-Tetrahydropyridines, 2,3-Dihydropyridin-4(1H)-ones, and Pyridines from Tandem Reactions Initiated by [5+1] Cycloaddition of N-Formylmethyl-Substituted Enamides to Isocyanides: Mechanistic Insight and Synthetic Application

C-H. Lei; D-X. Wang; L. Zhao; J. Zhu; M-X. Wang 

Catalytic Enantioselective Michael Addition of α-Aryl-α-Isocyanoacetates to Vinyl Selenone: Synthesis of α,α-Disubstituted α-Amino Acids and (+)- and (−)-Trigonoliimine A

T. Buyck; Q. Wang; J. Zhu 

Palladium-Catalyzed Through-Space C(sp3)-H and C(sp2)-H Bond Activation by 1,4-Palladium Migration: Efficient Synthesis of [3,4]- Fused Oxindoles

T. Piou; A. Bunescu; Q. Wang; L. Neuville; J. Zhu 

Heteroannulation of arynes with N-aryl-α-aminoketones for the synthesis of unsymmetrical N-aryl-2,3-disubstituted indoles: an aryne twist of Bischler–Möhlau indole synthesis

A. Bunescu; C. Piemontesi; Q. Wang; J. Zhu 

Zinc Bromide Promoted Coupling of Isonitriles with Carboxylic Acids To Form 2,4,5-Trisubstituted Oxazoles

Y. Odabachian; S. Tong; Q. Wang; M-X. Wang; J. Zhu 

Tertiary Amines as Synthetic Equivalents of Vinyl Cations: Zinc Bromide Promoted Coupling of Propargylamines with α-Isocyanoacetamides To Give 2,4,5-Trisubstituted Oxazoles Initiated by an Internal Redox Process

Y. Odabachian; Q. Wang; J. Zhu 

Synthetic Study towards Strictamine: The Oxidative Coupling Approach

W. Ren; N. Tappin; Q. Wang; J. Zhu 

Ugi Four-Component Reaction of Alcohols: Stoichiometric and Catalytic Oxidation/MCR Sequences

F. Drouet; G. Masson; J. Zhu 

Synthesis of Iminonitriles by Oxone/TBAB-Mediated One-Pot Oxidative Three-Component Strecker Reaction

J-B. Gualtierotti; X. Schumacher; Q. Wang; J. Zhu 

Pd(II)-catalyzed intramolecular aminopalladation/direct C–H arylation under aerobic conditions: synthesis of pyrrolo[1,2-a]indoles

T. Piou; L. Neuville; J. Zhu 

Synthesis of Substituted Pyridines from Cascade [1 + 5] Cycloaddition of Isonitriles to

C-H. Lei; D-X. Wang; L. Zhao; J. Zhu; M-X. Wang 

Palladium-Catalyzed Decarboxylative Vinylation of Potassium Nitrophenyl Acetate: Application to the Total Synthesis of (±)-Goniomitine

Z. Xu; Q. Wang; J. Zhu 

Synthesis of 3,3-disubstituted oxindoles by one-pot integrated Brønsted base-catalyzed trichloroacetimidation of 3-hydroxyoxindoles and Brønsted acid-catalyzed nucleophilic substitution reaction

C. Piemontesi; Q. Wang; J. Zhu 

From natural product to marketed drug: the tiacumicin odyssey

W. Erb; J. Zhu 

Enantioselctive Passerini Reaction

Total Synthesis of Natural Products and the Synergy with Synthetic Methodology

Copper Catalyzed N-Arylation of Amidines with Aryl Boronic Acids and One-Pot Synthesis of Benzimidazoles by a Chan–Lam–Evans N-Arylation and C–H Activation/C–N Bond Forming Process

J. Li; S. Bénard; L. Neuville; J. Zhu 

Synthesis of Indoles by Copper-Catalyzed Heteroannulation of o-Aminophenylboronic Acid Pinacol Esters with β-Keto Esters

A. Bunescu; Q. Wang; J. Zhu 

Palladium-Catalyzed Coupling of ortho-Alkynylanilines with Terminal Alkynes Under Aerobic Conditions: Efficient Synthesis of 2,3-Disubstituted 3-Alkynylindoles

B. Yao; Q. Wang; J. Zhu 

Activation of a C(sp3)H Bond by a Transient s-Alkylpalladium(II) Complex: Synthesis of Spirooxindoles Through a Palladium-Catalyzed Domino Carbopalladation/C(sp3)C(sp3) Bond-Forming Process

T. Piou; L. Neuville; J. Zhu 

Amidation of Aldehydes and Alcohols through α-Iminonitriles and a Sequential Oxidative Three-Component Strecker Reaction/Thio-Michael Addition/Alumina-Promoted Hydrolysis Process to Access β-Mercaptoamides from Aldehydes, Amines, and Thiols

J-B. Gualtierotti; X. Schumacher; P. Fontaine; G. Masson; Q. Wang et al. 

Organocatalytic Enantioselective One-Pot Four-Component Ugi-Type Multicomponent Reaction for the Synthesis of Epoxy-tetrahydropyrrolo[3,4-

Y. Su; M. J. Bouma; L. Alcaraz; M. Stocks; M. Furber et al. 

Synthesis of 4-amino-1,2,3,4-tetrahydropyridine derivatives by intramolecular nucleophilic addition of tertiary enamides to in-situ generated imines

S. Tong; X. Yang; D-X. Wang; L. Zhao; J. Zhu et al. 

Spirocyclization by Palladium-Catalyzed Domino Heck–Direct C–H Arylation Reactions: Synthesis of Spirodihydroquinolin-2-ones

T. Piou; L. Neuville; J. Zhu 

Development and Application of Isocyanide-based Multicomponent Reactions

Palladium(II)-Catalyzed Intramolecular Diamination of Alkynes under Aerobic Oxidative Conditions: Catalytic Turnover of an Iodide Ion

B. Yao; Q. Wang; J. Zhu 

Enantioselective Synthesis of 4-Hydroxytetrahydropyridine Derivatives by Intramolecular Addition of Tertiary Enamides to Aldehydes

S. Tong; D-X. Wang; L. Zhao; J. Zhu; M-X. Wang 

Synergistic Effect of Palladium and Copper Catalysts: Catalytic Cyclizative Dimerization of ortho-(1-Alkynyl)benzamides Leading to Axially Chiral 1,3-Butadienes

B. Yao; C. Jaccoud; Q. Wang; J. Zhu 

Chiral Phosphoric Acid-Catalyzed Enantioselective Three-Component Povarov Reaction Using Cyclic Enethioureas as Dienophiles: Stereocontrolled Access to Enantioenriched Hexahydropyrroloquinolines

G. Dagousset; P. Retailleau; G. Masson; J. Zhu 

A Concise Total Synthesis of (±)-Trigonoliimine B

T. Buyck; Q. Wang; J. Zhu 

Un nouveau venu dans la lutte contre le Clostridium difficile: Les antibiotiques accueillent un nouveau membre

W. Erb; J. Zhu 

Exploiting the Divergent Reactivity of Isocyanoacetates: One-Pot Three-Component Synthesis of Functionalized Angular Furoquinolines

M. J. Bouma; G. Masson; J. Zhu 

Unexpected C–C Bond Cleavage: Synthesis of 1,2,4-Oxadiazol-5-ones from Amidoximes with Pentafluorophenyl or Trifluoromethyl Anion Acting as Leaving Group

T. Gerfaud; H-L. Wei; L. Neuville; J. Zhu 

Trifluoroacetic Acid-Promoted Synthesis of 3-Hydroxy, 3-Amino and Spirooxindoles from α-Keto-N-Anilides

I. Gorokhovik; L. Neuville; J. Zhu 

Built-in 5-Aminooxazole as an Internal Activator of the Terminal Carboxylic Acid: An Alternative Access to Macrocyclodepsipeptides

J. Zhu 

Chiral Phosphoric Acid-Catalyzed Enantioselective Three-Component Povarov Reaction Using Enecarbamates as Dienophiles: Highly Diastereo- and Enantioselective Synthesis of Substituted 4-Aminotetrahydroquinolines

G. Dagousset; J. Zhu; G. Masson 

A Practical, One-Pot Multicomponent Synthesis of α-Amidosulfides and Their Application as Latent N-Acylimines in the Friedel-Crafts Reaction

N. George; M. Bekkaye; G. Masson; J. Zhu 

Cinchona Alkaloid-Amides Catalyzed Enantioselective Formal [2+2] Cycloadditions of Allenoates and Imines: Enantioselective Synthesis of 2,4-Substituted Azetidines

J-B. Denis; G. Masson; P. Retailleau; J. Zhu 

Protecting-Group-Free Total Synthesis of (E) and (Z)-Alstoscholarine

T. Gerfaud; C. Xie; L. Neuville; J. Zhu 

Iodo-Carbocyclization of Electron-Deficient Alkenes: Synthesis of Oxindoles and Spirooxindoles

H-L. Wei; T. Piou; J. Dufour; L. Neuville; J. Zhu 

Synthesis of Hydroxylated 3,4-Dihydropyridine-2-ones from Intramolecular Nucleophilic Addition Reaction of Oxirane-containing Tertiary Enamides

L. Yang; S. Tong; D-X. Wang; Z-T. Huang; J. Zhu et al. 

Asymmetric Synthesis of 2,4,6-Trideoxy-4-(dimethylamino)-3-C-methyl-Llyxohexopyranose (Lemonose)

G. Bernadat; N. George; C. Couturier; G. Masson; T. Schlama et al. 

Access to Macrocycles with an endo Aryl ether and an endo Aryl-Aryl Bond, Development and Application

Q. Wang; J. Zhu 

Exploiting the Divergent Reactivity of a-Isocyanoacetate: Multicomponent Synthesis of 5-Alkoxyoxazoles and Related Heterocycles

C. Lalli; M. J. Bouma; D. Bonne; G. Masson; J. Zhu 

Chiral Calcium Organophosphate-Catalyzed Enantioselective Electrophilic Amination of Enamides

F. Drouet; C. Lalli; H. Liu; G. Masson; J. Zhu 

Asymmetric Morita–Baylis–Hillman Reaction and Its Aza Analogue

1-Isocyanocyclohex-1-ene

1-Isocyano-2-nitrobenzene

1-(2,2-Dimethoxyethyl)-2-isocyanobenzene

Multicomponent Syntheses of Macrocycles

Enantioselective Aza-Morita-Baylis-Hillman Reaction Using Aliphatic alpha -Amidosulfones as Imine Surrogates

N. Abermil; G. Masson; J. Zhu 

Copper-promoted N-cyclopropylation of anilines and amines by cyclopropylboronic acid

S. Benard; L. Neuville; J. Zhu 

Zinc Chloride Promoted Formal Oxidative Coupling of Aromatic Aldehydes and Isocyanides to alpha -Ketoamides

M. Bouma; G. Masson; J. Zhu 

Passerini Three-Component Reaction of Alcohols under Catalytic Aerobic Oxidative Conditions

J. Brioche; G. Masson; J. Zhu 

Intramolecular Suzuki-Miyaura reaction for the total synthesis of signal peptidase inhibitors, arylomycins A2 and B2

J. Dufour; L. Neuville; J. Zhu 

Palladium-catalyzed domino Heck/cyanation: synthesis of 3-cyanomethyloxindoles and their conversion to spirooxoindoles

S. Jaegli; J-P. Vors; L. Neuville; J. Zhu 

Palladium-Catalyzed Carbo-Heterofunctionalization of Alkenes for the Synthesis of Oxindoles and Spirooxindoles

S. Jaegli; J. Dufour; H-l. Wei; T. Piou; X-H. Duan et al. 

Palladium-Catalyzed Domino Process to Spirooxindoles: Ligand Effect on Aminopalladation versus Carbopalladation

S. Jaegli; W. Erb; P. Retailleau; J-P. Vors; L. Neuville et al. 

Efficient Synthesis of alpha -Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and alpha -Isocyanoacetamides

R. Mossetti; T. Pirali; G. C. Tron; J. Zhu 

Total synthesis of complestatin (Chloropeptin II)

Z. Wang; M. Bois-Choussy; Y. Jia; J. Zhu 

Invertible Enantioselectivity in 6′-Deoxy-6′-acylamino-beta -isocupreidine-Catalyzed Asymmetric Aza-Morita-Baylis-Hillman Reaction: Key Role of Achiral Additive

N. Abermil; G. Masson; J. Zhu 

Chiral Bronsted Acid-Catalyzed Enantioselective Multicomponent Mannich Reaction: Synthesis of anti-1,3-Diamines Using Enecarbamates as Nucleophiles

G. Dagousset; F. Drouet; G. Masson; J. Zhu 

Synthesis of L-3-hydroxy-4-methoxy-5-methylphenylalanol

N. Demoulin; J. Zhu 

IBX/TBAB-mediated oxidation of primary amines to nitriles

F. Drouet; P. Fontaine; G. Masson; J. Zhu 

Ugi-post functionalization, from a single set of Ugi-adducts to two distinct heterocycles by microwave-assisted palladium-catalyzed cyclizations: tuning the reaction pathways by ligand switch

W. Erb; L. Neuville; J. Zhu 

Synthesis of Pyrroles by Consecutive Multicomponent Reaction/[4 + 1] Cycloaddition of alpha -Iminonitriles with Isocyanides

P. Fontaine; G. Masson; J. Zhu 

Palladium-catalyzed annulation of acyloximes with arynes (or alkynes): synthesis of phenanthridines and isoquinolines

T. Gerfaud; L. Neuville; J. Zhu 

Total synthesis of horsfiline: a palladium-catalyzed domino Heck-cyanation strategy

S. Jaegli; J-P. Vors; L. Neuville; J. Zhu 

Chiral Bronsted Acid-Catalyzed Enantioselective Three-Component Povarov Reaction

H. Liu; G. Dagousset; G. Masson; P. Retailleau; J. Zhu 

Palladium-catalyzed domino N-arylation/carbopalladation/C-H functionalization: three-component synthesis of 3-(diarylmethylene)oxindoles

A. Pinto; L. Neuville; J. Zhu 

Combination of lithium chloride and hexafluoroisopropanol for Friedel-Crafts reactions

M. Willot; J. C. Chen; J. Zhu 

Asymmetric Total Syntheses of (-)-Renieramycin M and G and (-)-Jorumycin Using Aziridine as a Lynchpin

Y-C. Wu; J. Zhu 

Synthetic Studies on (-)-Lemonomycin: An Efficient Asymmetric Synthesis of Lemonomycinone Amide

Y-C. Wu; G. Bernadat; G. Masson; C. Couturier; T. Schlama et al. 

Catalytic Asymmetric Passerini-Type Reaction: Chiral Aluminum-Organophosphate-Catalyzed Enantioselective alpha -Addition of Isocyanides to Aldehydes

T. Yue; M-X. Wang; D-X. Wang; G. Masson; J. Zhu 

Bronsted Acid Catalyzed Enantioselective Three-Component Reaction Involving the alpha Addition of Isocyanides to Imines

T. Yue; M-X. Wang; D-X. Wang; G. Masson; J. Zhu 

Highly Enantioselective Aza Morita-Baylis-Hillman Reaction Catalyzed by Bifunctional beta -Isocupreidine Derivatives

N. Abermil; G. Masson; J. Zhu 

Copper-Mediated N-Cyclopropylation of Azoles, Amides, and Sulfonamides by Cyclopropylboronic Acid

S. Benard; L. Neuville; J. Zhu 

Synthesis of dihydrophenanthridines by a sequence of Ugi-4CR and palladium-catalyzed intramolecular C-H functionalization

F. Bonnaterre; M. Bois-Choussy; J. Zhu 

Total synthesis of arylomycin A2, a signal peptidase I (SPase I) inhibitor

J. Dufour; L. Neuville; J. Zhu 

One-Pot Three-Component Synthesis of alpha -Iminonitriles by IBX/TBAB-Mediated Oxidative Strecker Reaction

P. Fontaine; A. Chiaroni; G. Masson; J. Zhu 

Synthesis of alpha -keto amides by a molecular-sieves-promoted formal oxidative coupling of aliphatic aldehydes with isocyanides

J-M. Grassot; G. Masson; J. Zhu 

Synthesis of diastereomers of complestatin and chloropeptin I: substrate-dependent atropstereoselectivity of the intramolecular Suzuki-Miyaura reaction

Y. Jia; M. Bois-Choussy; J. Zhu 

Development of multicomponent and domino reactions based on alpha -isocyanoacetamide and 5-aminooxazole

G. Masson; L. Neuville; J. Zhu 

Palladium-Catalyzed Intramolecular C-Arylation of Benzylic Carbon: Synthesis of 3-Benzoxazolylisoindolinones by a Sequence of Ugi-4CR/Postfunctionalization

A. Salcedo; L. Neuville; J. Zhu 

Palladium-Catalyzed Domino Intramolecular N-Arylation/Intermolecular C-C Bond Formation for the Synthesis of Functionalized Benzodiazepinediones

A. Salcedo; L. Neuville; C. Rondot; P. Retailleau; J. Zhu 

Catalytic enantioselective Passerini three-component reaction

S-X. Wang; M-X. Wang; D-X. Wang; J. Zhu 

Hafnium Trifluoromethanesulfonate (Hafnium Triflate) as a Highly Efficient Catalyst for Chemoselective Thioacetalization and Transthioacetalization of Carbonyl Compounds

Y-C. Wu; J. Zhu 

Asymmetric Total Synthesis of (-)-Quinocarcin

Y-C. Wu; M. Liron; J. Zhu 

Asymmetric synthesis of 5-(1-hydroxyalkyl)tetrazoles by catalytic enantioselective Passerini-type reactions

T. Yue; M-X. Wang; D-X. Wang; J. Zhu 

Modulating the reactivity of alpha -isocyanoacetates: multicomponent synthesis of 5-methoxyoxazoles and furopyrrolones

D. Bonne; M. Dekhane; J. Zhu 

Rapid synthesis of cyclodepsipeptides containing a sugar amino acid or a sugar amino alcohol by a sequence of a multicomponent reaction and acid-mediated macrocyclization

C. Bughin; G. Masson; J. Zhu 

Total synthesis of the marine natural product (-)-cribrostatin 4 (renieramycin H)

X. Chen; J. Zhu 

Lithium bromide-promoted three-component synthesis of oxa-bridged tetracyclic tetrahydroisoquinoline derivatives

A. Fayol; E. Gonzalez-Zamora; M. Bois-Choussy; J. Zhu 

Synthesis of DEFG ring of complestatin and chloropeptin I: highly atropdiastereoselective macrocyclization by intramolecular Suzuki-Miyaura reaction

Y. Jia; M. Bois-Choussy; J. Zhu 

The enantioselective Morita-Baylis-Hillman reaction and its aza counterpart

G. Masson; C. Housseman; J. Zhu 

IBX-mediated oxidative Ugi-type multicomponent reactions: application to the N and C1 functionalization of tetrahydroisoquinoline

T. Ngouansavanh; J. Zhu 

Palladium-catalyzed three-component synthesis of 3-(diarylmethylene)oxindoles through a domino Sonogashira/carbopalladation/C-H activation/C-C bond-forming sequence

A. Pinto; L. Neuville; J. Zhu 

Palladium-catalyzed enantioselective domino Heck-cyanation sequence: development and application to the total synthesis of esermethole and physostigmine

A. Pinto; Y. Jia; L. Neuville; J. Zhu 

Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and Its Subsequent Transformation to Macrocyclodepsipeptide

T. Pirali; G. C. Tron; G. Masson; J. Zhu 

Synthesis of Protected Chiral Vicinal Diaminoalcohols by Diastereoselective Intramolecular Benzylic Substitution from Bistrichloroacetimidates

C. Rondot; P. Retailleau; J. Zhu 

Asymmetric Lewis acid catalyzed addition of isocyanides to aldehydes. Synthesis of 5-amino-2-(1-hydroxyalkyl)oxazoles

S. Wang; M-X. Wang; D-X. Wang; J. Zhu 

Chiral Salen-Aluminum Complex as a Catalyst for Enantioselective alpha -Addition of Isocyanides to Aldehydes: Asymmetric Synthesis of 2-(1-Hydroxyalkyl)-5-aminooxazoles

S-X. Wang; M-X. Wang; D-X. Wang; J. Zhu 

New Frontiers in Asymmetric Catalysis edited by Koichi Mikami and Mark Lautens

J. Zhu 

Preparation of ecteinascidin alkaloids, such as ecteinascidins 583 and 597

J. Zhu; M. Bois-Choussy; J. Chen; X. Chen 

Rapid access to oxindoles by the combined use of an Ugi four-component reaction and a microwave-assisted intramolecular Buchwald-Hartwig amidation reaction

F. Bonnaterre; M. Bois-Choussy; J. Zhu 

5-aminooxazole as an internal traceless activator of C-terminal carboxylic acid: rapid access to diversely functionalized cyclodepsipeptides

C. Bughin; G. Zhao; H. Bienayme; J. Zhu 

Asymmetric total syntheses of ecteinascidin 597 and ecteinascidin 583

J. Chen; X. Chen; M. Willot; J. Zhu 

Synthetic studies on ecteinascidin 743 (Et 743): asymmetric synthesis of a highly oxygenated tetrahydroisoquinoline via a key phenolic Mannich reaction

X. Chen; J. Chen; J. Zhu 

Total Synthesis of Ecteinascidin 743

J. Chen; X. Chen; M. Bois-Choussy; J. Zhu 

Synthetic studies towards (-)-lemonomycin, synthesis of fused tetracycles

C. Couturier; T. Schlama; J. Zhu 

Aziridinium from N,N-dibenzyl serine methyl ester: Synthesis of enantiomerically pure beta -amino and alpha ,beta -diamino esters

C. Couturier; J. Blanchet; T. Schlama; J. Zhu 

Rapid synthesis of cyclopeptide alkaloid-like para-cyclophanes by combined use of Ugi-4CR and intramolecular SNAr reaction

P. Cristau; J-P. Vors; J. Zhu 

Mono alkylation of alpha -isocyano acetamide to its higher homologues

C. Housseman; J. Zhu 

Importance of the structure of vancomycin binding pocket in designing compounds active against vancomycin-resistant enterococci (VRE)

Y. Jia; M. Bois-Choussy; A. Malabarba; C. Brunati; J. Zhu 

Palladium-Catalyzed, Modular Synthesis of Highly Functionalized Indoles and Tryptophans by Direct Annulation of Substituted o-Haloanilines and Aldehydes

Y. Jia; J. Zhu 

Design and synthesis of simple macrocycles active against vancomycin-resistant Enterococci (VRE)

Y. Jia; N. Ma; Z. Liu; M. Bois-Choussy; E. Gonzalez-Zamora et al. 

Synthesis of 4-nitrophenyl sulfones and application in the modified Julia olefination

D. Mirk; J-M. Grassot; J. Zhu 

Alcohols in isonitrile-based multicomponent reaction: Passerini reaction of alcohols in the presence of o-iodoxybenzoic acid

T. Ngouansavanh; J. Zhu 

Synthesis of 3-(Diarylmethylenyl)oxindole by a Palladium-Catalyzed Domino Carbopalladation/C-H Activation/C-C Bond-Forming Process

A. Pinto; L. Neuville; P. Retailleau; J. Zhu 

One-pot synthesis of macrocycles by a tandem three-component reaction and intramolecular [3+2] cycloaddition

T. Pirali; G. C. Tron; J. Zhu 

Preparation of beta-amino or alpha ,beta-diamino esters derived from serine

J. Zhu; C. Couturier; J. Blanchet 

Multicomponent Reaction, an overview

One or More CH Bond(s) Formed by Substitution: Reduction of C-N, -P, -Arsenic, -Antimony, -Bismuth, -Carbon, -Silicon, -Germanium, -Boron, and –Metal Bonds

Nouveau Composes Chiraux Dérives d’une Diamine ou d’un Aminoalcool, Monosulfonylés et carbonylés Porteurs d’un Groupe Pyrrolidinyle. Leur Préparation et Leurs Applications en Catalyse Asymétrique

G. Mignani; J. Turcono; J. Zhu 

One or more C-H bond(s) formed by substitution: reduction of carbon-nitrogen, -phosphorus, -arsenic, -antimony, -bismuth, -carbon, -boron and -metal bonds

Conformation-directed macrocyclization reactions

J. Blankenstein; J. Zhu 

Exploiting the Dual Reactivity of o-Isocyanobenzamide: Three-Component Synthesis of 4-Imino-4H-3,1-benzoxazines

D. Bonne; M. Dekhane; J. Zhu 

Mild Oxidative One-Carbon Homologation of Aldehyde to Amide

D. Bonne; M. Dekhane; J. Zhu 

Synthetic Studies toward Ecteinascidin 743

X. Chen; J. Chen; M. De Paolis; J. Zhu 

Asymmetric synthesis of protected γ-carboxy-L-glutamic acid

C. Couturier; M. Liron; T. Schlama; J. Zhu 

Total synthesis of mauritines A, B, C, and F: Cyclopeptide alkaloids with a 14-membered paracyclophane unit

P. Cristau; T. Temal-Laib; M. Bois-Choussy; M-T. Martin; J-P. Vors et al. 

Multicomponent synthesis of epoxy-tetrahydronaphthyridine and structural diversification by subsequent fragmentation

A. Fayol; J. Zhu 

Synthesis of alpha -isocyano-alpha -alkyl(aryl)acetamides and their use in the multicomponent synthesis of 5-aminooxazole, pyrrolo[3,4-b]pyridin-5-one and 4,5,6,7-tetrahydrofuro[2,3-c]pyridine

A. Fayol; C. Housseman; X. Sun; P. Janvier; H. Bienayme et al. 

Three-component synthesis of polysubstituted 6-azaindolines and its tricyclic derivatives

A. Fayol; J. Zhu 

Synthesis of ring-A-substituted tryptophan by a palladium-catalyzed heteroannulation reaction

Y. Jia; J. Zhu 

Identification of synthetic compounds active against VRE: the role of the lipidated aminoglucose and the structure of glycopeptide binding pocket

Y. Jia; E. Gonzalez-Zamora; N. Ma; Z. Liu; M. Bois-Choussy et al. 

Microwave-Assisted Intramolecular Suzuki-Miyaura Reaction to Macrocycle, a Concise Asymmetric Total Synthesis of Biphenomycin B

R. Lepine; J. Zhu 

Synthesis of beta -amino-alpha -hydroxy esters and beta -amino-alpha -azido ester by Sharpless asymmetric aminohydroxylation, byproducts analysis

Z. Liu; N. Ma; Y. Jia; M. Bois-Choussy; A. Malabarba et al. 

Design and synthesis of macrocycles active against vancomycin-resistant enterococci (VRE): the interplay between D-Ala-D-Lac binding and hydrophobic effect

N. Ma; Y. Jia; Z. Liu; E. Gonzalez-Zamora; M. Bois-Choussy et al. 

Synthesis of Chiral Vicinal Diamines by Highly Diastereoselective Three-Component Phenolic Mannich Reaction: Temperature-Dependent Stereodivergency

C. Rondot; J. Zhu 

A three-component synthesis of (1,3-oxazol-2-yl)-1,2-dihydro(iso)quinoline and its further structural diversifications

G. C. Tron; J. Zhu 

Multicomponent Reactions

Reeve’s synthesis of 2-imino-4-thiazolidinone from alkyl (aryl) trichloromethylcarbinol revisited, a three-component process from aldehyde, chloroform, and thiourea

J. Blanchet; J. Zhu 

Ammonium Chloride Promoted Ugi Four-Component, Five-Center Reaction of alpha -Substituted alpha -Isocyano Acetic Acid: A Strong Solvent Effect

D. Bonne; M. Dekhane; J. Zhu 

Strained-Cyclophane-Induced beta -Turn Template: Design, Synthesis, and Spectroscopic Characterization

P. Cristau; M-T. Martin; M-E. T. H. Dau; J-P. Vors; J. Zhu 

Palladium- and Copper-Catalyzed Synthesis of Medium- and Large-Sized Ring-Fused Dihydroazaphenanthrenes and 1,4-Benzodiazepine-2,5-diones. Control of Reaction Pathway by Metal-Switching

G. Cuny; M. Bois-Choussy; J. Zhu 

Truncated diastereoselective Passerini reaction, a rapid construction of polysubstituted oxazole and peptides having an alpha -hydroxy-beta -amino acid component

G. Cuny; R. Gamez-Montano; J. Zhu 

A short enantioselective synthesis of protected L-3-hydroxy-4-methoxy-5-methyl phenylalanine and its corresponding aldehyde – a common subunit of ecteinascidin-743, safracin and congeners

M. De Paolis; X. Chen; J. Zhu 

Synthesis of Polysubstituted 4,5,6,7-Tetrahydrofuro[2,3-c]pyridines by a Novel Multicomponent Reaction

A. Fayol; J. Zhu 

A short synthesis of (-)-deoxoprosophylline

A. Jourdant; J. Zhu 

Total synthesis of an atropdiastereomer of RP-66453 and determination of its absolute configuration

M. Bois-Choussy; P. Cristau; J. Zhu 

Rapid and diverse route to natural product-like biaryl ether containing macrocycles

P. Cristau; J-P. Vors; J. Zhu 

Solid-phase synthesis of natural product-like macrocycles by a sequence of Ugi-4CR and SNAr-based cycloetherification

P. Cristau; J-P. Vors; J. Zhu 

One-pot synthesis of polyheterocycles by a palladium-catalyzed intramolecular N-arylation/C[bond]H activation/aryl[bond]aryl bond-forming domino process

G. Cuny; M. Bois-Choussy; J. Zhu 

Synthetic studies on ecteinascidin 743: rapid access to the fully functionalized tetrahydroisoquinoline with a bridged 10-membered sulfur containing macrocycle

M. De Paolis; A. Chiaroni; J. Zhu 

From central to planar chirality, the first example of atropenantioselective cycloetherification

G. Islas-Gonzalez; M. Bois-Choussy; J. Zhu 

A one-pot four-component (ABC2) synthesis of macrocycles

P. Janvier; M. Bois-Choussy; H. Bienayme; J. Zhu 

Asymmetric synthesis of orthogonally protected (2S,4R)- and (2S,4S)-4-hydroxyornithine

R. Lepine; A-C. Carbonnelle; J. Zhu 

Allo-aromadendrane- and picrotoxane-type sesquiterpenes from Dendrobium moniliforme

W. Zhao; Q. Ye; J. Dai; M-T. Martin; J. Zhu 

Synthesis of isocyano peptides by dehydration of the N-formyl derivatives

G. Zhao; C. Bughin; H. Bienayme; J. Zhu 

Recent developments in the isonitrile-based multicomponent synthesis of heterocycles

J. Zhu 

Studies toward the total synthesis of RP-66453

S. Boisnard; J. Zhu 

N-Carbamate-Assisted Stereoselective Synthesis of Chiral Vicinal Amino Sulfides

M. De Paolis; J. Blankenstein; M. Bois-Choussy; J. Zhu 

Synthesis of furoquinolines by a multicomponent domino process

A. Fayol; J. Zhu 

Rapid access to tetracyclic ring system of lennoxamine type natural product by combined use of a novel three-component reaction and Pummerer cyclization

R. Gamez Montano; J. Zhu 

Multicomponent domino process to oxa-bridged polyheterocycles and pyrrolopyridines, structural diversity derived from work-up procedure

R. Gamez-Montano; E. Gonzalez-Zamora; P. Potier; J. Zhu 

A five-component synthesis of hexasubstituted benzenes

P. Janvier; H. Bienayme; J. Zhu 

Ammonium Chloride-Promoted Four-Component Synthesis of Pyrrolo[3,4-b]pyridin-5-ones

P. Janvier; X. Sun; H. Bienayme; J. Zhu 

Wilkinson’s Catalyst Catalyzed Selective Hydrogenation of Olefin in the Presence of an Aromatic Nitro Function: A Remarkable Solvent Effect

A. Jourdant; E. Gonzalez-Zamora; J. Zhu 

A Convergent Approach to Cyclopeptide Alkaloids: Total Synthesis of Sanjoinine G1

T. Temal-Laieb; J. Chastanet; J. Zhu 

An autoxidative approach to 1,2,3,4-tetrahydroisoquinolin-1-one and tetrahydro-β-carbolin-1-one

M. Bois-Choussy; M. De Paolis; J. Zhu 

Asymmetric total synthesis of (-)-deoxoprosophylline

A. Jourdant; J. Zhu 

Studies on the Total Synthesis of RP 66453: Synthesis of Fully Functionalized 15-Membered Biaryl-Containing Macrocycle

S. Boisnard; A-C. Carbonnelle; J. Zhu 

A Rapid Access to Biaryl Ether Containing Macrocycles by Pairwise Use of Ugi 4CR and Intramolecular SNAr-Based Cycloetherification

P. Cristau; J-P. Vors; J. Zhu 

Three component synthesis of oxa-bridged tetracyclic tetrahydroquinolines

E. Gonzalez-Zamora; A. Fayol; M. Bois-Choussy; A. Chiaroni; J. Zhu 

4-Nitrophenyltriflate

A Novel Multicomponent Synthesis of Polysubstituted 5-Aminooxazole and Its New Scaffold-Generating Reaction to Pyrrolo[3,4-b]pyridine

X. Sun; P. Janvier; G. Zhao; H. Bienayme; J. Zhu 

Activation of a terminal carboxylic acid by an internal oxazole: a novel synthesis of macrocyclodepsipeptide

G. Zhao; X. Sun; H. Bienayme; J. Zhu 

1,3,4,6,7,8-Hexahydro-1-methyl-2H-pyr- imido[1,2-a]pyrimidine (MTBD)

Polymer-Supported 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (PTBD)

An efficient stereoselective and stereodivergent synthesis of (2R,3R)- and (2R,3S)-3-hydroxypipecolic acids

A. Jourdant; J. Zhu