…A system where we know many of the players, but not everything is as it seems….Investigate for yourself by reading our new paper soon appearing in eLife
—– Our studies in zebrafish and mammalian cells have shed new light on how Keap1 functions. By studying the different paralogs of Keap1 in zebrafish we unearthed that although both paralogs are able to inhibit antioxidant response in the ground state, only one of these paralogs is able to respond to electrophiles. The other one is dominant negative for antioxidant signaling. Using mutagenesis, we could recapitulate these behaviors in the human protein.