Publications

2020

Journal Articles

The FDA-Approved Drug Nelfinavir Inhibits Lytic Cell-Free but Not Cell-Associated Nonlytic Transmission of Human Adenovirus

F. Georgi; V. Andriasyan; R. Witte; L. Murer; S. Hemmi et al. 

Antimicrobial Agents and Chemotherapy. 2020-08-20. Vol. 64, num. 9. DOI : 10.1128/AAC.01002-20.

A high-content image-based drug screen of clinical compounds against cell transmission of adenovirus

F. Georgi; F. Kuttler; L. Murer; V. Andriasyan; R. Witte et al. 

Scientific Data. 2020-08-12. Vol. 7, num. 1. DOI : 10.1038/s41597-020-00604-0.

Loss of Bacterial Cell Pole Stabilization in Caulobacter crescentus Sensitizes to Outer Membrane Stress and Peptidoglycan-Directed Antibiotics

S-U. Vallet; L. H. Hansen; F. C. Bistrup; S. A. Laursen; J. Bortoli Chapalay et al. 

mBio. 2020-05-05. Vol. 11, num. 3. DOI : 10.1128/mBio.00538-20.

Macrocycle synthesis strategy based on step-wise “adding and reacting” three components enables screening of large combinatorial libraries

G. K. Mothukuri; S. S. Kale; C. L. Stenbratt; A. Zorzi; J. Vesin et al. 

Chemical Science. 2020-06-26. Vol. 11, num. 30, p. 7858-7863. DOI : 10.1039/D0SC01944E.

High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays

N. Brandenberg; S. Hoehnel; F. Kuttler; K. Homicsko; C. Ceroni et al. 

Nature Biomedical Engineering. 2020-06-08. DOI : 10.1038/s41551-020-0565-2.

Marker-Free Automatic Quantification of Drug-Treated Cardiomyocytes with Digital Holographic Imaging

K. Jaferzadeh; B. Rappaz; F. Kuttler; B. K. Kim; I. Moon et al. 

Acs Photonics. 2020-01-01. Vol. 7, num. 1, p. 105-113. DOI : 10.1021/acsphotonics.9b01152.

2019

Journal Articles

Image-Based Marker-Free Screening of GABA(A) Agonists, Antagonists, and Modulators

B. Rappaz; P. Jourdain; D. Banfi; F. Kuttler; P. Marquet et al. 

Slas Discovery. 2019-11-28.  p. 2472555219887142. DOI : 10.1177/2472555219887142.

Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands

S. S. Kale; M. Bergeron-Brlek; Y. Wu; M. G. Kumar; M. V. Pham et al. 

Science Advances. 2019-08-21. Vol. 5, num. 8, p. eaaw2851. DOI : 10.1126/sciadv.aaw2851.

An optimized and validated 384-well plate assay to test platelet function in a high-throughput screening format

A. M. Lima; M. E. Bragina; O. Burri; J. B. Chapalay; F. P. Costa-Fraga et al. 

Platelets. 2019-01-01. Vol. 30, num. 5, p. 563-571. DOI : 10.1080/09537104.2018.1514106.

Screening-based approach to discover effective platinum-based chemotherapies for cancers with poor prognosis

H. P. Varbanov; F. Kuttler; D. Banfi; G. Turcatti; P. J. Dyson 

Plos One. 2019-01-29. Vol. 14, num. 1, p. e0211268. DOI : 10.1371/journal.pone.0211268.

A Universal Assay for Aminopeptidase Activity and Its Application for Dipeptidyl Peptidase-4 Drug Discovery

A. A. Bazhin; M. Chambon; J. Vesin; J. Bortoli; J. W. Collins et al. 

Analytical Chemistry. 2019-01-01. Vol. 91, num. 1, p. 1098-1104. DOI : 10.1021/acs.analchem.8b04672.

Patents

Sting inhibitors

A. Ablasser; S. Haag; L. Reymond 

WO2019201939; EP3556362.

2019.

2018

Journal Articles

Quantification of stored red blood cell fluctuations by time-lapse holographic cell imaging

K. Jaferzadeh; I. Moon; M. Bardyn; M. Prudent; J-D. Tissot et al. 

Biomedical Optics Express. 2018-10-01. Vol. 9, num. 10, p. 4714-4729. DOI : 10.1364/BOE.9.004714.

Targeting STING with covalent small-molecule inhibitors

S. Haag; M. Gulen; L. Reymond; A. Gibelin; L. Abrami et al. 

Nature. 2018. Vol. 559, num. 7713, p. 269-+. DOI : 10.1038/s41586-018-0287-8.

High-throughput, nonperturbing quantification of lipid droplets with digital holographic microscopy

V. Campos; B. Rappaz; F. Kuttler; G. Turcatti; O. Naveiras 

JOURNAL OF LIPID RESEARCH. 2018. Vol. 59, num. 7, p. 1301-1310. DOI : 10.1194/jlr.D085217.

2017

Journal Articles

Red blood cells ageing markers: a multi-parametric analysis

M. Bardyn; B. Rappaz; K. Jaferzadeh; D. Crettaz; J-D. Tissot et al. 

Blood Transfusion. 2017. Vol. 15, num. 3, p. 239-S2. DOI : 10.2450/2017.0318-16.

Repositioning approved drugs for the treatment of problematic cancers using a screening approach

H. P. Varbanov; F. Kuttler; D. Banfi; G. Turcatti; P. J. Dyson 

Plos One. 2017. Vol. 12, num. 2, p. e0171052. DOI : 10.1371/journal.pone.0171052.

2016

Journal Articles

Screening out irrelevant cell-based models of disease

P. Horvath; N. Aulner; M. Bickle; A. M. Davies; E. Del Nery et al. 

Nature Reviews Drug Discovery. 2016. Vol. 15, num. 11, p. 751-769. DOI : 10.1038/nrd.2016.175.

Growth control switch by a DNA-damage-inducible toxin–antitoxin system in Caulobacter crescentus

C. L. Kirkpatrick; D. Martins; P. Redder; A. Frandi; J. Mignolet et al. 

Nature Microbiology. 2016. Vol. 1, num. 4, p. 16008. DOI : 10.1038/nmicrobiol.2016.8.

Automated tracking of temporal displacements of a red blood cell obtained by time-lapse digital holographic microscopy

I. Moon; F. Yi; B. Rappaz 

Applied Optics. 2016. Vol. 55, num. 3, p. A86-A94. DOI : 10.1364/Ao.55.000A86.

Conference Papers

Development Of A Novel First-In-Class Oral Inhibitor Of The Notch Pathway

R. Lehal; V. Frismantas; V. Reinmuller; G. Turcatti; J. P. Bourquin et al. 

2016. 21st Congress of the European-Hematology-Association, Copenhagen, DENMARK, JUN 09-12, 2016. p. 29-29.

2015

Journal Articles

Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis

C. C. Scott; S. Vossio; F. Vacca; B. Snijder; J. Larios et al. 

Embo Reports. 2015. Vol. 16, num. 6, p. 741-752. DOI : 10.15252/embr.201540081.

Automated multi-parameter measurement of cardiomyocytes dynamics with digital holographic microscopy

B. Rappaz; I. Moon; F. Yi; B. Javidi; P. Marquet et al. 

Optics Express. 2015. Vol. 23, num. 10, p. 13333-13347. DOI : 10.1364/OE.23.013333.

Conference Papers

Identification of CDC-48 inhibitors in C. elegans

A. F. Conchas; F. Schwager; M. Chambon; G. Turcatti; M. Gotta 

2015. 40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) – The Biochemical Basis of Life, Berlin, GERMANY, JUL 04-09, 2015. p. 389-389.

Book Chapters

Digital Holographic Imaging for Label-Free Phenotypic Profiling, Cytotoxicity, and Chloride Channels Target Screening

B. Rappaz; F. Kuttler; B. Breton; G. Turcatti 

Label-Free Biosensor Methods in Drug Discovery; New York: Springer, 2015. p. 307-325.

2014

Journal Articles

Non-specific SIRT inhibition as a mechanism for the cytotoxicity of ginkgolic acids and urushiols

L. Ryckewaert; L. Sacconnay; P-A. Carrupt; A. Nurisso; C. Simões-Pires 

Toxicology Letters. 2014. Vol. 229, num. 2, p. 374-380. DOI : 10.1016/j.toxlet.2014.07.002.

Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion

J. Rybniker; J. M. Chen; C. Sala; R. C. Hartkoorn; A. Vocat et al. 

Cell Host & Microbe. 2014. Vol. 16, num. 4, p. 538-548. DOI : 10.1016/j.chom.2014.09.008.

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

U. F. Roehrig; S. R. Majjigapu; M. Chambon; S. Bron; L. Pilotte et al. 

European Journal Of Medicinal Chemistry. 2014. Vol. 84, p. 284-301. DOI : 10.1016/j.ejmech.2014.06.078.

Developing the Biomolecular Screening Facility at the EPFL into the Chemical Biology Screening Platform for Switzerland

G. Turcatti 

Combinatorial Chemistry & High Throughput Screening. 2014. Vol. 17, num. 4, p. 369-376.

Digital holographic microscopy: a quantitative label-free microscopy technique for phenotypic screening

B. Rappaz; B. Breton; E. Shaffer; G. Turcatti 

Combinatorial chemistry & high throughput screening. 2014. Vol. 17, num. 1, p. 80-8. DOI : 10.2174/13862073113166660062.

Conference Papers

Loss of Protein Tyr-phosphorylation During in vitro Storage of Human Erythrocytes: Impact on RBC Morphology

M. Prudent; B. Rappaz; R. Hamelin; J. Delobel; M. Mueller et al. 

2014. AABB Annual Meeting, Philadelphia, PA, OCT 25-28, 2014. p. 49A-50A.

2013

Journal Articles

Telomerase Inhibitors from Cyanobacteria: Isolation and Synthesis of Sulfoquinovosyl Diacylglycerols from

M. Makhlouf Brahmi; C. Portmann; D. D’Ambrosio; T. M. Woods; D. Banfi et al. 

Chemistry – A European Journal. 2013. Vol. 19, num. 14, p. 4596-4601. DOI : 10.1002/chem.201203296.

Label-Free Cytotoxicity Screening Assay by Digital Holographic Microscopy

J. Kühn; E. Shaffer; J. Mena; B. Breton; J. Parent et al. 

ASSAY and Drug Development Technologies. 2013. Vol. 11, num. 2, p. 101-107. DOI : 10.1089/adt.2012.476.

2012

Journal Articles

Enumeration of 166 Billion Organic Small Molecules in the Chemical Universe Database GDB-17

L. Ruddigkeit; R. Van Deursen; L. C. Blum; J-L. Reymond 

Journal Of Chemical Information And Modeling. 2012. Vol. 52, num. 11, p. 2864-2875. DOI : 10.1021/ci300415d.

2011

Journal Articles

Exploring the Chemical Space of Known and Unknown Organic Small Molecules at www.gdb.unibe.ch

J-L. Reymond; L. C. Blum; R. van Deursen 

Chimia. 2011. Vol. 65, p. 863-867. DOI : 10.2533/chimia.2011.863.

Chemical Biology Approaches to Membrane Homeostasis and Function

M. Takahashi-Umebayashi; L. Pineau; T. Hannich; A. Zumbuehl; D. A. Doval et al. 

Chimia. 2011. Vol. 65, p. 849-852. DOI : 10.2533/chimia.2011.849.

Student Projects

Multiplexed detection of nucleic acids – testing and benchmarking of a novel platform developed by Biocartis

J. Emery 

2011.

2010

Journal Articles

Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action

H. Ouertatani-Sakouhi; F. El-Turk; B. Fauvet; M-K. Cho; D. Pinar Karpinar et al. 

The Journal of biological chemistry. 2010. Vol. 285, num. 34, p. 26581-98. DOI : 10.1074/jbc.M110.113951.

Leads for antitubercular compounds from kinase inhibitor library screens

S. Magnet; R. C. Hartkoorn; R. Székely; J. Pató; J. A. Triccas et al. 

Tuberculosis. 2010. Vol. 90, num. 6, p. 354-60. DOI : 10.1016/j.tube.2010.09.001.

Optimization of microfluidic single cell trapping for long-term on-chip culture

S. Kobel; A. Valero; J. Latt; P. Renaud; M. Lutolf 

Lab on a Chip. 2010. Vol. 10, num. 7, p. 857-863. DOI : 10.1039/b918055a.

An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity

F. El Turk; B. Fauvet; H. Ouertatani-Sakouhi; A. Lugari; S. Betzi et al. 

Bioorganic & medicinal chemistry. 2010. Vol. 18, num. 14, p. 5425-40. DOI : 10.1016/j.bmc.2010.05.010.

Patents

Preparation of nucleic acid templates for solid phase amplification

N. Gormley; J. Boutell; G. Turcatti; C. Barnes 

EP2918686; EP1957668; WO2007060456; US8168388; US2010041561; EP1957668; WO2007060456; GB0524069.

2010.

Student Projects

Development of high content image-based cell viability assays

J. Mena 

2010.

Cellular transfection of small interfering ribonucleic acids. Electroporation as an alternative to liposome-based delivery transfection methods

G. Jacot 

2010.

2009

Journal Articles

A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor

H. Ouertatani-Sakouhi; F. El-Turk; B. Fauvet; T. Roger; D. Le Roy et al. 

Biochemistry. 2009. Vol. 48, num. 41, p. 9858-70. DOI : 10.1021/bi900957e.

Patents

Preparation of templates for nucleic acid sequencing

X. Liu; J. Milton; G. Smith; C. Barnes; I. Rasolonjatovo et al. 

US10710046; US2018353926; US9999866; US2017021325; US9498763; US2015343410; US9085802; US2014349891; US8715966; HK1154636; ES2398808; EP2298930; US2012208194; EP1910559; EP2298930; US2009118128; EP1910559; WO2007010251; WO2007010251; GB0514936.

2009.

2008

Journal Articles

Accurate whole human genome sequencing using reversible terminator chemistry

D. R. Bentley; S. Balasubramanian; H. P. Swerdlow; G. P. Smith; J. Milton et al. 

Nature. 2008. Vol. 456, num. 7218, p. 53-9. DOI : 10.1038/nature07517.

A new class of cleavable fluorescent nucleotides: synthesis and optimization as reversible terminators for DNA sequencing by synthesis

G. Turcatti; A. Romieu; M. Fedurco; A. Tairi 

Nucleic Acids Research. 2008. Vol. 36, num. 4, p. e25. DOI : 10.1093/nar/gkn021.

Patents

Method of Nucleotide Detection

M. Fedurco; A. Romieu; G. Turcatti 

EP1828412; US9970055; US2016208324; US9303290; US9217178; US2014378323; EP1828412; US2008280773; EP1828412; WO2006064199; GB0514933; GB0427236.

2008.

2007

Journal Articles

Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha

P. Maillard; S. Reynard; F. Serhan; P. Turelli; D. Trono 

PLOS Pathogens. 2007. Vol. 3, num. 12, p. e200. DOI : 10.1371/journal.ppat.0030200.

Low- to high-throughput analysis of telomerase modulators with Telospot

G. Cristofari; P. Reichenbach; P. O. Regamey; D. Banfi; M. Chambon et al. 

Nature Methods. 2007. Vol. 4, num. 10, p. 851-853. DOI : 10.1038/nmeth1099.

Patents

Conversion of amine- to carboxyl groups on solid surfaces

M. Fedurco; A. Romieu; G. Turcatti 

US7704543; US2007042109; EP1692090; WO2005030695.

2007.

Improved method of nucleotide detection

M. Fedurco; A. Romieu; G. Turcatti 

EP1828412; US9970055; US2016208324; US9303290; US9217178; US2014378323; EP1828412; US2008280773; EP1828412; WO2006064199; GB0514933; GB0427236.

2007.

2006

Journal Articles

Aryldithioethyloxycarbonyl (Ardec): A new family of amine protecting groups removable under mild reducing conditions and their applications to peptide synthesis

M. Lapeyre; J. Leprince; M. Massonneau; H. Oulyadi; P. Y. Renard et al. 

Chemistry – A European Journal. 2006. Vol. 12, num. 13, p. 3655-3671. DOI : 10.1002/chem.200501538.

BTA, a novel reagent for DNA attachment on glass and efficient generation of solid-phase amplified DNA colonies

M. Fedurco; A. Romieu; S. Williams; I. Lawrence; G. Turcatti 

Nucleic Acids Research. 2006. Vol. 34, num. 3, p. e22. DOI : 10.1093/nar/gnj023.