Publications

2019

Journal Articles

Image-Based Marker-Free Screening of GABA(A) Agonists, Antagonists, and Modulators

B. Rappaz; P. Jourdain; D. Banfi; F. Kuttler; P. Marquet et al. 

Slas Discovery. 2019-11-28.  p. UNSP 2472555219887142. DOI : 10.1177/2472555219887142.

Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands

S. S. Kale; M. Bergeron-Brlek; Y. Wu; M. G. Kumar; M. V. Pham et al. 

Science Advances. 2019-08-21. Vol. 5, num. 8, p. eaaw2851. DOI : 10.1126/sciadv.aaw2851.

An optimized and validated 384-well plate assay to test platelet function in a high-throughput screening format

A. M. Lima; M. E. Bragina; O. Burri; J. B. Chapalay; F. P. Costa-Fraga et al. 

Platelets. 2019-01-01. Vol. 30, num. 5, p. 563-571. DOI : 10.1080/09537104.2018.1514106.

Screening-based approach to discover effective platinum-based chemotherapies for cancers with poor prognosis

H. P. Varbanov; F. Kuttler; D. Banfi; G. Turcatti; P. J. Dyson 

Plos One. 2019-01-29. Vol. 14, num. 1, p. e0211268. DOI : 10.1371/journal.pone.0211268.

A Universal Assay for Aminopeptidase Activity and Its Application for Dipeptidyl Peptidase-4 Drug Discovery

A. A. Bazhin; M. Chambon; J. Vesin; J. Bortoli; J. W. Collins et al. 

Analytical Chemistry. 2019-01-01. Vol. 91, num. 1, p. 1098-1104. DOI : 10.1021/acs.analchem.8b04672.

2018

Journal Articles

Quantification of stored red blood cell fluctuations by time-lapse holographic cell imaging

K. Jaferzadeh; I. Moon; M. Bardyn; M. Prudent; J-D. Tissot et al. 

Biomedical Optics Express. 2018-10-01. Vol. 9, num. 10, p. 4714-4729. DOI : 10.1364/BOE.9.004714.

Targeting STING with covalent small-molecule inhibitors

S. Haag; M. Gulen; L. Reymond; A. Gibelin; L. Abrami et al. 

NATURE. 2018. Vol. 559, num. 7713, p. 269-+. DOI : 10.1038/s41586-018-0287-8.

High-throughput, nonperturbing quantification of lipid droplets with digital holographic microscopy

V. Campos; B. Rappaz; F. Kuttler; G. Turcatti; O. Naveiras 

JOURNAL OF LIPID RESEARCH. 2018. Vol. 59, num. 7, p. 1301-1310. DOI : 10.1194/jlr.D085217.

2017

Journal Articles

Red blood cells ageing markers: a multi-parametric analysis

M. Bardyn; B. Rappaz; K. Jaferzadeh; D. Crettaz; J-D. Tissot et al. 

Blood Transfusion. 2017. Vol. 15, num. 3, p. 239-S2. DOI : 10.2450/2017.0318-16.

Repositioning approved drugs for the treatment of problematic cancers using a screening approach

H. P. Varbanov; F. Kuttler; D. Banfi; G. Turcatti; P. J. Dyson 

Plos One. 2017. Vol. 12, num. 2, p. e0171052. DOI : 10.1371/journal.pone.0171052.

2016

Journal Articles

Screening out irrelevant cell-based models of disease

P. Horvath; N. Aulner; M. Bickle; A. M. Davies; E. Del Nery et al. 

Nature Reviews Drug Discovery. 2016. Vol. 15, num. 11, p. 751-769. DOI : 10.1038/nrd.2016.175.

Growth control switch by a DNA-damage-inducible toxin–antitoxin system in Caulobacter crescentus

C. L. Kirkpatrick; D. Martins; P. Redder; A. Frandi; J. Mignolet et al. 

Nature Microbiology. 2016. Vol. 1, num. 4, p. 16008. DOI : 10.1038/nmicrobiol.2016.8.

Automated tracking of temporal displacements of a red blood cell obtained by time-lapse digital holographic microscopy

I. Moon; F. Yi; B. Rappaz 

Applied Optics. 2016. Vol. 55, num. 3, p. A86-A94. DOI : 10.1364/Ao.55.000A86.

Conference Papers

Development Of A Novel First-In-Class Oral Inhibitor Of The Notch Pathway

R. Lehal; V. Frismantas; V. Reinmuller; G. Turcatti; J. P. Bourquin et al. 

2016. 21st Congress of the European-Hematology-Association, Copenhagen, DENMARK, JUN 09-12, 2016. p. 29-29.

2015

Journal Articles

Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis

C. C. Scott; S. Vossio; F. Vacca; B. Snijder; J. Larios et al. 

Embo Reports. 2015. Vol. 16, num. 6, p. 741-752. DOI : 10.15252/embr.201540081.

Automated multi-parameter measurement of cardiomyocytes dynamics with digital holographic microscopy

B. Rappaz; I. Moon; F. Yi; B. Javidi; P. Marquet et al. 

Optics Express. 2015. Vol. 23, num. 10, p. 13333-13347. DOI : 10.1364/OE.23.013333.

Conference Papers

Identification of CDC-48 inhibitors in C. elegans

A. F. Conchas; F. Schwager; M. Chambon; G. Turcatti; M. Gotta 

2015. 40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) – The Biochemical Basis of Life, Berlin, GERMANY, JUL 04-09, 2015. p. 389-389.

Book Chapters

Digital Holographic Imaging for Label-Free Phenotypic Profiling, Cytotoxicity, and Chloride Channels Target Screening

B. Rappaz; F. Kuttler; B. Breton; G. Turcatti 

Label-Free Biosensor Methods in Drug Discovery; New York: Springer, 2015. p. 307-325.

2014

Journal Articles

Non-specific SIRT inhibition as a mechanism for the cytotoxicity of ginkgolic acids and urushiols

L. Ryckewaert; L. Sacconnay; P-A. Carrupt; A. Nurisso; C. Simões-Pires 

Toxicology Letters. 2014. Vol. 229, num. 2, p. 374-380. DOI : 10.1016/j.toxlet.2014.07.002.

Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion

J. Rybniker; J. M. Chen; C. Sala; R. C. Hartkoorn; A. Vocat et al. 

Cell Host & Microbe. 2014. Vol. 16, num. 4, p. 538-548. DOI : 10.1016/j.chom.2014.09.008.

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

U. F. Roehrig; S. R. Majjigapu; M. Chambon; S. Bron; L. Pilotte et al. 

European Journal Of Medicinal Chemistry. 2014. Vol. 84, p. 284-301. DOI : 10.1016/j.ejmech.2014.06.078.

Developing the Biomolecular Screening Facility at the EPFL into the Chemical Biology Screening Platform for Switzerland

G. Turcatti 

Combinatorial Chemistry & High Throughput Screening. 2014. Vol. 17, num. 4, p. 369-376.

Digital holographic microscopy: a quantitative label-free microscopy technique for phenotypic screening

B. Rappaz; B. Breton; E. Shaffer; G. Turcatti 

Combinatorial chemistry & high throughput screening. 2014. Vol. 17, num. 1, p. 80-8. DOI : 10.2174/13862073113166660062.

Conference Papers

Loss of Protein Tyr-phosphorylation During in vitro Storage of Human Erythrocytes: Impact on RBC Morphology

M. Prudent; B. Rappaz; R. Hamelin; J. Delobel; M. Mueller et al. 

2014. AABB Annual Meeting, Philadelphia, PA, OCT 25-28, 2014. p. 49A-50A.

2013

Journal Articles

Telomerase Inhibitors from Cyanobacteria: Isolation and Synthesis of Sulfoquinovosyl Diacylglycerols from

M. Makhlouf Brahmi; C. Portmann; D. D’Ambrosio; T. M. Woods; D. Banfi et al. 

Chemistry – A European Journal. 2013. Vol. 19, num. 14, p. 4596-4601. DOI : 10.1002/chem.201203296.

Label-Free Cytotoxicity Screening Assay by Digital Holographic Microscopy

J. Kühn; E. Shaffer; J. Mena; B. Breton; J. Parent et al. 

ASSAY and Drug Development Technologies. 2013. Vol. 11, num. 2, p. 101-107. DOI : 10.1089/adt.2012.476.

2012

Journal Articles

Enumeration of 166 Billion Organic Small Molecules in the Chemical Universe Database GDB-17

L. Ruddigkeit; R. Van Deursen; L. C. Blum; J-L. Reymond 

Journal Of Chemical Information And Modeling. 2012. Vol. 52, num. 11, p. 2864-2875. DOI : 10.1021/ci300415d.

2011

Journal Articles

Exploring the Chemical Space of Known and Unknown Organic Small Molecules at www.gdb.unibe.ch

J-L. Reymond; L. C. Blum; R. van Deursen 

Chimia. 2011. Vol. 65, p. 863-867. DOI : 10.2533/chimia.2011.863.

Chemical Biology Approaches to Membrane Homeostasis and Function

M. Takahashi-Umebayashi; L. Pineau; T. Hannich; A. Zumbuehl; D. A. Doval et al. 

Chimia. 2011. Vol. 65, p. 849-852. DOI : 10.2533/chimia.2011.849.

2010

Journal Articles

Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action

H. Ouertatani-Sakouhi; F. El-Turk; B. Fauvet; M-K. Cho; D. Pinar Karpinar et al. 

The Journal of biological chemistry. 2010. Vol. 285, num. 34, p. 26581-98. DOI : 10.1074/jbc.M110.113951.

Leads for antitubercular compounds from kinase inhibitor library screens

S. Magnet; R. C. Hartkoorn; R. Székely; J. Pató; J. A. Triccas et al. 

Tuberculosis. 2010. Vol. 90, num. 6, p. 354-60. DOI : 10.1016/j.tube.2010.09.001.

Optimization of microfluidic single cell trapping for long-term on-chip culture

S. Kobel; A. Valero; J. Latt; P. Renaud; M. Lutolf 

Lab on a Chip. 2010. Vol. 10, num. 7, p. 857-863. DOI : 10.1039/b918055a.

An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity

F. El Turk; B. Fauvet; H. Ouertatani-Sakouhi; A. Lugari; S. Betzi et al. 

Bioorganic & medicinal chemistry. 2010. Vol. 18, num. 14, p. 5425-40. DOI : 10.1016/j.bmc.2010.05.010.

Patents

Preparation of nucleic acid templates for solid phase amplification

N. Gormley; J. Boutell; G. Turcatti; C. Barnes 

EP2918686; EP1957668; WO2007060456; US8168388; US2010041561; EP1957668; WO2007060456; GB0524069.

2010.

2009

Journal Articles

A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor

H. Ouertatani-Sakouhi; F. El-Turk; B. Fauvet; T. Roger; D. Le Roy et al. 

Biochemistry. 2009. Vol. 48, num. 41, p. 9858-70. DOI : 10.1021/bi900957e.

Patents

Preparation of templates for nucleic acid sequencing

X. Liu; J. Milton; G. Smith; C. Barnes; I. Rasolonjatovo et al. 

US2018353926; US9999866; US2017021325; US9498763; US2015343410; US9085802; US2014349891; US8715966; HK1154636; ES2398808; EP2298930; US2012208194; EP1910559; EP2298930; US2009118128; EP1910559; WO2007010251; WO2007010251; GB0514936.

2009.

2008

Journal Articles

Accurate whole human genome sequencing using reversible terminator chemistry

D. R. Bentley; S. Balasubramanian; H. P. Swerdlow; G. P. Smith; J. Milton et al. 

Nature. 2008. Vol. 456, num. 7218, p. 53-9. DOI : 10.1038/nature07517.

A new class of cleavable fluorescent nucleotides: synthesis and optimization as reversible terminators for DNA sequencing by synthesis

G. Turcatti; A. Romieu; M. Fedurco; A. Tairi 

Nucleic Acids Research. 2008. Vol. 36, num. 4, p. e25. DOI : 10.1093/nar/gkn021.

Patents

Method of Nucleotide Detection

M. Fedurco; A. Romieu; G. Turcatti 

EP1828412; US9970055; US2016208324; US9303290; US9217178; US2014378323; EP1828412; US2008280773; EP1828412; WO2006064199; GB0514933; GB0427236.

2008.

2007

Journal Articles

Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha

P. Maillard; S. Reynard; F. Serhan; P. Turelli; D. Trono 

PLOS Pathogens. 2007. Vol. 3, num. 12, p. e200. DOI : 10.1371/journal.ppat.0030200.

Low- to high-throughput analysis of telomerase modulators with Telospot

G. Cristofari; P. Reichenbach; P. O. Regamey; D. Banfi; M. Chambon et al. 

Nat Methods. 2007. Vol. 4, num. 10, p. 851-853. DOI : 10.1038/nmeth1099.

Patents

Conversion of amine- to carboxyl groups on solid surfaces

M. Fedurco; A. Romieu; G. Turcatti 

US7704543; US2007042109; EP1692090; WO2005030695.

2007.

Improved method of nucleotide detection

M. Fedurco; A. Romieu; G. Turcatti 

EP1828412; US9970055; US2016208324; US9303290; US9217178; US2014378323; EP1828412; US2008280773; EP1828412; WO2006064199; GB0514933; GB0427236.

2007.

2006

Journal Articles

Aryldithioethyloxycarbonyl (Ardec): A new family of amine protecting groups removable under mild reducing conditions and their applications to peptide synthesis

M. Lapeyre; J. Leprince; M. Massonneau; H. Oulyadi; P. Y. Renard et al. 

Chemistry – A European Journal. 2006. Vol. 12, num. 13, p. 3655-3671. DOI : 10.1002/chem.200501538.

BTA, a novel reagent for DNA attachment on glass and efficient generation of solid-phase amplified DNA colonies

M. Fedurco; A. Romieu; S. Williams; I. Lawrence; G. Turcatti 

Nucleic Acids Research. 2006. Vol. 34, num. 3, p. e22. DOI : 10.1093/nar/gnj023.