Current Master Projects Propostitions
- Classifying compounds according to mode-of-action through multiplexed automated-fluorescence microscopy assays.
- Development of in vitro enzymatic assays of cytochrome P450 for the characterization of bioactive compounds.
- High throughput generation of fluorescent bioactive compounds for the discovery of new specific cellular probes.
Past Master Projects
Since 2010, twelve final master thesis projects were performed at the Biomolecular Screening Facility under the direction of Gerardo Turcatti, co-supervised by different members of the platform.
Maryam SOLOMON (Pharmacy School, EPGL)
Développement d’un test fluorimétrique de criblage de l’inhibition de l’activité des cytochromes P450 3A4 et 2C9
Bo Kyoung KIM (University of Geneva / EPFL, Chemical Biology)
lmage-based quantification of cardiomyocytes beating dynamics by Digital Holographic Microscopy (supervised by Benjamin Rappaz & Fabien Kuttler)
Céline Dind (Pharmacy School, EPGL)
Caractérisation biologique et physico-chimique de hits actifs sur les cyclooxygénases (supervised by Marc Chambon)
Sabrina AYOUB (Pharmacy School, EPGL)
Studying CFTR receptor activity by digital holographic microscopy (supervised by Benjamin Rappaz)
Oumaima LAHOUEGUE (Pharmacy School, EPGL)
Identification of selective inhibitors of COX-1 using enzymatic and cellular screening approaches (supervised by Marc Chambon)
Kilian COCHET (EPFL)
Compounds toxicity screening by High Content Analysis using automated fluorescence microscopy and digital holographic imaging (supervised by Fabien Kuttler)
miRNAs as biomarkers for chronic pain in humans. IRR-institut de recherche en réadpation-réinsertion (Sion)
Profiling chemical collections: Determining the quality, spectral and toxic properties of compounds
Developing a screening assay for the discovery of Acid Sensing Ion Channels (ASICs) inhibitors
Development of amplification strategies to improve sensitivity of nucleic acid detection assays on the multiplex detection platform of Biocartis
Multiplexed detection of nucleic acids – testing and benchmarking a novel platform developed by Biocartis
Cellular transfection of small interfering RNA’s (siRNAs). Electroporation as an alternative to liposome-based delivery transfection methods.
Development of high content image-based cell viability assays
Julien Mena has been awarded with the price 2010 for the best Master thesis in Biotechnology of the master of Biotechnology and Bioengineering