Home of REX technologies: T-REX™ delivery and G-REX™ profiling – Electrophile signaling and stress response – Nucleotide signaling and genome maintenance
NEWS & ANNOUNCEMENTS
Shooting straight at the heart!
Our new protocol paper (“accepted in principle” by Nature Protocols) discloses how to perform T-REX in a tissue specific manner in live fish (Z-REX). We hope it is a pulsating read! Huang and Poganik et al. 2022
The lab was awarded an ERC CoG grant of 2M Euros
We are grateful for the support from the European Research Council (ERC) and SERI (State Secretariat for Education, Research and Innovation, Switzerland)
Minority governance!
By engineering and applying function-guided proximity-mapping approach, Localis-REX, we have uncovered (Zhao, Miranda, et al., PNAS) that even small fractions of endogenous proteins existing outside their canonical locale can show significantly-elevated electrophilic-metabolite sensing against the protein in its canonical locale. This minority of electrophile-sensing proteins can strongly influence activity of the bulk protein and hence (…)
2022 Tetrahedron Young Investigator Award
We are hugely humbled to receive the 2022 TYI Award in Bioorganic & Medicinal Chemistry and grateful for the honor.
Catch of the day!
Our latest work leveraging T-REX and zebrafish immune models has helped to uncover the precise mode-of-mechanism of pleiotropic electrophilic drugs (Poganik, Huang et al Nature Communications). We thank all of the contributing team members and funders supporting this study.”A tool to interrogate a new class of drugs” by EPFL-SB news
2021 ACS Cope Scholars Award
We are incredibly honored to be recognized as one of the labs selected as ‘2021 ACS Arthur C. Cope Scholars’. We thank the American Chemical Society (ACS) for this prestigious honor.