Home of REX technologies: T-REX™ delivery and G-REX™ profiling – Electrophile signaling and stress response – Nucleotide signaling and genome maintenance
NEWS & ANNOUNCEMENTS
The Ring Master is born
Training of natural electrophiles to target a single protein leads to improved target specificity and drug activity, but retains the electrophile’s privileged properties.The first step to translation of T-REX, by Xuyu et al., is set to appear in ACS Central Science:Precision targeting of pten-null triple-negative breast tumors guided by electrophilic metabolite sensingWe thank all the (…)
2020 EFMC Award
Our lab was recognized by the 2020 EFMC Award in Medicinal Chemistry – we are grateful for the prestigious recognition
HuR you too!
Invited contribution to a special issue in honor of Prof. Michael Graetzel’s 75th birthday, was made by Jesse et al. through the sequel of HuR.The mRNA‐Binding Protein HuR Is a Kinetically‐Privileged Electrophile SensorHelvetica Wiley: Just Accepted 2020 AprilSee here for our earlier publication on HuR by Jesse et al.We thank all former and present members (…)
Jinmin pockets Master Thesis Prize in Chemical Biology!
We are excited to congratulate Jinmin for snatching the best master thesis prize award in NCCR Chemical Biology!For more information about this one-of-a-kind interface training program for master students, please check out: NCCR master program in chemical biologyWe are now accepting program applications from aspiring chemical biologists worldwide: the upcoming deadline is end of Feb (…)
2020 ACS Award in Biological Chemistry
We thank the American Chemical Society (ACS) and the award sponsor, Eli Lilly & Co., for recognizing our lab with the prestigious ACS Eli Lilly Award.Previous awardees since 1935
The role of the ZRANB3/RNR signaling axis in cancer comes into focus
Our new paper detailing how ZRANB3 is a poignant example of non-oncogene addiction in H-RasG12V-induced transformation and how nuclear RNR-alpha can inhibit this function is set to appear in Cell Chemical Biology. Critically, some approved anti-cancer drugs targeting RNR-alpha such as clofarabine also taps into this pathway:Clofarabine commandeers the RNR-α—ZRANB3 nuclear signaling axisWe thank our (…)