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NEWS & ANNOUNCEMENTS
The role of the ZRANB3/RNR signaling axis in cancer comes into focus
Our new paper detailing how ZRANB3 is a poignant example of non-oncogene addiction in H-RasG12V-induced transformation and how nuclear RNR-alpha can inhibit this function is set to appear in Cell Chemical Biology. Critically, some approved anti-cancer drugs targeting RNR-alpha such as clofarabine also taps into this pathway:Clofarabine commandeers the RNR-α—ZRANB3 nuclear signaling axisWe thank our (…)
Three is not a crowd!
(W)Hu ‘R’ you? A key transcription factor in a druggable pathway is regulated by two mRNA-binding proteins in a mechanism conserved from humans to zebrafish:Post-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1Poganik et al. Just AcceptedFASEB Journal Gotta get with my friends!: in this invited opinion piece (in Current Opinion in Chem (…)
2020 ACS award in biological chemistry
We thank the ACS and the award sponsor, Eli Lilly & Co., for recognizing our lab with the prestigious ACS Eli Lilly Award.Previous awardees since 1935