Home of REX technologies: T-REX™ delivery and G-REX™ profiling – Electrophile signaling and stress response – Nucleotide signaling and genome maintenance
NEWS & ANNOUNCEMENTS
The Mystery of Twin Keaps …
…A system where we know many of the players, but not everything is as it seems….Investigate for yourself by reading our new paper soon appearing in eLife —– Our studies in zebrafish and mammalian cells have shed new light on how Keap1 functions. By studying the different paralogs of Keap1 in zebrafish we unearthed that (…)
Shooting straight at the heart!
Our new protocol paper (“accepted in principle” by Nature Protocols) discloses how to perform T-REX in a tissue specific manner in live fish (Z-REX). We hope it is a pulsating read! Huang and Poganik et al. 2022
Minority governance!
By engineering and applying function-guided proximity-mapping approach, Localis-REX, we have uncovered (Zhao, Miranda, et al., PNAS) that even small fractions of endogenous proteins existing outside their canonical locale can show significantly-elevated electrophilic-metabolite sensing against the protein in its canonical locale. This minority of electrophile-sensing proteins can strongly influence activity of the bulk protein and hence (…)
The lab was awarded an ERC CoG grant of 2M Euros
We are grateful for the support from the European Research Council (ERC) and SERI (State Secretariat for Education, Research and Innovation, Switzerland)
2022 Tetrahedron Young Investigator Award
We are hugely humbled to receive the 2022 TYI Award in Bioorganic & Medicinal Chemistry and grateful for the honor.
Catch of the day!
Our latest work leveraging T-REX and zebrafish immune models has helped to uncover the precise mode-of-mechanism of pleiotropic electrophilic drugs (Poganik, Huang et al Nature Communications). We thank all of the contributing team members and funders supporting this study.”A tool to interrogate a new class of drugs” by EPFL-SB news