Category: line2
Welcome Mathilde
We are delighted to welcome Mathilde Solyga as a new postdoctoral scientist to our group. Mathilde will work on the mechanisms that link miniature neurotransmission to synapse aging.
Thank you Target ALS
Thank you to Target ALS for highlighting the work on #ALS in our laboratory together with Bernard Schneider and Sabine Liebscher. We are very grateful for your funding and unflagging support – www.targetals.org/2025/03/04/i… [image or embed] — McCabe Lab (@mccabelab.org) March 5, 2025 at 2:59 PM
Medha wins EPFL MT180
Many congratulations to lab member Medha Raman for winning the EPFL final of MT180 – My Thesis in 180 seconds [image or embed] — McCabe Lab (@mccabelab.org) March 30, 2025 at 5:36 PM
Combating Age-Related Motor Decline
Many thanks to The Scientist for covering our work on delaying motor decline during aging – https://www.the-scientist.com/combating-age-related-motor-decline-72095
Trio preserves motor ability during aging
Is the weakening of motor ability with age inevitable? In a new study we show that motor neuron synapse levels of the conserved Rac GEF protein Trio reduce with age in Drosophila. Increasing Trio expression during aging (including by expression of transgenic human Trio) preserves the structure of motor synapses during aging, improving their function (…)
Protein ‘traffic jam’ linked to neurodegeneration
The Cruelest Cut: EPFL article about our new paper, led by Jamshid, which shows that Retromer deficiency, which is implicated in both Parkinson’s and Alzheimer’s Disease, increases human Tau truncation and toxicity. In the paper we also describe new tools to quantitate neurodegeneration with single synapse or axon resolution in intact Drosophila brains.
Brain metrics reveal sex differences
EPFL article about our paper using genetic tools built for computer assisted science – which we have dubbed ‘robogenetics’. Using these tools to quantitate the entire Drosophila larval Central Nervous System, we find less neurons (10.3K) plus more glia than predicted and that females have 10% more neurons than males. EPFL article, eLife paper