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New Paper – Highly frequent undesired insertional mutagenesis during Drosophila genome editing
CRISPR/Cas9 based genome editing employing Homology Directed Repair (HDR) from template vector sequences is a widely used technique to enable precise insertions, deletions or modifications to genes. Here, we describe an undesired and highly frequent editing event when using conventional CRISPR/Cas9 plus HDR methods for Drosophila melanogaster germline genome editing. We find that the template (…)
New preprint – Spontaneous neurotransmission is regulated!
New manuscript – Spontaneous neurotransmitter release is regulated by Unc-5For decades, spontaneous neurotransmitter vesicle release (also known as miniature neurotransmission or ‘minis’), which occurs at every chemical synapse in the brain, was considered little more than synaptic noise — a background hum without meaningful function. Our lab has spent years showing that’s wrong. Minis are (…)
pBID2 vectors including a new QF/Gal4 hybrid binary system released
Binary gene regulatory expression systems are a linchpin technology critical for genetic manipulations of many model organisms including in Drosophila. In a new manuscript, Evelyne has generated a standardized & optimized series of vectors (pBID2) that support the parallel construction of Drosophila enhancer-driven ‘activator’ Gal4, LexA, or QF2 lines, along with matched vectors for generating (…)
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Welcome Mathilde
We are delighted to welcome Mathilde Solyga as a new postdoctoral scientist to our group. Mathilde will work on the mechanisms that link miniature neurotransmission to synapse aging.
Thank you Target ALS
Thank you to Target ALS for highlighting the work on #ALS in our laboratory together with Bernard Schneider and Sabine Liebscher. We are very grateful for your funding and unflagging support – www.targetals.org/2025/03/04/i…[image or embed]— McCabe Lab (@mccabelab.org) March 5, 2025 at 2:59 PM
Medha wins EPFL MT180
Many congratulations to lab member Medha Raman for winning the EPFL final of MT180 – My Thesis in 180 seconds[image or embed]— McCabe Lab (@mccabelab.org) March 30, 2025 at 5:36 PM