Protein ‘traffic jam’ linked to neurodegeneration
The Cruelest Cut: EPFL article about our new paper, led by Jamshid, which shows that Retromer deficiency, which is implicated in both Parkinson’s and Alzheimer’s Disease, increases human Tau truncation and toxicity. In the paper we also describe new tools to quantitate neurodegeneration with single synapse or axon resolution in intact Drosophila brains.
Welcome New Lab Members
Welcome to new lab members Medha, Amin and Rebecca. Delighted to have you join us and work on projects in synaptic plasticity, miniature neurotransmission and neurotransmitter logic.
Congratulations to Soumya on his new position as senior scientist at Epiterna. We are very happy you are staying in Lausanne and continuing to work on ageing.
Brain metrics reveal sex differences
EPFL article about our paper using genetic tools built for computer assisted science – which we have dubbed ‘robogenetics’. Using these tools to quantitate the entire Drosophila larval Central Nervous System, we find less neurons (10.3K) plus more glia than predicted and that females have 10% more neurons than males. EPFL article, eLife paper
Innosuisse article on ALS project
Innosuisse support enables us to develop novel potential gene therapies for the motor neuron disease Amyotrophic lateral sclerosis (ALS). Read more in this article by Innosuisse about the project.
Well done Wei
Congratulations to Wei on her new position at our neighboring institute of the University of Lausanne – UNIL. We are very happy you are staying in Lausanne and we look forward to collaborating.
New Review by Emma
Graduate student Emma Källstig has published a new review on the links between the NF-κB pathway and the motor neuron disease ALS. Read it here.
We are delighted to welcome Greta Limoni to our group as a postdoctoral scientist. Greta received her PhD from the University of Geneva where she worked on understanding interneuron development. Greta now turns her attention to investigating molecular and cellular mechanisms that may contribute to the motor system diseases SMA and ALS.
Interview with Jamshid
Nice interview with Jamshid about his efforts helping to form and act as the first president of the new EPFL Postdoc association.
A new publication with our clinical collaborators at Columbia University Medical Center in New York reveals sensory-motor circuit dysfunction in human Spinal Muscular Atrophy (SMA) patients as was predicted by our Drosophila model of SMA. Unfortunately 4-AP treatment, which we found was efficacious in models to correct sensory-motor deficits, at lower levels does not seem (…)
We are delighted to welcome Marine Van Campenhoudt to our group as a Ph.D. student in the EDNE neuroscience program. Marine previously carried out her masters research in the lab and is working on molecular and cellular mechanisms that may contribute to motor neuron disease (ALS).