Publications

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2019

Live imaging screen reveals that TYRO3 and GAK ensure accurate spindle positioning in human cells

B. Wolf; C. Busso; P. Goenczy 

Nature Communications. 2019-06-28. Vol. 10, p. 2859. DOI : 10.1038/s41467-019-10446-z.

Aurora A depletion reveals centrosome-independent polarization mechanism in Caenorhabditis elegans

K. Klinkert; N. Levernier; P. Gross; C. Gentili; L. von Tobel et al. 

Elife. 2019-02-26. Vol. 8, p. e44552. DOI : 10.7554/eLife.44552.

Multicolor Single-Particle Reconstruction of Protein Complexes

C. Sieben; N. Banterle; K. M. Douglass; P. Gönczy; S. Manley 

2019-02-15. 63rd Annual Meeting of the Biophysical-Society, Baltimore, MD, Mar 02-06, 2019. p. 25A-25A.

Tissue- and sex-specific small RNAomes reveal sex differences in response to the environment

A. Bezler; F. Braukmann; S. M. West; A. Duplan; R. Conconi et al. 

Plos Genetics. 2019-02-01. Vol. 15, num. 2, p. e1007905. DOI : 10.1371/journal.pgen.1007905.

Centriole assembly at a glance

P. Gönczy; G. Hatzopoulos 

Journal Of Cell Science. 2019-02-01. Vol. 132, num. 4, p. jcs228833. DOI : 10.1242/jcs.228833.

2018

Multicolor single-particle reconstruction of protein complexes

C. Sieben; N. Banterle; P. Gönczy; K. M. Douglass; S. Manley 

Nature Methods. 2018-10-01. Vol. 15, num. 10, p. 777-+. DOI : 10.1038/s41592-018-0140-x.

High-speed photothermal off-resonance atomic force microscopy reveals assembly routes of centriolar scaffold protein SAS-6

A. P. Nievergelt; N. Banterle; S. H. Andany; P. Gönczy; G. E. Fantner 

Nature Nanotechnology. 2018-08-13. Vol. 13, num. 8, p. 696-701. DOI : 10.1038/s41565-018-0149-4.

ZYG-1 promotes limited centriole amplification in the C. elegans seam lineage

B. Wolf; F. Balestra; A. Spahr; P. Gönczy 

DEVELOPMENTAL BIOLOGY. 2018. Vol. 434, num. 2, p. 221-230. DOI : 10.1016/j.ydbio.2018.01.001.

Uncovering the balance of forces driving microtubule aster migration in C. elegans zygotes

A. De Simone; A. Spahr; C. Busso; P. Gönczy 

Nature Communications. 2018. Vol. 9. DOI : 10.1038/s41467-018-03118-x.

The Rise of the Cartwheel: Seeding the Centriole Organelle

P. Guichard; V. Hamel; P. Gönczy 

BIOESSAYS. 2018. Vol. 40, num. 4. DOI : 10.1002/bies.201700241.

Reconstruction From Multiple Particles for 3D Isotropic Resolution in Fluorescence Microscopy

D. Fortun; P. Guichard; V. Hamel; C. Sorzano; N. Banterle et al. 

IEEE TRANSACTIONS ON MEDICAL IMAGING. 2018. Vol. 37, num. 5, p. 1235-1246. DOI : 10.1109/TMI.2018.2795464.

PI(4,5)P-2 forms dynamic cortical structures and directs actin distribution as well as polarity in Caenorhabditis elegans embryos

M. Scholze; K. Barbieux; A. De Simone; M. Boumasmoud; C. Suess et al. 

DEVELOPMENT. 2018. Vol. 145, num. 11. DOI : 10.1242/dev.164988.

Membrane protein insertion through a mitochondrial beta-barrel gate

A. Hohr; C. Lindau; C. Wirth; J. Qiu; D. Stroud et al. 

SCIENCE. 2018. Vol. 359, num. 6373, p. 289-+. DOI : 10.1126/science.aah6834.

Interaction between the Caenorhabditis elegans centriolar protein SAS-5 and microtubules facilitates organelle assembly

S. Bianchi; K. Rogala; N. Dynes; M. Hilbert; S. Leidel et al. 

MOLECULAR BIOLOGY OF THE CELL. 2018. Vol. 29, num. 6, p. 722-735. DOI : 10.1091/mbc.E17-06-0412.

Integrated Microfluidic Device for Drug Studies of Early C. Elegans Embryogenesis

L. Dong; R. Jankele; M. Cornaglia; T. Lehnert; P. Gönczy et al. 

ADVANCED SCIENCE. 2018. Vol. 5, num. 5. DOI : 10.1002/advs.201700751.

2017

Computer simulations reveal mechanisms that organize nuclear dynein forces to separate centrosomes

A. De Simone; P. Gönczy 

Molecular Biology Of The Cell. 2017. Vol. 28, num. 23, p. 3165-3170. DOI : 10.1091/mbc.E16-12-0823.

Centriole Biogenesis: From Identifying the Characters to Understanding the Plot

N. Banterle; P. Gönczy 

Annual Review Of Cell And Developmental Biology, Vol 33; Palo Alto: Annual Reviews, 2017. p. 23-49.

Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis

V. Hamel; E. Steib; R. Hamelin; F. Armand; S. Borgers et al. 

Current Biology. 2017. Vol. 27, num. 16, p. 2486-+. DOI : 10.1016/j.cub.2017.07.011.

TRACMIT: An effective pipeline for tracking and analyzing cells on micropatterns through mitosis

O. Burri; B. Wolf; A. Seitz; P. Gönczy 

Plos One. 2017. Vol. 12, num. 7, p. e0179752. DOI : 10.1371/journal.pone.0179752.

An Integrated Microfluidic Device For C-Elegans Early Embryogenesis Studies And Drug Assays

L. Dong; R. Jankele; J. Zhang; M. Cornaglia; T. Lehnert et al. 

2017. 30th IEEE International Conference on Micro Electro Mechanical Systems (MEMS), Las Vegas, NV, JAN 22-26, 2017. p. 1244-1247.

Cell-free reconstitution reveals centriole cartwheel assembly mechanisms

P. Guichard; V. Hamel; M. Le Guennec; N. Banterle; I. Iacovache et al. 

Nature Communications. 2017. Vol. 8. DOI : 10.1038/ncomms14813.

Zika virus causes supernumerary foci with centriolar proteins and impaired spindle positioning

B. Wolf; F. Diop; P. Ferraris; S. Wichit; C. Busso et al. 

Open biology. 2017. Vol. 7, num. 1. DOI : 10.1098/rsob.160231.

2016

Basal body structure in Trichonympha

P. Guichard; P. Gönczy 

Cilia. 2016-03-05. 

KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification

M. Fournier; M. Orpinell; C. Grauffel; E. Scheer; J-M. Garnier et al. 

Nature Communications. 2016. Vol. 7, p. 13227. DOI : 10.1038/ncomms13227.

The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding

S. Kraatz; P. Guichard; J. Obbineni; N. Olieric; G. Hatzopoulos et al. 

Structure. 2016. Vol. 24, num. 8, p. 1358-1371. DOI : 10.1016/j.str.2016.06.011.

Chemical Genetic Screen Identifies Natural Products that Modulate Centriole Number

M. Graciotti; Z. Fang; K. Johnsson; P. Gönczy 

ChemBioChem. 2016. Vol. 17, num. 21, p. 2063-2074. DOI : 10.1002/cbic.201600327.

Aurora A kinase regulates proper spindle positioning in C-elegans and in human cells

S. Kotak; K. Afshar; C. Busso; P. Gönczy 

Journal Of Cell Science. 2016. Vol. 129, num. 15, p. 3015-3025. DOI : 10.1242/jcs.184416.

Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening

F. Kilchmann; M. J. Marcaida; S. Kotak; T. Schick; S. D. Boss et al. 

Journal Of Medicinal Chemistry. 2016. Vol. 59, num. 15, p. 7188-7211. DOI : 10.1021/acs.jmedchem.6b00709.

Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth

A. Sharma; A. Aher; N. J. Dynes; D. Frey; E. A. Katrukha et al. 

Developmental Cell. 2016. Vol. 37, num. 4, p. 362-376. DOI : 10.1016/j.devcel.2016.04.024.

Computational support for a scaffolding mechanism of centriole assembly

H. C. R. Klein; P. Guichard; V. Hamel; P. Gönczy; U. S. Schwarz 

Scientific Reports. 2016. Vol. 6, p. 27075. DOI : 10.1038/srep27075.

Distinct mechanisms eliminate mother and daughter centrioles in meiosis of starfish oocytes

J. Borrego-Pinto; K. Somogyi; M. A. Karreman; J. Koenig; T. Mueller-Reichert et al. 

Journal Of Cell Biology. 2016. Vol. 212, num. 7, p. 815-827. DOI : 10.1083/jcb.201510083.

SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture

M. Hilbert; A. Noga; D. Frey; V. Hamel; P. Guichard et al. 

Nature Cell Biology. 2016. Vol. 18, num. 4, p. 393-+. DOI : 10.1038/ncb3329.

Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation

A. De Simone; F. Nédélec; P. Gönczy 

Cell Reports. 2016. Vol. 14, num. 9, p. 2250-2262. DOI : 10.1016/j.celrep.2016.01.077.

2015

Cellular hallmarks reveal restricted aerobic metabolism at thermal limits

A. Neves; C. Busso; P. Gönczy 

eLife. 2015-05-02. 

Isolation, cryotomography, and three-dimensional reconstruction of centrioles

P. Guichard; V. Hamel; A. Neves; P. Gönczy 

Centrosome & Centriole; Elsevier, 2015. p. 191-209.

The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation

K. B. Rogala; N. J. Dynes; G. N. Hatzopoulos; J. Yan; S. K. Pong et al. 

eLife. 2015. Vol. 4, p. e07410. DOI : 10.7554/eLife.07410.

Cortical Dynein Powered by Polarized Actomyosin Contractions and Pronuclear Dynein Separate Centrosomes

A. De Simone; P. Gönczy 

2015.  p. 180A-180A.

Centrosomes and cancer: revisiting a long-standing relationship

P. Gönczy 

Nature Reviews Cancer. 2015. Vol. 15, num. 11, p. 639-652. DOI : 10.1038/nrc3995.

Paternally contributed centrioles exhibit exceptional persistence in C-elegans embryos

F. R. Balestra; L. Von Tobel; P. Gönczy 

Cell Research. 2015. Vol. 25, num. 5, p. 642-644. DOI : 10.1038/cr.2015.49.

Polarity-Dependent Asymmetric Distribution and MEX-5/6-Mediated Translational Activation of the Era-1 mRNA in C. elegans Embryos

Z. Spiró; P. Gönczy 

PloS One. 2015. Vol. 10, num. 3, p. e0120984. DOI : 10.1371/journal.pone.0120984.

Quantitative Analysis and Modeling Probe Polarity Establishment in C. elegans Embryos

S. Blanchoud; C. Busso; F. Naef; P. Gönczy 

Biophysical journal. 2015. Vol. 108, num. 4, p. 799-809. DOI : 10.1016/j.bpj.2014.12.022.

2014

Polarity establishment, asymmetric division and segregation of fate determinants in early C. elegans embryos

L. Rose; P. Gönczy 

WormBook. 2014-12-31. 

NuMA links the mitotic spindle with plasma membrane lipids

S. Kotak; C. Busso; P. Gönczy 

2014. ASCB/IFCB Meeting.

SAS-1 Is a C2 Domain Protein Critical for Centriole Integrity in C. elegans

L. von Tobel; T. Mikeladze-Dvali; M. Delattre; F. R. Balestra; S. Blanchoud et al. 

Plos Genetics. 2014. Vol. 10, num. 11, p. e1004777. DOI : 10.1371/journal.pgen.1004777.

Correlative multicolor 3D SIM and STORM microscopy

V. Hamel; P. Guichard; M. Fournier; R. Guiet; I. Flückiger et al. 

Biomedical Optics Express. 2014. Vol. 5, num. 10, p. 3326-3336. DOI : 10.1364/BOE.5.003326.

NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane

S. Kotak; C. Busso; P. Gönczy 

Embo Journal. 2014. Vol. 33, num. 16, p. 1815-1830. DOI : 10.15252/embj.201488147.

NuMA phosphorylation dictates dynein-dependent spindle positioning

S. Kotak; P. Goenczy 

Cell Cycle. 2014. Vol. 13, num. 2, p. 177-178. DOI : 10.4161/cc.27040.

A missense mutation in the PISA domain of HsSAS-6 causes autosomal recessive primary microcephaly in a large consanguineous Pakistani family

M. A. Khan; V. M. Rupp; M. Orpinell; M. S. Hussain; J. Altmüller et al. 

Human molecular genetics. 2014. Vol. 23, num. 22, p. 5940-5949. DOI : 10.1093/hmg/ddu318.

Multiciliogenesis: multicilin directs transcriptional activation of centriole formation

F. R. Balestra; P. Gönczy 

Current biology : CB. 2014. Vol. 24, num. 16, p. R746-9. DOI : 10.1016/j.cub.2014.07.006.

Centrosomes back in the limelight

M. Bornens; P. Gönczy 

Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2014. Vol. 369, num. 1650. DOI : 10.1098/rstb.2013.0452.

Clathrin regulates centrosome positioning by promoting acto-myosin cortical tension in C. elegans embryos

Z. Spiró; K. Thyagarajan; A. De Simone; S. Träger; K. Afshar et al. 

Development (Cambridge, England). 2014. Vol. 141, num. 13, p. 2712-23. DOI : 10.1242/dev.107508.

Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells

D. Keller; M. Orpinell; N. Olivier; M. Wachsmuth; R. Mahen et al. 

The Journal of cell biology. 2014. Vol. 204, num. 5, p. 697-712. DOI : 10.1083/jcb.201307049.

Stereotyped distribution of midbody remnants in early C. elegans embryos requires cell death genes and is dispensable for development

G. Ou; C. Gentili; P. Gönczy 

Cell Research. 2014. Vol. 24, num. 2, p. 251-253. DOI : 10.1038/cr.2013.140.

2013

Mechanisms of spindle positioning: cortical force generators in the limelight

S. Kotak; P. Gönczy 

Current Opinion In Cell Biology. 2013. Vol. 25, num. 6, p. 741-748. DOI : 10.1016/j.ceb.2013.07.008.

Commercial Cdk1 antibodies recognize the centrosomal protein Cep152

G. Lukinavičius; D. Lavogina; P. Gönczy; K. Johnsson 

Biotechniques. 2013. Vol. 55, num. 3, p. 111-114. DOI : 10.2144/000114074.

Native Architecture of the Centriole Proximal Region Reveals Features Underlying Its 9-Fold Radial Symmetry

P. Guichard; V. Hachet; N. Majubu; A. Neves; D. Demurtas et al. 

Current Biology. 2013. Vol. 23, num. 17, p. 1620-1628. DOI : 10.1016/j.cub.2013.06.061.

NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function

S. Kotak; C. Busso; P. Gönczy 

The EMBO journal. 2013. DOI : 10.1038/emboj.2013.172.

Resolution Doubling in 3D-STORM Imaging through Improved Buffers

N. Olivier; D. Keller; P. Gönczy; S. Manley 

PloS One. 2013. Vol. 8, num. 7, p. e69004. DOI : 10.1371/journal.pone.0069004.

Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry

M. Hilbert; M. C. Erat; V. Hachet; P. Guichard; I. D. Blank et al. 

Proceedings of the National Academy of Sciences. 2013. DOI : 10.1073/pnas.1302721110.

MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression

M. Zhu; F. Settele; S. Kotak; L. Sanchez-Pulido; L. Ehret et al. 

The Journal of cell biology. 2013. Vol. 200, num. 6, p. 773-87. DOI : 10.1083/jcb.201207050.

Simple buffers for 3D STORM microscopy

N. Olivier; D. Keller; V. S. Rajan; P. Gönczy; S. Manley 

Biomedical optics express. 2013. Vol. 4, num. 6, p. 885-99. DOI : 10.1364/BOE.4.000885.

Discovering Regulators of Centriole Biogenesis through siRNA-Based Functional Genomics in Human Cells

F. R. Balestra; P. Strnad; I. Flückiger; P. Gönczy 

Developmental cell. 2013. Vol. 25, num. 6, p. 555-571. DOI : 10.1016/j.devcel.2013.05.016.

Selective Chemical Crosslinking Reveals a Cep57-Cep63-Cep152 Centrosomal Complex

G. Lukinavičius; D. Lavogina; M. Orpinell; K. Umezawa; L. Reymond et al. 

Current Biology. 2013. Vol. 23, num. 3, p. 265-270. DOI : 10.1016/j.cub.2012.12.030.

2012

The nucleoporin Nup205/NPP-3 is lost near centrosomes at mitotic onset and can modulate the timing of this process in Caenorhabditis elegans embryos

V. Hachet; C. Busso; M. Toya; A. Sugimoto; P. Askjaer et al. 

Molecular biology of the cell. 2012. Vol. 23, num. 16, p. 3111-21. DOI : 10.1091/mbc.E12-03-0204.

Cortical dynein is critical for proper spindle positioning in human cells

S. Kotak; C. Busso; P. Gönczy 

The Journal of Cell Biology. 2012. DOI : 10.1083/jcb.201203166.

Cartwheel Architecture of Trichonympha Basal Body

P. Guichard; A. Desfosses; A. Maheshwari; V. Hachet; C. Dietrich et al. 

Science. 2012. Vol. 337, num. 6094, p. 553-553. DOI : 10.1126/science.1222789.

Towards a molecular architecture of centriole assembly

P. Gönczy 

Nature Reviews Molecular Cell Biology. 2012. Vol. 13, num. 7, p. 425-435. DOI : 10.1038/nrm3373.

Analysis of centriole elimination during C. elegans oogenesis

T. Mikeladze-Dvali; L. von Tobel; P. Strnad; G. Knott; H. Leonhardt et al. 

Development. 2012. Vol. 139, num. 9, p. 1670-1679. DOI : 10.1242/dev.075440.

2011

Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STIL

D. Kitagawa; G. Kohlmaier; D. Keller; P. Strnad; F. R. Balestra et al. 

Journal Of Cell Science. 2011. Vol. 124, num. 22, p. 3884-3893. DOI : 10.1242/jcs.089888.

Structural Basis of the 9-Fold Symmetry of Centrioles

D. Kitagawa; I. Vakonakis; N. Olieric; M. Hilbert; D. Keller et al. 

Cell. 2011. Vol. 144, num. 3, p. 364-375. DOI : 10.1016/j.cell.2011.01.008.

PP2A Phosphatase Acts upon SAS-5 to Ensure Centriole Formation in C. elegans Embryos

D. Kitagawa; I. Flueckiger; J. Polanowska; D. Keller; J. Reboul et al. 

Developmental Cell. 2011. Vol. 20, num. 4, p. 550-562. DOI : 10.1016/j.devcel.2011.02.005.

Polarity mediates asymmetric trafficking of the G beta heterotrimeric G-protein subunit GPB-1 in C. elegans embryos

K. Thyagarajan; K. Afshar; P. Gönczy 

Development. 2011. Vol. 138, num. 13, p. 2773-2782. DOI : 10.1242/dev.063354.

The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication

A. Puklowski; Y. Homsi; D. Keller; M. May; S. Chauhan et al. 

Nature Cell Biology. 2011. Vol. 13, num. 8, p. 1004-U291. DOI : 10.1038/ncb2282.

2010

Mutual Antagonism Between the Anaphase Promoting Complex and the Spindle Assembly Checkpoint Contributes to Mitotic Timing in Caenorhabditis elegans

A. Bezler; P. Gönczy 

Genetics. 2010. Vol. 186, num. 4, p. 1271-U339. DOI : 10.1534/genetics.110.123133.

ASSET: A robust algorithm for the automated segmentation and standardization of early Caenorhabditis elegans embryos

S. Blanchoud; Y. Budirahardja; F. Naef; P. Gönczy 

Developmental dynamics. 2010. Vol. 239, num. 12, p. 3285-96. DOI : 10.1002/dvdy.22486.

Temperature gradient stimulation for cell division in C. Elegans Embryos on chip

S. Baranek; A. Bezler; C. Adamczyk; P. Gönczy; P. Renaud 

2010. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2010), groningen, The Netherlands, 3-7 october 2010. p. 190-192.

Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos

K. Afshar; M. E. Werner; Y. C. Tse; M. Glotzer; P. Gönczy 

Development. 2010. Vol. 137, num. 2, p. 237-47. DOI : 10.1242/dev.042754.

2009

Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos

D. Kitagawa; C. Busso; I. Fluckiger; P. Gönczy 

Developmental cell. 2009. Vol. 17, num. 6, p. 900-7. DOI : 10.1016/j.devcel.2009.11.002.

NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha

M. van der Voet; C. W. H. Berends; A. Perreault; T. Nguyen-Ngoc; P. Gönczy et al. 

Nature cell biology. 2009. Vol. 11, num. 3, p. 269-77. DOI : 10.1038/ncb1834.

Overly long centrioles and defective cell division upon excess of the SAS-4-related protein CPAP

G. Kohlmaier; J. Loncarek; X. Meng; B. F. McEwen; M. M. Mogensen et al. 

Current biology. 2009. Vol. 19, num. 12, p. 1012-8. DOI : 10.1016/j.cub.2009.05.018.

Coupling the cell cycle to development

Y. Budirahardja; P. Gönczy 

Development. 2009. Vol. 136, num. 17, p. 2861-72. DOI : 10.1242/dev.021931.

2008

Mechanisms of procentriole formation

P. Strnad; P. Gönczy 

Trends in cell biology. 2008. Vol. 18, num. 8, p. 389-96. DOI : 10.1016/j.tcb.2008.06.004.

PLK-1 asymmetry contributes to asynchronous cell division of C. elegans embryos

Y. Budirahardja; P. Gönczy 

Development. 2008. Vol. 135, num. 7, p. 1303-1313. DOI : 10.1242/dev.019075.

Mechanisms of asymmetric cell division: flies and worms pave the way

P. Gönczy 

Nature reviews. Molecular cell biology. 2008. Vol. 9, num. 5, p. 355-366. DOI : 10.1038/nrm2388.

Structural determinants underlying the temperature-sensitive nature of a Galpha mutant in asymmetric cell division of Caenorhabditis elegans

C. A. Johnston; K. Afshar; J. T. Snyder; G. G. Tall; P. Gönczy et al. 

The Journal of biological chemistry. 2008. Vol. 283, num. 31, p. 21550-21558. DOI : 10.1074/jbc.M803023200.

2007

Centrosomes promote timely mitotic entry in C. elegans embryos

V. Hachet; C. Canard; P. Gönczy 

Developmental cell. 2007. Vol. 12, num. 4, p. 531-41. DOI : 10.1016/j.devcel.2007.02.015.

Coupling of cortical dynein and Galpha proteins mediates spindle positioning in Caenorhabditis elegans

T. Nguyen-Ngoc; K. Afshar; P. Gönczy 

Nat Cell Biol. 2007. Vol. 9, num. 11, p. 1294-1302. DOI : 10.1038/ncb1649.

Regulated HsSAS-6 levels ensure formation of a single procentriole per centriole during the centrosome duplication cycle

P. Strnad; S. Leidel; T. Vinogradova; U. Euteneuer; A. Khodjakov et al. 

Dev Cell. 2007. Vol. 13, num. 2, p. 203-213. DOI : 10.1016/j.devcel.2007.07.004.

ZYG-9, TAC-1 and ZYG-8 together ensure correct microtubule function throughout the cell cycle of C. elegans embryos

J. M. Bellanger; J. C. Carter; J. B. Phillips; C. Canard; B. Bowerman et al. 

Journal of Cell Science. 2007. Vol. 120, num. Pt 16, p. 2963-2973. DOI : 10.1242/jcs.004812.

2006

Sequential Protein Recruitment in C. elegans Centriole Formation

M. Delattre; C. Canard; P. Gönczy 

Current Biology. 2006. Vol. 16, num. 18, p. 1844-1849. DOI : 10.1016/j.cub.2006.07.059.

2005

Centrosome duplication and nematodes: recent insights from an old relationship

S. Leidel; P. Gönczy 

Developmental cell. 2005. Vol. 9, num. 3, p. 317-25. DOI : 10.1016/j.devcel.2005.08.004.

Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans

B. Sonnichsen; L. B. Koski; A. Walsh; P. Marschall; B. Neumann et al. 

Nature. 2005. Vol. 434, num. 7032, p. 462-9.

SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells

S. Leidel; M. Delattre; L. Cerutti; K. Baumer; P. Gönczy 

Nat Cell Biol. 2005. Vol. 7, num. 2, p. 115-25. DOI : 10.1038/ncb1220.

Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division

K. Afshar; F. S. Willard; K. Colombo; D. P. Siderovski; P. Gönczy 

Development. 2005. Vol. 132, num. 20, p. 4449-59. DOI : 10.1242/dev.02039.

Asymmetric cell division and axis formation in the embryo

P. Gönczy; L. Rose 

WormBook; 2005.

2004

The arithmetic of centrosome biogenesis

M. Delattre; P. Gönczy 

Journal of cell science. 2004. Vol. 117, num. Pt 9, p. 1619-30. DOI : 10.1242/jcs.01128.

Zyg-11 and cul-2 regulate progression through meiosis II and polarity establishment in C. elegans

R. Sonneville; P. Gönczy 

Development. 2004. Vol. 131, num. 15, p. 3527-43. DOI : 10.1242/dev.01244.

Centrosomes: hooked on the nucleus

P. Gönczy 

Curr Biol. 2004. Vol. 14, num. 7, p. R268-70.

Myosin assembly: the power of multiubiquitylation

P. Gönczy 

Cell. 2004. Vol. 118, num. 3, p. 272-4.

Centriolar SAS-5 is required for centrosome duplication in C. elegans

M. Delattre; S. Leidel; K. Wani; K. Baumer; J. Bamat et al. 

Nat Cell Biol. 2004. Vol. 6, num. 7, p. 656-64. DOI : 10.1038/ncb1146.

lis-1 is required for dynein-dependent cell division processes in C. elegans embryos

M. M. Cockell; K. Baumer; P. Gönczy 

Journal of Cell Science. 2004. Vol. 117, num. 19, p. 4571-82. DOI : 10.1242/jcs.01344.

RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos

K. Afshar; F. S. Willard; K. Colombo; C. A. Johnston; C. R. McCudden et al. 

Cell. 2004. Vol. 119, num. 2, p. 219-30. DOI : 10.1016/j.cell.2004.09.026.

2003

SAS-4 is essential for centrosome duplication in C elegans and is recruited to daughter centrioles once per cell cycle

S. Leidel; P. Gönczy 

Dev Cell. 2003. Vol. 4, num. 3, p. 431-9. DOI : 10.1016/S1534-5807(03)00062-5.

[Mechanisms of cell division: lessons from a nematode]

P. Gönczy 

Med Sci (Paris). 2003. Vol. 19, num. 6-7, p. 735-42.

Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos

K. Colombo; S. W. Grill; R. J. Kimple; F. S. Willard; D. P. Siderovski et al. 

Science. 2003. Vol. 300, num. 5627, p. 1957-61. DOI : 10.1126/science.1084146.

Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos

M. Brauchle; K. Baumer; P. Gönczy 

Curr Biol. 2003. Vol. 13, num. 10, p. 819-27. DOI : 10.1016/S0960-9822(03)00295-1.

TAC-1 and ZYG-9 form a complex that promotes microtubule assembly in C. elegans embryos

J. M. Bellanger; P. Gönczy 

Curr Biol. 2003. Vol. 13, num. 17, p. 1488-98. DOI : 10.1016/S0960-9822(03)00582-7.

2002

Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway

T. Kurz; L. Pintard; J. H. Willis; D. R. Hamill; P. Gönczy et al. 

Science. 2002. Vol. 295, num. 5558, p. 1294-8. DOI : 10.1126/science.1067765.

The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is gamma-tubulin dependent

E. Hannak; K. Oegema; M. Kirkham; P. Gönczy; B. Habermann et al. 

Journal of Cell Biology. 2002. Vol. 157, num. 4, p. 591-602. DOI : 10.1083/jcb.200202047.

Nuclear envelope: torn apart at mitosis

P. Gönczy 

Curr Biol. 2002. Vol. 12, num. 7, p. R242-4.

Mechanisms of spindle positioning: focus on flies and worms

P. Gönczy 

Trends in Cell Biology. 2002. Vol. 12, num. 7, p. 332-9. DOI : 10.1016/S0962-8924(02)02306-1.

2001

Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo

S. W. Grill; P. Gönczy; E. H. Stelzer; A. A. Hyman 

Nature. 2001. Vol. 409, num. 6820, p. 630-3. DOI : 10.1038/35054572.

Spindle positioning during the asymmetric first cell division of Caenorhabditis elegans embryos

P. Gönczy; S. Grill; E. H. Stelzer; M. Kirkham; A. A. Hyman 

Novartis Found Symp. 2001. Vol. 237, p. 164-75; discussion 176-81.

zyg-8, a gene required for spindle positioning in C. elegans, encodes a doublecortin-related kinase that promotes microtubule assembly

P. Gönczy; J. M. Bellanger; M. Kirkham; A. Pozniakowski; K. Baumer et al. 

Dev Cell. 2001. Vol. 1, num. 3, p. 363-75.

fumble encodes a pantothenate kinase homolog required for proper mitosis and meiosis in Drosophila melanogaster

K. Afshar; P. Gönczy; S. DiNardo; S. A. Wasserman 

Genetics. 2001. Vol. 157, num. 3, p. 1267-76.

2000

OOC-3, a novel putative transmembrane protein required for establishment of cortical domains and spindle orientation in the P(1) blastomere of C. elegans embryos

S. Pichler; P. Gönczy; H. Schnabel; A. Pozniakowski; A. Ashford et al. 

Development. 2000. Vol. 127, num. 10, p. 2063-73.

CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis

V. Jantsch-Plunger; P. Gönczy; A. Romano; H. Schnabel; D. Hamill et al. 

Journal of Cell Biology. 2000. Vol. 149, num. 7, p. 1391-404. DOI : 10.1083/jcb.149.7.1391.

Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III

P. Gönczy; C. Echeverri; K. Oegema; A. Coulson; S. J. Jones et al. 

Nature. 2000. Vol. 408, num. 6810, p. 331-6.

1999

Dissection of cell division processes in the one cell stage Caenorhabditis elegans embryo by mutational analysis

P. Gönczy; H. Schnabel; T. Kaletta; A. D. Amores; T. Hyman et al. 

Journal of Cell Biology. 1999. Vol. 144, num. 5, p. 927-46.

Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo

P. Gönczy; S. Pichler; M. Kirkham; A. A. Hyman 

Journal of Cell Biology. 1999. Vol. 147, num. 1, p. 135-50.

1998

Mechanisms of nuclear positioning

S. Reinsch; P. Gönczy 

Journal of Cell Science. 1998. Vol. 111, num. 16, p. 2283-95.

1997

punt and schnurri regulate a somatically derived signal that restricts proliferation of committed progenitors in the germline

E. Matunis; J. Tran; P. Gönczy; K. Caldwell; S. DiNardo 

Development. 1997. Vol. 124, num. 21, p. 4383-91.

bag-of-marbles and benign gonial cell neoplasm act in the germline to restrict proliferation during Drosophila spermatogenesis

P. Gönczy; E. Matunis; S. DiNardo 

Development. 1997. Vol. 124, num. 21, p. 4361-71.

1996

Cortical domains and the mechanisms of asymmetric cell division

P. Gönczy; A. A. Hyman 

Trends in Cell Biology. 1996. Vol. 6, num. 10, p. 382-7. DOI : 10.1016/0962-8924(96)10035-0.

The germ line regulates somatic cyst cell proliferation and fate during Drosophila spermatogenesis

P. Gönczy; S. DiNardo 

Development. 1996. Vol. 122, num. 8, p. 2437-47.

1994

roughex is a dose-dependent regulator of the second meiotic division during Drosophila spermatogenesis

P. Gönczy; B. J. Thomas; S. DiNardo 

Cell. 1994. Vol. 77, num. 7, p. 1015-25.

1993

Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis

D. H. Castrillon; P. Gönczy; S. Alexander; R. Rawson; C. G. Eberhart et al. 

Genetics. 1993. Vol. 135, num. 2, p. 489-505.

1992

Probing spermatogenesis in Drosophila with P-element enhancer detectors

P. Gönczy; S. Viswanathan; S. DiNardo 

Development. 1992. Vol. 114, num. 1, p. 89-98.

1989

A single amino acid can determine the DNA binding specificity of homeodomain proteins

J. Treisman; P. Gönczy; M. Vashishtha; E. Harris; C. Desplan 

Cell. 1989. Vol. 59, num. 3, p. 553-62.

Inherited immunodeficiency with a defect in a major histocompatibility complex class II promoter-binding protein differs in the chromatin structure of the HLA-DRA gene

P. Gönczy; W. Reith; E. Barras; B. Lisowska-Grospierre; C. Griscelli et al. 

Mol Cell Biol. 1989. Vol. 9, num. 1, p. 296-302.