Licensing Opportunities

Digital/Data

Learning based subsampling

Learning-based sampling outperforms the state-of-the-art sampling in terms of visual quality, PSNR (peak signal-to-noise) and SSIM (structural similarity), on a knee that is scanned with 6 times acceleration

LIFT – method for training a feature detector of an image processor

Method, System, and Device for Learned Invariant Feature Transform for Computer Images

Method and device for proving his identity

Robust distance-bounding method and devices allowing a user to prove his identity and proximity to a verifier

Parameter-free image resolution estimation

A new powerful tool to quantify the effective resolution in super-resolution microscopy for expedited microscopy setup alignment, characterization and optimization as well as for automated microscopes

Polisis

Automated Analysis and Presentation of Privacy Policies Using Machine Learing

JPEG Compatible Media Content Processing

Protection procedure of secure JPEG transmorphing

FindeX: Ranking of Growing Networks

Ranking algorithm to rank nodes in a network accounting for the network growth and possible changes in its links

Virtual Reality Add-On Device for Stereotactic Neurosurgery

Add-on device that can fit a stereotactic apparatus and that allows to use VR with patients during perioperative or awake phases of a neurosurgical intervention

Postprocessing approach for efficient and accurate high-dimensional parameter estimation in magnetic resonance fingerprinting

Postprocessing approach to overcome parameter estimations limitations in MRF of high order multi-parameter estimation including e.g. chemical exchange rates, relaxation times and multi-pool systems: allowing to reduce simulation and fitting time, computational requirements (memory size) and the possibility for online reconstruction on MRI scanners

Method for in-line quality control of engineered inorganic nanoparticle production processes

Inductively-coupled plasma mass spectrometry (ICP-MS) based method that allows for the comprehensive in-line characterization of EINPs with a single technique and at single-particle level of detection. Particle size and composition distributions can be obtained in a single measurement and with ensemble representative statistics

Toolbox for instrumented dual motor-cognitive tasks assessment using multimodal data recorded with iPhone

Algorithms to detect and characterize motor activity (gait, body sway and balance, turning) and cognitive tasks. The motor-cognition interaction is quantified using clinically validated metrics (dual-task cost)

Device and system as human interactive surface

A force-feedback surface that creates a distinctive profile and stiffness to interact with the user in contact

Generate, verify and deny an undeniable signature

Undeniable signature with small signature length, i.e. less than 80 bits, providing full scalability of the signature length against security

Manufacturing/Materials

Ligands for Metal-Organic Frameworks

A new strategy for designing Metal-Organic Frameworks ligands for custom-made pore size, shape, and surface functionality of the resulting MOF

Variable Stiffness Fiber with Self-Healing Capability

A variable stiffness fiber made of silicone and low melting point alloys quickly becomes >700 times softer and >400 times more deformable when heated above 62 °C

Partial Discharge Localization Using Time Reversal

Time reversal, a novel technique to 3D-locate partial discharge sources in power equipment and electric vehicles

Encapsulated alloy catalysts and their methods of preparation

Novel composite catalysts for CO2 electroreduction in solid oxide electrolysis cell (SOEC) consisting of non-precious alloys encapsulated by oxide showing high efficiency and stability

New Composites for extraction of metal or contaminating chemical species

Metallic Organic Frameworks (MOFs) for extraction of metals or precious metals

Method for synthesis of metal organic framework composites (MOFs)

Metallic Organic Frameworks (MOFs) with enhanced stability in aqueous environment for heterogeneous catalysis, selective gas separation, storage, drug delivery, water decontamination

Hydrogen Storage Material

New carbon material combining graphene oxide and carbon nanotubes (GONT), absorbing more than 5 mass% of hydrogen and desorbs at up to 350 K, combined with complete reversibility of the hydrogen sorption

A colloidal atomic layer deposition method for producing Quantum dots

A new method to grow a metal oxide shell by atomic layer deposition with a tunable thickness

MIMO-friendly Window

Glazing unit comprising a pair of windowpanes adapted to allow low and balanced transmission loss for EM radiation

Fabrication method to remove scalloping and tapering effects in through-silicon vias

A new scallop free and non-tapered approach to overcome this challenge by adding a new step to the standard TSV procedure exploiting the crystalline orientation of silicon wafers

Manufacturing of nanoscale orifices in glass like materials

A new process for manufacturing in a controllable manner nano-scale orifices in glass like materials with a tubular shape

Method for the synthesis of new triazenes

New process using nitric oxide (N2O) for for the synthesis of trisubstituted triazene

Two-component embedded system for strong angular-dependent transmittance and light redirection

Window transmitting or reflecting sunlight function of the incident angle

Methods for electrocatalysts for hydrogen evolution and oxidation reactions

One-step electrodeposition method for producing transition metal catalyst operating at high current density and with good stability

Adsorbent Material for Sequestrating Toxic Materials in Perovskite Solar Cells

Equipment of lead-based perovskite solar cells with a metal-organic framework polymer composite that highly selects and efficiently absorbs lead to address potential environmental concerns in the event of device failure

Laser Shock Peening in Additive Manufacturing

Novel hybrid additive manufacturing process

Label-free optical detection of targeted nucleic acids

Label-free sensor based on Single Walled Carbon Nanotubes for the tageted detection of olignucleotides (e.g. SNPs, miRNA)

Functional coatings

Functional coatings for efficient laser-based ultrasound generation and detection

MOFs for wet flue gas CO2 capture

Metal Organic Frameworks (MOF) that can uniquely adsorb and capture CO2 in the presence of water

Synthesis of Functionalized Diaryl Ethers from lignin

Highly efficient strategy to extract the aromatic monomers from lignin affording functionalized diaryl ethers using Chan-Lam coupling

Field Concentration Smoothing

Field grading in multilayer elastomer actuator

Synthesis of moving and beating moiré shapes

A method for producing an authenticable moiré shape that simultaneously moves and shows a beating effect

Bacterial detection

Superparamagnetic particles functionalised to capture target bacteria via electrochemical methods

Photostable Biosensor for continuous analyte monitoring

Optical sensors for continuous sensing in-vivo rely on a molecular recognition element that selectively interacts with the analyte of interest and an optical transducer that converts this interaction into a measurable optical signal

Systems (Electronics, Sensors & Analytics)

Flexure pivots with exact circular rotation and high radial stiffness

A novel family of 2D kinematic architectures providing exact rotations over large angular stroke that can easily be implemented with flexures

Majority Logic Synthesis

A logic synthesis tool which significantly improves the performance of digital integrated circuits

Parameter-free image resolution estimation

A new powerful tool to quantify the effective resolution in super-resolution microscopy for expedited microscopy setup alignment, characterization and optimization as well as for automated microscopes

Foldable and self-deployable aerial vehicle

Foldable quadrator technology for self-deployment of the arms

Polisis

Automated Analysis and Presentation of Privacy Policies Using Machine Learing

Intuitive teleoperation

Intuitive gesture-based control interface for real and simulated robots for teleoperations

Clic-Clac: constant-force surgical tool for objective assessment of ossicular chain mobility

Surgical tool based on a novel passive constant-force compliant mechanism used to apply predefined forces to the structure of interest (e.g., ear ossicles)

Single-layer MoS2 transistors

Semiconductor devices such as transistors or inverters comprising a part made of one or two 2-dimensional layers of MoS2, MoSe2, WS2, WSe2, MoTe2, or WTe2

Highly energy-area efficient SAR ADC architecture

An ultra-small and low-power 10-bit successive approximation register analog-to-digital converter (SAR ADC) architecture, having up to 1 MS/s sampling rate

Osmotic Power Generator

Power generator using nanopore technology to convert an osmotic salt gradient into electricity.

Noninvasive Estimation of Cardiovascular Parameters

System for the non-invasive measurement of cardivascular parameters

ATLAS: Accurate xy-Table with LArge Stiffness

Flexure-based xy-stage canceling parasitic motions

Koehler integrator device for multi-focal confocal microscope

New flat fielding element for multifocal excitation enabling large field of view at double the diffraction limited resolution

A Method for Operating and Protecting a Converter

Method to operate a resonant DC-DC converter and achieve protection against the short circuit in the switching leg

Diagnostic method for fast detection of biomarkers in Point-Of-Care settings

Electrokinetic manipulation of beads within a microfluidic channel for sequentially incubate the analytes with functionalized beads for signal amplification

Flying jacket

Intuitive flying jacket for remote drone control

Virtual Reality Add-On Device for Stereotactic Neurosurgery

Add-on device that can fit a stereotactic apparatus and that allows to use VR with patients during perioperative or awake phases of a neurosurgical intervention

Unified prefetching into instruction cache and branch target buffer

Redundancy in the control flow metadata for prefetchers

ATOMIC OBJECT READS FOR IN-MEMORY RACK-SCALE COMPUTING

Lightweight mechanism is implemented to extend a network interface to provide atomic reads

High precision organoid positioning and patterning using hydraulic resistance at microscale

Hybrid hydrogel-microfluidic device offering a stable gradient of the compound(s) of interest to the positioned organoids without cumbersome flow generating systems and a precise and simple organoid positioning module

Automated system for dynamic stem cell and organoid culture in standard multi-well plates

Automated system to dynamically control cell culture media composition in standard cell culture plates

Postprocessing approach for efficient and accurate high-dimensional parameter estimation in magnetic resonance fingerprinting

Postprocessing approach to overcome parameter estimations limitations in MRF of high order multi-parameter estimation including e.g. chemical exchange rates, relaxation times and multi-pool systems: allowing to reduce simulation and fitting time, computational requirements (memory size) and the possibility for online reconstruction on MRI scanners

Ultra-sensitive water permeation sensor

Ultra-sensitive sensor to quantitatively monitor in real-time water or moisture permeation of ultrathin barrier encapsulations

System for detecting intentions of voluntary action

System and method for predicting the intention of performing voluntary actions for applications in brain machine interfaces

Device for ultrasound signal interpretation

Reconfigurable devices for ultrasound signal interpretation

Pressure Limiter

System for adjusting pressure locally acting on the skin

Multispectral dielectric metasurfaces for FTIR-less infrared spectroscopic biosensing

Broadband mid-infrared imaging chip comprising a pixelated dielectric sensor metasurface for measuring the infrared absorption fingerprint of various analytes

Soft Cardiac Assist Device

First dielectric-elastomer augmented aorta (DEAA) consisting of a tubular DEA with an electrically driven compliance, designed to assist the pulsatile nature of the heart by means of an innovative aortic counter-pulsation approach

Method for in-line quality control of engineered inorganic nanoparticle production processes

Inductively-coupled plasma mass spectrometry (ICP-MS)-based method that allows for the comprehensive in-line characterization of EINPs with a single technique and at single-particle level of detection. Particle size and composition distributions can be obtained in a single measurement and with ensemble representative statistics

Device and system as human interactive surface

A force-feedback surface that creates a distinctive profile and stiffness to interact with the user in contact

A Gate Unit for Integrated Gate Commutated Thyristor

A gate unit for integrated gate commutated thyristors (IGCTs) and method to operate it, optimized for a resonant soft switched DC-DC converter

TF-CSMA/CA

Decentralized scheduling algorithm that adjusts both time and frequency access intensities in a random-access fashion

Real-Time Control of an Electric Vehicle Charging Station

Method for controlling the charging of electrical vehicles (EVs) connected to a single charging station (CS) in real-time

Microfluidic 3D-printer nozzle with cell concentrator

Microfluidic device for particles/cells concentration, particularly suitable for embedding into a 3D bioprinter nozzle

Multi-channel system for combined transcranial focused ultrasound and magnetic resonance imaging

Multiple, custom-designed, flexible structures used as ultrasonic couplers for ultrasound transducer arrays acting as a multi-channel, loop-dipole fed dielectric resonator antenna array for brain MRI at 7T

Thermal sensory feedback system

Non-invasive system that improves restoration of natural thermal sensation in amputees

Life science

New method for cancer diagnosis

Method for cancer diagnosis through the analysis of cholesterol-rich lipoprotein nanoparticles in a patient’s blood sample

Prodrugs of 6-diazo-5-oxo-L-norleucine for immunotherapies

Newly designed and synthesized variety of DON prodrugs to deliver DON to the target cancer cells and efficiently kill them with reduced toxicity

Cyclic peptide-based KLK5 and KLK7 inhibitors

Potent tissue Kallikrein inhibitors towards a first therapy for the Netherton Syndrome

Variable Stiffness Fiber with Self-Healing Capability

A variable stiffness fiber made of silicone and low melting point alloys quickly becomes >700 times softer and >400 times more deformable when heated above 62 °C.

Novel Antibody Tools for Targeting Beta-Amyloid Peptide Oligomerization

Anti-Aβ peptide antibodies detecting new targets associated with early Aβ fragment seeds and small oligomeric entities

Mutant Aerolysin for nanopore sensing

Mutant Aerolysin nanopores for nucleotide sequencing and analytes detection

Broad spectrum antivirals

Biocompatible anti-viral nanoparticles with broad-spectrum virucidal effect

PM20D1 and Alzheimer’s Disease

Therapeutic and diagnostic biomarker for Alzheimer’s disease (AD)

Learning Based Subsampling

Learning-based sampling outperforms the state-of-the-art sampling in terms of visual quality, PSNR (peak signal-to-noise) and SSIM (structural similarity), on a knee that is scanned with 6 times acceleration

Method for engineering fine-tuned protein variants

A method for drug discovery and screening of protein target

Tetracycline derivative for disease tolerance against viral infections

Tetracycline derivatives having minimal antimicrobial activity, yet retaining full capacity to induce the mitochondrial stress response (MSR), to help the immune system to defeat viral infections and neurodegenerative disorders

Ultra-sensitive water permeation sensor

Ultra-sensitive sensor to quantitatively monitor in real-time water or moisture permeation of ultrathin barrier encapsulations

Treatment and prevention of age-related diseases by the inhibition of sphingolipid synthesis

Inactivation of sphingolipid synthesis do increase muscle mass and grip strength, improve endurance and muscle regeneration and are validated genetically as drug target in humans

Koehler integrator device for multi-focal confocal microscope

New flat fielding element for multifocal excitation enabling large field of view at double the diffraction limited resolution

Manufacturing of nanoscale orifices in glass like materials

A new process for manufacturing in a controllable manner nano-scale orifices in glass like materials with a tubular shape.

Noninvasive Estimation of Cardiovascular Parameters

System for the non-invasive measurement of cardiovascular parameters

Method for the synthesis of new triazenes

New process using nitric oxide (N2O) for the synthesis of trisubstituted triazene

Photostable Biosensor for continuous analyte monitoring

Optical sensors for continuous sensing in-vivo rely on a molecular recognition element that selectively interacts with the analyte of interest and an optical transducer that converts this interaction into a measurable optical signal

Device for in vivo cell transplantation

Transplantation of stem cells onto the cornea in order to regenerate a functional epithelium

Diagnostic method for fast detection of biomarkers in Point-Of-Care settings

Electrokinetic manipulation of beads within a microfluidic channel for sequentially incubate the analytes with functionalized beads and accumulate the beads in a dedicated location for signal amplification

Digital information decoding and data storage in hybrid macromolecules

Alternative support for data storage aiming at higher density and longer-term storage

High-density implantable electrode arrays

New fabrication process on soft and flexible materials resulting in soft and flexible arrays with an unprecedented density of electrodes for interfacing with biological tissues

Wireless high-density implantable neurostimulator

Photosensitive polymeric pixels to generate an electric signal via a photovoltaic process

Virtual Reality Add-On Device for Stereotactic Neurosurgery

Add-on device that can fit a stereotactic apparatus and that allows to use VR with patients during perioperative or awake phases of a neurosurgical intervention

Non-natural peptides inhibiting cathepsins, mAb conjugated

Specific non-natural peptide inhibitors of two cysteine proteases, as well as a tumor delivery system based on peptide conjugation to cancer-targeting antibodies

High precision organoid positioning and patterning using hydraulic resistance at microscale

Hybrid hydrogel-microfluidic device offering a stable gradient of the compound(s) of interest to the positioned organoids without cumbersome flow generating systems and a precise and simple organoid positioning module

Bacterial detection

Superparamagnetic particles functionalised to capture target bacteria via electrochemical methods

Microfluidic 3D-printer nozzle with cell concentrator

Microfluidic device for particles/cells concentration, particularly suitable for embedding into a 3D bioprinter nozzle

Thermal sensory feedback system

Non-invasive system that improves restoration of natural thermal sensation in amputees

Automated system for dynamic stem cell and organoid culture in standard multi-well plates

Automated system to dynamically control cell culture media composition in standard cell culture plates

Construction of Sequencing libraries from RNA using tailing and ligation of cDNA (TLC)

TLC allowing the generation of sequencing libraries from low amounts of RNA through a fully bead-based library preparation strategy that can be implemented on liquid-handling platforms

Label-free optical detection of targeted nucleic acids

Label-free sensor based on Single Walled Carbon Nanotubes for the targeted detection of oligonucleotides (e.g. SNPs, miRNA)

Engineered CXCL12 ligand-CXCR4 receptor signaling complexes for enhanced chemotaxix

Method for engineering very sensitive and potent receptor biosensors that can sense either native or designed chemokines

Method for engineering peptide-receptor signaling complexes for enhanced chemotaxis

Method for engineering very sensitive and potent receptor biosensors that can sense either native or designed chemokines

Micelles for delivery of nitric oxide

NO-releasing micelles for drug delivery wherein a drug forms a complex with a water-soluble diblock copolymer for micellization

Rapid Multiplexing Digital Biomarker Detection with a Point-of-Care (or Portable) (Nano)Plasmonic Sensor

Nanoparticle-enhanced imaging-based plasmonic biosensing technique using gold nanohole arrays that enables highly sensitive protein biomarker detection with single analyte resolution

A Wearable System for Real-Time Detection of Epileptic Seizures

Lighting control system to increase visual comfort and reduce electricity consumption

Pressure Limiter

System for adjusting pressure locally acting on the skin

Field Concentration Smoothing

Field grading in multilayer elastomer actuator

Soft Cardiac Assist Device

First dielectric-elastomer augmented aorta (DEAA) consisting of a tubular DEA with an electrically driven compliance, designed to assist the pulsatile nature of the heart by means of an innovative aortic counter-pulsation approach

Miniatured ex vivo assay for drug / hormone screen in normal or malignant breast tissue

Biomaterial-based 3D ex vivo culture system for normal and malignant breast tissue microstructures that can maintain the most important features of breast tissue, hormone receptors and hormone responses

DEP Surfing for multiplexed biomarker analysis

Preparation of cDNA libraries from pooled RNA samples. The quantity of each bulk sample within a library is controlled and normalized for efficient bulk RNA high-throughput sequencing

Toolbox for instrumented dual motor-cognitive tasks assessment using multimodal data recorded with iPhone

Algorithms to detect and characterize motor activity (gait, body sway and balance, turning) and cognitive tasks. The motor-cognition interaction is quantified using clinically validated metrics (dual-task cost)

RAPTA: compounds that modulate the tumour microenvironment

First-in class ruthenium based compound (RAPTA) with low toxicity and effective at inhibiting both primary tumor growth and the spreading and growth of solid metastatic tumors

BTZ derivatives for multiresistant tuberculosis

Antibacterial New Chemical Entities, in particular against tuberculosis (TB), Buruli ulcer and leprosy caused by mycobacteria

LAT-based NK CARs and their use

CAR T cells and CAR NK cells genetically engineered with the activating domain derived from linker for activation of T cells (LAT)

Polypeptide ligands for targeting cartilage

Therapeutic agents such as therapeutic polypeptides equipped with cartilage targeting capability by the use of the polypeptide ligands

New Aerolysin Mutant for High Accuracy DNA sequencing

Mutant polypeptides derived from the aerolysin protein for single-nucleotide resolution DNA sequencing and more sensitive measurements

New Method for in vivo Evolution of Dynamic and Multi-state Proteins

A new method named Optovolution that allows for the simultaneous evolution of all the states of a protein and switches among them via light inputs

Multi-channel system for combined transcranial focused ultrasound and magnetic resonance imaging

Multiple, custom-designed, flexible structures used as ultrasonic couplers for ultrasound transducer arrays acting as a multi-channel, loop-dipole fed dielectric resonator antenna array for brain MRI at 7T

Use of Aerolysin Nanopores for protein isoform discrimination

Aerolysin nanopores to discriminate between isoforms of peptides, polypeptides, or proteins based on their post-translational modifications

Energy

MOFs for wet flue gas CO2 capture

Metal Organic Frameworks (MOF) that can uniquely adsorb and capture CO2 in the presence of water

Partial Discharge Localization Using Time Reversal

Time reversal, a novel technique to 3D-locate partial discharge sources in power equipment and electric vehicles

Osmotic Power Generator

Power generator using nanopore technology to convert an osmotic salt gradient into electricity

Hydrogen Storage Material

New carbon material combining graphene oxide and carbon nanotubes (GONT), absorbing more than 5 mass% of hydrogen and desorbs at up to 350 K, combined with complete reversibility of the hydrogen sorption

Adsorbent Material for Sequestrating Toxic Materials in Perovskite Solar Cells

Equipment of lead-based perovskite solar cells with a metal-organic framework polymer composite that highly selects and efficiently absorbs lead to address potential environmental concerns in the event of device failure

Offshore floating wind platform for green energy production

Sea platform with first-in-class design to generate and store clean energy sources

Two-component embedded system for strong angular-dependent transmittance and light redirection

Window transmitting or reflecting sunlight function of the incident angle

Sun Shading and Electric Lighting Control based on HDR Vision Sensor

Lighting control system to increase visual comfort and reduce electricity consumption

Real-Time Control of an Electric Vehicle Charging Station

Method for controlling the charging of electrical vehicles (EVs) connected to a single charging station (CS) in real-time

A Method for Operating a DCDC Converter

Seamless power reversal between terminals, without receiving external set-points or commands

Ligands for Metal-Organic Frameworks

A new strategy for designing Metal-Organic Frameworks ligands for custom-made pore size, shape, and surface functionality of the resulting MOF

Encapsulated alloy catalysts and their methods of preparation

Novel composite catalysts for CO2 electroreduction in solid oxide electrolysis cell (SOEC) consisting of non-precious alloys encapsulated by oxide showing high efficiency and stability

Synthesis of Functionalized Diaryl Ethers from lignin

Highly efficient strategy to extract the aromatic monomers from lignin affording functionalized diaryl ethers using Chan-Lam coupling


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