Androgen Receptor Signaling in in vivo models of Estrogen Receptor-positive Breast Cancer and Normal Breast Epithelium

A. Agnoletto / C. Brisken (Dir.)  

Lausanne, EPFL, 2024. 

The role of LRRK2 in lung adenocarcinoma

A. Gkasti / D. Constam; E. Meylan (Dir.)  

Lausanne, EPFL, 2024. 

Inhibition of anti-tumor immunity by melanoma cell-derived Activin-A depends on STING

K. Pinjusic; G. Ambrosini; J. Lourenco; N. Fournier; C. Iseli et al. 

Frontiers In Immunology. 2024-01-18. Vol. 14, p. 1335207. DOI : 10.3389/fimmu.2023.1335207.


Regulation and function of a hemicleaved Activin-A processing intermediate in melanoma

M. Bulliard / D. Constam (Dir.)  

Lausanne, EPFL, 2023. 

Bicc1 ribonucleoprotein complexes specifying organ laterality are licensed by ANKS6-induced structural remodeling of associated ANKS3

B. Rothe; Y. Ikawa; Z. Zhang; T. A. Katoh; E. Kajikawa et al. 

Plos Biology. 2023-09-01. Vol. 21, num. 9, p. e3002302. DOI : 10.1371/journal.pbio.3002302.

Metabolic dependencies of metastasis-initiating cells in breast cancer

C. M. T. Young / J. Hülsken (Dir.)  

Lausanne, EPFL, 2023. 

Development of a novel Chimeric Antigen Receptor (CAR) for its use in Natural Killer (NK) cells for cancer treatment and beyond

A. Madurga Alonso / J. Hülsken (Dir.)  

Lausanne, EPFL, 2023. 

Unlocking Hidden Potential: Exploring the Complexities of Signaling in Immune Cell Activation to Optimize CAR Therapy

M. Girardin / J. Hülsken; B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2023. 

Antagonistic interactions among structured domains in the multivalent Bicc1-ANKS3-ANKS6 protein network govern phase transitioning of target mRNAs

B. Rothe; S. Fortier; C. Gagnieux; C. Schmuziger; D. B. Constam 

Iscience. 2023-06-16. Vol. 26, num. 6, p. 106855. DOI : 10.1016/j.isci.2023.106855.

New roles of Bicc1 in cilia formation, cell adhesion, and in adult kidneys

C. Gagnieux / D. Constam (Dir.)  

Lausanne, EPFL, 2023. 


Role of the androgen receptor in the human breast epithelium

F. De Martino / C. Brisken (Dir.)  

Lausanne, EPFL, 2022. 

Activin-A impairs CD8 T cell-mediated immunity and immune checkpoint therapy response in melanoma

K. Pinjusic; O. A. Dubey; O. Egorova; S. Nassiri; E. Meylan et al. 

Journal For Immunotherapy Of Cancer. 2022-05-01. Vol. 10, num. 5, p. e004533. DOI : 10.1136/jitc-2022-004533.

Immunosuppressive roles of Activin-A in melanoma and characterization of its precursor cleavage

K. Pinjusic / D. Constam (Dir.)  

Lausanne, EPFL, 2022. 

The role of nicotinamide riboside metabolism in pancreatic beta cells

A. S. Cercillieux / C. Canto Alvarez; J. Auwerx (Dir.)  

Lausanne, EPFL, 2022. 


Time-Resolved Scanning Ion Conductance Microscopy for Three-Dimensional Tracking of Nanoscale Cell Surface Dynamics

S. M. Leitao; B. Drake; K. Pinjusic; X. Pierrat; V. Navikas et al. 

Acs Nano. 2021-11-23. Vol. 15, num. 11, p. 17613-17622. DOI : 10.1021/acsnano.1c05202.

Intestinal stem cells differentiation and its application in cancer therapy

M. Norkin / J. Hülsken (Dir.)  

Lausanne, EPFL, 2021. 

Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex

K. Minegishi; B. Rothe; K. R. Komatsu; H. Ono; Y. Ikawa et al. 

Nature Communications. 2021-07-01. Vol. 12, num. 1, p. 4071. DOI : 10.1038/s41467-021-24295-2.

Intraductal xenografts model estrogen receptor-positive (ER+) breast cancer dormancy and reveal a critical role for epithelial-mesenchymal transition (EMT) in its establishment

P. Aouad / C. Brisken (Dir.)  

Lausanne, EPFL, 2021. 


Metabolic plasticity and glucose transporter redundancy dictate lung adenocarcinoma growth

C. A-L. Contat / E. Meylan (Dir.)  

Lausanne, EPFL, 2020. 

Role of the RNA-binding protein Bicaudal-C1 and interacting factors in cystic kidney diseases

B. Rothe; C. Gagnieux; L. C. Leal-Esteban; D. B. Constam 

Cellular Signalling. 2020-04-01. Vol. 68, p. 109499. DOI : 10.1016/j.cellsig.2019.109499.


Role of Activin-A signaling in melanoma

O. A. Dubey / D. Constam (Dir.)  

Lausanne, EPFL, 2019. 

Targeting mitochondrial bioenergetics and NAD+ metabolism during sarcopenia and regeneration of skeletal muscle

T. Sonntag / J. Feige; E. Meylan (Dir.)  

Lausanne, EPFL, 2019. 

A novel cell-based sensor detecting the activity of individual basic proprotein convertases

K. Loew; K. Hardes; C. Fedeli; N. G. Seidah; D. B. Constam et al. 

Febs Journal. 2019-07-24. Vol. 286, num. 22, p. 4597-4620. DOI : 10.1111/febs.14979.

Comment on “Human dignity and gene editing”

D. B. Constam 

Embo Reports. 2019-01-01. Vol. 20, num. 1, p. e47220. DOI : 10.15252/embr.201847220.

Adamts18 Function in Mammary Gland Development

D. Ataca / C. Brisken (Dir.)  

Lausanne, EPFL, 2019. 


Quantitative single cell dynamics of signaling and transcriptional response in mammalian cells

O. Tidin / D. M. Suter; F. Naef (Dir.)  

Lausanne, EPFL, 2018. 

Role of Bicaudal C1 in renal gluconeogenesis and its novel interaction with the CTLH complex

L. Leal-Esteban; B. Rothe; S. Fortier; M. Isenschmid; D. Constam 

PLOS Genetics. 2018. Vol. 14, num. 7, p. e1007487. DOI : 10.1371/journal.pgen.1007487.

Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6

B. Rothe; C. Leettola; L. Leal-Esteban; D. Cascio; S. Fortier et al. 

Structure. 2018. Vol. 26, num. 2, p. 209-224.e6. DOI : 10.1016/j.str.2017.12.002.

Compartment-Specific Biosensors Reveal a Complementary Subcellular Distribution of Bioactive Furin and PC7

P. Ginefra; B. Filippi; P. Donovan; S. Bessonnard; D. Constam 

CELL REPORTS. 2018. Vol. 22, num. 8, p. 2176-2189. DOI : 10.1016/j.celrep.2018.02.005.

Probing the distribution of cortical components, including PtdIns(4,5)P2, during asymmetric division of C. elegans embryos

M. J. Scholze / P. Gönczy (Dir.)  

Lausanne, EPFL, 2018. 

Progestins used for hormonal contraception in Switzerland: study of their effects on the breast epithelium

M. Shamseddin / C. Brisken (Dir.)  

Lausanne, EPFL, 2018. 

Novel compartment-specific biosensors reveal a complementary subcellular distribution of bioactive Furin and PC7

P. Ginefra / D. Constam (Dir.)  

Lausanne, EPFL, 2018. 


Functional analysis of Bicc1 and novel interacting proteins in renal tubule cell metabolism and polycystic kidneys

L. C. Leal Esteban / D. Constam (Dir.)  

Lausanne, EPFL, 2017. 

Paracrine Activin-A Signaling Promotes Melanoma Growth and Metastasis through Immune Evasion

P. Donovan; O. A. Dubey; S. Kallioinen; K. W. Rogers; K. Muehlethaler et al. 

Journal Of Investigative Dermatology. 2017. Vol. 137, num. 12, p. 2578-2587. DOI : 10.1016/j.jid.2017.07.845.

Targeting cancer stem cells by T cell engineering

N. P. Desbaillets / J. Hülsken (Dir.)  

Lausanne, EPFL, 2017. 

The role of nicotinamide riboside kinases in mammalian NAD⁺ metabolism

J. Ratajczak / C. Canto Alvarez; J. Auwerx (Dir.)  

Lausanne, EPFL, 2017. 

Genomic targets and molecular partners of the chromatin regulator KAP1

A. Kauzlaric / D. Trono (Dir.)  

Lausanne, EPFL, 2017. 


Epiblast-specific loss of HCF-1 leads to failure in anterior-posterior axis specification

S. Minocha; S. Bessonnard; T-L. Sung; C. Moret; D. B. Constam et al. 

Developmental Biology. 2016. Vol. 418, num. 1, p. 75-88. DOI : 10.1016/j.ydbio.2016.08.008.

Capturing epidermal stemness

A. Zaffalon / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2016. 

AMP-activated protein kinase

S. T. S. Ducommun / K. Sakamoto; J. Auwerx (Dir.)  

Lausanne, EPFL, 2016. 

Development of microfluidic devices for chemotaxis of primary stem cells

Z. Tatárová / J. Hülsken; S. Maerkl (Dir.)  

Lausanne, EPFL, 2016. 

A balancing act between stratification and EMT in cultured human thymic epithelial cells

M. Pluchinotta / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2016. 


Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA

B. Rothe; L. Leal-Esteban; F. Bernet; S. Urfer; N. Doerr et al. 

Molecular And Cellular Biology. 2015. Vol. 35, num. 19, p. 3339-3353. DOI : 10.1128/Mcb.00341-15.

ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm

P. S. Ellis; S. Burbridge; S. Soubes; K. Ohyama; N. Ben-Haim et al. 

Development. 2015. Vol. 142, num. 22, p. 3821-3832. DOI : 10.1242/dev.119628.

GLUT1 and GLUT3 in non-small cell lung cancer

M. J. Masin / E. Meylan (Dir.)  

Lausanne, EPFL, 2015. 

Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression

N. Piazzon; F. Bernet; L. Guihard; W. N. Leonhard; S. Urfer et al. 

Journal of translational medicine. 2015. Vol. 13, p. 103. DOI : 10.1186/s12967-015-0463-7.

PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation

S. Bessonnard; D. Mesnard; D. B. Constam 

The Journal of cell biology. 2015. Vol. 210, num. 7, p. 1185-97. DOI : 10.1083/jcb.201503042.

Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

L. A. E. Lemaire / D. Constam; A. Grapin-Botton (Dir.)  

Lausanne, EPFL, 2015. 

Regulation of the mRNA silencing activity of Bicaudal-C

F. U. Bernet / D. Constam (Dir.)  

Lausanne, EPFL, 2015. 

Mechanisms underlying cell-fate determination in the mammary gland development

D. Buric / C. Brisken (Dir.)  

Lausanne, EPFL, 2015. 

Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

L. A. Lemaire; J. Goulley; Y. H. Kim; S. Carat; P. Jacquemin et al. 

Development (Cambridge, England). 2015. Vol. 142, num. 5, p. 858-70. DOI : 10.1242/dev.114611.


Regulation of TGF beta and related signals by precursor processing

D. B. Constam 

Seminars In Cell & Developmental Biology. 2014. Vol. 32, p. 85-97. DOI : 10.1016/j.semcdb.2014.01.008.

Characterizing the localization and role of lin-5 and era-1 mRNAs in early C. elegans embryos

Z. P. Spiró / P. Gönczy (Dir.)  

Lausanne, EPFL, 2014. 

Spatio-temporal synchronization of biological oscillators

J. Bieler / F. Naef (Dir.)  

Lausanne, EPFL, 2014. 

Nodal.Gdf1 Heterodimers with Bound Prodomains Enable Serum-independent Nodal Signaling and Endoderm Differentiation

C. Fuerer; M. C. Nostro; D. B. Constam 

Journal Of Biological Chemistry. 2014. Vol. 289, num. 25, p. 17854-17871. DOI : 10.1074/jbc.M114.550301.

The useful gate-crasher

J. C. Paredes Escobar / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2014. 

Identification of tumor-stroma interactions crucial for the establishment of liver metastasis

C. Urech / J. Huelsken (Dir.)  

Lausanne, EPFL, 2014. 

NMDAR signaling in cancer

L. Li / D. Hanahan (Dir.)  

Lausanne, EPFL, 2014. 

Pathogen-free husbandry conditions alleviate behavioral deficits and neurodegeneration in AD10 anti-NGF mice

S. Tzanoulinou; R. Brandi; I. Arisi; M. D’Onofrio; S. M. Urfer et al. 

J Alzheimers Dis. 2014. Vol. 38, num. 4, p. 951-64. DOI : 10.3233/JAD-131037.


Furin Is the Primary in Vivo Convertase of Angiopoietin-like 3 and Endothelial Lipase in Hepatocytes

R. Essalmani; D. Susan-Resiga; A. Chamberland; M-C. Asselin; M. Canuel et al. 

Journal Of Biological Chemistry. 2013. Vol. 288, num. 37, p. 26410-26418. DOI : 10.1074/jbc.M113.501304.

Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice

W. C. Wetsel; R. M. Rodriguiz; J. Guillemot; E. Rousselet; R. Essalmani et al. 

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2013. Vol. 110, num. 43, p. 17362-17367. DOI : 10.1073/pnas.1314698110.


Cellular Heterogeneity During Embryonic Stem Cell Differentiation to Epiblast Stem Cells Is Revealed by the ShcD/RaLP Adaptor Protein

M. Y. Turco; L. Furia; A. Dietze; L. F. Diaz; S. Ronzoni et al. 

Stem Cells. 2012. Vol. 30, num. 11, p. 2423-2436. DOI : 10.1002/stem.1217.

Automated design of ligands to polypharmacological profiles

J. Besnard; G. F. Ruda; V. Setola; K. Abecassis; R. M. Rodriguiz et al. 

Nature. 2012. Vol. 492, num. 7428, p. 215-220. DOI : 10.1038/nature11691.

Planar Cell Polarity Controls Pancreatic Endocrine Differentiation

C. Cortijo / A. Grapin-Botton (Dir.)  

Lausanne, EPFL, 2012. 

Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing

N. Piazzon; C. Maisonneuve; I. Guilleret; S. Rotman; D. B. Constam 

Journal of Molecular Cell Biology. 2012. Vol. 4, num. 6, p. 398–408. DOI : 10.1093/jmcb/mjs027.

Activin Signalling in Human Melanoma Cells

S. E. Kallioinen / D. Constam (Dir.)  

Lausanne, EPFL, 2012. 


Visualization of proprotein convertase activity in living cells and tissues

D. Mesnard; D. Constam 



Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia

M. R-C. Kraus; S. Clauin; Y. Pfister; M. Di Maïo; T. Ulinski et al. 

Human mutation. 2011. Vol. 33, num. 1, p. 86-90. DOI : 10.1002/humu.21610.

The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities

D. Mesnard; M. Donnison; C. Fuerer; P. L. Pfeffer; D. B. Constam 

Genes & Development. 2011. Vol. 25, p. 1871-1880. DOI : 10.1101/gad.16738711.

The Role of Nodal Processing in Pluripotent Progenitors

A. Dietze / D. Constam (Dir.)  

Lausanne, EPFL, 2011. 

Furin Is the Major Processing Enzyme of the Cardiac-specific Growth Factor Bone Morphogenetic Protein 10

D. Susan-Resiga; R. Essalmani; J. Hamelin; M-C. Asselin; S. Benjannet et al. 

Journal of Biological Chemistry. 2011. Vol. 286, num. 26, p. 22785-22794. DOI : 10.1074/jbc.M111.233577.


Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst

D. Mesnard; D. B. Constam 

The Journal of Cell Biology. 2010. Vol. 191, num. 1, p. 129-139. DOI : 10.1083/jcb.201005026.

Role of Bicaudal-C in Left-Right Axis Formation and Kidney Morphogenesis

C. Maisonneuve / D. Constam (Dir.)  

Lausanne, EPFL, 2010. 

KAP1 controls endogenous retroviruses in embryonic stem cells

H. M. Rowe; J. Jakobsson; D. Mesnard; J. Rougemont; S. Reynard et al. 

Nature. 2010. Vol. 463, num. 7278, p. 237-40. DOI : 10.1038/nature08674.


Riding shotgun: a dual role for the epidermal growth factor-Cripto/FRL-1/Cryptic protein Cripto in Nodal trafficking

D. B. Constam 

Traffic. 2009. Vol. 10, num. 7, p. 783-91. DOI : 10.1111/j.1600-0854.2009.00874.x.

Running the gauntlet: an overview of the modalities of travel employed by the putative morphogen Nodal

D. B. Constam 

Current opinion in genetics & development. 2009. Vol. 19, num. 4, p. 302-7. DOI : 10.1016/j.gde.2009.06.006.

Intracellular trafficking and signaling in development

D. B. Constam 

F1000 biology reports. 2009. Vol. 1, p. 59. DOI : 10.3410/B1-59.

Endoderm specification

A. Grapin-Botton 

Stembook; Cambridge, USA: Harvard Stem Cell Institute, 2009. p. 1-30.

Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow

C. Maisonneuve; I. Guilleret; P. Vick; T. Weber; P. Andre et al. 

Development. 2009. Vol. 136, num. 17, p. 3019-30. DOI : 10.1242/dev.038174.


Role of paracrine Furin activity during gastrulation

D. Mesnard; M. Donnison; P. L. Pfeffer; D. B. Constam 

2008. 67th Annual Meeting of the Society-for-Developmental-Biology, Philadelphia, PA, Jul 25-30, 2008. p. 583-583. DOI : 10.1016/j.ydbio.2008.05.413.

Cripto localizes nodal at the limiting membrane of early endosomes

M. Blanchet; J. Le Good; V. Oorschot; S. Baflast; G. Minchiotti et al. 

Sci Signal. 2008. Vol. 1, num. 45, p. ra13. DOI : 10.1126/scisignal.1165027.

Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation

M. Blanchet; J. Le Good; D. Mesnard; V. Oorschot; S. Baflast et al. 

The EMBO journal. 2008. Vol. 27, num. 19, p. 2580-91. DOI : 10.1038/emboj.2008.174.

VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5

D. Szumska; G. Pieles; R. Essalmani; M. Bilski; D. Mesnard et al. 

Genes & development. 2008. Vol. 22, num. 11, p. 1465-1477. DOI : 10.1101/gad.479408.

Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction

D. D’Andrea; G. L. Liguori; J. A. Le Good; E. Lonardo; O. Andersson et al. 

Journal of Cell Biology. 2008. Vol. 180, num. 3, p. 597-605. DOI : 10.1083/jcb.200709090.


Evolution of the mechanisms and molecular control of endoderm formation

A. Grapin-Botton; D. Constam 

Mechanisms of development. 2007. Vol. 124, num. 4, p. 253-78. DOI : 10.1016/j.mod.2007.01.001.


The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4

N. Ben-Haim; C. Lu; M. Guzman-Ayala; L. Pescatore; D. Mesnard et al. 

Developmental Cell. 2006. Vol. 11, num. 3, p. 313-23. DOI : 10.1016/j.devcel.2006.07.005.

Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning

D. Mesnard; M. Guzman-Ayala; D. B. Constam 

Development. 2006. Vol. 133, num. 13, p. 2497-2505. DOI : 10.1242/dev.02413.


Nodal stability determines signaling range

J. A. Le Good; K. Joubin; A. J. Giraldez; N. Ben-Haim; S. Beck et al. 

Current Biology. 2005. Vol. 15, num. 1, p. 31-6. DOI : 10.1016/j.cub.2004.12.062.


A gene network establishing polarity in the early mouse embryo

S-L. Ang; D. B. Constam 

Seminars in cell & developmental biology. 2004. Vol. 15, num. 5, p. 555-61. DOI : 10.1016/j.semcdb.2004.04.009.

Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment

M. Guzman-Ayala; N. Ben-Haim; S. Beck; D. B. Constam 

Proc Natl Acad Sci U.S.A. 2004. Vol. 101, num. 44, p. 15656-60. DOI : 10.1073/pnas.0405429101.

Asymmetric Nodal expression in the mouse is governed by the combinatorial activities of two distinct regulatory elements

S. D. Vincent; D. P. Norris; J. A. Le Good; D. B. Constam; E. J. Robertson 

Mech Dev. 2004. Vol. 121, num. 11, p. 1403-15. DOI : 10.1016/j.mod.2004.06.002.

Endoderm development

A. Grapin-Botton; D. Constam 

Gastrulation: from cells to embryo; Cold Spring Harbor, N.Y: CSH Laboratory Press, 2004. p. 433-448.


Watch thy neighbor: Proprotein convertases activate TGFß-related signals across tissue boundaries

D. Constam 

Swiss Cancer Bulletin. 2003. Vol. 23, num. 3, p. 141-144.


Extraembryonic proteases regulate Nodal signalling during gastrulation

S. Beck; J. A. Le Good; M. Guzman; N. Ben Haim; K. Roy et al. 

Nature Cell Biology. 2002. Vol. 4, num. 12, p. 981-5. DOI : 10.1038/ncb890.


Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping

D. B. Constam; E. J. Robertson 

Development. 2000. Vol. 127, num. 2, p. 245-54.

SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

D. B. Constam; E. J. Robertson 

Genes & development. 2000. Vol. 14, num. 9, p. 1146-55.


Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases

D. B. Constam; E. J. Robertson 

The Journal of Cell Biology. 1999. Vol. 144, num. 1, p. 139-49. DOI : 10.1083/jcb.144.1.139.


Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin

A. J. Roebroek; L. Umans; I. G. Pauli; E. J. Robertson; F. van Leuven et al. 

Development. 1998. Vol. 125, num. 24, p. 4863-76.


Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons

A. R. Tobler; D. B. Constam; A. Schmitt-Gräff; U. Malipiero; R. Schlapbach et al. 

Journal of neurochemistry. 1997. Vol. 68, num. 3, p. 889-97. DOI : 10.1046/j.1471-4159.1997.68030889.x.


Neurons induced to express major histocompatibility complex class I antigen are killed via the perforin and not the Fas (APO-1/CD95) pathway

A. Rensing-Ehl; U. Malipiero; M. Irmler; J. Tschopp; D. Constam et al. 

European journal of immunology. 1996. Vol. 26, num. 9, p. 2271-4. DOI : 10.1002/eji.1830260945.