EDBB Open positions

This page will be updated more often as the EDBB program will be informed of new positions becoming available for the January 2023 Hiring Days event. Meanwhile, do not hesitate to contact the laboratories which interest you to find out whether they have upcoming openings for PhD students as this list is non-exhaustive.

We have several positions opening in the Aye laboratory in Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland, both at PhD student and postdoctoral researcher levels. Our laboratory is a multidisciplinary laboratory focusing on small-molecule- and nucleotide-driven signaling mechanisms as they pertain to intra- and intercellular communications often conserved across evolution, and also to drug discovery. We have pioneered numerous novel and multi-award-winning interdisciplinary concepts and techniques that have been applied to important biological questions.

 The available projects will build on previously-published foundational studies, and encompass wide-ranging areas in the broader context of bioengineering and chemical biology: such as, (i) development of precision medicine targeting proteins/pathways essential in several cancer subtypes, based off two successful lead compounds that we recently discovered, and assessing their efficacies in cell culture and the best will be continued to more advanced models; (ii) projects aimed at understanding and reprogramming subcellular metabolite trafficking and signaling mechanisms; and (iii) projects targeted to advance spatial and functional omics methods in multiple living models.

More information about both of our research groups, including other active research themes, can be found at

https://leago.epfl.ch/ For questions or additional information, please contact [email protected]

Start date :

For all positions, they are available immediately, funding is available, and the start date is flexible. All applications should include in PDF format:
(i) Cover letter, 
(ii) CV, 
(iii) the contact information of three references. 

 

CIBM

Developments of innovative fast acquisition and metabolic modelling strategies for clinical and preclinical deuterium MR imaging in the brain at ultra-high field

Dr Bernard Lanz from the MRI EPFL Animal Imaging and Technology Section is looking for a highly motivated PhD candidate in the area of metabolic imaging using dynamic quantitative deuterium magnetic resonance spectroscopic imaging (2H-MRSI) and cross-validation with dynamic 13C-MRS and FDG-PET: advanced methodological 2H-MRSI developments (i.e. pulse sequence development and implementation, reconstruction, post-processing, denoising techniques), implementation and acquisition of in vivo dynamic 13C-MRS and FDG-PET, development of adapted metabolic models to analyse the different dynamic metabolic data, validate and combine the obtained metabolic fluxes and applications in a rat model of epilepsy.

The candidate will be supervised by Dr Bernard Lanz and Prof. Dimitri Van De Ville, in the framework of an SNSF Weave project.

View full description: CIBM Open Position 2H MRSI CIBM AIT EDBB

LBNC

We are looking to hire a graduate student in cell-free synthetic biology.

The prospective graduate student will work on building the foundations for the development of a synthetic cell. This project will involve developing state-of-art techniques and approaches in cell-free synthetic biology combined with microfluidic technologies to push the current boundaries of in vitro synthetic biology and cell-free transcription – translation systems. The graduate student will be embedded in a highly international and dynamic research environment.

Requirements:

Candidates should hold a Master’s Degree in Biochemistry, Bioengineering, Chemical Engineering, Chemistry, Microengineering, or related field. Exceptional candidates with a bachelor degree will also be considered. The candidate should either have prior experience in protein biochemistry, molecular engineering, synthetic biology and / or cell-free systems, or experience in developing and applying state-of-the art microfluidic technologies to biological applications, particularly devices fabricated by multilayer soft lithography.

Candidates should send their curriculum vitae and a cover letter to:

Prof. Sebastian Maerkl

Email: [email protected]

Evaluation of applications will commence immediately. The position is expected to be filled and begin in Q1/Q2 of 2022.

www.p-lab.science

Microbiota mechanobiology
Commensals from our gut microbiota colonize epithelial surfaces that are covered with loose mucus. While animal and human experiments have taught us about the species that are able to colonize this environment, we know little about the biophysical principles guiding colonization of mucus. We are looking for a PhD student who will investigate colonization of the gut mucosa by commensals in a tissue-engineered gut organoid system. 

For more details, see web pages of the EDBB program’s potential thesis directors.