Lipid Cell Biology Laboratory – Kristian Gerhard Jebsen Chair on Metabolism

The focus of our laboratory is that to understand the role of membrane lipids in the establishment of cell identity and in development. We do approach this issue by combining advanced lipidomics and lipid imaging with biochemical and cell biology techniques.

Our research

Lipids are fundamental constituents of nearly all living-objects as their biophysical properties account for the formation of the bilayer structure characteristic of biological membranes. The membrane structure is conserved from prokaryotes to animal cells where it defines the minimal unit of life : the Cell, represents the first line of communication between the cell and the environment, enwraps the cytosol and the different intracellular organelles allowing for intracellular compartmentalization. The functional properties of cell membranes strongly depend on their lipid composition and different membranes both within the cell and among different cells have different lipid composition. At D’Angelo Lab, we aim at understanding the meaning of compositional variability in cell membranes by studying the mechanisms by which the lipid composition is determined.

In-situ single cell lipidomics by Imaging Mass Spectrometry

See more

Regulation of sphingolipid metabolism in neurogenesis

See more

Making a Plasma Membrane: The dynamic role of lipid processing transport and processing in membrane assembly

See more

NEWS

iStock

S-acylation enhances COVID-19 infection

— Like many viruses, SARS-CoV-2 relies on lipid modifications carried by host enzymes to organize their membrane structure and coordinate the function of virulence proteins. Scientists at EPFL have discovered the enzymes that transfer fatty acids to one of the main components of SARS-CoV-2, its fusion protein Spike. The findings reveal that such fatty acids are important for the production of infectious SARS-CoV-2 particles, and can help develop new drugs for treating coronaviruses and other viruses like herpes and influenza.

Logo © Swiss National Science Foundation

SNF funds new LCBL project

— SNF funds new LCBL project to study "Changing Plasma Membrane : The dynamic role of the sphingolipid processing enzymes in membrane remodelling".

Giovani D’Angelo (credit: Alban Kakulya/EPFL)

“Cell sociology”: An interview with Giovanni D'Angelo

— Professor Giovanni D’Angelo recently joined EPFL’s School of Life Sciences, where he directs a lab in the Interschool Institute of Bioengineering (IBI). An expert in lipids, D’Angelo’s previous work looked at how proteins shuttle lipids from one cell membrane to another, and how cells can maintain compartments with different lipid compositions. At EPFL, he plans to take his research to the next level: the single cell and its social life.

All news

Head of Laboratory:

Prof. Giovanni D’Angelo

Office : AI 1109

[email protected]

Phone : +41 21 693 42 76

Administration:

Sonia Marchegiano

Office: AAB 109

[email protected]

Phone: + 41 21 693 13 70

Mailing address :

EPFL

SV / IBI/ UPDANGELO

Station 19

1015 Lausanne

Switzerland