D’Angelo Lab – Lipid Cell Biology Laboratory
Lipids are fundamental constituents of nearly all living-objects as their biophysical properties account for the formation of the bilayer structure characteristic of biological membranes. The membrane structure is conserved from prokaryotes to animal cells where it defines the minimal unit of life : the Cell, represents the first line of communication between the cell and the environment, enwraps the cytosol and the different intracellular organelles allowing for intracellular compartmentalization. The functional properties of cell membranes strongly depend on their lipid composition and different membranes both within the cell and among different cells have different lipid composition. At D’Angelo Lab, we aim at understanding the meaning of compositional variability in cell membranes by studying the mechanisms by which the lipid composition is determined.