EDBB Published theses

It is our pleasure to present the theses undertaken in the frame of the EPFL PhD Program in Biotechnology & Bioengineering.

2026

Advanced human lung organoids-on-a-chip to model epithelial-immune responses to viral infection

Y. Tinguely / M. Lütolf; L. Tang (Dir.)  

Lausanne, EPFL, 2026. 

From Functional Genomics to Tissue Models: Investigating Pseudomonas aeruginosa-Macrophage Interactions

T. Distler / A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2026. 

Plasmonic Nanostructure Biosensors for Continuous Monitoring and Multiplexed Profiling with Ultra-Broad Dynamic Range

A. Saateh / H. Altug (Dir.)  

Lausanne, EPFL, 2026. 

Collective organisation of the circadian clock in the intestinal epithelium: insights from an organoid-on-array model

E. Tonin / F. Naef (Dir.)  

Lausanne, EPFL, 2026. 

Mechanoadaptation of bacterial physiology and antibiotic tolerance in confined environments

S. M. Kuppanda Jafri / A. L. A. Persat; M. S. Sakar (Dir.)  

Lausanne, EPFL, 2026. 

Quantitative Holographic Imaging for Single-Cell Phenotyping in a Microfluidic System

J. A. Vasquez Porto Viso / B. Deplancke (Dir.)  

Lausanne, EPFL, 2026. 

From Phase to Fate: Multi-Modal Characterisation of Cell Cycle Dynamics and Their Role in Early Development

M. Leonardi / F. Naef (Dir.)  

Lausanne, EPFL, 2026. 

Reprogramming GPCR Specificity: Engineering CXCR2 for Selective CXCL5 Binding and Cellular Signaling

A. P. Rico Villarreal / P. D. Barth (Dir.)  

Lausanne, EPFL, 2026. 

2025

Decoding single-cell heterogeneity and plasticity

W. Liu / B. Deplancke (Dir.)  

Lausanne, EPFL, 2025. 

Rational cytokine and receptor engineering for enhanced safety and efficacy of cancer immunotherapy

L. Bonati / L. Tang; B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2025. 

Next-generation in vitro liver models through stem cell-derived organoids and bioengineering

B. S. Elçi / M. Lütolf; K. Schoonjans (Dir.)  

Lausanne, EPFL, 2025. 

Multimodal Imaging Platform for Spatiotemporal Interrogation of Dynamics in Single Cells and Spheroids

S. Ansaryan / H. Altug (Dir.)  

Lausanne, EPFL, 2025. 

Gravitational and acoustic micromanipulation platforms for high-content histological analysis of organoids and spheroids

E. Vuille-Dit-Bille / M. S. Sakar; G. Weder (Dir.)  

Lausanne, EPFL, 2025. 

Heartbeat on repeat: noncanonical KZFP and its transposable element targets shape cardiac cell specification

D. Milovanovic / D. Trono (Dir.)  

Lausanne, EPFL, 2025. 

Soft microelectrode arrays for 3D in vitro brain models

E. Martinelli / S. Lacour (Dir.)  

Lausanne, EPFL, 2025. 

Towards Conformational Targeting of Alpha-Synuclein Fibrils

A. S. S. Z. M. Sadek / B. E. Ferreira De Sousa Correia; H. Lashuel (Dir.)  

Lausanne, EPFL, 2025. 

Programmable supramolecular nanoarchitectures for targeting biological patterns

A. Kononenko / M. M. C. Bastings (Dir.)  

Lausanne, EPFL, 2025. 

Bioengineering of morphologically and functionally accurate in vitro intestinal models

J. J. Langer / M. Lütolf; K. Schoonjans (Dir.)  

Lausanne, EPFL, 2025. 

Experimental Characterization of an Adhesion GPCR Mechanotransduction

G. Gambardella / P. D. Barth; A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2025. 

Translational AI in Digital Health: Applications in Plant Disease Detection, Food Recognition, Postprandial Glycemic Response Forecasting and Musculoskeletal Modeling

S. P. Mohanty / M. Salathé (Dir.)  

Lausanne, EPFL, 2025. 

Mapping the Operative Space for Polymer-Biostabilized DNA Origami

H. J. Rodríguez Franco / M. M. C. Bastings (Dir.)  

Lausanne, EPFL, 2025. 

PURE system optimization and exploration of self-regeneration for synthetic cell applications

R. Bava Ganesh / S. Maerkl (Dir.)  

Lausanne, EPFL, 2025. 

Exploring the Role of Unstable L-Forms in the Survival of Uropathogenic Escherichia coli Under Fosfomycin Exposure

F. Normandeau / J. McKinney; N. Dhar (Dir.)  

Lausanne, EPFL, 2025. 

Advancing high-resolution microscopes to enable time-lapse nano-characterization of pathogenic micro-organisms in-vitro

E. Braun / J. McKinney; G. Fantner (Dir.)  

Lausanne, EPFL, 2025. 

Droplet microfluidic platforms for multiplexed library-against-library antibody screening

L. Kolmar / C. Merten (Dir.)  

Lausanne, EPFL, 2025. 

Computational Design of Protein Switches

S. M. Buckley / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2025. 

2024

Multi-motif scaffolding for de novo pathogen antigen mimetics by deep generative learning

K. M. Castro Gilabert / B. Correia (Dir.)  

Lausanne, EPFL, 2024. 

Dielectrophoretic Manipulation of Biological Species: Novel Microfluidic Approaches to Study Cell-Cell Interactions and the Role of Alpha-Synuclein in Neurodegeneration

T. J. Ryser / C. Guiducci; H. Lashuel (Dir.)  

Lausanne, EPFL, 2024. 

Advancing Cell-Free Synthetic Biology: From sustained PURE protein synthesis to an isothermal one-pot DNA replication system

L. S. Grasemann / S. Maerkl (Dir.)  

Lausanne, EPFL, 2024. 

Exploring the therapeutic potential of Huntingtin native state stabilization through targeting its interacting partners

E. Morro / H. Lashuel (Dir.)  

Lausanne, EPFL, 2024. 

Resolving bacterial cell biology: from replisome dynamics to cell wall synthesis

C. Zhang / S. Manley (Dir.)  

Lausanne, EPFL, 2024. 

Unraveling mitochondrial dynamics: exploring asymmetries and function through advanced microscopy

J. H. B. Winter / S. Manley (Dir.)  

Lausanne, EPFL, 2024. 

Characterization of the gut-bone marrow axis through bile acid signaling

A. Alonso Calleja / K. Schoonjans; O. M. Naveiras Torres-Quiroga (Dir.)  

Lausanne, EPFL, 2024. 

Advancements in Nanomechanical Characterization and Biomolecular Imaging with Atomic force Microscopy

V. Cencen / G. Fantner (Dir.)  

Lausanne, EPFL, 2024. 

The Slc25a47-Wars1 locus: characterization of its role in metabolic homeostasis and stress pathways

F. Pontanari / K. Schoonjans (Dir.)  

Lausanne, EPFL, 2024. 

Drug Screening in C. elegans to identify new pharmacological mitochondrial stress inducers

A. Lalou / J. Auwerx (Dir.)  

Lausanne, EPFL, 2024. 

Single-cell analysis of the interactions between Mycobacterium tuberculosis and macrophages

O. Rutschmann / J. McKinney (Dir.)  

Lausanne, EPFL, 2024. 

Quantitative characterization of the inorganic phosphate gene regulatory networks in S. cerevisiae and bottom up engineering an orthogonal gene network

S. Cheng / S. Maerkl (Dir.)  

Lausanne, EPFL, 2024. 

ER+ breast cancer in 3D scaffold ex vivo for transcriptomics-based functional drug screening and personalized medicine

Y. Zhang / C. Brisken; C. Merten (Dir.)  

Lausanne, EPFL, 2024. 

Engineering novel protein interactions with therapeutic potential using deep learning-guided surface design

A. Marchand / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2024. 

Development and evaluation of a near-infrared photovoltaic implant for wireless neural stimulation

D. I. Medagoda / S. Lacour; D. Ghezzi (Dir.)  

Lausanne, EPFL, 2024. 

Engineering Split HaloTag for Advanced Fluorescence Microscopy

Y-H. Lin / K. Johnsson (Dir.)  

Lausanne, EPFL, 2024. 

Exploring ion and analyte transport in beta-barrel forming biological nanopores

S. F. Mayer / M. Dal Peraro; A. Radenovic (Dir.)  

Lausanne, EPFL, 2024. 

Bioengineering functional organoid models across scales

T. Hübscher / M. Lütolf (Dir.)  

Lausanne, EPFL, 2024. 

Unraveling behavior and cortical signals to guide the development of soft neuroprostheses for auditory restoration and spreading depolarization

E. C. M. Revol / S. Lacour (Dir.)  

Lausanne, EPFL, 2024. 

Targeting TDP-43 Proteinopathies in Neurodegeneration by its Native-State Stabilization

L. Yang / H. Lashuel (Dir.)  

Lausanne, EPFL, 2024. 

Targeting Cellular Senescence and NAD+ Metabolism Disruption in Early-Stage Chronic Kidney Disease

L. C. Chanvillard / J. Feige; K. Schoonjans (Dir.)  

Lausanne, EPFL, 2024. 

Accessible and highly observable gastrointestinal organoid model systems for studying host-pathogen interactions

M. Hofer / M. Lütolf (Dir.)  

Lausanne, EPFL, 2024. 

2023

Development of new volcano-shaped microelectrodes for single cell electrochemistry, electrophysiology and impedance studies

N. G. Maïno / P. Renaud; A. Bertsch (Dir.)  

Lausanne, EPFL, 2023. 

Novel quantitative bioengineered tools to track human bone marrow niche cellular constituents in health and disease

R. Sarkis / B. Deplancke; O. M. Naveiras Torres-Quiroga (Dir.)  

Lausanne, EPFL, 2023. 

Label-free plasmonic microarray for multiplexed analysis of cells and tumor organoids

Y-C. Liu / H. Altug (Dir.)  

Lausanne, EPFL, 2023. 

Tracking spatiotemporal localisation and interactions of the innate immune sensor STING

S. M. E. Rivara / A. Ablasser (Dir.)  

Lausanne, EPFL, 2023. 

Bioengineering human mini-intestines with in vivo-like complexity and function

O. Mitrofanova / M. Lütolf (Dir.)  

Lausanne, EPFL, 2023. 

Bacterial colonization in realistic environments: how mechanics impact biofilm formation in the wild and during infection

T. Rossy / A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2023. 

Compliance-matching vascular grafts with personalization potential

G. Rovas / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2023. 

How are cells instructed to form somite boundaries by the zebrafish segmentation clock?

O. F. Venzin / A. C. Oates (Dir.)  

Lausanne, EPFL, 2023. 

Engineering Innate and Adaptive Immunity for Enhanced Cancer Immunotherapy

M. Gao / L. Tang (Dir.)  

Lausanne, EPFL, 2023. 

Characterization of Cyclo His-Pro for the prevention and treatment of liver disease and muscular dystrophy

A. De Masi / J. Auwerx (Dir.)  

Lausanne, EPFL, 2023. 

Exploring the interplay of molecular pattern and valency for selective interactions at the bio-interface

K. Paloja / M. M. C. Bastings (Dir.)  

Lausanne, EPFL, 2023. 

Countering T cell exhaustion and senescence for enhanced adoptive T cell therapies against solid tumors

Y. Zhao / L. Tang (Dir.)  

Lausanne, EPFL, 2023. 

Time-Resolved Scanning Ion Conductance Microscopy and Single-Molecule Spectroscopy

S. Mendes Leitão / G. Fantner (Dir.)  

Lausanne, EPFL, 2023. 

Engineering Hydrogel-coated Neural Interfaces for Chronic Deep Brain Recording

N. S. A. Alwahab / S. Lacour (Dir.)  

Lausanne, EPFL, 2023. 

Nanotechnology enabled modulation of T cell immunity for cancer treatment

X. Hu / L. Tang (Dir.)  

Lausanne, EPFL, 2023. 

Advancing atomic force microscopy through open source instrumentation

M. Kangül / G. Fantner (Dir.)  

Lausanne, EPFL, 2023. 

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

X. Li / J. Auwerx (Dir.)  

Lausanne, EPFL, 2023. 

Cross-anatomical single-cell definition and characterization of human adipose progenitor niche

R. Ferrero / B. Deplancke (Dir.)  

Lausanne, EPFL, 2023. 

The Effects of Spatial Organization and Fluid Flow on the Social Interactions in Microbial Communities

J. P. H. Wong / A. L. A. Persat; T. I. Battin (Dir.)  

Lausanne, EPFL, 2023. 

2022

Towards automating de novo protein design for novel functionalities: controlling protein folds and protein-protein interactions

Z. Harteveld / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2022. 

Sensor-integrated ultraflexible endovascular devices

L. F. Pancaldi-Giubbini / M. S. Sakar (Dir.)  

Lausanne, EPFL, 2022. 

Characterization of Pseudomonas aeruginosa mechanosensing through label-free imaging of type IV pili

L. A-L. Talà / A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2022. 

Identification of genes required for host-cell adhesion and antibiotic persistence of uropathogenic Escherichia coli via high-content screening

T. M. Simonet / J. McKinney (Dir.)  

Lausanne, EPFL, 2022. 

DNA-based biomaterials for nanoscale controlled modulation of immune cells

A. Comberlato / M. M. C. Bastings (Dir.)  

Lausanne, EPFL, 2022. 

Rational design of protein switches: applications in synthetic biology and cancer immunotherapy

S. Shui / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2022. 

Engineering synthetic adhesins for biophysical investigation and rewiring of host-microbe interactions

X. J-Y. Pierrat / A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2022. 

Hunting for the wavefront: investigation of somite boundary positioning in zebrafish

A. Bercowsky Rama / A. C. Oates (Dir.)  

Lausanne, EPFL, 2022. 

Dissecting the role of the asparagine synthesis in acute liver injury

Y. Sun / K. Schoonjans (Dir.)  

Lausanne, EPFL, 2022. 

Targeting molecular surfaces to engineer novel protein-based immunogens and inhibitors

S. Wehrle / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2022. 

Understanding the mechanisms of non-thermal plasma treatments on seeds

A. Waskow / I. Furno (Dir.)  

Lausanne, EPFL, 2022. 

Systematic analysis of biomolecular binding reactions using microfluidic systems

A. Shahein / S. Maerkl (Dir.)  

Lausanne, EPFL, 2022. 

Engineering T Cell Trafficking and Function for Enhanced Cancer Immunotherapy

Y. Xie / L. Tang (Dir.)  

Lausanne, EPFL, 2022. 

In vitro endoderm emergence and self-organisation in the absence of extraembryonic tissues and embryonic architecture

S. D. Vianello / M. Lütolf (Dir.)  

Lausanne, EPFL, 2022. 

Methods for acute and long-term imaging of the ventral nerve cord in behaving adult Drosophila

L. J. Hermans / P. P. Ramdya; M. S. Sakar (Dir.)  

Lausanne, EPFL, 2022. 

Molecular Regulation of Muscle Stem Cell Fate during Skeletal Muscle Regeneration and Aging

S. Ancel / J. Feige; B. Deplancke (Dir.)  

Lausanne, EPFL, 2022. 

Fabrication and validation of an intraneural interface tailored for optic nerve stimulation

E. Borda / D. Ghezzi (Dir.)  

Lausanne, EPFL, 2022. 

Development of a Transient Neural Interface for Minimally Invasive Recording and Stimulation

A. Fanelli / D. Ghezzi (Dir.)  

Lausanne, EPFL, 2022. 

Dissecting the role of biliary epithelial cells during non-alcoholic fatty liver disease progression

E. Yildiz / K. Schoonjans (Dir.)  

Lausanne, EPFL, 2022. 

Multidisciplinary Investigation of the Gut-Brain Ecosystem in a Model of Alzheimer’s Disease

A. L. Planchette / A. Radenovic; A. J. Macpherson (Dir.)  

Lausanne, EPFL, 2022. 

2021

Circadian dynamics of RNA localisation in the mammalian liver

C. Y. S. Hurni / F. Naef (Dir.)  

Lausanne, EPFL, 2021. 

Non-invasive monitoring of key hemodynamical and cardiac parameters using physics-based modelling and artificial intelligence

V. Bikia / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2021. 

Towards scalable and deterministic single cell gene expression profiling

J. J. Bues / B. Deplancke (Dir.)  

Lausanne, EPFL, 2021. 

Engineering next generation organoids through guided stem cell self-organisation

M. Nikolaev / M. Lütolf (Dir.)  

Lausanne, EPFL, 2021. 

Microtissue models for studying the dynamics of host-pathogen interactions in the urinary bladder

K. Sharma / J. McKinney; N. Dhar (Dir.)  

Lausanne, EPFL, 2021. 

Towards engineering an artificial neural tube

J. Park / M. Lütolf (Dir.)  

Lausanne, EPFL, 2021. 

Microfluidics and cell-free synthetic biology in the development of new diagnostic and therapeutic platforms

G. Michielin / S. Maerkl (Dir.)  

Lausanne, EPFL, 2021. 

An autonomous microfluidic device for identification and analysis of individual clinically-relevant mammalian cells

F. L. C. R. Jammes / S. Maerkl (Dir.)  

Lausanne, EPFL, 2021. 

On the exploration of novel methodological approaches for immunogen design: case studies in influenza and hepatitis C

A. Scheck / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2021. 

Toward a mechanistic understanding of variable chromatin modules

G. Llimos Aubach / B. Deplancke (Dir.)  

Lausanne, EPFL, 2021. 

In situ photopolymerizable hydrogels for intracranial aneurysms treatment

O. Poupart / D. Pioletti; C. Moser (Dir.)  

Lausanne, EPFL, 2021. 

Biophysical applications of correlative scanning probe and super-resolution microscopy

V. Navikas / A. Radenovic (Dir.)  

Lausanne, EPFL, 2021. 

KRAB zinc finger protein-mediated control of transposon-embedded regulatory sequences from human germline to early embryos

A. Iouranova / D. Trono; P. Turelli (Dir.)  

Lausanne, EPFL, 2021. 

Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in mouse

A. M. Bachmann / J. Auwerx (Dir.)  

Lausanne, EPFL, 2021. 

Organisation and dynamics of mitochondria and their RNA.

T. H. R. Rey / S. Manley (Dir.)  

Lausanne, EPFL, 2021. 

Mechanical principles of engineering fibrous tissues with programmable shape

E. Mailand / M. S. Sakar (Dir.)  

Lausanne, EPFL, 2021. 

Co-regulation of endothelial and myogenic cell fates through intercellular crosstalk in skeletal muscle

U. Lee / J. Feige; B. D. Cosgrove (Dir.)  

Lausanne, EPFL, 2021. 

Development and applications of hyperpolarized 13C and 1H MR spectroscopy of cerebral metabolism at ultra-high field

E. I. Flatt / R. Gruetter (Dir.)  

Lausanne, EPFL, 2021. 

Coordination between cell growth, division and chromosome replication cycles in mycobacteria

G. M. Vuaridel / J. McKinney; N. Dhar (Dir.)  

Lausanne, EPFL, 2021. 

Single-cell lipidomics reveals a role for cell-to-cell sphingolipid heterogeneity in fibroblast activation

L. Capolupo / G. D’Angelo (Dir.)  

Lausanne, EPFL, 2021. 

The genetic architecture of complex human traits at the dawn of genomic medicine

O. N. M. Naret / J. Fellay (Dir.)  

Lausanne, EPFL, 2021. 

Wireless soft microscale actuators and robotic devices to study mechanobiology

R. F. Penacho Parreira / M. S. Sakar (Dir.)  

Lausanne, EPFL, 2021. 

Reprogramming G Protein-Coupled Receptor Structure, Function And Signaling By Computational Design

D. Kéri / P. D. Barth (Dir.)  

Lausanne, EPFL, 2021. 

Towards an artificial cell: Development of a system which self-regenerates the protein components of the PURE system in microfluidic reactors

B. Lavickova / S. Maerkl (Dir.)  

Lausanne, EPFL, 2021. 

Decoding of error-related potentials in continuous feedback protocols for personalized human computer interaction

F. Iwane / A. Billard; J. d. R. Millán Ruiz (Dir.)  

Lausanne, EPFL, 2021. 

Post-translational regulation of neuronal differentiation

J. S. Loomba / G. D’Angelo (Dir.)  

Lausanne, EPFL, 2021. 

Developing new tools to study and program cell fate at the single-cell level

M. Biocanin / B. Deplancke (Dir.)  

Lausanne, EPFL, 2021. 

Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease

M. Romani / J. Auwerx (Dir.)  

Lausanne, EPFL, 2021. 

2020

Gait analysis in children with cerebral palsy: bridging the gap between the laboratory and real life

L. Carcreff / K. Aminian; S. Armand (Dir.)  

Lausanne, EPFL, 2020. 

Beneficial axis of the renin-angiotensin system: from applications to drug discovery

M. Bragina / N. Stergiopulos; M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2020. 

Time-lapse high-resolution microscopy to study the morphogenesis of microorganisms

M. T. M. Hannebelle / G. Fantner; J. McKinney (Dir.)  

Lausanne, EPFL, 2020. 

Metabolic rescue of muscle and muscle stem cells in muscle disease

P. Luan / J. Auwerx (Dir.)  

Lausanne, EPFL, 2020. 

Microfluidic iMITOMI platform to study the architecture of low-affinity transcription factor binding site clusters

I. Istomin / S. Maerkl (Dir.)  

Lausanne, EPFL, 2020. 

Quantitative approaches to unravel bone marrow adipocyte site-specificity and its implication in hematopoiesis

J. C. P. Tratwal / O. M. Naveiras Torres-Quiroga (Dir.)  

Lausanne, EPFL, 2020. 

High-throughput microfluidic platforms for characterizing and engineering cell-free gene regulatory circuits

Z. N. Swank / S. Maerkl (Dir.)  

Lausanne, EPFL, 2020. 

Sensor and the Beast: Generalised Methods to Recognise Animal Behaviour and Quantify Energy Expenditure Using Inertial Sensors, and Applications

P. Chakravarty / K. Aminian (Dir.)  

Lausanne, EPFL, 2020. 

Multidisciplinary Approach to Treat Erectile Dysfunction

M. N. Sturny / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2020. 

In vitro modeling of early mouse development

M. U. Girgin / M. Lütolf (Dir.)  

Lausanne, EPFL, 2020. 

Functional de novo Protein Design for Targeted Vaccines and Synthetic Biology Applications

C. Yang / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2020. 

Development of novel methods and tools to decipher the huntingtin post-translation modifications code

A. Chiki / H. Lashuel (Dir.)  

Lausanne, EPFL, 2020. 

Characterization of Protein-Membrane Interfaces through a Synergistic Computational-Experimental Approach

A. Prunotto / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2020. 

Bioengineering Methods to Improve in vitro Adoptive Cell Therapy based on Tumor-Infiltrating Lymphocytes

F. R. Rivest / M. Lütolf; L. L. Sohn (Dir.)  

Lausanne, EPFL, 2020. 

Hemodynamics of ageing, ventricular-arterial coupling and noninvasive assessment of key hemodynamical and cardiac quantities

S. Z. Pagoulatou / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2020. 

Microfluidic devices for the study of cell-cell, cell-particle and particle-particle interactions

M. C. M. Duchamp / P. Renaud; A. Harari (Dir.)  

Lausanne, EPFL, 2020. 

2019

Label-free plasmonic biosensors for real-time live cell analysis

X. Li / H. Altug (Dir.)  

Lausanne, EPFL, 2019. 

Modeling hematopoietic stem cell dynamics in bioengineered niches

S. Giger / M. Lütolf (Dir.)  

Lausanne, EPFL, 2019. 

The onset of cardiovascular disease in mice: an image-based, computational-experimental approach

L. Aslanidou / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2019. 

Tailoring the Mechanical Properties of Tissue Engineering Scaffolds made from Decellularized Cartilage

J. Antons / D. Pioletti; L. A. Laurent-Applegate (Dir.)  

Lausanne, EPFL, 2019. 

2D nanopores: fabrication, energy harvesting and field-effect sensing

M. Graf / A. Radenovic (Dir.)  

Lausanne, EPFL, 2019. 

Characterization of Coenzyme Q Biosynthesis Proteins through Integrative Modeling at the Protein-Membrane Interface

D. Aydin / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2019. 

Metabolic and microenvironmental strategies to accelerate hematopoietic recovery post-aplasia

V. Ledebur de Antas de Campos / O. M. Naveiras Torres-Quiroga (Dir.)  

Lausanne, EPFL, 2019. 

Soft multimodal neural interfaces for unravelling sensory neurological circuits

F. P. G. Michoud / S. Lacour (Dir.)  

Lausanne, EPFL, 2019. 

Engineering Dynamic Hydrogels For In Vitro Organoid Culture

D. L. P. Blondel / M. Lütolf (Dir.)  

Lausanne, EPFL, 2019. 

Integrated microfluidic tools for the characterization of protein/DNA interactions in vitro and in vivo

R. Dainese / B. Deplancke (Dir.)  

Lausanne, EPFL, 2019. 

Application of anti-amyloid beta immunization using encapsulated cell technology in mouse models of Alzheimer’s disease

V. Laversenne / B. Schneider; P. Aebischer (Dir.)  

Lausanne, EPFL, 2019. 

Structural and functional characterisation of the KRAB-domain associated protein 1

G. Fonti / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2019. 

Bioengineering human bone marrow models to elucidate the triggers of the stem cell niche

Q. Vallmajó Martín / M. Lütolf; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2019. 

Anti-angiogenic immunotherapy for lung cancer

E. Kadioglu / M. De Palma (Dir.)  

Lausanne, EPFL, 2019. 

Bioengineering the Human Muscle Stem-Cell Niche for Therapeutic Applications

O. Mashinchian / J. Feige; M. Lütolf (Dir.)  

Lausanne, EPFL, 2019. 

Optical projection tomography for whole organ imaging

D. Nguyen / T. Lasser; D. N. A. Van De Ville (Dir.)  

Lausanne, EPFL, 2019. 

The role of OCT4 and SOX2 in regulating chromatin accessibility and cell fate across the cell cycle in embryonic stem cells

T. E. Friman / D. M. Suter (Dir.)  

Lausanne, EPFL, 2019. 

Microchannel-based technologies for nerve interfacing

S. Gribi / S. Lacour (Dir.)  

Lausanne, EPFL, 2019. 

Expanding beyond the natural protein repertoire to engineer targeted vaccines and diagnostics

F. Sesterhenn / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2019. 

Elucidating regulatory mechanisms shaping the transcriptome and proteome of the gut immune response in Drosophila melanogaster

M. V. Frochaux / B. Deplancke (Dir.)  

Lausanne, EPFL, 2019. 

Single-cell studies of Mycobacterium smegmatis cell cycle using time-lapse fluorescence microscopy

J. X. Y. Ven / J. McKinney (Dir.)  

Lausanne, EPFL, 2019. 

Tissue-specific circadian transcriptional regulation

J. Yeung / F. Naef (Dir.)  

Lausanne, EPFL, 2019. 

2018

Quantitative analysis of SOX2 and OCT4 expression in pluripotency and differentiation

D. Strebinger / D. M. Suter (Dir.)  

Lausanne, EPFL, 2018. 

In vitro fate mapping of stem cell development at the single cell level

V. Trachsel / M. Lütolf (Dir.)  

Lausanne, EPFL, 2018. 

Likelihood-free Inference of Population Genetic Parameters from Time-Sampled Genetic Data

H. Shim / F. G. van der Goot Grunberg (Dir.)  

Lausanne, EPFL, 2018. 

Quantitative single cell dynamics of signaling and transcriptional response in mammalian cells

O. Tidin / D. M. Suter; F. Naef (Dir.)  

Lausanne, EPFL, 2018. 

Quantitative analysis of gene expression and transcriptional memory in mouse embryonic stem cells

A. Mandic / D. M. Suter (Dir.)  

Lausanne, EPFL, 2018. 

More Medicines for Tuberculosis: Fuelling Drug Discovery against Mycobacterium tuberculosis

S-Y. C. Foo / S. Cole (Dir.)  

Lausanne, EPFL, 2018. 

Computational and Statistical analyses of Molecular Evolution and Demography using Large-scale Sequencing Data

A. Kapopoulou / B. Deplancke; J. D. Jensen (Dir.)  

Lausanne, EPFL, 2018. 

Mid-Infrared plasmonic nanoantennas for ultrasensitive detection of proteins and their secondary structure

D. Etezadi / H. Altug (Dir.)  

Lausanne, EPFL, 2018. 

Circadian clock- and feeding-dependent regulation of translation initiation and elongation in the liver

C. A. Gobet / F. Naef; K. Sakamoto (Dir.)  

Lausanne, EPFL, 2018. 

New roles of the lymphatic endothelium in modulating adaptive immunity: implications for immune tolerance and cancer immunotherapy

L. C. F. Potin / M. Swartz; D. Hanahan (Dir.)  

Lausanne, EPFL, 2018. 

Single-cell division and killing dynamics of bacteria exposed to isocratic and time-dependent concentrations of antibiotic

K. E. Schneider / J. McKinney; N. Dhar (Dir.)  

Lausanne, EPFL, 2018. 

Electronic dura mater soft, multimodal neural interfaces : technology, integration and implementation to surface implants

A. E. Hirsch / S. Lacour (Dir.)  

Lausanne, EPFL, 2018. 

Novel tools to dissect stem cell metabolism at single cell level

G. Nikitin / M. Lütolf; A. Meibom (Dir.)  

Lausanne, EPFL, 2018. 

Modeling and analysis of parts and devices of genetic regulation

Y. Berset / V. Hatzimanikatis; J. R. van der Meer (Dir.)  

Lausanne, EPFL, 2018. 

Constrained optimization applied to multiscale integrative modeling

G. E. Tamo / M. Dal Peraro (Dir.)  

EPFL, 2018. 

Introducing tolerance to foreign and partly foreign proteins by erythrocyte binding and artificial glycosylations

K. L. Brünggel / M. Lütolf; J. A. Hubbell (Dir.)  

EPFL, 2018. 

The phenotypic impact of naturally occurring genetic and molecular mitochondrial variation in a Drosophila Genetic Reference Population

R. P. J. Bevers / B. Deplancke (Dir.)  

Lausanne, EPFL, 2018. 

What is the role of fish intestine as environment-organism barrier? Mechanistic investigations using fish intestinal cells on a chip

C. Drieschner / P. Renaud; K. Schirmer (Dir.)  

Lausanne, EPFL, 2018. 

Development of microfluidic tools and methods for the biochemical characterization of scFv and Cas9 affinity reagents and their applications in molecular detection

E. E. Petrova / S. Maerkl (Dir.)  

Lausanne, EPFL, 2018. 

Ultra high magnetic field for glial contribution into brain metabolism studied by MR spectroscopy and CEST methods for molecular imaging of glycogen

E. M. C. Vinckenbosch / R. Gruetter (Dir.)  

Lausanne, EPFL, 2018. 

Advancing immunotherapy for HPV-related cancers: Improving therapeutic vaccination approaches and understanding the immunosuppressive role of myeloid cells

G. Galliverti / M. Swartz; D. Hanahan (Dir.)  

Lausanne, EPFL, 2018. 

Genetic determinants of healthy human immune variance: from humoral response to microbiome diversity

P. Scepanovic / J. Fellay; B. Deplancke (Dir.)  

Lausanne, EPFL, 2018. 

Mitochondrial stress signalling and its impacts on physiology

A. J. L. Mottis / J. Auwerx (Dir.)  

Lausanne, EPFL, 2018. 

2017

A Microfluidic Brain Interface for In Vivo Recording of Neurochemical Activity

G. C. Y. Petitpierre / P. Renaud (Dir.)  

Lausanne, EPFL, 2017. 

In vitro modeling of complex microenvironmental regulation of stem cells

Y. Tabata / M. Lütolf (Dir.)  

Lausanne, EPFL, 2017. 

The therapeutic role of NAD+ modulation in fatty liver disease

K. L. Gariani / J. Auwerx (Dir.)  

Lausanne, EPFL, 2017. 

Advanced technologies to control stem-cell based organogenesis

N. Brandenberg / M. Lütolf (Dir.)  

Lausanne, EPFL, 2017. 

Investigating the Biological Mechanisms underlying the Initiation of Autoimmunity against Beta Cell Antigens in Type 1 Diabetes

C. Cianciaruso / J. A. Hubbell; S. Baekkeskov Hanahan (Dir.)  

Lausanne, EPFL, 2017. 

AAV based gene therapy for rare diseases : targeting astrocytes for functional recovery in Amyotrophic Lateral Sclerosis

C. C. Rochat / P. Aebischer; B. Schneider (Dir.)  

Lausanne, EPFL, 2017. 

Novel systems biology approaches for design and analysis of palmitoylation networks reveal its regulatory effects on protein stability, activity and localization

T. Dallavilla / V. Hatzimanikatis; F. G. van der Goot Grunberg (Dir.)  

Lausanne, EPFL, 2017. 

The role of the polyglutamine and N-terminal domains in regulating the aggregation and structural properties of Huntingtin Exon 1

S. Vieweg / H. Lashuel (Dir.)  

Lausanne, EPFL, 2017. 

Cell lineage tracing in human tissues using somatic mitochondrial mutations

P. Refinetti / S. Morgenthaler; P. O. Ekstrom (Dir.)  

Lausanne, EPFL, 2017. 

A Microfluidic Platform Enables Large-Scale Single-Cell Screening to Identify Genes Involved in Bacterial Persistence

A. Verpoorte / J. McKinney; S. Maerkl (Dir.)  

Lausanne, EPFL, 2017. 

Elucidating the role of lymphatic vessels within the tumor microenvironment of breast cancer

I. M. van Mier / M. Swartz; M. De Palma (Dir.)  

Lausanne, EPFL, 2017. 

Gene regulatory dynamics underlying brown fat cell differentiation

R. N. Pradhan / B. Deplancke (Dir.)  

Lausanne, EPFL, 2017. 

Deciphering the subcapsular epithelial cells in human fetal and postnatal thymus

D. S. E. Hemon / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2017. 

Group Decisions Influence Emergence and Regulation of Leaders during Collective Migration of Epithelial Cells

M. Vishwakarma / J. A. Hubbell; J. Spatz (Dir.)  

Lausanne, EPFL, 2017. 

Nanocapillaries combined with optical tweezers as a single molecule technique for studying DNA-protein complexes

R. Bulushev / A. Radenovic (Dir.)  

Lausanne, EPFL, 2017. 

Inferring the age and strength of mutations evolving under positive selection

N. L. Ormond / J. D. Jensen (Dir.)  

Lausanne, EPFL, 2017. 

Human and eco-toxicological impacts of organometallic halide perovskites

R. I. Benmessaoud / L. Forró; H. Lashuel (Dir.)  

Lausanne, EPFL, 2017. 

Microfluidic platforms for high-throughput mammalian cell printing, transfection, and dosage-dependent studies

K. P. Woodruff / S. Maerkl (Dir.)  

Lausanne, EPFL, 2017. 

Selective electrical and optical neuromodulation of the central nervous system with conformable microfabricated implants

A. A. Guex / S. Lacour (Dir.)  

Lausanne, EPFL, 2017. 

Computational methods and modeling of cellular function for the optimization of protein production and the study of cellular disease states

J. R. Pinto Vieira / V. Hatzimanikatis (Dir.)  

Lausanne, EPFL, 2017. 

Evaluation of oxidation-sensitive polymersomes as vaccine nanocarriers to enhance humoral responses against arenavirus envelope glycoproteins

C. Galan Navarro / M. Dal Peraro; M. Swartz (Dir.)  

Lausanne, EPFL, 2017. 

Role of ACMSD in regulation of NAD+ metabolism and mitochondrial function

E. Katsyuba / J. Auwerx (Dir.)  

Lausanne, EPFL, 2017. 

Lipid membrane characterization with second harmonic scattering : surface potentials, ionization, membrane asymmetry and hydration

C. U. Lütgebaucks / S. Roke (Dir.)  

Lausanne, EPFL, 2017. 

Microfluidic and Electrokinetic Manipulation of Single Cells

S. Kilchenmann / C. Guiducci (Dir.)  

Lausanne, EPFL, 2017. 

Exploring the potency of normal and pathological human thymic epithelial cells

T. M. C. Arlabosse / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2017. 

Regulation of Endoplasmic Reticulum Architecture by Protein S-Palmitoylation

P. A. Sandoz / F. G. van der Goot Grunberg (Dir.)  

Lausanne, EPFL, 2017. 

Fighting preterm birth with novel surgical tools and biomaterials engineering

Y. R. Devaud / M. Lütolf; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2017. 

2016

Host and pathogen genomics of severe pediatric infections

S. Asgari / J. Fellay (Dir.)  

Lausanne, EPFL, 2016. 

Engineering the Extra Domain A of fibronectin as a vaccine adjuvant and study of its role in tissue regeneration

Z. Julier / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

Protrusion-retraction switches and traction forces in spontaneous cell polarization

A. C. Bornert / A. Verkhovsky (Dir.)  

Lausanne, EPFL, 2016. 

Integrating Gene Synthesis and MITOMI for Rapid Protein Engineering

M. C. Blackburn / S. Maerkl (Dir.)  

Lausanne, EPFL, 2016. 

Unraveling the KRAB/KAP1 control of transposable elements in pluripotent and somatic cells

G. Ecco / D. Trono; P. Turelli (Dir.)  

Lausanne, EPFL, 2016. 

Tunable and cell-responsive 3D poly(ethylene glycol) microenvironments for the development of tissue models

S. E. Metzger / J. A. Hubbell; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2016. 

Mechanical and Functional Study of Cell Physiology at the Nanoscale

P. D. Odermatt / G. Fantner (Dir.)  

Lausanne, EPFL, 2016. 

Stem cell niche engineering through photopatterning and microfluidics

L. Kolb / M. Lütolf (Dir.)  

Lausanne, EPFL, 2016. 

Mechanisms of tolerance induction by erythrocyte-targeted antigens

A. J. Grimm / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

Allosteric regulation and targeting of Abl SH2-kinase interface and other cytoplasmic tyrosine kinases

A. J. Lamontanara / O. Hantschel (Dir.)  

Lausanne, EPFL, 2016. 

In vivo mechanical loading combined with cell therapy in a bone tissue engineering scaffold

T. C. Hausherr / D. Pioletti (Dir.)  

Lausanne, EPFL, 2016. 

Metabolic control of muscle and muscle stem cell function

H. Zhang / J. Auwerx (Dir.)  

Lausanne, EPFL, 2016. 

Microwell and impedance-based approaches to isolate single cells for life sciences

G. Muller / Y. Barrandon; P. Renaud (Dir.)  

Lausanne, EPFL, 2016. 

Nanoscopy in nonlinear scanning fluorescence imaging systems

G. P. J. Laporte / D. Psaltis (Dir.)  

Lausanne, EPFL, 2016. 

Engineering nanoparticle-based vaccines: Implications for the quality of humoral and cellular immunity

M. Rincón-Restrepo / M. Swartz; S. Hirosue (Dir.)  

Lausanne, EPFL, 2016. 

Mitochondrial unfolded protein response, its molecular mechanism and physiological impact

V. Jovaisaite / J. Auwerx (Dir.)  

Lausanne, EPFL, 2016. 

Bioengineering approaches in immunotherapy : from basic to translational applications

M. Damo / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

Role of microRNAs in tumor-associated macrophages

C. M. Baer / M. De Palma (Dir.)  

Lausanne, EPFL, 2016. 

Therapeutic Proteins Engineered for Super-Affinity to the Extracellular Matrix in Regenerative Medicine

P. S. M. Briquez / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

Microdevices for Locomotion in Complex Biological Fluids

T. Qiu / J. A. Hubbell; P. Fischer (Dir.)  

Lausanne, EPFL, 2016. 

Deciphering the Role of LRH-1 in Liver Intermediary Metabolism and Cancer

P. Xu / K. Schoonjans (Dir.)  

Lausanne, EPFL, 2016. 

Engineering Lymphangiogenesis : Implications for Cancer Immunotherapy and Beyond

M. A. Fankhauser / M. Swartz (Dir.)  

Lausanne, EPFL, 2016. 

From the early steps of whisker formation to its evolutionary disappearance: the (curious) case of Prdm1 and its regulation

P. G. Manti / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2016. 

Quantitative Single-Cell Analysis of Host-Pathogen Interactions

M. J-H. Delincé / J. McKinney (Dir.)  

Lausanne, EPFL, 2016. 

Instrumented shoes for daily activity monitoring in healthy and at risk populations

C. Moufawad El Achkar / K. Aminian (Dir.)  

Lausanne, EPFL, 2016. 

Towards brain-on-a-chip : microfluidic and microelectrode array platforms for morphological and electrophysiological observations on the propagation of Alzheimer’s disease

Y. Ren / P. Renaud (Dir.)  

Lausanne, EPFL, 2016. 

New immunomodulatory roles of lymphatic endothelium and implications for immunotherapy

E. Vokali / M. Swartz (Dir.)  

Lausanne, EPFL, 2016. 

Protein engineering approaches for direct antigen targeting in CD8+ T cell inducing vaccines

V. Panagiotou / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

BCI based on Neural Correlates of Anticipatory Behavior during Driving

Z. Khaliliardali / J. d. R. Millán Ruiz (Dir.)  

Lausanne, EPFL, 2016. 

Novel interventions to recover the regenerative capacity of aged skeletal muscle by targeting the interactions in the stem cell niche

L. Lukjanenko / J. Feige; J. Auwerx (Dir.)  

Lausanne, EPFL, 2016. 

2015

Microfluidic engineering of artificial stem cell niches

S. Allazetta / M. Lütolf (Dir.)  

Lausanne, EPFL, 2015. 

Transposable elements and their KRAB/KAP1 controllers broadly regulate transcription in adult human cells

F. Marzetta / D. Trono; P. Turelli (Dir.)  

Lausanne, EPFL, 2015. 

Interactions of Peripheral Nerve Cells with Soft Micropillar Interfaces

C. X. Paulou / S. Lacour (Dir.)  

Lausanne, EPFL, 2015. 

Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson’s Disease

M-B. Fares / H. Lashuel (Dir.)  

Lausanne, EPFL, 2015. 

Connectivity Analysis of Brain States and Applications in Brain-Computer Interfaces

H. Zhang / J. d. R. Millán Ruiz (Dir.)  

Lausanne, EPFL, 2015. 

Bio-engineered collagen-fibrin scaffolds for enhancing urological tissue regeneration

E. Vardar / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2015. 

Bioengineering approaches to emulate the stem cell niche

S. Höhnel / M. Lütolf (Dir.)  

Lausanne, EPFL, 2015. 

Deciphering Metabolic Regulation of Hematopoietic Stem Cell Fate

M. Girotra / M. Lütolf (Dir.)  

Lausanne, EPFL, 2015. 

Superresolution Reconstruction for Magnetic Resonance Spectroscopic Imaging Exploiting Low-Rank Spatio-Spectral Structure

J. A. Kasten / D. Van De Ville; F. Lazeyras (Dir.)  

Lausanne, EPFL, 2015. 

Study of transposon-mediated cell pool and cell line generation in CHO cells

S. Balasubramanian / F. M. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2015. 

Quantitative single-cell analysis of S. cerevisiae using a microfluidic live-cell imaging platform

J. Becker / F. Naef; S. Maerkl (Dir.)  

Lausanne, EPFL, 2015. 

Functional Perturbation of the Gab2 Multiprotein Complex by High-affinity SH2-binding Monobodies in Chronic Myelogenous Leukemia

E. B. Gencer Akçok / O. Hantschel (Dir.)  

Lausanne, EPFL, 2015. 

Modeling and Engineering Proteins Thermostability

H. Pezeshgi Modarres / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2015. 

Reconstruction and systems analysis of metabolism in apicomplexan parasites Toxoplasma gondii and Plasmodium falciparum

S. Tymoshenko / V. Hatzimanikatis; D. Soldati-Favre (Dir.)  

Lausanne, EPFL, 2015. 

Tissue engineering for prenatal applications

A-S. J. Kiveliö / J. A. Hubbell; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2015. 

Implementation and Characterization of Dynamic Genetic Networks in Vitro

H. M. Niederholtmeyer / S. Maerkl (Dir.)  

Lausanne, EPFL, 2015. 

Quantification of low molecular weight drugs : from the selection of nucleic acid-based capture molecules to the characterization in patient samples

A. Ferretti / C. Guiducci (Dir.)  

Lausanne, EPFL, 2015. 

Analytical Methods, Correlative Microscopy and Software Tools for Quantitative Single Molecule Localization Microscopy

A. Shivanandan / A. Radenovic; I. Sbalzarini (Dir.)  

Lausanne, EPFL, 2015. 

2014

Active Transport Mechanisms by Lymphatic Endothelium and their Modulation by Inflammatory Mediators

V. Triacca / M. Swartz (Dir.)  

Lausanne, EPFL, 2014. 

Development of plasmid-based expression technology for rapid and sustained production of recombinant proteins in insect cells

X. Shen / F. M. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2014. 

The Effectual Hitchhiker : Mechanisms and Consequences of Interactions Between Endosymbiotic Spiroplasma and Host Drosophila

J. K. Herren / B. Lemaître (Dir.)  

Lausanne, EPFL, 2014. 

Engineering adjuvants for prophylactic and therapeutic subunit vaccines

A. de Titta / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2014. 

Experimental and theoretical studies on the effects of smooth muscle on the mechanical response and remodeling of arteries

A. Agianniotis / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2014. 

Genetic analysis of the decaprenyl-phospho-D-arabinofuranose pathway in Mycobacterium tuberculosis

G. S. Kolly / S. Cole (Dir.)  

Lausanne, EPFL, 2014. 

New Tools for Hydrogel-Based 3D Bioprinting

A. Negro / M. Lütolf (Dir.)  

Lausanne, EPFL, 2014. 

Thermal gradients on a chip for the local stimulation of biological systems

S. Delasoie-Baranek / P. Renaud (Dir.)  

Lausanne, EPFL, 2014. 

An integrative genomics approach toward deciphering the regulatory logic of phase-specific circadian transcription in the mouse liver

I. Krier / B. Deplancke; J. Rougemont (Dir.)  

Lausanne, EPFL, 2014. 

The Engineering of a Scalable Disposable Orbitally Shaken Bioreactor System for Animal Cell Cultivation and Therapeutic Protein Production

D. T. Monteil Jr / F. M. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2014. 

Pharmacological and biochemical assessment of γ-secretase-mediated APP processing involved in Alzheimer’s disease

M. Dimitrov / P. Fraering (Dir.)  

Lausanne, EPFL, 2014. 

The regulatory circuit of natural competence for transformation in the human pathogen Vibrio cholerae

M. Lo Scrudato / M. Blokesch (Dir.)  

Lausanne, EPFL, 2014. 

Dynamic brain networks explored by structure-revealing methods

N. Leonardi / D. Van De Ville (Dir.)  

Lausanne, EPFL, 2014. 

Automated long-term single cell analysis of Schizosaccharomyces pombe on a microfluidic microchemostat array

J-B. Nobs / S. Maerkl (Dir.)  

Lausanne, EPFL, 2014. 

Engineering lymphangiogenesis : methods, characterization and functional consequences

E. Güç / M. Swartz (Dir.)  

Lausanne, EPFL, 2014. 

Direct Somatic Cell Reprogramming in Synthetic 3D Microenvironments

Y. Okawa / M. Lütolf (Dir.)  

Lausanne, EPFL, 2014. 

Label-free Analytics by Transmission Localized-SPR and its Application to Small Molecules Monitoring in Serum

G. Cappi / C. Guiducci; L. Benini (Dir.)  

Lausanne, EPFL, 2014. 

A New Noninvasively Adjustable Glaucoma Drainage Device

A. Villamarin / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2014. 

Engineering the lymphatic microenvironment for investigating tumor invasion, immune cell traficking and parasite infection under relevant biomechanical conditions

M. Pisano / M. Swartz (Dir.)  

Lausanne, EPFL, 2014. 

Dissecting the DNA binding principles of transcription factor monomers and heterodimers

A. Isakova / B. Deplancke (Dir.)  

Lausanne, EPFL, 2014. 

Novel non-invasive techniques for hemodynamic monitoring

O. Vardoulis / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2014. 

A Systems Approach to Identify Genetic and Environmental Regulators of Metabolism

E. G. Williams / J. Auwerx (Dir.)  

Lausanne, EPFL, 2014. 

Reversible attachment of Cell-Penetrating Peptides for the efficient delivery of α-synuclein to HeLa cells and primary cortical neurons

C. Desobry / H. Lashuel (Dir.)  

Lausanne, EPFL, 2014. 

In vitro Fate Mapping of Single Hematopoietic Stem Cells

A. Roch / M. Lütolf (Dir.)  

Lausanne, EPFL, 2014. 

A systems approach to elucidate the genetic architecture of molecular phenotypes

S. M. Waszak / B. Deplancke (Dir.)  

Lausanne, EPFL, 2014. 

From Genes to Organisms : Bioinformatics System Models and Software

T. Schaffter / D. Floreano; M. Affolter (Dir.)  

Lausanne, EPFL, 2014. 

Development of a Bisphosphonate Delivering Hydrogel for the Augmentation of Impaired Peri-Implant Bone

U. Kettenberger / D. Pioletti (Dir.)  

Lausanne, EPFL, 2014. 

Modeling of transcription mechanisms in mammals from kinetic measurements in single cells

B. Zoller / F. Naef (Dir.)  

Lausanne, EPFL, 2014. 

Tissue Engineering Bone by Matrix-Assisted MSC Recruitment

P. S. Lienemann / M. Lütolf; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2014. 

Structure-function analysis of the EspR virulence regulator of Mycobacterium tuberculosis

B. Blasco / S. Cole (Dir.)  

Lausanne, EPFL, 2014. 

Subject-specific computational fluid dynamics modelling and measurement of cerebrospinal fluid motion in the cervical spine

T. Yiallourou / N. Stergiopulos; B. A. Martin (Dir.)  

Lausanne, EPFL, 2014. 

2013

Discovery and functional characterisation of structural genomic variation in a natural population

A. Massouras / B. Deplancke (Dir.)  

Lausanne, EPFL, 2013. 

Systematic Analysis of Yeast Gene Expression by Synthetic Promoter Libraries

A. S. Rajkumar / S. Maerkl (Dir.)  

Lausanne, EPFL, 2013. 

Temperature impacts human epidermal stem cell behaviour through thermoTRPs and mTOR signalling

J. A. Mosig Rodriguez / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2013. 

Generating microarrays for protein interaction studies using microfluidic devices

S. Rockel / S. Maerkl (Dir.)  

Lausanne, EPFL, 2013. 

Development of Novel Nanoparticle-Based Vaccines and Immunotherapies : Tuberculosis, Lung Metastasis and Allergy as Models

M. Ballester / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2013. 

Identification of genetic determinants and pharmacological modulators of mitochondrial function

P. Andreux / J. Auwerx (Dir.)  

Lausanne, EPFL, 2013. 

The Phosphate Specific Transport (Pst) System in Fast- and Slow-Growing Mycobacteria

C. De Piano / J. McKinney (Dir.)  

Lausanne, EPFL, 2013. 

Engineering nanoparticle vaccines : design principles for lymphatic targeting

S. Raghunathan / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2013. 

Multiscale simulations of protein dynamics

E. Spiga / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2013. 

The Use of Valproic Acid in Transient Gene Expression with HEK-293E Cells

D. Kiseljak / F. M. Wurm (Dir.)  

Lausanne, EPFL, 2013. 

Flexible Micro/Nanofabricated Systems for Medical Devices and Implants

W. Hasenkamp Carreira / P. Renaud (Dir.)  

Lausanne, EPFL, 2013. 

Dissipation as variable in cartilage mechanobiology

P. Abdel-Sayed / D. Pioletti (Dir.)  

Lausanne, EPFL, 2013. 

Systems Biology of 3D Stem Cell-Niche Interactions

A. Ranga / M. Lutolf (Dir.)  

Lausanne, EPFL, 2013. 

Development and application of experimental tools to elucidate the gene regulatory network underlying adipogenesis

C. Delattre-Gubelmann / B. Deplancke (Dir.)  

Lausanne, EPFL, 2013. 

Control of calcification in a biphasic osteochondral construct and enhancing interface integration

J. Hollenstein / D. Pioletti; R. L-Y. Sah (Dir.)  

Lausanne, EPFL, 2013. 

Molecular Modeling of Membrane Embedded Proteins

T. Lemmin / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2013. 

A microfluidic live-cell imaging platform to study large collections of microbial genotypes

N. Dénervaud / S. Maerkl; F. Naef (Dir.)  

Lausanne, EPFL, 2013. 

Role of the bile acid membrane receptor TGR5 in macrophages and metabolism

M. Nomura / J. Auwerx; K. Schoonjans (Dir.)  

Lausanne, EPFL, 2013. 

Metabolic modeling and experimental studies on carbon and energy metabolism of Mycobacterium tuberculosis

M. E. Özdemir / J. McKinney; V. Hatzimanikatis (Dir.)  

Lausanne, EPFL, 2013. 

Targeting and Modulating Tumor-Associated Sites with Novel Nanoparticle-Based Immunotherapies

L. Jeanbart / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2013. 

Computational Studies on Cellular Bioenergetics

K. C. Soh / V. Hatzimanikatis (Dir.)  

Lausanne, EPFL, 2013. 

Structure and function of proteins involved in attachment and piercing of the bacterial cell envelope

L. Sycheva / P. Leiman (Dir.)  

Lausanne, EPFL, 2013. 

A Simple High Yielding Transient Gene Expression System for CHO Cells

Y. Rajendra / F. M. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2013. 

Epiphyseal Chondro-Progenitor Cell Therapy For Articular Cartilage Regeneration

S. E. Darwiche / D. Pioletti; L. A. Laurent-Applegate (Dir.)  

Lausanne, EPFL, 2013. 

2012

Hydrogel Microfluidics to Control Stem Cell Fate

S. Cosson / M. Lutolf (Dir.)  

Lausanne, EPFL, 2012. 

Single-Cell Analysis of Mycobacterial Persistence Using Microfabricated Tools

M. Elitas / J. McKinney; S. Maerkl (Dir.)  

Lausanne, EPFL, 2012. 

Early Fate Choice Determines in vivo Engraftment and in vitro Behavior of Epidermal Stem Cells

F. Gorostidi / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2012. 

Therapeutic Immunomodulation of the Lymphoid-like Tumor Environment Using Nanoparticulate Formulations

I. Kourtis / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2012. 

Photopatterning of Synthetic Hydrogels

K. Mosiewicz / M. Lutolf (Dir.)  

Lausanne, EPFL, 2012. 

Nanopore sensing of single molecules application to RNAP-DNA complexes, fabrication of graphene-nanopore devices and translocation algorithm analysis

C. Raillon / A. Radenovic; N. Hernandez (Dir.)  

Lausanne, EPFL, 2012. 

Immune Engineering Via Differential Antigen Carriers and Co-Stimulatory Molecules

J. Eby / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2012. 

Toxicity study of nanostructures

L. Horváth / L. Forró; B. Schwaller (Dir.)  

Lausanne, EPFL, 2012. 

Molecular and Functional Characterization of Clonogenic Human Thymic Epithelial Cells

M. Maggioni / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2012. 

Improving Immunogenicity of Subunit Vaccines Using Nanocarrier Systems

A. Stano / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2012. 

Genomics and transcriptomics of the Mycobacterium tuberculosis complex

S. Uplekar / S. Cole; J. Rougemont (Dir.)  

Lausanne, EPFL, 2012. 

Structural Studies and Protein Engineering of Human O6-Alkylguanine-DNA Alkyltransferase

B. Mollwitz / K. Johnsson (Dir.)  

Lausanne, EPFL, 2012. 

Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

F. Zagari / F. Wurm; M. Jordan (Dir.)  

Lausanne, EPFL, 2012. 

Microtechnologies to Map the Fate of Single Stem Cells and their Progeny

S. Kobel / M. Lutolf; P. Renaud (Dir.)  

Lausanne, EPFL, 2012. 

Dissecting Gene Regulatory Networks Using Targeted Quantitative Proteomics

J. Simicevic / B. Deplancke (Dir.)  

Lausanne, EPFL, 2012. 

Culture and Characterization of Human and Porcine Urothelial Progenitor Cells

H. M. Larsson / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2012. 

Elucidating the role of post-translational modifications of alpha-synuclein using semisynthesis : phosphorylation at Tyrosine 125 and monoubiquitination at Lysine 6

M. Hejjaoui / H. Lashuel (Dir.)  

Lausanne, EPFL, 2012. 

KRAB/KAP1 Regulation of Embryonic Stem Cell Pluripotent Self-renewal

A. Corsinotti / D. Trono (Dir.)  

Lausanne, EPFL, 2012. 

Molecular Modeling of Bacterial Nanomachineries

M. T. Degiacomi / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2012. 

2011

Molecular Mechanisms Underlying Hyaline Fibromatosis Syndrome

J. Deuquet Ariosa / F. G. v. d. Goot Grunberg (Dir.)  

Lausanne, EPFL, 2011. 

Studies on KRAB/KAP1-Mediated Transcriptional Repression

A. C. Groner / D. Trono (Dir.)  

Lausanne, EPFL, 2011. 

Pressure and Flow Wave Propagation in Patient-Specific Models of the Arterial Tree

P. Reymond / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2011. 

In Vivo Studies on the Control of Gene Expression and Protein Degradation

K. Bojkowska / K. Johnsson; D. Trono (Dir.)  

Lausanne, EPFL, 2011. 

Identification and Functional Response of “Interstitial Cells of Cajal”-like Cells from Rat Mesenteric Artery

A. Formey de Saint Louvent / J-J. Meister; J-L. Bény (Dir.)  

Lausanne, EPFL, 2011. 

On the Precision of Circadian Oscillators

T. D’Eysmond / F. Naef (Dir.)  

Lausanne, EPFL, 2011. 

The Role of LEKTI in the Fate Determination of Keratinocyte Stem Cells

A. W. Amici / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2011. 

Hydrogels for Urinary Tract Tissue Engineering

L. A. Micol / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2011. 

Engineering Erythrocyte Affinity for Improved Pharmacokinetics and Immune Tolerogenesis

S. Kontos / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2011. 

Force Transmission in Migrating Cells

M. Fournier / A. Verkhovski (Dir.)  

Lausanne, EPFL, 2011. 

Assessment of Body Motion and Muscle Weakness : Outcome Evaluation in Frail Elderly and DMD Subjects

R. L. Ganea / K. Aminian (Dir.)  

Lausanne, EPFL, 2011. 

Cellular Responses to Bacterial Pore-Forming Toxins

R. M. Gonzalez / F. G. v. d. Goot Grunberg (Dir.)  

Lausanne, EPFL, 2011. 

In vitro lymphatic endothelial morphogenesis : molecular vs. biophysical regulation

C. Yong Pullin / M. Swartz (Dir.)  

Lausanne, EPFL, 2011. 

New/Surface-Modified Biocompatible Polymer for ICD Lead Insulation

R. B. Pisarek / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2011. 

Folding and Structure of the Pore Forming Toxin Aerolysin

M. I. Iacovache / F. G. v. d. Goot Grunberg (Dir.)  

Lausanne, EPFL, 2011. 

Biofunctional Scaffold Design for Soft Tissue Regeneration

K. Lorentz / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2011. 

OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up

S. Tissot / F. Wurm (Dir.)  

Lausanne, EPFL, 2011. 

Engineering of Signaling Microenvironments with Fibronectin Domains to Enhance Tissue Regeneration

M. Martino / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2011. 

2010

Identification of genetic insulator elements to increase the safety of viral gene therapy vectors

A. Gaussin / J. A. Hubbell; N. Mermod (Dir.)  

Lausanne, EPFL, 2010. 

Genomic Context and KRAB/KAP1-mediated Transcriptional Repression

S. Meylan / D. Trono (Dir.)  

Lausanne, EPFL, 2010. 

Arterial remodeling using a constituent-based approach

A. Tsamis / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2010. 

The Interplay between Cytidine Deaminases, HIV and Domesticated Genetic Parasites

Y. Bulliard / D. Trono (Dir.)  

Lausanne, EPFL, 2010. 

Biomechanics of Vascular Wall : the Role of Structural Organization of Elastin and Collagen

R. Saitta-Rezakhaniha / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2010. 

Rat bladder muscle regeneration induced by local delivery of an engineered insulin-like growth factor 1 in fibrin gels

L. Yang / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2010. 

Small Molecule Based Approaches to Inhibit Macrophage Migration Inhibitory Factor (MIF) Activities and Elucidate its Role in Health and Disease

H. Ouertatani-Sakouhi / H. Lashuel (Dir.)  

Lausanne, EPFL, 2010. 

Ambulatory Assessment of Foot Kinematics and Kinetics : Outcome Evaluation of Ankle Osteoarthritis Treatments

H. Rouhani / K. Aminian (Dir.)  

Lausanne, EPFL, 2010. 

Biophysical Regulation of Lymphatic Vessel Function : Flow as a Mediator of Immune Cell and Fluid Transport

D. Miteva / M. Swartz (Dir.)  

Lausanne, EPFL, 2010. 

Dendritic cell chemotaxis in 3D : new tools and insights

U. Haessler / M. Swartz (Dir.)  

Lausanne, EPFL, 2010. 

Elucidating the Role of Quaternary Structure in Modulating Macrophage Migration Inhibitory Factor (MIF) Functions

F. El Turk / H. Lashuel (Dir.)  

Lausanne, EPFL, 2010. 

Transient Gene Expression in HEK-293E Cells for Recombinant Protein Production : Process Characterization towards GMP Approval

S. Nallet / F. Wurm (Dir.)  

Lausanne, EPFL, 2010. 

Innate Barriers to Genome Invasion : how TRIM5a Restricts Retroelements

P. Maillard / D. Trono (Dir.)  

Lausanne, EPFL, 2010. 

Lentiviral Vector-Mediated Gene Delivery for the Generation of Chinese Hamster Ovary Cell Lines with Improved Productivity and Stability

A. Oberbek / F. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2010. 

2009

Investigation of novel calcium-related events as suspected contributors to neurodegeneration

N. Rudinskiy / R. Luthi-Carter (Dir.)  

Lausanne, EPFL, 2009. 

The tissue reaction to neuroprostheses

A. Mercanzini / P. Renaud (Dir.)  

Lausanne, EPFL, 2009. 

Fetal cells for intervertebral disc regeneration

A. Quintin / D. Pioletti; L. A. Laurent-Applegate (Dir.)  

Lausanne, EPFL, 2009. 

Transient recombinant protein expression in mammalian cells : the role of mRNA level and stability

S. Wulhfard / F. Wurm (Dir.)  

Lausanne, EPFL, 2009. 

Studies on scaffold design for tissue engineering applications : contribution of synthetic, natural and recombinant materials

E-M. Engelhardt / F. Wurm; P. Frey (Dir.)  

Lausanne, EPFL, 2009. 

Orbitally shaken bioreactors for mammalian cell culture : engineering characterization and bioprocess scale-up

X. Zhang / F. Wurm (Dir.)  

Lausanne, EPFL, 2009. 

Peptide ligands for targeting and retention of nanoparticles and protein therapeutics in articular cartilage

D. A. Rothenfluh / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2009. 

Tissue engineering of the bladder : exploiting a 3D hydrogel for modulation of the smooth muscle cell phenotype

C. Adelöw / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2009. 

Protein-binding microarray technology and ChIP-sequencing for the identification of novel targets of the human tumor suppressor AP2[alpha]

J. Kerschgens / J. A. Hubbell; N. Mermod (Dir.)  

Lausanne, EPFL, 2009. 

The role of TIF1 gamma during adult murine hematopoiesis

K. Shakhbazov / F. Radtke; A. Trumpp (Dir.)  

Lausanne, EPFL, 2009. 

Stem cell-based cardiovascular tissue engineering

T. Krähenbühl / J. A. Hubbell; R. S. Langer (Dir.)  

Lausanne, EPFL, 2009. 

Studies on lentiviral-mediated transgenesis

M-O. Sauvain / D. Trono (Dir.)  

Lausanne, EPFL, 2009. 

The interplay between the VEGF-C/VEGFR-3 axis and CCL21/CCR7 axis in tumor cell invasion

A. Issa / M. Swartz (Dir.)  

Lausanne, EPFL, 2009. 

Differential effects of reduced cyclic stretch and perturbed shear stress within the arterial wall

T. Thacher / N. Stergiopulos; R. F. d. Silva (Dir.)  

Lausanne, EPFL, 2009. 

Immunoisolated cell implants for intracerebral delivery of anti-Aß single chain Fv antibodies in the APP23 Alzheimer’s mouse model

O. Marroquin Belaunzaran / P. Aebischer (Dir.)  

Lausanne, EPFL, 2009. 

2008

Prevention of micromotion-related periprosthetic bone loss using local release of bisphosphonate : theoretical developments and experimental validations

V. Stadelmann / D. Pioletti (Dir.)  

Lausanne, EPFL, 2008. 

Mechanical orchestration of tissue remodeling

P-J. Wipff / B. Hinz (Dir.)  

Lausanne, EPFL, 2008. 

Molecular and mechanical regulators of lymphatic biology

J. M. Rutkowski / M. Swartz (Dir.)  

Lausanne, EPFL, 2008. 

Effects of base-pair sequence, nicks and gaps on DNA minicircle shapes : analysis and experiment

A. Amzallag / J. H. Maddocks (Dir.)  

Lausanne, EPFL, 2008. 

Accelerating the development time of recombinant mammalian cell lines producing high titers of protein therapeutics

S. Chenuet / F. Wurm (Dir.)  

Lausanne, EPFL, 2008. 

A novel cell culture approach for tissue engineering based on surface expansion

H. Majd / B. Hinz (Dir.)  

Lausanne, EPFL, 2008. 

Tissue engineering complex and mechanically active microenvironments for studies in asthma and cancer

A. A. Tomei / M. Swartz (Dir.)  

Lausanne, EPFL, 2008. 

Development of high-titer transient gene expression processes for manufacturing recombinant proteins

G. Backliwal / F. Wurm (Dir.)  

Lausanne, EPFL, 2008. 

Exploiting immunofunctional nanoparticles as vaccines and synthetic pathogens

S. T. Reddy / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2008. 

Vascular physiology : effects of vascular smooth muscle alteration on arterial wall biomechanics

S. Roy / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2008. 

Role and mechanism of transient receptor potential (TRP) channels in gustatory and chemesthetic sensations associated with dietary molecules

C. Riera / H. Vogel (Dir.)  

Lausanne, EPFL, 2008. 

Polymeric carriers for therapeutic agents : drug and gene delivery systems by reversible addition-fragmentation transfer (RAFT) polymerization

Y. S. Jo / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2008. 

Novel applications of poly(ethylene glycol)-bl-poly(propylene sulfide) block copolymers

C. O’Neil / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2008. 

Development of an in vitro microenvironment for maturing oocytes

J. E. Ihm / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2008. 

2007

Bioreactor processes based on disposable materials for the production of recombinant proteins from mammalian cells

M. Stettler / F. Wurm (Dir.)  

Lausanne, EPFL, 2007. 

Effects of dynamic environments on extracellular morphogen gradients

M. E. Fleury / M. Swartz (Dir.)  

Lausanne, EPFL, 2007. 

Polynucleotide cytidine deaminases, innate immunity and hepatitis B infection

S. Jost / D. Trono (Dir.)  

Lausanne, EPFL, 2007. 

2005

Development of a novel drug delivery system based on polymeric, thermoresponsive, hydrogel nanoparticles

D. Misirlis / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2005.