EDBB Published theses

It is our pleasure to present the theses undertaken in the frame of the EPFL PhD Program in Biotechnology & Bioengineering.

2026

From Functional Genomics to Tissue Models: Investigating Pseudomonas aeruginosa-Macrophage Interactions

T. Distler / A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2026. 

Mechanoadaptation of bacterial physiology and antibiotic tolerance in confined environments

S. M. Kuppanda Jafri / A. L. A. Persat; M. S. Sakar (Dir.)  

Lausanne, EPFL, 2026. 

Quantitative Holographic Imaging for Single-Cell Phenotyping in a Microfluidic System

J. A. Vasquez Porto Viso / B. Deplancke (Dir.)  

Lausanne, EPFL, 2026. 

Advanced human lung organoids-on-a-chip to model epithelial-immune responses to viral infection

Y. Tinguely / M. Lütolf; L. Tang (Dir.)  

Lausanne, EPFL, 2026. 

Plasmonic Nanostructure Biosensors for Continuous Monitoring and Multiplexed Profiling with Ultra-Broad Dynamic Range

A. Saateh / H. Altug (Dir.)  

Lausanne, EPFL, 2026. 

From Phase to Fate: Multi-Modal Characterisation of Cell Cycle Dynamics and Their Role in Early Development

M. Leonardi / F. Naef (Dir.)  

Lausanne, EPFL, 2026. 

Reprogramming GPCR Specificity: Engineering CXCR2 for Selective CXCL5 Binding and Cellular Signaling

A. P. Rico Villarreal / P. D. Barth (Dir.)  

Lausanne, EPFL, 2026. 

Collective organisation of the circadian clock in the intestinal epithelium: insights from an organoid-on-array model

E. Tonin / F. Naef (Dir.)  

Lausanne, EPFL, 2026. 

2025

Multimodal Imaging Platform for Spatiotemporal Interrogation of Dynamics in Single Cells and Spheroids

S. Ansaryan / H. Altug (Dir.)  

Lausanne, EPFL, 2025. 

Rational cytokine and receptor engineering for enhanced safety and efficacy of cancer immunotherapy

L. Bonati / L. Tang; B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2025. 

Gravitational and acoustic micromanipulation platforms for high-content histological analysis of organoids and spheroids

E. Vuille-Dit-Bille / M. S. Sakar; G. Weder (Dir.)  

Lausanne, EPFL, 2025. 

Exploring the Role of Unstable L-Forms in the Survival of Uropathogenic Escherichia coli Under Fosfomycin Exposure

F. Normandeau / J. McKinney; N. Dhar (Dir.)  

Lausanne, EPFL, 2025. 

Computational Design of Protein Switches

S. M. Buckley / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2025. 

PURE system optimization and exploration of self-regeneration for synthetic cell applications

R. Bava Ganesh / S. Maerkl (Dir.)  

Lausanne, EPFL, 2025. 

Experimental Characterization of an Adhesion GPCR Mechanotransduction

G. Gambardella / P. D. Barth; A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2025. 

Heartbeat on repeat: noncanonical KZFP and its transposable element targets shape cardiac cell specification

D. Milovanovic / D. Trono (Dir.)  

Lausanne, EPFL, 2025. 

Translational AI in Digital Health: Applications in Plant Disease Detection, Food Recognition, Postprandial Glycemic Response Forecasting and Musculoskeletal Modeling

S. P. Mohanty / M. Salathé (Dir.)  

Lausanne, EPFL, 2025. 

Towards Conformational Targeting of Alpha-Synuclein Fibrils

A. S. S. Z. M. Sadek / B. E. Ferreira De Sousa Correia; H. Lashuel (Dir.)  

Lausanne, EPFL, 2025. 

Droplet microfluidic platforms for multiplexed library-against-library antibody screening

L. Kolmar / C. Merten (Dir.)  

Lausanne, EPFL, 2025. 

Bioengineering of morphologically and functionally accurate in vitro intestinal models

J. J. Langer / M. Lütolf; K. Schoonjans (Dir.)  

Lausanne, EPFL, 2025. 

Programmable supramolecular nanoarchitectures for targeting biological patterns

A. Kononenko / M. M. C. Bastings (Dir.)  

Lausanne, EPFL, 2025. 

Decoding single-cell heterogeneity and plasticity

W. Liu / B. Deplancke (Dir.)  

Lausanne, EPFL, 2025. 

Next-generation in vitro liver models through stem cell-derived organoids and bioengineering

B. S. Elçi / M. Lütolf; K. Schoonjans (Dir.)  

Lausanne, EPFL, 2025. 

Soft microelectrode arrays for 3D in vitro brain models

E. Martinelli / S. Lacour (Dir.)  

Lausanne, EPFL, 2025. 

Mapping the Operative Space for Polymer-Biostabilized DNA Origami

H. J. Rodríguez Franco / M. M. C. Bastings (Dir.)  

Lausanne, EPFL, 2025. 

Advancing high-resolution microscopes to enable time-lapse nano-characterization of pathogenic micro-organisms in-vitro

E. Braun / J. McKinney; G. Fantner (Dir.)  

Lausanne, EPFL, 2025. 

2024

Bioengineering functional organoid models across scales

T. Hübscher / M. Lütolf (Dir.)  

Lausanne, EPFL, 2024. 

Accessible and highly observable gastrointestinal organoid model systems for studying host-pathogen interactions

M. Hofer / M. Lütolf (Dir.)  

Lausanne, EPFL, 2024. 

Exploring the therapeutic potential of Huntingtin native state stabilization through targeting its interacting partners

E. Morro / H. Lashuel (Dir.)  

Lausanne, EPFL, 2024. 

Quantitative characterization of the inorganic phosphate gene regulatory networks in S. cerevisiae and bottom up engineering an orthogonal gene network

S. Cheng / S. Maerkl (Dir.)  

Lausanne, EPFL, 2024. 

Engineering Split HaloTag for Advanced Fluorescence Microscopy

Y-H. Lin / K. Johnsson (Dir.)  

Lausanne, EPFL, 2024. 

Resolving bacterial cell biology: from replisome dynamics to cell wall synthesis

C. Zhang / S. Manley (Dir.)  

Lausanne, EPFL, 2024. 

Drug Screening in C. elegans to identify new pharmacological mitochondrial stress inducers

A. Lalou / J. Auwerx (Dir.)  

Lausanne, EPFL, 2024. 

Advancing Cell-Free Synthetic Biology: From sustained PURE protein synthesis to an isothermal one-pot DNA replication system

L. S. Grasemann / S. Maerkl (Dir.)  

Lausanne, EPFL, 2024. 

Targeting Cellular Senescence and NAD+ Metabolism Disruption in Early-Stage Chronic Kidney Disease

L. C. Chanvillard / J. Feige; K. Schoonjans (Dir.)  

Lausanne, EPFL, 2024. 

Targeting TDP-43 Proteinopathies in Neurodegeneration by its Native-State Stabilization

L. Yang / H. Lashuel (Dir.)  

Lausanne, EPFL, 2024. 

Multi-motif scaffolding for de novo pathogen antigen mimetics by deep generative learning

K. M. Castro Gilabert / B. Correia (Dir.)  

Lausanne, EPFL, 2024. 

Characterization of the gut-bone marrow axis through bile acid signaling

A. Alonso Calleja / K. Schoonjans; O. M. Naveiras Torres-Quiroga (Dir.)  

Lausanne, EPFL, 2024. 

Advancements in Nanomechanical Characterization and Biomolecular Imaging with Atomic force Microscopy

V. Cencen / G. Fantner (Dir.)  

Lausanne, EPFL, 2024. 

Dielectrophoretic Manipulation of Biological Species: Novel Microfluidic Approaches to Study Cell-Cell Interactions and the Role of Alpha-Synuclein in Neurodegeneration

T. J. Ryser / C. Guiducci; H. Lashuel (Dir.)  

Lausanne, EPFL, 2024. 

Unraveling behavior and cortical signals to guide the development of soft neuroprostheses for auditory restoration and spreading depolarization

E. C. M. Revol / S. Lacour (Dir.)  

Lausanne, EPFL, 2024. 

Single-cell analysis of the interactions between Mycobacterium tuberculosis and macrophages

O. Rutschmann / J. McKinney (Dir.)  

Lausanne, EPFL, 2024. 

Unraveling mitochondrial dynamics: exploring asymmetries and function through advanced microscopy

J. H. B. Winter / S. Manley (Dir.)  

Lausanne, EPFL, 2024. 

The Slc25a47-Wars1 locus: characterization of its role in metabolic homeostasis and stress pathways

F. Pontanari / K. Schoonjans (Dir.)  

Lausanne, EPFL, 2024. 

Exploring ion and analyte transport in beta-barrel forming biological nanopores

S. F. Mayer / M. Dal Peraro; A. Radenovic (Dir.)  

Lausanne, EPFL, 2024. 

Development and evaluation of a near-infrared photovoltaic implant for wireless neural stimulation

D. I. Medagoda / S. Lacour; D. Ghezzi (Dir.)  

Lausanne, EPFL, 2024. 

ER+ breast cancer in 3D scaffold ex vivo for transcriptomics-based functional drug screening and personalized medicine

Y. Zhang / C. Brisken; C. Merten (Dir.)  

Lausanne, EPFL, 2024. 

Engineering novel protein interactions with therapeutic potential using deep learning-guided surface design

A. Marchand / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2024. 

2023

Nanotechnology enabled modulation of T cell immunity for cancer treatment

X. Hu / L. Tang (Dir.)  

Lausanne, EPFL, 2023. 

Label-free plasmonic microarray for multiplexed analysis of cells and tumor organoids

Y-C. Liu / H. Altug (Dir.)  

Lausanne, EPFL, 2023. 

Novel quantitative bioengineered tools to track human bone marrow niche cellular constituents in health and disease

R. Sarkis / B. Deplancke; O. M. Naveiras Torres-Quiroga (Dir.)  

Lausanne, EPFL, 2023. 

Development of new volcano-shaped microelectrodes for single cell electrochemistry, electrophysiology and impedance studies

N. G. Maïno / P. Renaud; A. Bertsch (Dir.)  

Lausanne, EPFL, 2023. 

How are cells instructed to form somite boundaries by the zebrafish segmentation clock?

O. F. Venzin / A. C. Oates (Dir.)  

Lausanne, EPFL, 2023. 

Exploring the interplay of molecular pattern and valency for selective interactions at the bio-interface

K. Paloja / M. M. C. Bastings (Dir.)  

Lausanne, EPFL, 2023. 

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

X. Li / J. Auwerx (Dir.)  

Lausanne, EPFL, 2023. 

Cross-anatomical single-cell definition and characterization of human adipose progenitor niche

R. Ferrero / B. Deplancke (Dir.)  

Lausanne, EPFL, 2023. 

Tracking spatiotemporal localisation and interactions of the innate immune sensor STING

S. M. E. Rivara / A. Ablasser (Dir.)  

Lausanne, EPFL, 2023. 

Bioengineering human mini-intestines with in vivo-like complexity and function

O. Mitrofanova / M. Lütolf (Dir.)  

Lausanne, EPFL, 2023. 

Characterization of Cyclo His-Pro for the prevention and treatment of liver disease and muscular dystrophy

A. De Masi / J. Auwerx (Dir.)  

Lausanne, EPFL, 2023. 

Engineering Innate and Adaptive Immunity for Enhanced Cancer Immunotherapy

M. Gao / L. Tang (Dir.)  

Lausanne, EPFL, 2023. 

Countering T cell exhaustion and senescence for enhanced adoptive T cell therapies against solid tumors

Y. Zhao / L. Tang (Dir.)  

Lausanne, EPFL, 2023. 

Time-Resolved Scanning Ion Conductance Microscopy and Single-Molecule Spectroscopy

S. Mendes Leitão / G. Fantner (Dir.)  

Lausanne, EPFL, 2023. 

Engineering Hydrogel-coated Neural Interfaces for Chronic Deep Brain Recording

N. S. A. Alwahab / S. Lacour (Dir.)  

Lausanne, EPFL, 2023. 

Advancing atomic force microscopy through open source instrumentation

M. Kangül / G. Fantner (Dir.)  

Lausanne, EPFL, 2023. 

The Effects of Spatial Organization and Fluid Flow on the Social Interactions in Microbial Communities

J. P. H. Wong / A. L. A. Persat; T. I. Battin (Dir.)  

Lausanne, EPFL, 2023. 

Compliance-matching vascular grafts with personalization potential

G. Rovas / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2023. 

Bacterial colonization in realistic environments: how mechanics impact biofilm formation in the wild and during infection

T. Rossy / A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2023. 

2022

Development of a Transient Neural Interface for Minimally Invasive Recording and Stimulation

A. Fanelli / D. Ghezzi (Dir.)  

Lausanne, EPFL, 2022. 

Rational design of protein switches: applications in synthetic biology and cancer immunotherapy

S. Shui / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2022. 

Dissecting the role of biliary epithelial cells during non-alcoholic fatty liver disease progression

E. Yildiz / K. Schoonjans (Dir.)  

Lausanne, EPFL, 2022. 

Methods for acute and long-term imaging of the ventral nerve cord in behaving adult Drosophila

L. J. Hermans / P. P. Ramdya; M. S. Sakar (Dir.)  

Lausanne, EPFL, 2022. 

Multidisciplinary Investigation of the Gut-Brain Ecosystem in a Model of Alzheimer’s Disease

A. L. Planchette / A. Radenovic; A. J. Macpherson (Dir.)  

Lausanne, EPFL, 2022. 

Understanding the mechanisms of non-thermal plasma treatments on seeds

A. Waskow / I. Furno (Dir.)  

Lausanne, EPFL, 2022. 

Engineering synthetic adhesins for biophysical investigation and rewiring of host-microbe interactions

X. J-Y. Pierrat / A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2022. 

Sensor-integrated ultraflexible endovascular devices

L. F. Pancaldi-Giubbini / M. S. Sakar (Dir.)  

Lausanne, EPFL, 2022. 

Systematic analysis of biomolecular binding reactions using microfluidic systems

A. Shahein / S. Maerkl (Dir.)  

Lausanne, EPFL, 2022. 

Engineering T Cell Trafficking and Function for Enhanced Cancer Immunotherapy

Y. Xie / L. Tang (Dir.)  

Lausanne, EPFL, 2022. 

Identification of genes required for host-cell adhesion and antibiotic persistence of uropathogenic Escherichia coli via high-content screening

T. M. Simonet / J. McKinney (Dir.)  

Lausanne, EPFL, 2022. 

Towards automating de novo protein design for novel functionalities: controlling protein folds and protein-protein interactions

Z. Harteveld / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2022. 

Fabrication and validation of an intraneural interface tailored for optic nerve stimulation

E. Borda / D. Ghezzi (Dir.)  

Lausanne, EPFL, 2022. 

In vitro endoderm emergence and self-organisation in the absence of extraembryonic tissues and embryonic architecture

S. D. Vianello / M. Lütolf (Dir.)  

Lausanne, EPFL, 2022. 

DNA-based biomaterials for nanoscale controlled modulation of immune cells

A. Comberlato / M. M. C. Bastings (Dir.)  

Lausanne, EPFL, 2022. 

Molecular Regulation of Muscle Stem Cell Fate during Skeletal Muscle Regeneration and Aging

S. Ancel / J. Feige; B. Deplancke (Dir.)  

Lausanne, EPFL, 2022. 

Dissecting the role of the asparagine synthesis in acute liver injury

Y. Sun / K. Schoonjans (Dir.)  

Lausanne, EPFL, 2022. 

Targeting molecular surfaces to engineer novel protein-based immunogens and inhibitors

S. Wehrle / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2022. 

Hunting for the wavefront: investigation of somite boundary positioning in zebrafish

A. Bercowsky Rama / A. C. Oates (Dir.)  

Lausanne, EPFL, 2022. 

Characterization of Pseudomonas aeruginosa mechanosensing through label-free imaging of type IV pili

L. A-L. Talà / A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2022. 

2021

Post-translational regulation of neuronal differentiation

J. S. Loomba / G. D’Angelo (Dir.)  

Lausanne, EPFL, 2021. 

Towards engineering an artificial neural tube

J. Park / M. Lütolf (Dir.)  

Lausanne, EPFL, 2021. 

Microtissue models for studying the dynamics of host-pathogen interactions in the urinary bladder

K. Sharma / J. McKinney; N. Dhar (Dir.)  

Lausanne, EPFL, 2021. 

Wireless soft microscale actuators and robotic devices to study mechanobiology

R. F. Penacho Parreira / M. S. Sakar (Dir.)  

Lausanne, EPFL, 2021. 

Mechanical principles of engineering fibrous tissues with programmable shape

E. Mailand / M. S. Sakar (Dir.)  

Lausanne, EPFL, 2021. 

Developing new tools to study and program cell fate at the single-cell level

M. Biocanin / B. Deplancke (Dir.)  

Lausanne, EPFL, 2021. 

Coordination between cell growth, division and chromosome replication cycles in mycobacteria

G. M. Vuaridel / J. McKinney; N. Dhar (Dir.)  

Lausanne, EPFL, 2021. 

Microfluidics and cell-free synthetic biology in the development of new diagnostic and therapeutic platforms

G. Michielin / S. Maerkl (Dir.)  

Lausanne, EPFL, 2021. 

Towards scalable and deterministic single cell gene expression profiling

J. J. Bues / B. Deplancke (Dir.)  

Lausanne, EPFL, 2021. 

Reprogramming G Protein-Coupled Receptor Structure, Function And Signaling By Computational Design

D. Kéri / P. D. Barth (Dir.)  

Lausanne, EPFL, 2021. 

Engineering next generation organoids through guided stem cell self-organisation

M. Nikolaev / M. Lütolf (Dir.)  

Lausanne, EPFL, 2021. 

Single-cell lipidomics reveals a role for cell-to-cell sphingolipid heterogeneity in fibroblast activation

L. Capolupo / G. D’Angelo (Dir.)  

Lausanne, EPFL, 2021. 

Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease

M. Romani / J. Auwerx (Dir.)  

Lausanne, EPFL, 2021. 

Towards an artificial cell: Development of a system which self-regenerates the protein components of the PURE system in microfluidic reactors

B. Lavickova / S. Maerkl (Dir.)  

Lausanne, EPFL, 2021. 

On the exploration of novel methodological approaches for immunogen design: case studies in influenza and hepatitis C

A. Scheck / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2021. 

Non-invasive monitoring of key hemodynamical and cardiac parameters using physics-based modelling and artificial intelligence

V. Bikia / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2021. 

Development and applications of hyperpolarized 13C and 1H MR spectroscopy of cerebral metabolism at ultra-high field

E. I. Flatt / R. Gruetter (Dir.)  

Lausanne, EPFL, 2021. 

In situ photopolymerizable hydrogels for intracranial aneurysms treatment

O. Poupart / D. Pioletti; C. Moser (Dir.)  

Lausanne, EPFL, 2021. 

The genetic architecture of complex human traits at the dawn of genomic medicine

O. N. M. Naret / J. Fellay (Dir.)  

Lausanne, EPFL, 2021. 

An autonomous microfluidic device for identification and analysis of individual clinically-relevant mammalian cells

F. L. C. R. Jammes / S. Maerkl (Dir.)  

Lausanne, EPFL, 2021. 

Toward a mechanistic understanding of variable chromatin modules

G. Llimos Aubach / B. Deplancke (Dir.)  

Lausanne, EPFL, 2021. 

Co-regulation of endothelial and myogenic cell fates through intercellular crosstalk in skeletal muscle

U. Lee / J. Feige; B. D. Cosgrove (Dir.)  

Lausanne, EPFL, 2021. 

KRAB zinc finger protein-mediated control of transposon-embedded regulatory sequences from human germline to early embryos

A. Iouranova / D. Trono; P. Turelli (Dir.)  

Lausanne, EPFL, 2021. 

Decoding of error-related potentials in continuous feedback protocols for personalized human computer interaction

F. Iwane / A. Billard; J. d. R. Millán Ruiz (Dir.)  

Lausanne, EPFL, 2021. 

Organisation and dynamics of mitochondria and their RNA.

T. H. R. Rey / S. Manley (Dir.)  

Lausanne, EPFL, 2021. 

Biophysical applications of correlative scanning probe and super-resolution microscopy

V. Navikas / A. Radenovic (Dir.)  

Lausanne, EPFL, 2021. 

Circadian dynamics of RNA localisation in the mammalian liver

C. Y. S. Hurni / F. Naef (Dir.)  

Lausanne, EPFL, 2021. 

Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in mouse

A. M. Bachmann / J. Auwerx (Dir.)  

Lausanne, EPFL, 2021. 

2020

Characterization of Protein-Membrane Interfaces through a Synergistic Computational-Experimental Approach

A. Prunotto / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2020. 

Microfluidic devices for the study of cell-cell, cell-particle and particle-particle interactions

M. C. M. Duchamp / P. Renaud; A. Harari (Dir.)  

Lausanne, EPFL, 2020. 

Gait analysis in children with cerebral palsy: bridging the gap between the laboratory and real life

L. Carcreff / K. Aminian; S. Armand (Dir.)  

Lausanne, EPFL, 2020. 

Beneficial axis of the renin-angiotensin system: from applications to drug discovery

M. Bragina / N. Stergiopulos; M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2020. 

High-throughput microfluidic platforms for characterizing and engineering cell-free gene regulatory circuits

Z. N. Swank / S. Maerkl (Dir.)  

Lausanne, EPFL, 2020. 

Bioengineering Methods to Improve in vitro Adoptive Cell Therapy based on Tumor-Infiltrating Lymphocytes

F. R. Rivest / M. Lütolf; L. L. Sohn (Dir.)  

Lausanne, EPFL, 2020. 

Multidisciplinary Approach to Treat Erectile Dysfunction

M. N. Sturny / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2020. 

Functional de novo Protein Design for Targeted Vaccines and Synthetic Biology Applications

C. Yang / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2020. 

Metabolic rescue of muscle and muscle stem cells in muscle disease

P. Luan / J. Auwerx (Dir.)  

Lausanne, EPFL, 2020. 

Hemodynamics of ageing, ventricular-arterial coupling and noninvasive assessment of key hemodynamical and cardiac quantities

S. Z. Pagoulatou / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2020. 

Sensor and the Beast: Generalised Methods to Recognise Animal Behaviour and Quantify Energy Expenditure Using Inertial Sensors, and Applications

P. Chakravarty / K. Aminian (Dir.)  

Lausanne, EPFL, 2020. 

Microfluidic iMITOMI platform to study the architecture of low-affinity transcription factor binding site clusters

I. Istomin / S. Maerkl (Dir.)  

Lausanne, EPFL, 2020. 

Quantitative approaches to unravel bone marrow adipocyte site-specificity and its implication in hematopoiesis

J. C. P. Tratwal / O. M. Naveiras Torres-Quiroga (Dir.)  

Lausanne, EPFL, 2020. 

Development of novel methods and tools to decipher the huntingtin post-translation modifications code

A. Chiki / H. Lashuel (Dir.)  

Lausanne, EPFL, 2020. 

Time-lapse high-resolution microscopy to study the morphogenesis of microorganisms

M. T. M. Hannebelle / G. Fantner; J. McKinney (Dir.)  

Lausanne, EPFL, 2020. 

In vitro modeling of early mouse development

M. U. Girgin / M. Lütolf (Dir.)  

Lausanne, EPFL, 2020. 

2019

Microchannel-based technologies for nerve interfacing

S. Gribi / S. Lacour (Dir.)  

Lausanne, EPFL, 2019. 

Bioengineering human bone marrow models to elucidate the triggers of the stem cell niche

Q. Vallmajó Martín / M. Lütolf; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2019. 

The role of OCT4 and SOX2 in regulating chromatin accessibility and cell fate across the cell cycle in embryonic stem cells

T. E. Friman / D. M. Suter (Dir.)  

Lausanne, EPFL, 2019. 

Single-cell studies of Mycobacterium smegmatis cell cycle using time-lapse fluorescence microscopy

J. X. Y. Ven / J. McKinney (Dir.)  

Lausanne, EPFL, 2019. 

Engineering Dynamic Hydrogels For In Vitro Organoid Culture

D. L. P. Blondel / M. Lütolf (Dir.)  

Lausanne, EPFL, 2019. 

Optical projection tomography for whole organ imaging

D. Nguyen / T. Lasser; D. N. A. Van De Ville (Dir.)  

Lausanne, EPFL, 2019. 

Elucidating regulatory mechanisms shaping the transcriptome and proteome of the gut immune response in Drosophila melanogaster

M. V. Frochaux / B. Deplancke (Dir.)  

Lausanne, EPFL, 2019. 

Tissue-specific circadian transcriptional regulation

J. Yeung / F. Naef (Dir.)  

Lausanne, EPFL, 2019. 

2D nanopores: fabrication, energy harvesting and field-effect sensing

M. Graf / A. Radenovic (Dir.)  

Lausanne, EPFL, 2019. 

Expanding beyond the natural protein repertoire to engineer targeted vaccines and diagnostics

F. Sesterhenn / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2019. 

Bioengineering the Human Muscle Stem-Cell Niche for Therapeutic Applications

O. Mashinchian / J. Feige; M. Lütolf (Dir.)  

Lausanne, EPFL, 2019. 

Anti-angiogenic immunotherapy for lung cancer

E. Kadioglu / M. De Palma (Dir.)  

Lausanne, EPFL, 2019. 

Characterization of Coenzyme Q Biosynthesis Proteins through Integrative Modeling at the Protein-Membrane Interface

D. Aydin / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2019. 

Modeling hematopoietic stem cell dynamics in bioengineered niches

S. Giger / M. Lütolf (Dir.)  

Lausanne, EPFL, 2019. 

Tailoring the Mechanical Properties of Tissue Engineering Scaffolds made from Decellularized Cartilage

J. Antons / D. Pioletti; L. A. Laurent-Applegate (Dir.)  

Lausanne, EPFL, 2019. 

Structural and functional characterisation of the KRAB-domain associated protein 1

G. Fonti / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2019. 

Metabolic and microenvironmental strategies to accelerate hematopoietic recovery post-aplasia

V. Ledebur de Antas de Campos / O. M. Naveiras Torres-Quiroga (Dir.)  

Lausanne, EPFL, 2019. 

Soft multimodal neural interfaces for unravelling sensory neurological circuits

F. P. G. Michoud / S. Lacour (Dir.)  

Lausanne, EPFL, 2019. 

The onset of cardiovascular disease in mice: an image-based, computational-experimental approach

L. Aslanidou / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2019. 

Application of anti-amyloid beta immunization using encapsulated cell technology in mouse models of Alzheimer’s disease

V. Laversenne / B. Schneider; P. Aebischer (Dir.)  

Lausanne, EPFL, 2019. 

Integrated microfluidic tools for the characterization of protein/DNA interactions in vitro and in vivo

R. Dainese / B. Deplancke (Dir.)  

Lausanne, EPFL, 2019. 

Label-free plasmonic biosensors for real-time live cell analysis

X. Li / H. Altug (Dir.)  

Lausanne, EPFL, 2019. 

2018

Development of microfluidic tools and methods for the biochemical characterization of scFv and Cas9 affinity reagents and their applications in molecular detection

E. E. Petrova / S. Maerkl (Dir.)  

Lausanne, EPFL, 2018. 

Quantitative analysis of SOX2 and OCT4 expression in pluripotency and differentiation

D. Strebinger / D. M. Suter (Dir.)  

Lausanne, EPFL, 2018. 

Advancing immunotherapy for HPV-related cancers: Improving therapeutic vaccination approaches and understanding the immunosuppressive role of myeloid cells

G. Galliverti / M. Swartz; D. Hanahan (Dir.)  

Lausanne, EPFL, 2018. 

In vitro fate mapping of stem cell development at the single cell level

V. Trachsel / M. Lütolf (Dir.)  

Lausanne, EPFL, 2018. 

Likelihood-free Inference of Population Genetic Parameters from Time-Sampled Genetic Data

H. Shim / F. G. van der Goot Grunberg (Dir.)  

Lausanne, EPFL, 2018. 

Introducing tolerance to foreign and partly foreign proteins by erythrocyte binding and artificial glycosylations

K. L. Brünggel / M. Lütolf; J. A. Hubbell (Dir.)  

EPFL, 2018. 

Mitochondrial stress signalling and its impacts on physiology

A. J. L. Mottis / J. Auwerx (Dir.)  

Lausanne, EPFL, 2018. 

Modeling and analysis of parts and devices of genetic regulation

Y. Berset / V. Hatzimanikatis; J. R. van der Meer (Dir.)  

Lausanne, EPFL, 2018. 

Ultra high magnetic field for glial contribution into brain metabolism studied by MR spectroscopy and CEST methods for molecular imaging of glycogen

E. M. C. Vinckenbosch / R. Gruetter (Dir.)  

Lausanne, EPFL, 2018. 

Genetic determinants of healthy human immune variance: from humoral response to microbiome diversity

P. Scepanovic / J. Fellay; B. Deplancke (Dir.)  

Lausanne, EPFL, 2018. 

Novel tools to dissect stem cell metabolism at single cell level

G. Nikitin / M. Lütolf; A. Meibom (Dir.)  

Lausanne, EPFL, 2018. 

More Medicines for Tuberculosis: Fuelling Drug Discovery against Mycobacterium tuberculosis

S-Y. C. Foo / S. Cole (Dir.)  

Lausanne, EPFL, 2018. 

Quantitative single cell dynamics of signaling and transcriptional response in mammalian cells

O. Tidin / D. M. Suter; F. Naef (Dir.)  

Lausanne, EPFL, 2018. 

Computational and Statistical analyses of Molecular Evolution and Demography using Large-scale Sequencing Data

A. Kapopoulou / B. Deplancke; J. D. Jensen (Dir.)  

Lausanne, EPFL, 2018. 

Constrained optimization applied to multiscale integrative modeling

G. E. Tamo / M. Dal Peraro (Dir.)  

EPFL, 2018. 

New roles of the lymphatic endothelium in modulating adaptive immunity: implications for immune tolerance and cancer immunotherapy

L. C. F. Potin / M. Swartz; D. Hanahan (Dir.)  

Lausanne, EPFL, 2018. 

Circadian clock- and feeding-dependent regulation of translation initiation and elongation in the liver

C. A. Gobet / F. Naef; K. Sakamoto (Dir.)  

Lausanne, EPFL, 2018. 

Mid-Infrared plasmonic nanoantennas for ultrasensitive detection of proteins and their secondary structure

D. Etezadi / H. Altug (Dir.)  

Lausanne, EPFL, 2018. 

What is the role of fish intestine as environment-organism barrier? Mechanistic investigations using fish intestinal cells on a chip

C. Drieschner / P. Renaud; K. Schirmer (Dir.)  

Lausanne, EPFL, 2018. 

Electronic dura mater soft, multimodal neural interfaces : technology, integration and implementation to surface implants

A. E. Hirsch / S. Lacour (Dir.)  

Lausanne, EPFL, 2018. 

Quantitative analysis of gene expression and transcriptional memory in mouse embryonic stem cells

A. Mandic / D. M. Suter (Dir.)  

Lausanne, EPFL, 2018. 

The phenotypic impact of naturally occurring genetic and molecular mitochondrial variation in a Drosophila Genetic Reference Population

R. P. J. Bevers / B. Deplancke (Dir.)  

Lausanne, EPFL, 2018. 

Single-cell division and killing dynamics of bacteria exposed to isocratic and time-dependent concentrations of antibiotic

K. E. Schneider / J. McKinney; N. Dhar (Dir.)  

Lausanne, EPFL, 2018. 

2017

Regulation of Endoplasmic Reticulum Architecture by Protein S-Palmitoylation

P. A. Sandoz / F. G. van der Goot Grunberg (Dir.)  

Lausanne, EPFL, 2017. 

In vitro modeling of complex microenvironmental regulation of stem cells

Y. Tabata / M. Lütolf (Dir.)  

Lausanne, EPFL, 2017. 

Computational methods and modeling of cellular function for the optimization of protein production and the study of cellular disease states

J. R. Pinto Vieira / V. Hatzimanikatis (Dir.)  

Lausanne, EPFL, 2017. 

Evaluation of oxidation-sensitive polymersomes as vaccine nanocarriers to enhance humoral responses against arenavirus envelope glycoproteins

C. Galan Navarro / M. Dal Peraro; M. Swartz (Dir.)  

Lausanne, EPFL, 2017. 

Role of ACMSD in regulation of NAD+ metabolism and mitochondrial function

E. Katsyuba / J. Auwerx (Dir.)  

Lausanne, EPFL, 2017. 

Microfluidic and Electrokinetic Manipulation of Single Cells

S. Kilchenmann / C. Guiducci (Dir.)  

Lausanne, EPFL, 2017. 

Human and eco-toxicological impacts of organometallic halide perovskites

R. I. Benmessaoud / L. Forró; H. Lashuel (Dir.)  

Lausanne, EPFL, 2017. 

Elucidating the role of lymphatic vessels within the tumor microenvironment of breast cancer

I. M. van Mier / M. Swartz; M. De Palma (Dir.)  

Lausanne, EPFL, 2017. 

A Microfluidic Brain Interface for In Vivo Recording of Neurochemical Activity

G. C. Y. Petitpierre / P. Renaud (Dir.)  

Lausanne, EPFL, 2017. 

Lipid membrane characterization with second harmonic scattering : surface potentials, ionization, membrane asymmetry and hydration

C. U. Lütgebaucks / S. Roke (Dir.)  

Lausanne, EPFL, 2017. 

The role of the polyglutamine and N-terminal domains in regulating the aggregation and structural properties of Huntingtin Exon 1

S. Vieweg / H. Lashuel (Dir.)  

Lausanne, EPFL, 2017. 

Group Decisions Influence Emergence and Regulation of Leaders during Collective Migration of Epithelial Cells

M. Vishwakarma / J. A. Hubbell; J. Spatz (Dir.)  

Lausanne, EPFL, 2017. 

The therapeutic role of NAD+ modulation in fatty liver disease

K. L. Gariani / J. Auwerx (Dir.)  

Lausanne, EPFL, 2017. 

Nanocapillaries combined with optical tweezers as a single molecule technique for studying DNA-protein complexes

R. Bulushev / A. Radenovic (Dir.)  

Lausanne, EPFL, 2017. 

Investigating the Biological Mechanisms underlying the Initiation of Autoimmunity against Beta Cell Antigens in Type 1 Diabetes

C. Cianciaruso / J. A. Hubbell; S. Baekkeskov Hanahan (Dir.)  

Lausanne, EPFL, 2017. 

Fighting preterm birth with novel surgical tools and biomaterials engineering

Y. R. Devaud / M. Lütolf; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2017. 

Gene regulatory dynamics underlying brown fat cell differentiation

R. N. Pradhan / B. Deplancke (Dir.)  

Lausanne, EPFL, 2017. 

Novel systems biology approaches for design and analysis of palmitoylation networks reveal its regulatory effects on protein stability, activity and localization

T. Dallavilla / V. Hatzimanikatis; F. G. van der Goot Grunberg (Dir.)  

Lausanne, EPFL, 2017. 

Microfluidic platforms for high-throughput mammalian cell printing, transfection, and dosage-dependent studies

K. P. Woodruff / S. Maerkl (Dir.)  

Lausanne, EPFL, 2017. 

A Microfluidic Platform Enables Large-Scale Single-Cell Screening to Identify Genes Involved in Bacterial Persistence

A. Verpoorte / J. McKinney; S. Maerkl (Dir.)  

Lausanne, EPFL, 2017. 

Selective electrical and optical neuromodulation of the central nervous system with conformable microfabricated implants

A. A. Guex / S. Lacour (Dir.)  

Lausanne, EPFL, 2017. 

Exploring the potency of normal and pathological human thymic epithelial cells

T. M. C. Arlabosse / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2017. 

AAV based gene therapy for rare diseases : targeting astrocytes for functional recovery in Amyotrophic Lateral Sclerosis

C. C. Rochat / P. Aebischer; B. Schneider (Dir.)  

Lausanne, EPFL, 2017. 

Inferring the age and strength of mutations evolving under positive selection

N. L. Ormond / J. D. Jensen (Dir.)  

Lausanne, EPFL, 2017. 

Advanced technologies to control stem-cell based organogenesis

N. Brandenberg / M. Lütolf (Dir.)  

Lausanne, EPFL, 2017. 

Deciphering the subcapsular epithelial cells in human fetal and postnatal thymus

D. S. E. Hemon / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2017. 

Cell lineage tracing in human tissues using somatic mitochondrial mutations

P. Refinetti / S. Morgenthaler; P. O. Ekstrom (Dir.)  

Lausanne, EPFL, 2017. 

2016

Novel interventions to recover the regenerative capacity of aged skeletal muscle by targeting the interactions in the stem cell niche

L. Lukjanenko / J. Feige; J. Auwerx (Dir.)  

Lausanne, EPFL, 2016. 

Engineering the Extra Domain A of fibronectin as a vaccine adjuvant and study of its role in tissue regeneration

Z. Julier / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

BCI based on Neural Correlates of Anticipatory Behavior during Driving

Z. Khaliliardali / J. d. R. Millán Ruiz (Dir.)  

Lausanne, EPFL, 2016. 

Integrating Gene Synthesis and MITOMI for Rapid Protein Engineering

M. C. Blackburn / S. Maerkl (Dir.)  

Lausanne, EPFL, 2016. 

Unraveling the KRAB/KAP1 control of transposable elements in pluripotent and somatic cells

G. Ecco / D. Trono; P. Turelli (Dir.)  

Lausanne, EPFL, 2016. 

Engineering nanoparticle-based vaccines: Implications for the quality of humoral and cellular immunity

M. Rincón-Restrepo / M. Swartz; S. Hirosue (Dir.)  

Lausanne, EPFL, 2016. 

Microwell and impedance-based approaches to isolate single cells for life sciences

G. Muller / Y. Barrandon; P. Renaud (Dir.)  

Lausanne, EPFL, 2016. 

Deciphering the Role of LRH-1 in Liver Intermediary Metabolism and Cancer

P. Xu / K. Schoonjans (Dir.)  

Lausanne, EPFL, 2016. 

In vivo mechanical loading combined with cell therapy in a bone tissue engineering scaffold

T. C. Hausherr / D. Pioletti (Dir.)  

Lausanne, EPFL, 2016. 

Mitochondrial unfolded protein response, its molecular mechanism and physiological impact

V. Jovaisaite / J. Auwerx (Dir.)  

Lausanne, EPFL, 2016. 

Role of microRNAs in tumor-associated macrophages

C. M. Baer / M. De Palma (Dir.)  

Lausanne, EPFL, 2016. 

New immunomodulatory roles of lymphatic endothelium and implications for immunotherapy

E. Vokali / M. Swartz (Dir.)  

Lausanne, EPFL, 2016. 

Protein engineering approaches for direct antigen targeting in CD8+ T cell inducing vaccines

V. Panagiotou / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

Metabolic control of muscle and muscle stem cell function

H. Zhang / J. Auwerx (Dir.)  

Lausanne, EPFL, 2016. 

Mechanical and Functional Study of Cell Physiology at the Nanoscale

P. D. Odermatt / G. Fantner (Dir.)  

Lausanne, EPFL, 2016. 

Tunable and cell-responsive 3D poly(ethylene glycol) microenvironments for the development of tissue models

S. E. Metzger / J. A. Hubbell; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2016. 

Engineering Lymphangiogenesis : Implications for Cancer Immunotherapy and Beyond

M. A. Fankhauser / M. Swartz (Dir.)  

Lausanne, EPFL, 2016. 

From the early steps of whisker formation to its evolutionary disappearance: the (curious) case of Prdm1 and its regulation

P. G. Manti / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2016. 

Protrusion-retraction switches and traction forces in spontaneous cell polarization

A. C. Bornert / A. Verkhovsky (Dir.)  

Lausanne, EPFL, 2016. 

Allosteric regulation and targeting of Abl SH2-kinase interface and other cytoplasmic tyrosine kinases

A. J. Lamontanara / O. Hantschel (Dir.)  

Lausanne, EPFL, 2016. 

Towards brain-on-a-chip : microfluidic and microelectrode array platforms for morphological and electrophysiological observations on the propagation of Alzheimer’s disease

Y. Ren / P. Renaud (Dir.)  

Lausanne, EPFL, 2016. 

Mechanisms of tolerance induction by erythrocyte-targeted antigens

A. J. Grimm / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

Quantitative Single-Cell Analysis of Host-Pathogen Interactions

M. J-H. Delincé / J. McKinney (Dir.)  

Lausanne, EPFL, 2016. 

Bioengineering approaches in immunotherapy : from basic to translational applications

M. Damo / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

Nanoscopy in nonlinear scanning fluorescence imaging systems

G. P. J. Laporte / D. Psaltis (Dir.)  

Lausanne, EPFL, 2016. 

Host and pathogen genomics of severe pediatric infections

S. Asgari / J. Fellay (Dir.)  

Lausanne, EPFL, 2016. 

Microdevices for Locomotion in Complex Biological Fluids

T. Qiu / J. A. Hubbell; P. Fischer (Dir.)  

Lausanne, EPFL, 2016. 

Stem cell niche engineering through photopatterning and microfluidics

L. Kolb / M. Lütolf (Dir.)  

Lausanne, EPFL, 2016. 

Therapeutic Proteins Engineered for Super-Affinity to the Extracellular Matrix in Regenerative Medicine

P. S. M. Briquez / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

Instrumented shoes for daily activity monitoring in healthy and at risk populations

C. Moufawad El Achkar / K. Aminian (Dir.)  

Lausanne, EPFL, 2016. 

2015

Tissue engineering for prenatal applications

A-S. J. Kiveliö / J. A. Hubbell; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2015. 

Interactions of Peripheral Nerve Cells with Soft Micropillar Interfaces

C. X. Paulou / S. Lacour (Dir.)  

Lausanne, EPFL, 2015. 

Implementation and Characterization of Dynamic Genetic Networks in Vitro

H. M. Niederholtmeyer / S. Maerkl (Dir.)  

Lausanne, EPFL, 2015. 

Quantification of low molecular weight drugs : from the selection of nucleic acid-based capture molecules to the characterization in patient samples

A. Ferretti / C. Guiducci (Dir.)  

Lausanne, EPFL, 2015. 

Bio-engineered collagen-fibrin scaffolds for enhancing urological tissue regeneration

E. Vardar / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2015. 

Reconstruction and systems analysis of metabolism in apicomplexan parasites Toxoplasma gondii and Plasmodium falciparum

S. Tymoshenko / V. Hatzimanikatis; D. Soldati-Favre (Dir.)  

Lausanne, EPFL, 2015. 

Analytical Methods, Correlative Microscopy and Software Tools for Quantitative Single Molecule Localization Microscopy

A. Shivanandan / A. Radenovic; I. Sbalzarini (Dir.)  

Lausanne, EPFL, 2015. 

Functional Perturbation of the Gab2 Multiprotein Complex by High-affinity SH2-binding Monobodies in Chronic Myelogenous Leukemia

E. B. Gencer Akçok / O. Hantschel (Dir.)  

Lausanne, EPFL, 2015. 

Study of transposon-mediated cell pool and cell line generation in CHO cells

S. Balasubramanian / F. M. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2015. 

Transposable elements and their KRAB/KAP1 controllers broadly regulate transcription in adult human cells

F. Marzetta / D. Trono; P. Turelli (Dir.)  

Lausanne, EPFL, 2015. 

Deciphering Metabolic Regulation of Hematopoietic Stem Cell Fate

M. Girotra / M. Lütolf (Dir.)  

Lausanne, EPFL, 2015. 

Superresolution Reconstruction for Magnetic Resonance Spectroscopic Imaging Exploiting Low-Rank Spatio-Spectral Structure

J. A. Kasten / D. Van De Ville; F. Lazeyras (Dir.)  

Lausanne, EPFL, 2015. 

Bioengineering approaches to emulate the stem cell niche

S. Höhnel / M. Lütolf (Dir.)  

Lausanne, EPFL, 2015. 

Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson’s Disease

M-B. Fares / H. Lashuel (Dir.)  

Lausanne, EPFL, 2015. 

Microfluidic engineering of artificial stem cell niches

S. Allazetta / M. Lütolf (Dir.)  

Lausanne, EPFL, 2015. 

Connectivity Analysis of Brain States and Applications in Brain-Computer Interfaces

H. Zhang / J. d. R. Millán Ruiz (Dir.)  

Lausanne, EPFL, 2015. 

Quantitative single-cell analysis of S. cerevisiae using a microfluidic live-cell imaging platform

J. Becker / F. Naef; S. Maerkl (Dir.)  

Lausanne, EPFL, 2015. 

Modeling and Engineering Proteins Thermostability

H. Pezeshgi Modarres / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2015. 

2014

A systems approach to elucidate the genetic architecture of molecular phenotypes

S. M. Waszak / B. Deplancke (Dir.)  

Lausanne, EPFL, 2014. 

Structure-function analysis of the EspR virulence regulator of Mycobacterium tuberculosis

B. Blasco / S. Cole (Dir.)  

Lausanne, EPFL, 2014. 

Active Transport Mechanisms by Lymphatic Endothelium and their Modulation by Inflammatory Mediators

V. Triacca / M. Swartz (Dir.)  

Lausanne, EPFL, 2014. 

Development of plasmid-based expression technology for rapid and sustained production of recombinant proteins in insect cells

X. Shen / F. M. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2014. 

The Effectual Hitchhiker : Mechanisms and Consequences of Interactions Between Endosymbiotic Spiroplasma and Host Drosophila

J. K. Herren / B. Lemaître (Dir.)  

Lausanne, EPFL, 2014. 

A Systems Approach to Identify Genetic and Environmental Regulators of Metabolism

E. G. Williams / J. Auwerx (Dir.)  

Lausanne, EPFL, 2014. 

Reversible attachment of Cell-Penetrating Peptides for the efficient delivery of α-synuclein to HeLa cells and primary cortical neurons

C. Desobry / H. Lashuel (Dir.)  

Lausanne, EPFL, 2014. 

The regulatory circuit of natural competence for transformation in the human pathogen Vibrio cholerae

M. Lo Scrudato / M. Blokesch (Dir.)  

Lausanne, EPFL, 2014. 

Automated long-term single cell analysis of Schizosaccharomyces pombe on a microfluidic microchemostat array

J-B. Nobs / S. Maerkl (Dir.)  

Lausanne, EPFL, 2014. 

Engineering lymphangiogenesis : methods, characterization and functional consequences

E. Güç / M. Swartz (Dir.)  

Lausanne, EPFL, 2014. 

Pharmacological and biochemical assessment of γ-secretase-mediated APP processing involved in Alzheimer’s disease

M. Dimitrov / P. Fraering (Dir.)  

Lausanne, EPFL, 2014. 

Experimental and theoretical studies on the effects of smooth muscle on the mechanical response and remodeling of arteries

A. Agianniotis / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2014. 

Engineering the lymphatic microenvironment for investigating tumor invasion, immune cell traficking and parasite infection under relevant biomechanical conditions

M. Pisano / M. Swartz (Dir.)  

Lausanne, EPFL, 2014. 

Tissue Engineering Bone by Matrix-Assisted MSC Recruitment

P. S. Lienemann / M. Lütolf; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2014. 

Genetic analysis of the decaprenyl-phospho-D-arabinofuranose pathway in Mycobacterium tuberculosis

G. S. Kolly / S. Cole (Dir.)  

Lausanne, EPFL, 2014. 

Novel non-invasive techniques for hemodynamic monitoring

O. Vardoulis / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2014. 

Dynamic brain networks explored by structure-revealing methods

N. Leonardi / D. Van De Ville (Dir.)  

Lausanne, EPFL, 2014. 

Development of a Bisphosphonate Delivering Hydrogel for the Augmentation of Impaired Peri-Implant Bone

U. Kettenberger / D. Pioletti (Dir.)  

Lausanne, EPFL, 2014. 

From Genes to Organisms : Bioinformatics System Models and Software

T. Schaffter / D. Floreano; M. Affolter (Dir.)  

Lausanne, EPFL, 2014. 

Subject-specific computational fluid dynamics modelling and measurement of cerebrospinal fluid motion in the cervical spine

T. Yiallourou / N. Stergiopulos; B. A. Martin (Dir.)  

Lausanne, EPFL, 2014. 

An integrative genomics approach toward deciphering the regulatory logic of phase-specific circadian transcription in the mouse liver

I. Krier / B. Deplancke; J. Rougemont (Dir.)  

Lausanne, EPFL, 2014. 

Dissecting the DNA binding principles of transcription factor monomers and heterodimers

A. Isakova / B. Deplancke (Dir.)  

Lausanne, EPFL, 2014. 

Modeling of transcription mechanisms in mammals from kinetic measurements in single cells

B. Zoller / F. Naef (Dir.)  

Lausanne, EPFL, 2014. 

New Tools for Hydrogel-Based 3D Bioprinting

A. Negro / M. Lütolf (Dir.)  

Lausanne, EPFL, 2014. 

Engineering adjuvants for prophylactic and therapeutic subunit vaccines

A. de Titta / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2014. 

Thermal gradients on a chip for the local stimulation of biological systems

S. Delasoie-Baranek / P. Renaud (Dir.)  

Lausanne, EPFL, 2014. 

Label-free Analytics by Transmission Localized-SPR and its Application to Small Molecules Monitoring in Serum

G. Cappi / C. Guiducci; L. Benini (Dir.)  

Lausanne, EPFL, 2014. 

Direct Somatic Cell Reprogramming in Synthetic 3D Microenvironments

Y. Okawa / M. Lütolf (Dir.)  

Lausanne, EPFL, 2014. 

In vitro Fate Mapping of Single Hematopoietic Stem Cells

A. Roch / M. Lütolf (Dir.)  

Lausanne, EPFL, 2014. 

The Engineering of a Scalable Disposable Orbitally Shaken Bioreactor System for Animal Cell Cultivation and Therapeutic Protein Production

D. T. Monteil Jr / F. M. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2014. 

A New Noninvasively Adjustable Glaucoma Drainage Device

A. Villamarin / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2014. 

2013

Role of the bile acid membrane receptor TGR5 in macrophages and metabolism

M. Nomura / J. Auwerx; K. Schoonjans (Dir.)  

Lausanne, EPFL, 2013. 

A microfluidic live-cell imaging platform to study large collections of microbial genotypes

N. Dénervaud / S. Maerkl; F. Naef (Dir.)  

Lausanne, EPFL, 2013. 

Metabolic modeling and experimental studies on carbon and energy metabolism of Mycobacterium tuberculosis

M. E. Özdemir / J. McKinney; V. Hatzimanikatis (Dir.)  

Lausanne, EPFL, 2013. 

Computational Studies on Cellular Bioenergetics

K. C. Soh / V. Hatzimanikatis (Dir.)  

Lausanne, EPFL, 2013. 

Development and application of experimental tools to elucidate the gene regulatory network underlying adipogenesis

C. Delattre-Gubelmann / B. Deplancke (Dir.)  

Lausanne, EPFL, 2013. 

Epiphyseal Chondro-Progenitor Cell Therapy For Articular Cartilage Regeneration

S. E. Darwiche / D. Pioletti; L. A. Laurent-Applegate (Dir.)  

Lausanne, EPFL, 2013. 

The Phosphate Specific Transport (Pst) System in Fast- and Slow-Growing Mycobacteria

C. De Piano / J. McKinney (Dir.)  

Lausanne, EPFL, 2013. 

Molecular Modeling of Membrane Embedded Proteins

T. Lemmin / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2013. 

Discovery and functional characterisation of structural genomic variation in a natural population

A. Massouras / B. Deplancke (Dir.)  

Lausanne, EPFL, 2013. 

Structure and function of proteins involved in attachment and piercing of the bacterial cell envelope

L. Sycheva / P. Leiman (Dir.)  

Lausanne, EPFL, 2013. 

Temperature impacts human epidermal stem cell behaviour through thermoTRPs and mTOR signalling

J. A. Mosig Rodriguez / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2013. 

Systems Biology of 3D Stem Cell-Niche Interactions

A. Ranga / M. Lutolf (Dir.)  

Lausanne, EPFL, 2013. 

Identification of genetic determinants and pharmacological modulators of mitochondrial function

P. Andreux / J. Auwerx (Dir.)  

Lausanne, EPFL, 2013. 

A Simple High Yielding Transient Gene Expression System for CHO Cells

Y. Rajendra / F. M. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2013. 

Multiscale simulations of protein dynamics

E. Spiga / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2013. 

Control of calcification in a biphasic osteochondral construct and enhancing interface integration

J. Hollenstein / D. Pioletti; R. L-Y. Sah (Dir.)  

Lausanne, EPFL, 2013. 

Engineering nanoparticle vaccines : design principles for lymphatic targeting

S. Raghunathan / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2013. 

Systematic Analysis of Yeast Gene Expression by Synthetic Promoter Libraries

A. S. Rajkumar / S. Maerkl (Dir.)  

Lausanne, EPFL, 2013. 

Flexible Micro/Nanofabricated Systems for Medical Devices and Implants

W. Hasenkamp Carreira / P. Renaud (Dir.)  

Lausanne, EPFL, 2013. 

Targeting and Modulating Tumor-Associated Sites with Novel Nanoparticle-Based Immunotherapies

L. Jeanbart / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2013. 

Development of Novel Nanoparticle-Based Vaccines and Immunotherapies : Tuberculosis, Lung Metastasis and Allergy as Models

M. Ballester / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2013. 

Dissipation as variable in cartilage mechanobiology

P. Abdel-Sayed / D. Pioletti (Dir.)  

Lausanne, EPFL, 2013. 

Generating microarrays for protein interaction studies using microfluidic devices

S. Rockel / S. Maerkl (Dir.)  

Lausanne, EPFL, 2013. 

The Use of Valproic Acid in Transient Gene Expression with HEK-293E Cells

D. Kiseljak / F. M. Wurm (Dir.)  

Lausanne, EPFL, 2013. 

2012

Culture and Characterization of Human and Porcine Urothelial Progenitor Cells

H. M. Larsson / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2012. 

Molecular Modeling of Bacterial Nanomachineries

M. T. Degiacomi / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2012. 

Early Fate Choice Determines in vivo Engraftment and in vitro Behavior of Epidermal Stem Cells

F. Gorostidi / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2012. 

Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

F. Zagari / F. Wurm; M. Jordan (Dir.)  

Lausanne, EPFL, 2012. 

Nanopore sensing of single molecules application to RNAP-DNA complexes, fabrication of graphene-nanopore devices and translocation algorithm analysis

C. Raillon / A. Radenovic; N. Hernandez (Dir.)  

Lausanne, EPFL, 2012. 

Microtechnologies to Map the Fate of Single Stem Cells and their Progeny

S. Kobel / M. Lutolf; P. Renaud (Dir.)  

Lausanne, EPFL, 2012. 

Hydrogel Microfluidics to Control Stem Cell Fate

S. Cosson / M. Lutolf (Dir.)  

Lausanne, EPFL, 2012. 

Dissecting Gene Regulatory Networks Using Targeted Quantitative Proteomics

J. Simicevic / B. Deplancke (Dir.)  

Lausanne, EPFL, 2012. 

Immune Engineering Via Differential Antigen Carriers and Co-Stimulatory Molecules

J. Eby / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2012. 

Molecular and Functional Characterization of Clonogenic Human Thymic Epithelial Cells

M. Maggioni / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2012. 

Structural Studies and Protein Engineering of Human O6-Alkylguanine-DNA Alkyltransferase

B. Mollwitz / K. Johnsson (Dir.)  

Lausanne, EPFL, 2012. 

Single-Cell Analysis of Mycobacterial Persistence Using Microfabricated Tools

M. Elitas / J. McKinney; S. Maerkl (Dir.)  

Lausanne, EPFL, 2012. 

Therapeutic Immunomodulation of the Lymphoid-like Tumor Environment Using Nanoparticulate Formulations

I. Kourtis / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2012. 

Toxicity study of nanostructures

L. Horváth / L. Forró; B. Schwaller (Dir.)  

Lausanne, EPFL, 2012. 

Elucidating the role of post-translational modifications of alpha-synuclein using semisynthesis : phosphorylation at Tyrosine 125 and monoubiquitination at Lysine 6

M. Hejjaoui / H. Lashuel (Dir.)  

Lausanne, EPFL, 2012. 

Photopatterning of Synthetic Hydrogels

K. Mosiewicz / M. Lutolf (Dir.)  

Lausanne, EPFL, 2012. 

KRAB/KAP1 Regulation of Embryonic Stem Cell Pluripotent Self-renewal

A. Corsinotti / D. Trono (Dir.)  

Lausanne, EPFL, 2012. 

Improving Immunogenicity of Subunit Vaccines Using Nanocarrier Systems

A. Stano / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2012. 

Genomics and transcriptomics of the Mycobacterium tuberculosis complex

S. Uplekar / S. Cole; J. Rougemont (Dir.)  

Lausanne, EPFL, 2012. 

2011

In Vivo Studies on the Control of Gene Expression and Protein Degradation

K. Bojkowska / K. Johnsson; D. Trono (Dir.)  

Lausanne, EPFL, 2011. 

Engineering Erythrocyte Affinity for Improved Pharmacokinetics and Immune Tolerogenesis

S. Kontos / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2011. 

Pressure and Flow Wave Propagation in Patient-Specific Models of the Arterial Tree

P. Reymond / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2011. 

In vitro lymphatic endothelial morphogenesis : molecular vs. biophysical regulation

C. Yong Pullin / M. Swartz (Dir.)  

Lausanne, EPFL, 2011. 

Identification and Functional Response of “Interstitial Cells of Cajal”-like Cells from Rat Mesenteric Artery

A. Formey de Saint Louvent / J-J. Meister; J-L. Bény (Dir.)  

Lausanne, EPFL, 2011. 

Hydrogels for Urinary Tract Tissue Engineering

L. A. Micol / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2011. 

Assessment of Body Motion and Muscle Weakness : Outcome Evaluation in Frail Elderly and DMD Subjects

R. L. Ganea / K. Aminian (Dir.)  

Lausanne, EPFL, 2011. 

Force Transmission in Migrating Cells

M. Fournier / A. Verkhovski (Dir.)  

Lausanne, EPFL, 2011. 

OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up

S. Tissot / F. Wurm (Dir.)  

Lausanne, EPFL, 2011. 

Biofunctional Scaffold Design for Soft Tissue Regeneration

K. Lorentz / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2011. 

The Role of LEKTI in the Fate Determination of Keratinocyte Stem Cells

A. W. Amici / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2011. 

Studies on KRAB/KAP1-Mediated Transcriptional Repression

A. C. Groner / D. Trono (Dir.)  

Lausanne, EPFL, 2011. 

Engineering of Signaling Microenvironments with Fibronectin Domains to Enhance Tissue Regeneration

M. Martino / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2011. 

Cellular Responses to Bacterial Pore-Forming Toxins

R. M. Gonzalez / F. G. v. d. Goot Grunberg (Dir.)  

Lausanne, EPFL, 2011. 

On the Precision of Circadian Oscillators

T. D’Eysmond / F. Naef (Dir.)  

Lausanne, EPFL, 2011. 

New/Surface-Modified Biocompatible Polymer for ICD Lead Insulation

R. B. Pisarek / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2011. 

Molecular Mechanisms Underlying Hyaline Fibromatosis Syndrome

J. Deuquet Ariosa / F. G. v. d. Goot Grunberg (Dir.)  

Lausanne, EPFL, 2011. 

Folding and Structure of the Pore Forming Toxin Aerolysin

M. I. Iacovache / F. G. v. d. Goot Grunberg (Dir.)  

Lausanne, EPFL, 2011. 

2010

Elucidating the Role of Quaternary Structure in Modulating Macrophage Migration Inhibitory Factor (MIF) Functions

F. El Turk / H. Lashuel (Dir.)  

Lausanne, EPFL, 2010. 

Identification of genetic insulator elements to increase the safety of viral gene therapy vectors

A. Gaussin / J. A. Hubbell; N. Mermod (Dir.)  

Lausanne, EPFL, 2010. 

Transient Gene Expression in HEK-293E Cells for Recombinant Protein Production : Process Characterization towards GMP Approval

S. Nallet / F. Wurm (Dir.)  

Lausanne, EPFL, 2010. 

Arterial remodeling using a constituent-based approach

A. Tsamis / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2010. 

Biomechanics of Vascular Wall : the Role of Structural Organization of Elastin and Collagen

R. Saitta-Rezakhaniha / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2010. 

Genomic Context and KRAB/KAP1-mediated Transcriptional Repression

S. Meylan / D. Trono (Dir.)  

Lausanne, EPFL, 2010. 

Dendritic cell chemotaxis in 3D : new tools and insights

U. Haessler / M. Swartz (Dir.)  

Lausanne, EPFL, 2010. 

Small Molecule Based Approaches to Inhibit Macrophage Migration Inhibitory Factor (MIF) Activities and Elucidate its Role in Health and Disease

H. Ouertatani-Sakouhi / H. Lashuel (Dir.)  

Lausanne, EPFL, 2010. 

Rat bladder muscle regeneration induced by local delivery of an engineered insulin-like growth factor 1 in fibrin gels

L. Yang / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2010. 

Lentiviral Vector-Mediated Gene Delivery for the Generation of Chinese Hamster Ovary Cell Lines with Improved Productivity and Stability

A. Oberbek / F. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2010. 

Ambulatory Assessment of Foot Kinematics and Kinetics : Outcome Evaluation of Ankle Osteoarthritis Treatments

H. Rouhani / K. Aminian (Dir.)  

Lausanne, EPFL, 2010. 

Biophysical Regulation of Lymphatic Vessel Function : Flow as a Mediator of Immune Cell and Fluid Transport

D. Miteva / M. Swartz (Dir.)  

Lausanne, EPFL, 2010. 

Innate Barriers to Genome Invasion : how TRIM5a Restricts Retroelements

P. Maillard / D. Trono (Dir.)  

Lausanne, EPFL, 2010. 

The Interplay between Cytidine Deaminases, HIV and Domesticated Genetic Parasites

Y. Bulliard / D. Trono (Dir.)  

Lausanne, EPFL, 2010. 

2009

Differential effects of reduced cyclic stretch and perturbed shear stress within the arterial wall

T. Thacher / N. Stergiopulos; R. F. d. Silva (Dir.)  

Lausanne, EPFL, 2009. 

Investigation of novel calcium-related events as suspected contributors to neurodegeneration

N. Rudinskiy / R. Luthi-Carter (Dir.)  

Lausanne, EPFL, 2009. 

The tissue reaction to neuroprostheses

A. Mercanzini / P. Renaud (Dir.)  

Lausanne, EPFL, 2009. 

The interplay between the VEGF-C/VEGFR-3 axis and CCL21/CCR7 axis in tumor cell invasion

A. Issa / M. Swartz (Dir.)  

Lausanne, EPFL, 2009. 

Studies on scaffold design for tissue engineering applications : contribution of synthetic, natural and recombinant materials

E-M. Engelhardt / F. Wurm; P. Frey (Dir.)  

Lausanne, EPFL, 2009. 

Protein-binding microarray technology and ChIP-sequencing for the identification of novel targets of the human tumor suppressor AP2[alpha]

J. Kerschgens / J. A. Hubbell; N. Mermod (Dir.)  

Lausanne, EPFL, 2009. 

Stem cell-based cardiovascular tissue engineering

T. Krähenbühl / J. A. Hubbell; R. S. Langer (Dir.)  

Lausanne, EPFL, 2009. 

The role of TIF1 gamma during adult murine hematopoiesis

K. Shakhbazov / F. Radtke; A. Trumpp (Dir.)  

Lausanne, EPFL, 2009. 

Immunoisolated cell implants for intracerebral delivery of anti-Aß single chain Fv antibodies in the APP23 Alzheimer’s mouse model

O. Marroquin Belaunzaran / P. Aebischer (Dir.)  

Lausanne, EPFL, 2009. 

Peptide ligands for targeting and retention of nanoparticles and protein therapeutics in articular cartilage

D. A. Rothenfluh / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2009. 

Orbitally shaken bioreactors for mammalian cell culture : engineering characterization and bioprocess scale-up

X. Zhang / F. Wurm (Dir.)  

Lausanne, EPFL, 2009. 

Studies on lentiviral-mediated transgenesis

M-O. Sauvain / D. Trono (Dir.)  

Lausanne, EPFL, 2009. 

Transient recombinant protein expression in mammalian cells : the role of mRNA level and stability

S. Wulhfard / F. Wurm (Dir.)  

Lausanne, EPFL, 2009. 

Fetal cells for intervertebral disc regeneration

A. Quintin / D. Pioletti; L. A. Laurent-Applegate (Dir.)  

Lausanne, EPFL, 2009. 

Tissue engineering of the bladder : exploiting a 3D hydrogel for modulation of the smooth muscle cell phenotype

C. Adelöw / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2009. 

2008

Prevention of micromotion-related periprosthetic bone loss using local release of bisphosphonate : theoretical developments and experimental validations

V. Stadelmann / D. Pioletti (Dir.)  

Lausanne, EPFL, 2008. 

Vascular physiology : effects of vascular smooth muscle alteration on arterial wall biomechanics

S. Roy / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2008. 

Tissue engineering complex and mechanically active microenvironments for studies in asthma and cancer

A. A. Tomei / M. Swartz (Dir.)  

Lausanne, EPFL, 2008. 

Novel applications of poly(ethylene glycol)-bl-poly(propylene sulfide) block copolymers

C. O’Neil / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2008. 

Exploiting immunofunctional nanoparticles as vaccines and synthetic pathogens

S. T. Reddy / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2008. 

Mechanical orchestration of tissue remodeling

P-J. Wipff / B. Hinz (Dir.)  

Lausanne, EPFL, 2008. 

Polymeric carriers for therapeutic agents : drug and gene delivery systems by reversible addition-fragmentation transfer (RAFT) polymerization

Y. S. Jo / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2008. 

Development of high-titer transient gene expression processes for manufacturing recombinant proteins

G. Backliwal / F. Wurm (Dir.)  

Lausanne, EPFL, 2008. 

Development of an in vitro microenvironment for maturing oocytes

J. E. Ihm / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2008. 

Role and mechanism of transient receptor potential (TRP) channels in gustatory and chemesthetic sensations associated with dietary molecules

C. Riera / H. Vogel (Dir.)  

Lausanne, EPFL, 2008. 

Molecular and mechanical regulators of lymphatic biology

J. M. Rutkowski / M. Swartz (Dir.)  

Lausanne, EPFL, 2008. 

Effects of base-pair sequence, nicks and gaps on DNA minicircle shapes : analysis and experiment

A. Amzallag / J. H. Maddocks (Dir.)  

Lausanne, EPFL, 2008. 

A novel cell culture approach for tissue engineering based on surface expansion

H. Majd / B. Hinz (Dir.)  

Lausanne, EPFL, 2008. 

Accelerating the development time of recombinant mammalian cell lines producing high titers of protein therapeutics

S. Chenuet / F. Wurm (Dir.)  

Lausanne, EPFL, 2008. 

2007

Polynucleotide cytidine deaminases, innate immunity and hepatitis B infection

S. Jost / D. Trono (Dir.)  

Lausanne, EPFL, 2007. 

Bioreactor processes based on disposable materials for the production of recombinant proteins from mammalian cells

M. Stettler / F. Wurm (Dir.)  

Lausanne, EPFL, 2007. 

Effects of dynamic environments on extracellular morphogen gradients

M. E. Fleury / M. Swartz (Dir.)  

Lausanne, EPFL, 2007. 

2005

Development of a novel drug delivery system based on polymeric, thermoresponsive, hydrogel nanoparticles

D. Misirlis / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2005.