EDBB Published theses

It is our pleasure to present the theses undertaken in the frame of the EPFL PhD Program in Biotechnology & Bioengineering.

2025

Soft microelectrode arrays for 3D in vitro brain models

E. Martinelli / S. Lacour (Dir.)  

Lausanne, EPFL, 2025. 

Advancing high-resolution microscopes to enable time-lapse nano-characterization of pathogenic micro-organisms in-vitro

E. Braun / J. McKinney; G. Fantner (Dir.)  

Lausanne, EPFL, 2025. 

Rational cytokine and receptor engineering for enhanced safety and efficacy of cancer immunotherapy

L. Bonati / L. Tang; B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2025. 

Next-generation in vitro liver models through stem cell-derived organoids and bioengineering

B. S. Elçi / M. Lütolf; K. Schoonjans (Dir.)  

Lausanne, EPFL, 2025. 

Bioengineering of morphologically and functionally accurate in vitro intestinal models

J. J. Langer / M. Lütolf; K. Schoonjans (Dir.)  

Lausanne, EPFL, 2025. 

Multimodal Imaging Platform for Spatiotemporal Interrogation of Dynamics in Single Cells and Spheroids

S. Ansaryan / H. Altug (Dir.)  

Lausanne, EPFL, 2025. 

Gravitational and acoustic micromanipulation platforms for high-content histological analysis of organoids and spheroids

E. Vuille-Dit-Bille / M. S. Sakar; G. Weder (Dir.)  

Lausanne, EPFL, 2025. 

Decoding single-cell heterogeneity and plasticity

W. Liu / B. Deplancke (Dir.)  

Lausanne, EPFL, 2025. 

PURE system optimization and exploration of self-regeneration for synthetic cell applications

R. Bava Ganesh / S. Maerkl (Dir.)  

Lausanne, EPFL, 2025. 

Computational Design of Protein Switches

S. M. Buckley / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2025. 

Mapping the Operative Space for Polymer-Biostabilized DNA Origami

H. J. Rodríguez Franco / M. M. C. Bastings (Dir.)  

Lausanne, EPFL, 2025. 

Towards Conformational Targeting of Alpha-Synuclein Fibrils

A. S. S. Z. M. Sadek / B. E. Ferreira De Sousa Correia; H. Lashuel (Dir.)  

Lausanne, EPFL, 2025. 

Exploring the Role of Unstable L-Forms in the Survival of Uropathogenic Escherichia coli Under Fosfomycin Exposure

F. Normandeau / J. McKinney; N. Dhar (Dir.)  

Lausanne, EPFL, 2025. 

Droplet microfluidic platforms for multiplexed library-against-library antibody screening

L. Kolmar / C. Merten (Dir.)  

Lausanne, EPFL, 2025. 

Experimental Characterization of an Adhesion GPCR Mechanotransduction

G. Gambardella / P. D. Barth; A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2025. 

Translational AI in Digital Health: Applications in Plant Disease Detection, Food Recognition, Postprandial Glycemic Response Forecasting and Musculoskeletal Modeling

S. P. Mohanty / M. Salathé (Dir.)  

Lausanne, EPFL, 2025. 

Heartbeat on repeat: noncanonical KZFP and its transposable element targets shape cardiac cell specification

D. Milovanovic / D. Trono (Dir.)  

Lausanne, EPFL, 2025. 

Programmable supramolecular nanoarchitectures for targeting biological patterns

A. Kononenko / M. M. C. Bastings (Dir.)  

Lausanne, EPFL, 2025. 

2024

ER+ breast cancer in 3D scaffold ex vivo for transcriptomics-based functional drug screening and personalized medicine

Y. Zhang / C. Brisken; C. Merten (Dir.)  

Lausanne, EPFL, 2024. 

Dielectrophoretic Manipulation of Biological Species: Novel Microfluidic Approaches to Study Cell-Cell Interactions and the Role of Alpha-Synuclein in Neurodegeneration

T. J. Ryser / C. Guiducci; H. Lashuel (Dir.)  

Lausanne, EPFL, 2024. 

Characterization of the gut-bone marrow axis through bile acid signaling

A. Alonso Calleja / K. Schoonjans; O. M. Naveiras Torres-Quiroga (Dir.)  

Lausanne, EPFL, 2024. 

Resolving bacterial cell biology: from replisome dynamics to cell wall synthesis

C. Zhang / S. Manley (Dir.)  

Lausanne, EPFL, 2024. 

Advancements in Nanomechanical Characterization and Biomolecular Imaging with Atomic force Microscopy

V. Cencen / G. Fantner (Dir.)  

Lausanne, EPFL, 2024. 

Accessible and highly observable gastrointestinal organoid model systems for studying host-pathogen interactions

M. Hofer / M. Lütolf (Dir.)  

Lausanne, EPFL, 2024. 

Targeting TDP-43 Proteinopathies in Neurodegeneration by its Native-State Stabilization

L. Yang / H. Lashuel (Dir.)  

Lausanne, EPFL, 2024. 

Targeting Cellular Senescence and NAD+ Metabolism Disruption in Early-Stage Chronic Kidney Disease

L. C. Chanvillard / J. Feige; K. Schoonjans (Dir.)  

Lausanne, EPFL, 2024. 

Engineering Split HaloTag for Advanced Fluorescence Microscopy

Y-H. Lin / K. Johnsson (Dir.)  

Lausanne, EPFL, 2024. 

Single-cell analysis of the interactions between Mycobacterium tuberculosis and macrophages

O. Rutschmann / J. McKinney (Dir.)  

Lausanne, EPFL, 2024. 

Drug Screening in C. elegans to identify new pharmacological mitochondrial stress inducers

A. Lalou / J. Auwerx (Dir.)  

Lausanne, EPFL, 2024. 

Exploring ion and analyte transport in beta-barrel forming biological nanopores

S. F. Mayer / M. Dal Peraro; A. Radenovic (Dir.)  

Lausanne, EPFL, 2024. 

Quantitative characterization of the inorganic phosphate gene regulatory networks in S. cerevisiae and bottom up engineering an orthogonal gene network

S. Cheng / S. Maerkl (Dir.)  

Lausanne, EPFL, 2024. 

Bioengineering functional organoid models across scales

T. Hübscher / M. Lütolf (Dir.)  

Lausanne, EPFL, 2024. 

Multi-motif scaffolding for de novo pathogen antigen mimetics by deep generative learning

K. M. Castro Gilabert / B. Correia (Dir.)  

Lausanne, EPFL, 2024. 

Unraveling behavior and cortical signals to guide the development of soft neuroprostheses for auditory restoration and spreading depolarization

E. C. M. Revol / S. Lacour (Dir.)  

Lausanne, EPFL, 2024. 

Development and evaluation of a near-infrared photovoltaic implant for wireless neural stimulation

D. I. Medagoda / S. Lacour; D. Ghezzi (Dir.)  

Lausanne, EPFL, 2024. 

Exploring the therapeutic potential of Huntingtin native state stabilization through targeting its interacting partners

E. Morro / H. Lashuel (Dir.)  

Lausanne, EPFL, 2024. 

Unraveling mitochondrial dynamics: exploring asymmetries and function through advanced microscopy

J. H. B. Winter / S. Manley (Dir.)  

Lausanne, EPFL, 2024. 

Advancing Cell-Free Synthetic Biology: From sustained PURE protein synthesis to an isothermal one-pot DNA replication system

L. S. Grasemann / S. Maerkl (Dir.)  

Lausanne, EPFL, 2024. 

The Slc25a47-Wars1 locus: characterization of its role in metabolic homeostasis and stress pathways

F. Pontanari / K. Schoonjans (Dir.)  

Lausanne, EPFL, 2024. 

Engineering novel protein interactions with therapeutic potential using deep learning-guided surface design

A. Marchand / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2024. 

2023

Bioengineering human mini-intestines with in vivo-like complexity and function

O. Mitrofanova / M. Lütolf (Dir.)  

Lausanne, EPFL, 2023. 

Cross-anatomical single-cell definition and characterization of human adipose progenitor niche

R. Ferrero / B. Deplancke (Dir.)  

Lausanne, EPFL, 2023. 

Characterization of Cyclo His-Pro for the prevention and treatment of liver disease and muscular dystrophy

A. De Masi / J. Auwerx (Dir.)  

Lausanne, EPFL, 2023. 

How are cells instructed to form somite boundaries by the zebrafish segmentation clock?

O. F. Venzin / A. C. Oates (Dir.)  

Lausanne, EPFL, 2023. 

Engineering Innate and Adaptive Immunity for Enhanced Cancer Immunotherapy

M. Gao / L. Tang (Dir.)  

Lausanne, EPFL, 2023. 

Label-free plasmonic microarray for multiplexed analysis of cells and tumor organoids

Y-C. Liu / H. Altug (Dir.)  

Lausanne, EPFL, 2023. 

Development of new volcano-shaped microelectrodes for single cell electrochemistry, electrophysiology and impedance studies

N. G. Maïno / P. Renaud; A. Bertsch (Dir.)  

Lausanne, EPFL, 2023. 

Novel quantitative bioengineered tools to track human bone marrow niche cellular constituents in health and disease

R. Sarkis / B. Deplancke; O. M. Naveiras Torres-Quiroga (Dir.)  

Lausanne, EPFL, 2023. 

Countering T cell exhaustion and senescence for enhanced adoptive T cell therapies against solid tumors

Y. Zhao / L. Tang (Dir.)  

Lausanne, EPFL, 2023. 

Time-Resolved Scanning Ion Conductance Microscopy and Single-Molecule Spectroscopy

S. Mendes Leitão / G. Fantner (Dir.)  

Lausanne, EPFL, 2023. 

Exploring the interplay of molecular pattern and valency for selective interactions at the bio-interface

K. Paloja / M. M. C. Bastings (Dir.)  

Lausanne, EPFL, 2023. 

Tracking spatiotemporal localisation and interactions of the innate immune sensor STING

S. M. E. Rivara / A. Ablasser (Dir.)  

Lausanne, EPFL, 2023. 

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

X. Li / J. Auwerx (Dir.)  

Lausanne, EPFL, 2023. 

Engineering Hydrogel-coated Neural Interfaces for Chronic Deep Brain Recording

N. S. A. Alwahab / S. Lacour (Dir.)  

Lausanne, EPFL, 2023. 

Bacterial colonization in realistic environments: how mechanics impact biofilm formation in the wild and during infection

T. Rossy / A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2023. 

The Effects of Spatial Organization and Fluid Flow on the Social Interactions in Microbial Communities

J. P. H. Wong / A. L. A. Persat; T. I. Battin (Dir.)  

Lausanne, EPFL, 2023. 

Nanotechnology enabled modulation of T cell immunity for cancer treatment

X. Hu / L. Tang (Dir.)  

Lausanne, EPFL, 2023. 

Compliance-matching vascular grafts with personalization potential

G. Rovas / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2023. 

Advancing atomic force microscopy through open source instrumentation

M. Kangül / G. Fantner (Dir.)  

Lausanne, EPFL, 2023. 

2022

Systematic analysis of biomolecular binding reactions using microfluidic systems

A. Shahein / S. Maerkl (Dir.)  

Lausanne, EPFL, 2022. 

Identification of genes required for host-cell adhesion and antibiotic persistence of uropathogenic Escherichia coli via high-content screening

T. M. Simonet / J. McKinney (Dir.)  

Lausanne, EPFL, 2022. 

Multidisciplinary Investigation of the Gut-Brain Ecosystem in a Model of Alzheimer’s Disease

A. L. Planchette / A. Radenovic; A. J. Macpherson (Dir.)  

Lausanne, EPFL, 2022. 

Development of a Transient Neural Interface for Minimally Invasive Recording and Stimulation

A. Fanelli / D. Ghezzi (Dir.)  

Lausanne, EPFL, 2022. 

Dissecting the role of biliary epithelial cells during non-alcoholic fatty liver disease progression

E. Yildiz / K. Schoonjans (Dir.)  

Lausanne, EPFL, 2022. 

Hunting for the wavefront: investigation of somite boundary positioning in zebrafish

A. Bercowsky Rama / A. C. Oates (Dir.)  

Lausanne, EPFL, 2022. 

Targeting molecular surfaces to engineer novel protein-based immunogens and inhibitors

S. Wehrle / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2022. 

Understanding the mechanisms of non-thermal plasma treatments on seeds

A. Waskow / I. Furno (Dir.)  

Lausanne, EPFL, 2022. 

Dissecting the role of the asparagine synthesis in acute liver injury

Y. Sun / K. Schoonjans (Dir.)  

Lausanne, EPFL, 2022. 

Sensor-integrated ultraflexible endovascular devices

L. F. Pancaldi-Giubbini / M. S. Sakar (Dir.)  

Lausanne, EPFL, 2022. 

In vitro endoderm emergence and self-organisation in the absence of extraembryonic tissues and embryonic architecture

S. D. Vianello / M. Lütolf (Dir.)  

Lausanne, EPFL, 2022. 

Rational design of protein switches: applications in synthetic biology and cancer immunotherapy

S. Shui / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2022. 

Methods for acute and long-term imaging of the ventral nerve cord in behaving adult Drosophila

L. J. Hermans / P. P. Ramdya; M. S. Sakar (Dir.)  

Lausanne, EPFL, 2022. 

Towards automating de novo protein design for novel functionalities: controlling protein folds and protein-protein interactions

Z. Harteveld / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2022. 

Fabrication and validation of an intraneural interface tailored for optic nerve stimulation

E. Borda / D. Ghezzi (Dir.)  

Lausanne, EPFL, 2022. 

Molecular Regulation of Muscle Stem Cell Fate during Skeletal Muscle Regeneration and Aging

S. Ancel / J. Feige; B. Deplancke (Dir.)  

Lausanne, EPFL, 2022. 

DNA-based biomaterials for nanoscale controlled modulation of immune cells

A. Comberlato / M. M. C. Bastings (Dir.)  

Lausanne, EPFL, 2022. 

Engineering T Cell Trafficking and Function for Enhanced Cancer Immunotherapy

Y. Xie / L. Tang (Dir.)  

Lausanne, EPFL, 2022. 

Characterization of Pseudomonas aeruginosa mechanosensing through label-free imaging of type IV pili

L. A-L. Talà / A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2022. 

Engineering synthetic adhesins for biophysical investigation and rewiring of host-microbe interactions

X. J-Y. Pierrat / A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2022. 

2021

An autonomous microfluidic device for identification and analysis of individual clinically-relevant mammalian cells

F. L. C. R. Jammes / S. Maerkl (Dir.)  

Lausanne, EPFL, 2021. 

On the exploration of novel methodological approaches for immunogen design: case studies in influenza and hepatitis C

A. Scheck / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2021. 

Toward a mechanistic understanding of variable chromatin modules

G. Llimos Aubach / B. Deplancke (Dir.)  

Lausanne, EPFL, 2021. 

Decoding of error-related potentials in continuous feedback protocols for personalized human computer interaction

F. Iwane / A. Billard; J. d. R. Millán Ruiz (Dir.)  

Lausanne, EPFL, 2021. 

Engineering next generation organoids through guided stem cell self-organisation

M. Nikolaev / M. Lütolf (Dir.)  

Lausanne, EPFL, 2021. 

Towards engineering an artificial neural tube

J. Park / M. Lütolf (Dir.)  

Lausanne, EPFL, 2021. 

Reprogramming G Protein-Coupled Receptor Structure, Function And Signaling By Computational Design

D. Kéri / P. D. Barth (Dir.)  

Lausanne, EPFL, 2021. 

Mechanical principles of engineering fibrous tissues with programmable shape

E. Mailand / M. S. Sakar (Dir.)  

Lausanne, EPFL, 2021. 

Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease

M. Romani / J. Auwerx (Dir.)  

Lausanne, EPFL, 2021. 

Biophysical applications of correlative scanning probe and super-resolution microscopy

V. Navikas / A. Radenovic (Dir.)  

Lausanne, EPFL, 2021. 

The genetic architecture of complex human traits at the dawn of genomic medicine

O. N. M. Naret / J. Fellay (Dir.)  

Lausanne, EPFL, 2021. 

Towards an artificial cell: Development of a system which self-regenerates the protein components of the PURE system in microfluidic reactors

B. Lavickova / S. Maerkl (Dir.)  

Lausanne, EPFL, 2021. 

Towards scalable and deterministic single cell gene expression profiling

J. J. Bues / B. Deplancke (Dir.)  

Lausanne, EPFL, 2021. 

Organisation and dynamics of mitochondria and their RNA.

T. H. R. Rey / S. Manley (Dir.)  

Lausanne, EPFL, 2021. 

Developing new tools to study and program cell fate at the single-cell level

M. Biocanin / B. Deplancke (Dir.)  

Lausanne, EPFL, 2021. 

KRAB zinc finger protein-mediated control of transposon-embedded regulatory sequences from human germline to early embryos

A. Iouranova / D. Trono; P. Turelli (Dir.)  

Lausanne, EPFL, 2021. 

Circadian dynamics of RNA localisation in the mammalian liver

C. Y. S. Hurni / F. Naef (Dir.)  

Lausanne, EPFL, 2021. 

Microtissue models for studying the dynamics of host-pathogen interactions in the urinary bladder

K. Sharma / J. McKinney; N. Dhar (Dir.)  

Lausanne, EPFL, 2021. 

Microfluidics and cell-free synthetic biology in the development of new diagnostic and therapeutic platforms

G. Michielin / S. Maerkl (Dir.)  

Lausanne, EPFL, 2021. 

Co-regulation of endothelial and myogenic cell fates through intercellular crosstalk in skeletal muscle

U. Lee / J. Feige; B. D. Cosgrove (Dir.)  

Lausanne, EPFL, 2021. 

Development and applications of hyperpolarized 13C and 1H MR spectroscopy of cerebral metabolism at ultra-high field

E. I. Flatt / R. Gruetter (Dir.)  

Lausanne, EPFL, 2021. 

Single-cell lipidomics reveals a role for cell-to-cell sphingolipid heterogeneity in fibroblast activation

L. Capolupo / G. D’Angelo (Dir.)  

Lausanne, EPFL, 2021. 

Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in mouse

A. M. Bachmann / J. Auwerx (Dir.)  

Lausanne, EPFL, 2021. 

In situ photopolymerizable hydrogels for intracranial aneurysms treatment

O. Poupart / D. Pioletti; C. Moser (Dir.)  

Lausanne, EPFL, 2021. 

Non-invasive monitoring of key hemodynamical and cardiac parameters using physics-based modelling and artificial intelligence

V. Bikia / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2021. 

Coordination between cell growth, division and chromosome replication cycles in mycobacteria

G. M. Vuaridel / J. McKinney; N. Dhar (Dir.)  

Lausanne, EPFL, 2021. 

Post-translational regulation of neuronal differentiation

J. S. Loomba / G. D’Angelo (Dir.)  

Lausanne, EPFL, 2021. 

Wireless soft microscale actuators and robotic devices to study mechanobiology

R. F. Penacho Parreira / M. S. Sakar (Dir.)  

Lausanne, EPFL, 2021. 

2020

Sensor and the Beast: Generalised Methods to Recognise Animal Behaviour and Quantify Energy Expenditure Using Inertial Sensors, and Applications

P. Chakravarty / K. Aminian (Dir.)  

Lausanne, EPFL, 2020. 

Gait analysis in children with cerebral palsy: bridging the gap between the laboratory and real life

L. Carcreff / K. Aminian; S. Armand (Dir.)  

Lausanne, EPFL, 2020. 

High-throughput microfluidic platforms for characterizing and engineering cell-free gene regulatory circuits

Z. N. Swank / S. Maerkl (Dir.)  

Lausanne, EPFL, 2020. 

Microfluidic devices for the study of cell-cell, cell-particle and particle-particle interactions

M. C. M. Duchamp / P. Renaud; A. Harari (Dir.)  

Lausanne, EPFL, 2020. 

Development of novel methods and tools to decipher the huntingtin post-translation modifications code

A. Chiki / H. Lashuel (Dir.)  

Lausanne, EPFL, 2020. 

Characterization of Protein-Membrane Interfaces through a Synergistic Computational-Experimental Approach

A. Prunotto / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2020. 

In vitro modeling of early mouse development

M. U. Girgin / M. Lütolf (Dir.)  

Lausanne, EPFL, 2020. 

Hemodynamics of ageing, ventricular-arterial coupling and noninvasive assessment of key hemodynamical and cardiac quantities

S. Z. Pagoulatou / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2020. 

Metabolic rescue of muscle and muscle stem cells in muscle disease

P. Luan / J. Auwerx (Dir.)  

Lausanne, EPFL, 2020. 

Functional de novo Protein Design for Targeted Vaccines and Synthetic Biology Applications

C. Yang / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2020. 

Bioengineering Methods to Improve in vitro Adoptive Cell Therapy based on Tumor-Infiltrating Lymphocytes

F. R. Rivest / M. Lütolf; L. L. Sohn (Dir.)  

Lausanne, EPFL, 2020. 

Microfluidic iMITOMI platform to study the architecture of low-affinity transcription factor binding site clusters

I. Istomin / S. Maerkl (Dir.)  

Lausanne, EPFL, 2020. 

Beneficial axis of the renin-angiotensin system: from applications to drug discovery

M. Bragina / N. Stergiopulos; M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2020. 

Quantitative approaches to unravel bone marrow adipocyte site-specificity and its implication in hematopoiesis

J. C. P. Tratwal / O. M. Naveiras Torres-Quiroga (Dir.)  

Lausanne, EPFL, 2020. 

Time-lapse high-resolution microscopy to study the morphogenesis of microorganisms

M. T. M. Hannebelle / G. Fantner; J. McKinney (Dir.)  

Lausanne, EPFL, 2020. 

Multidisciplinary Approach to Treat Erectile Dysfunction

M. N. Sturny / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2020. 

2019

Bioengineering the Human Muscle Stem-Cell Niche for Therapeutic Applications

O. Mashinchian / J. Feige; M. Lütolf (Dir.)  

Lausanne, EPFL, 2019. 

Modeling hematopoietic stem cell dynamics in bioengineered niches

S. Giger / M. Lütolf (Dir.)  

Lausanne, EPFL, 2019. 

Anti-angiogenic immunotherapy for lung cancer

E. Kadioglu / M. De Palma (Dir.)  

Lausanne, EPFL, 2019. 

Expanding beyond the natural protein repertoire to engineer targeted vaccines and diagnostics

F. Sesterhenn / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2019. 

2D nanopores: fabrication, energy harvesting and field-effect sensing

M. Graf / A. Radenovic (Dir.)  

Lausanne, EPFL, 2019. 

Engineering Dynamic Hydrogels For In Vitro Organoid Culture

D. L. P. Blondel / M. Lütolf (Dir.)  

Lausanne, EPFL, 2019. 

Metabolic and microenvironmental strategies to accelerate hematopoietic recovery post-aplasia

V. Ledebur de Antas de Campos / O. M. Naveiras Torres-Quiroga (Dir.)  

Lausanne, EPFL, 2019. 

Soft multimodal neural interfaces for unravelling sensory neurological circuits

F. P. G. Michoud / S. Lacour (Dir.)  

Lausanne, EPFL, 2019. 

Single-cell studies of Mycobacterium smegmatis cell cycle using time-lapse fluorescence microscopy

J. X. Y. Ven / J. McKinney (Dir.)  

Lausanne, EPFL, 2019. 

Bioengineering human bone marrow models to elucidate the triggers of the stem cell niche

Q. Vallmajó Martín / M. Lütolf; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2019. 

Microchannel-based technologies for nerve interfacing

S. Gribi / S. Lacour (Dir.)  

Lausanne, EPFL, 2019. 

Structural and functional characterisation of the KRAB-domain associated protein 1

G. Fonti / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2019. 

Tailoring the Mechanical Properties of Tissue Engineering Scaffolds made from Decellularized Cartilage

J. Antons / D. Pioletti; L. A. Laurent-Applegate (Dir.)  

Lausanne, EPFL, 2019. 

Integrated microfluidic tools for the characterization of protein/DNA interactions in vitro and in vivo

R. Dainese / B. Deplancke (Dir.)  

Lausanne, EPFL, 2019. 

Tissue-specific circadian transcriptional regulation

J. Yeung / F. Naef (Dir.)  

Lausanne, EPFL, 2019. 

Application of anti-amyloid beta immunization using encapsulated cell technology in mouse models of Alzheimer’s disease

V. Laversenne / B. Schneider; P. Aebischer (Dir.)  

Lausanne, EPFL, 2019. 

Optical projection tomography for whole organ imaging

D. Nguyen / T. Lasser; D. N. A. Van De Ville (Dir.)  

Lausanne, EPFL, 2019. 

Characterization of Coenzyme Q Biosynthesis Proteins through Integrative Modeling at the Protein-Membrane Interface

D. Aydin / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2019. 

The onset of cardiovascular disease in mice: an image-based, computational-experimental approach

L. Aslanidou / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2019. 

Elucidating regulatory mechanisms shaping the transcriptome and proteome of the gut immune response in Drosophila melanogaster

M. V. Frochaux / B. Deplancke (Dir.)  

Lausanne, EPFL, 2019. 

The role of OCT4 and SOX2 in regulating chromatin accessibility and cell fate across the cell cycle in embryonic stem cells

T. E. Friman / D. M. Suter (Dir.)  

Lausanne, EPFL, 2019. 

Label-free plasmonic biosensors for real-time live cell analysis

X. Li / H. Altug (Dir.)  

Lausanne, EPFL, 2019. 

2018

Modeling and analysis of parts and devices of genetic regulation

Y. Berset / V. Hatzimanikatis; J. R. van der Meer (Dir.)  

Lausanne, EPFL, 2018. 

More Medicines for Tuberculosis: Fuelling Drug Discovery against Mycobacterium tuberculosis

S-Y. C. Foo / S. Cole (Dir.)  

Lausanne, EPFL, 2018. 

Computational and Statistical analyses of Molecular Evolution and Demography using Large-scale Sequencing Data

A. Kapopoulou / B. Deplancke; J. D. Jensen (Dir.)  

Lausanne, EPFL, 2018. 

Single-cell division and killing dynamics of bacteria exposed to isocratic and time-dependent concentrations of antibiotic

K. E. Schneider / J. McKinney; N. Dhar (Dir.)  

Lausanne, EPFL, 2018. 

Quantitative analysis of SOX2 and OCT4 expression in pluripotency and differentiation

D. Strebinger / D. M. Suter (Dir.)  

Lausanne, EPFL, 2018. 

Novel tools to dissect stem cell metabolism at single cell level

G. Nikitin / M. Lütolf; A. Meibom (Dir.)  

Lausanne, EPFL, 2018. 

Introducing tolerance to foreign and partly foreign proteins by erythrocyte binding and artificial glycosylations

K. L. Brünggel / M. Lütolf; J. A. Hubbell (Dir.)  

EPFL, 2018. 

Ultra high magnetic field for glial contribution into brain metabolism studied by MR spectroscopy and CEST methods for molecular imaging of glycogen

E. M. C. Vinckenbosch / R. Gruetter (Dir.)  

Lausanne, EPFL, 2018. 

Development of microfluidic tools and methods for the biochemical characterization of scFv and Cas9 affinity reagents and their applications in molecular detection

E. E. Petrova / S. Maerkl (Dir.)  

Lausanne, EPFL, 2018. 

Likelihood-free Inference of Population Genetic Parameters from Time-Sampled Genetic Data

H. Shim / F. G. van der Goot Grunberg (Dir.)  

Lausanne, EPFL, 2018. 

Advancing immunotherapy for HPV-related cancers: Improving therapeutic vaccination approaches and understanding the immunosuppressive role of myeloid cells

G. Galliverti / M. Swartz; D. Hanahan (Dir.)  

Lausanne, EPFL, 2018. 

In vitro fate mapping of stem cell development at the single cell level

V. Trachsel / M. Lütolf (Dir.)  

Lausanne, EPFL, 2018. 

The phenotypic impact of naturally occurring genetic and molecular mitochondrial variation in a Drosophila Genetic Reference Population

R. P. J. Bevers / B. Deplancke (Dir.)  

Lausanne, EPFL, 2018. 

Genetic determinants of healthy human immune variance: from humoral response to microbiome diversity

P. Scepanovic / J. Fellay; B. Deplancke (Dir.)  

Lausanne, EPFL, 2018. 

Constrained optimization applied to multiscale integrative modeling

G. E. Tamo / M. Dal Peraro (Dir.)  

EPFL, 2018. 

New roles of the lymphatic endothelium in modulating adaptive immunity: implications for immune tolerance and cancer immunotherapy

L. C. F. Potin / M. Swartz; D. Hanahan (Dir.)  

Lausanne, EPFL, 2018. 

Mitochondrial stress signalling and its impacts on physiology

A. J. L. Mottis / J. Auwerx (Dir.)  

Lausanne, EPFL, 2018. 

Circadian clock- and feeding-dependent regulation of translation initiation and elongation in the liver

C. A. Gobet / F. Naef; K. Sakamoto (Dir.)  

Lausanne, EPFL, 2018. 

Quantitative analysis of gene expression and transcriptional memory in mouse embryonic stem cells

A. Mandic / D. M. Suter (Dir.)  

Lausanne, EPFL, 2018. 

Electronic dura mater soft, multimodal neural interfaces : technology, integration and implementation to surface implants

A. E. Hirsch / S. Lacour (Dir.)  

Lausanne, EPFL, 2018. 

Mid-Infrared plasmonic nanoantennas for ultrasensitive detection of proteins and their secondary structure

D. Etezadi / H. Altug (Dir.)  

Lausanne, EPFL, 2018. 

What is the role of fish intestine as environment-organism barrier? Mechanistic investigations using fish intestinal cells on a chip

C. Drieschner / P. Renaud; K. Schirmer (Dir.)  

Lausanne, EPFL, 2018. 

Quantitative single cell dynamics of signaling and transcriptional response in mammalian cells

O. Tidin / D. M. Suter; F. Naef (Dir.)  

Lausanne, EPFL, 2018. 

2017

In vitro modeling of complex microenvironmental regulation of stem cells

Y. Tabata / M. Lütolf (Dir.)  

Lausanne, EPFL, 2017. 

Evaluation of oxidation-sensitive polymersomes as vaccine nanocarriers to enhance humoral responses against arenavirus envelope glycoproteins

C. Galan Navarro / M. Dal Peraro; M. Swartz (Dir.)  

Lausanne, EPFL, 2017. 

Investigating the Biological Mechanisms underlying the Initiation of Autoimmunity against Beta Cell Antigens in Type 1 Diabetes

C. Cianciaruso / J. A. Hubbell; S. Baekkeskov Hanahan (Dir.)  

Lausanne, EPFL, 2017. 

Lipid membrane characterization with second harmonic scattering : surface potentials, ionization, membrane asymmetry and hydration

C. U. Lütgebaucks / S. Roke (Dir.)  

Lausanne, EPFL, 2017. 

Fighting preterm birth with novel surgical tools and biomaterials engineering

Y. R. Devaud / M. Lütolf; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2017. 

Novel systems biology approaches for design and analysis of palmitoylation networks reveal its regulatory effects on protein stability, activity and localization

T. Dallavilla / V. Hatzimanikatis; F. G. van der Goot Grunberg (Dir.)  

Lausanne, EPFL, 2017. 

A Microfluidic Brain Interface for In Vivo Recording of Neurochemical Activity

G. C. Y. Petitpierre / P. Renaud (Dir.)  

Lausanne, EPFL, 2017. 

Cell lineage tracing in human tissues using somatic mitochondrial mutations

P. Refinetti / S. Morgenthaler; P. O. Ekstrom (Dir.)  

Lausanne, EPFL, 2017. 

Microfluidic and Electrokinetic Manipulation of Single Cells

S. Kilchenmann / C. Guiducci (Dir.)  

Lausanne, EPFL, 2017. 

Regulation of Endoplasmic Reticulum Architecture by Protein S-Palmitoylation

P. A. Sandoz / F. G. van der Goot Grunberg (Dir.)  

Lausanne, EPFL, 2017. 

Computational methods and modeling of cellular function for the optimization of protein production and the study of cellular disease states

J. R. Pinto Vieira / V. Hatzimanikatis (Dir.)  

Lausanne, EPFL, 2017. 

Exploring the potency of normal and pathological human thymic epithelial cells

T. M. C. Arlabosse / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2017. 

Nanocapillaries combined with optical tweezers as a single molecule technique for studying DNA-protein complexes

R. Bulushev / A. Radenovic (Dir.)  

Lausanne, EPFL, 2017. 

The therapeutic role of NAD+ modulation in fatty liver disease

K. L. Gariani / J. Auwerx (Dir.)  

Lausanne, EPFL, 2017. 

Role of ACMSD in regulation of NAD+ metabolism and mitochondrial function

E. Katsyuba / J. Auwerx (Dir.)  

Lausanne, EPFL, 2017. 

Inferring the age and strength of mutations evolving under positive selection

N. L. Ormond / J. D. Jensen (Dir.)  

Lausanne, EPFL, 2017. 

Deciphering the subcapsular epithelial cells in human fetal and postnatal thymus

D. S. E. Hemon / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2017. 

Human and eco-toxicological impacts of organometallic halide perovskites

R. I. Benmessaoud / L. Forró; H. Lashuel (Dir.)  

Lausanne, EPFL, 2017. 

Advanced technologies to control stem-cell based organogenesis

N. Brandenberg / M. Lütolf (Dir.)  

Lausanne, EPFL, 2017. 

Microfluidic platforms for high-throughput mammalian cell printing, transfection, and dosage-dependent studies

K. P. Woodruff / S. Maerkl (Dir.)  

Lausanne, EPFL, 2017. 

Gene regulatory dynamics underlying brown fat cell differentiation

R. N. Pradhan / B. Deplancke (Dir.)  

Lausanne, EPFL, 2017. 

Selective electrical and optical neuromodulation of the central nervous system with conformable microfabricated implants

A. A. Guex / S. Lacour (Dir.)  

Lausanne, EPFL, 2017. 

The role of the polyglutamine and N-terminal domains in regulating the aggregation and structural properties of Huntingtin Exon 1

S. Vieweg / H. Lashuel (Dir.)  

Lausanne, EPFL, 2017. 

AAV based gene therapy for rare diseases : targeting astrocytes for functional recovery in Amyotrophic Lateral Sclerosis

C. C. Rochat / P. Aebischer; B. Schneider (Dir.)  

Lausanne, EPFL, 2017. 

Group Decisions Influence Emergence and Regulation of Leaders during Collective Migration of Epithelial Cells

M. Vishwakarma / J. A. Hubbell; J. Spatz (Dir.)  

Lausanne, EPFL, 2017. 

Elucidating the role of lymphatic vessels within the tumor microenvironment of breast cancer

I. M. van Mier / M. Swartz; M. De Palma (Dir.)  

Lausanne, EPFL, 2017. 

A Microfluidic Platform Enables Large-Scale Single-Cell Screening to Identify Genes Involved in Bacterial Persistence

A. Verpoorte / J. McKinney; S. Maerkl (Dir.)  

Lausanne, EPFL, 2017. 

2016

New immunomodulatory roles of lymphatic endothelium and implications for immunotherapy

E. Vokali / M. Swartz (Dir.)  

Lausanne, EPFL, 2016. 

Integrating Gene Synthesis and MITOMI for Rapid Protein Engineering

M. C. Blackburn / S. Maerkl (Dir.)  

Lausanne, EPFL, 2016. 

Engineering nanoparticle-based vaccines: Implications for the quality of humoral and cellular immunity

M. Rincón-Restrepo / M. Swartz; S. Hirosue (Dir.)  

Lausanne, EPFL, 2016. 

Mechanical and Functional Study of Cell Physiology at the Nanoscale

P. D. Odermatt / G. Fantner (Dir.)  

Lausanne, EPFL, 2016. 

Protein engineering approaches for direct antigen targeting in CD8+ T cell inducing vaccines

V. Panagiotou / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

Stem cell niche engineering through photopatterning and microfluidics

L. Kolb / M. Lütolf (Dir.)  

Lausanne, EPFL, 2016. 

Unraveling the KRAB/KAP1 control of transposable elements in pluripotent and somatic cells

G. Ecco / D. Trono; P. Turelli (Dir.)  

Lausanne, EPFL, 2016. 

BCI based on Neural Correlates of Anticipatory Behavior during Driving

Z. Khaliliardali / J. d. R. Millán Ruiz (Dir.)  

Lausanne, EPFL, 2016. 

Protrusion-retraction switches and traction forces in spontaneous cell polarization

A. C. Bornert / A. Verkhovsky (Dir.)  

Lausanne, EPFL, 2016. 

Instrumented shoes for daily activity monitoring in healthy and at risk populations

C. Moufawad El Achkar / K. Aminian (Dir.)  

Lausanne, EPFL, 2016. 

Tunable and cell-responsive 3D poly(ethylene glycol) microenvironments for the development of tissue models

S. E. Metzger / J. A. Hubbell; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2016. 

Towards brain-on-a-chip : microfluidic and microelectrode array platforms for morphological and electrophysiological observations on the propagation of Alzheimer’s disease

Y. Ren / P. Renaud (Dir.)  

Lausanne, EPFL, 2016. 

Host and pathogen genomics of severe pediatric infections

S. Asgari / J. Fellay (Dir.)  

Lausanne, EPFL, 2016. 

Novel interventions to recover the regenerative capacity of aged skeletal muscle by targeting the interactions in the stem cell niche

L. Lukjanenko / J. Feige; J. Auwerx (Dir.)  

Lausanne, EPFL, 2016. 

Engineering Lymphangiogenesis : Implications for Cancer Immunotherapy and Beyond

M. A. Fankhauser / M. Swartz (Dir.)  

Lausanne, EPFL, 2016. 

Microwell and impedance-based approaches to isolate single cells for life sciences

G. Muller / Y. Barrandon; P. Renaud (Dir.)  

Lausanne, EPFL, 2016. 

Deciphering the Role of LRH-1 in Liver Intermediary Metabolism and Cancer

P. Xu / K. Schoonjans (Dir.)  

Lausanne, EPFL, 2016. 

Mitochondrial unfolded protein response, its molecular mechanism and physiological impact

V. Jovaisaite / J. Auwerx (Dir.)  

Lausanne, EPFL, 2016. 

Bioengineering approaches in immunotherapy : from basic to translational applications

M. Damo / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

Quantitative Single-Cell Analysis of Host-Pathogen Interactions

M. J-H. Delincé / J. McKinney (Dir.)  

Lausanne, EPFL, 2016. 

Therapeutic Proteins Engineered for Super-Affinity to the Extracellular Matrix in Regenerative Medicine

P. S. M. Briquez / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

Mechanisms of tolerance induction by erythrocyte-targeted antigens

A. J. Grimm / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

Metabolic control of muscle and muscle stem cell function

H. Zhang / J. Auwerx (Dir.)  

Lausanne, EPFL, 2016. 

Nanoscopy in nonlinear scanning fluorescence imaging systems

G. P. J. Laporte / D. Psaltis (Dir.)  

Lausanne, EPFL, 2016. 

In vivo mechanical loading combined with cell therapy in a bone tissue engineering scaffold

T. C. Hausherr / D. Pioletti (Dir.)  

Lausanne, EPFL, 2016. 

Engineering the Extra Domain A of fibronectin as a vaccine adjuvant and study of its role in tissue regeneration

Z. Julier / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

Role of microRNAs in tumor-associated macrophages

C. M. Baer / M. De Palma (Dir.)  

Lausanne, EPFL, 2016. 

Microdevices for Locomotion in Complex Biological Fluids

T. Qiu / J. A. Hubbell; P. Fischer (Dir.)  

Lausanne, EPFL, 2016. 

Allosteric regulation and targeting of Abl SH2-kinase interface and other cytoplasmic tyrosine kinases

A. J. Lamontanara / O. Hantschel (Dir.)  

Lausanne, EPFL, 2016. 

From the early steps of whisker formation to its evolutionary disappearance: the (curious) case of Prdm1 and its regulation

P. G. Manti / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2016. 

2015

Quantification of low molecular weight drugs : from the selection of nucleic acid-based capture molecules to the characterization in patient samples

A. Ferretti / C. Guiducci (Dir.)  

Lausanne, EPFL, 2015. 

Deciphering Metabolic Regulation of Hematopoietic Stem Cell Fate

M. Girotra / M. Lütolf (Dir.)  

Lausanne, EPFL, 2015. 

Reconstruction and systems analysis of metabolism in apicomplexan parasites Toxoplasma gondii and Plasmodium falciparum

S. Tymoshenko / V. Hatzimanikatis; D. Soldati-Favre (Dir.)  

Lausanne, EPFL, 2015. 

Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson’s Disease

M-B. Fares / H. Lashuel (Dir.)  

Lausanne, EPFL, 2015. 

Implementation and Characterization of Dynamic Genetic Networks in Vitro

H. M. Niederholtmeyer / S. Maerkl (Dir.)  

Lausanne, EPFL, 2015. 

Tissue engineering for prenatal applications

A-S. J. Kiveliö / J. A. Hubbell; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2015. 

Interactions of Peripheral Nerve Cells with Soft Micropillar Interfaces

C. X. Paulou / S. Lacour (Dir.)  

Lausanne, EPFL, 2015. 

Bio-engineered collagen-fibrin scaffolds for enhancing urological tissue regeneration

E. Vardar / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2015. 

Study of transposon-mediated cell pool and cell line generation in CHO cells

S. Balasubramanian / F. M. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2015. 

Functional Perturbation of the Gab2 Multiprotein Complex by High-affinity SH2-binding Monobodies in Chronic Myelogenous Leukemia

E. B. Gencer Akçok / O. Hantschel (Dir.)  

Lausanne, EPFL, 2015. 

Superresolution Reconstruction for Magnetic Resonance Spectroscopic Imaging Exploiting Low-Rank Spatio-Spectral Structure

J. A. Kasten / D. Van De Ville; F. Lazeyras (Dir.)  

Lausanne, EPFL, 2015. 

Quantitative single-cell analysis of S. cerevisiae using a microfluidic live-cell imaging platform

J. Becker / F. Naef; S. Maerkl (Dir.)  

Lausanne, EPFL, 2015. 

Modeling and Engineering Proteins Thermostability

H. Pezeshgi Modarres / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2015. 

Microfluidic engineering of artificial stem cell niches

S. Allazetta / M. Lütolf (Dir.)  

Lausanne, EPFL, 2015. 

Analytical Methods, Correlative Microscopy and Software Tools for Quantitative Single Molecule Localization Microscopy

A. Shivanandan / A. Radenovic; I. Sbalzarini (Dir.)  

Lausanne, EPFL, 2015. 

Connectivity Analysis of Brain States and Applications in Brain-Computer Interfaces

H. Zhang / J. d. R. Millán Ruiz (Dir.)  

Lausanne, EPFL, 2015. 

Transposable elements and their KRAB/KAP1 controllers broadly regulate transcription in adult human cells

F. Marzetta / D. Trono; P. Turelli (Dir.)  

Lausanne, EPFL, 2015. 

Bioengineering approaches to emulate the stem cell niche

S. Höhnel / M. Lütolf (Dir.)  

Lausanne, EPFL, 2015. 

2014

Active Transport Mechanisms by Lymphatic Endothelium and their Modulation by Inflammatory Mediators

V. Triacca / M. Swartz (Dir.)  

Lausanne, EPFL, 2014. 

Direct Somatic Cell Reprogramming in Synthetic 3D Microenvironments

Y. Okawa / M. Lütolf (Dir.)  

Lausanne, EPFL, 2014. 

Genetic analysis of the decaprenyl-phospho-D-arabinofuranose pathway in Mycobacterium tuberculosis

G. S. Kolly / S. Cole (Dir.)  

Lausanne, EPFL, 2014. 

An integrative genomics approach toward deciphering the regulatory logic of phase-specific circadian transcription in the mouse liver

I. Krier / B. Deplancke; J. Rougemont (Dir.)  

Lausanne, EPFL, 2014. 

The Engineering of a Scalable Disposable Orbitally Shaken Bioreactor System for Animal Cell Cultivation and Therapeutic Protein Production

D. T. Monteil Jr / F. M. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2014. 

Thermal gradients on a chip for the local stimulation of biological systems

S. Delasoie-Baranek / P. Renaud (Dir.)  

Lausanne, EPFL, 2014. 

New Tools for Hydrogel-Based 3D Bioprinting

A. Negro / M. Lütolf (Dir.)  

Lausanne, EPFL, 2014. 

Development of a Bisphosphonate Delivering Hydrogel for the Augmentation of Impaired Peri-Implant Bone

U. Kettenberger / D. Pioletti (Dir.)  

Lausanne, EPFL, 2014. 

From Genes to Organisms : Bioinformatics System Models and Software

T. Schaffter / D. Floreano; M. Affolter (Dir.)  

Lausanne, EPFL, 2014. 

Reversible attachment of Cell-Penetrating Peptides for the efficient delivery of α-synuclein to HeLa cells and primary cortical neurons

C. Desobry / H. Lashuel (Dir.)  

Lausanne, EPFL, 2014. 

Structure-function analysis of the EspR virulence regulator of Mycobacterium tuberculosis

B. Blasco / S. Cole (Dir.)  

Lausanne, EPFL, 2014. 

Novel non-invasive techniques for hemodynamic monitoring

O. Vardoulis / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2014. 

Subject-specific computational fluid dynamics modelling and measurement of cerebrospinal fluid motion in the cervical spine

T. Yiallourou / N. Stergiopulos; B. A. Martin (Dir.)  

Lausanne, EPFL, 2014. 

Development of plasmid-based expression technology for rapid and sustained production of recombinant proteins in insect cells

X. Shen / F. M. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2014. 

Dynamic brain networks explored by structure-revealing methods

N. Leonardi / D. Van De Ville (Dir.)  

Lausanne, EPFL, 2014. 

In vitro Fate Mapping of Single Hematopoietic Stem Cells

A. Roch / M. Lütolf (Dir.)  

Lausanne, EPFL, 2014. 

The regulatory circuit of natural competence for transformation in the human pathogen Vibrio cholerae

M. Lo Scrudato / M. Blokesch (Dir.)  

Lausanne, EPFL, 2014. 

A Systems Approach to Identify Genetic and Environmental Regulators of Metabolism

E. G. Williams / J. Auwerx (Dir.)  

Lausanne, EPFL, 2014. 

Automated long-term single cell analysis of Schizosaccharomyces pombe on a microfluidic microchemostat array

J-B. Nobs / S. Maerkl (Dir.)  

Lausanne, EPFL, 2014. 

The Effectual Hitchhiker : Mechanisms and Consequences of Interactions Between Endosymbiotic Spiroplasma and Host Drosophila

J. K. Herren / B. Lemaître (Dir.)  

Lausanne, EPFL, 2014. 

A systems approach to elucidate the genetic architecture of molecular phenotypes

S. M. Waszak / B. Deplancke (Dir.)  

Lausanne, EPFL, 2014. 

Pharmacological and biochemical assessment of γ-secretase-mediated APP processing involved in Alzheimer’s disease

M. Dimitrov / P. Fraering (Dir.)  

Lausanne, EPFL, 2014. 

Tissue Engineering Bone by Matrix-Assisted MSC Recruitment

P. S. Lienemann / M. Lütolf; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2014. 

A New Noninvasively Adjustable Glaucoma Drainage Device

A. Villamarin / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2014. 

Label-free Analytics by Transmission Localized-SPR and its Application to Small Molecules Monitoring in Serum

G. Cappi / C. Guiducci; L. Benini (Dir.)  

Lausanne, EPFL, 2014. 

Experimental and theoretical studies on the effects of smooth muscle on the mechanical response and remodeling of arteries

A. Agianniotis / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2014. 

Modeling of transcription mechanisms in mammals from kinetic measurements in single cells

B. Zoller / F. Naef (Dir.)  

Lausanne, EPFL, 2014. 

Engineering lymphangiogenesis : methods, characterization and functional consequences

E. Güç / M. Swartz (Dir.)  

Lausanne, EPFL, 2014. 

Dissecting the DNA binding principles of transcription factor monomers and heterodimers

A. Isakova / B. Deplancke (Dir.)  

Lausanne, EPFL, 2014. 

Engineering adjuvants for prophylactic and therapeutic subunit vaccines

A. de Titta / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2014. 

Engineering the lymphatic microenvironment for investigating tumor invasion, immune cell traficking and parasite infection under relevant biomechanical conditions

M. Pisano / M. Swartz (Dir.)  

Lausanne, EPFL, 2014. 

2013

Flexible Micro/Nanofabricated Systems for Medical Devices and Implants

W. Hasenkamp Carreira / P. Renaud (Dir.)  

Lausanne, EPFL, 2013. 

Dissipation as variable in cartilage mechanobiology

P. Abdel-Sayed / D. Pioletti (Dir.)  

Lausanne, EPFL, 2013. 

Discovery and functional characterisation of structural genomic variation in a natural population

A. Massouras / B. Deplancke (Dir.)  

Lausanne, EPFL, 2013. 

A microfluidic live-cell imaging platform to study large collections of microbial genotypes

N. Dénervaud / S. Maerkl; F. Naef (Dir.)  

Lausanne, EPFL, 2013. 

Multiscale simulations of protein dynamics

E. Spiga / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2013. 

Structure and function of proteins involved in attachment and piercing of the bacterial cell envelope

L. Sycheva / P. Leiman (Dir.)  

Lausanne, EPFL, 2013. 

Epiphyseal Chondro-Progenitor Cell Therapy For Articular Cartilage Regeneration

S. E. Darwiche / D. Pioletti; L. A. Laurent-Applegate (Dir.)  

Lausanne, EPFL, 2013. 

Temperature impacts human epidermal stem cell behaviour through thermoTRPs and mTOR signalling

J. A. Mosig Rodriguez / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2013. 

Systems Biology of 3D Stem Cell-Niche Interactions

A. Ranga / M. Lutolf (Dir.)  

Lausanne, EPFL, 2013. 

Metabolic modeling and experimental studies on carbon and energy metabolism of Mycobacterium tuberculosis

M. E. Özdemir / J. McKinney; V. Hatzimanikatis (Dir.)  

Lausanne, EPFL, 2013. 

Engineering nanoparticle vaccines : design principles for lymphatic targeting

S. Raghunathan / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2013. 

Computational Studies on Cellular Bioenergetics

K. C. Soh / V. Hatzimanikatis (Dir.)  

Lausanne, EPFL, 2013. 

Molecular Modeling of Membrane Embedded Proteins

T. Lemmin / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2013. 

Control of calcification in a biphasic osteochondral construct and enhancing interface integration

J. Hollenstein / D. Pioletti; R. L-Y. Sah (Dir.)  

Lausanne, EPFL, 2013. 

Development of Novel Nanoparticle-Based Vaccines and Immunotherapies : Tuberculosis, Lung Metastasis and Allergy as Models

M. Ballester / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2013. 

Systematic Analysis of Yeast Gene Expression by Synthetic Promoter Libraries

A. S. Rajkumar / S. Maerkl (Dir.)  

Lausanne, EPFL, 2013. 

The Use of Valproic Acid in Transient Gene Expression with HEK-293E Cells

D. Kiseljak / F. M. Wurm (Dir.)  

Lausanne, EPFL, 2013. 

A Simple High Yielding Transient Gene Expression System for CHO Cells

Y. Rajendra / F. M. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2013. 

Development and application of experimental tools to elucidate the gene regulatory network underlying adipogenesis

C. Delattre-Gubelmann / B. Deplancke (Dir.)  

Lausanne, EPFL, 2013. 

Identification of genetic determinants and pharmacological modulators of mitochondrial function

P. Andreux / J. Auwerx (Dir.)  

Lausanne, EPFL, 2013. 

Generating microarrays for protein interaction studies using microfluidic devices

S. Rockel / S. Maerkl (Dir.)  

Lausanne, EPFL, 2013. 

Targeting and Modulating Tumor-Associated Sites with Novel Nanoparticle-Based Immunotherapies

L. Jeanbart / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2013. 

Role of the bile acid membrane receptor TGR5 in macrophages and metabolism

M. Nomura / J. Auwerx; K. Schoonjans (Dir.)  

Lausanne, EPFL, 2013. 

The Phosphate Specific Transport (Pst) System in Fast- and Slow-Growing Mycobacteria

C. De Piano / J. McKinney (Dir.)  

Lausanne, EPFL, 2013. 

2012

Microtechnologies to Map the Fate of Single Stem Cells and their Progeny

S. Kobel / M. Lutolf; P. Renaud (Dir.)  

Lausanne, EPFL, 2012. 

Toxicity study of nanostructures

L. Horváth / L. Forró; B. Schwaller (Dir.)  

Lausanne, EPFL, 2012. 

Elucidating the role of post-translational modifications of alpha-synuclein using semisynthesis : phosphorylation at Tyrosine 125 and monoubiquitination at Lysine 6

M. Hejjaoui / H. Lashuel (Dir.)  

Lausanne, EPFL, 2012. 

Molecular Modeling of Bacterial Nanomachineries

M. T. Degiacomi / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2012. 

Structural Studies and Protein Engineering of Human O6-Alkylguanine-DNA Alkyltransferase

B. Mollwitz / K. Johnsson (Dir.)  

Lausanne, EPFL, 2012. 

Single-Cell Analysis of Mycobacterial Persistence Using Microfabricated Tools

M. Elitas / J. McKinney; S. Maerkl (Dir.)  

Lausanne, EPFL, 2012. 

Therapeutic Immunomodulation of the Lymphoid-like Tumor Environment Using Nanoparticulate Formulations

I. Kourtis / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2012. 

Early Fate Choice Determines in vivo Engraftment and in vitro Behavior of Epidermal Stem Cells

F. Gorostidi / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2012. 

Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

F. Zagari / F. Wurm; M. Jordan (Dir.)  

Lausanne, EPFL, 2012. 

Photopatterning of Synthetic Hydrogels

K. Mosiewicz / M. Lutolf (Dir.)  

Lausanne, EPFL, 2012. 

Hydrogel Microfluidics to Control Stem Cell Fate

S. Cosson / M. Lutolf (Dir.)  

Lausanne, EPFL, 2012. 

Genomics and transcriptomics of the Mycobacterium tuberculosis complex

S. Uplekar / S. Cole; J. Rougemont (Dir.)  

Lausanne, EPFL, 2012. 

Nanopore sensing of single molecules application to RNAP-DNA complexes, fabrication of graphene-nanopore devices and translocation algorithm analysis

C. Raillon / A. Radenovic; N. Hernandez (Dir.)  

Lausanne, EPFL, 2012. 

KRAB/KAP1 Regulation of Embryonic Stem Cell Pluripotent Self-renewal

A. Corsinotti / D. Trono (Dir.)  

Lausanne, EPFL, 2012. 

Dissecting Gene Regulatory Networks Using Targeted Quantitative Proteomics

J. Simicevic / B. Deplancke (Dir.)  

Lausanne, EPFL, 2012. 

Improving Immunogenicity of Subunit Vaccines Using Nanocarrier Systems

A. Stano / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2012. 

Molecular and Functional Characterization of Clonogenic Human Thymic Epithelial Cells

M. Maggioni / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2012. 

Immune Engineering Via Differential Antigen Carriers and Co-Stimulatory Molecules

J. Eby / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2012. 

Culture and Characterization of Human and Porcine Urothelial Progenitor Cells

H. M. Larsson / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2012. 

2011

On the Precision of Circadian Oscillators

T. D’Eysmond / F. Naef (Dir.)  

Lausanne, EPFL, 2011. 

The Role of LEKTI in the Fate Determination of Keratinocyte Stem Cells

A. W. Amici / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2011. 

Engineering Erythrocyte Affinity for Improved Pharmacokinetics and Immune Tolerogenesis

S. Kontos / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2011. 

In Vivo Studies on the Control of Gene Expression and Protein Degradation

K. Bojkowska / K. Johnsson; D. Trono (Dir.)  

Lausanne, EPFL, 2011. 

In vitro lymphatic endothelial morphogenesis : molecular vs. biophysical regulation

C. Yong Pullin / M. Swartz (Dir.)  

Lausanne, EPFL, 2011. 

Pressure and Flow Wave Propagation in Patient-Specific Models of the Arterial Tree

P. Reymond / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2011. 

OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up

S. Tissot / F. Wurm (Dir.)  

Lausanne, EPFL, 2011. 

New/Surface-Modified Biocompatible Polymer for ICD Lead Insulation

R. B. Pisarek / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2011. 

Folding and Structure of the Pore Forming Toxin Aerolysin

M. I. Iacovache / F. G. v. d. Goot Grunberg (Dir.)  

Lausanne, EPFL, 2011. 

Identification and Functional Response of “Interstitial Cells of Cajal”-like Cells from Rat Mesenteric Artery

A. Formey de Saint Louvent / J-J. Meister; J-L. Bény (Dir.)  

Lausanne, EPFL, 2011. 

Studies on KRAB/KAP1-Mediated Transcriptional Repression

A. C. Groner / D. Trono (Dir.)  

Lausanne, EPFL, 2011. 

Cellular Responses to Bacterial Pore-Forming Toxins

R. M. Gonzalez / F. G. v. d. Goot Grunberg (Dir.)  

Lausanne, EPFL, 2011. 

Hydrogels for Urinary Tract Tissue Engineering

L. A. Micol / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2011. 

Molecular Mechanisms Underlying Hyaline Fibromatosis Syndrome

J. Deuquet Ariosa / F. G. v. d. Goot Grunberg (Dir.)  

Lausanne, EPFL, 2011. 

Biofunctional Scaffold Design for Soft Tissue Regeneration

K. Lorentz / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2011. 

Assessment of Body Motion and Muscle Weakness : Outcome Evaluation in Frail Elderly and DMD Subjects

R. L. Ganea / K. Aminian (Dir.)  

Lausanne, EPFL, 2011. 

Force Transmission in Migrating Cells

M. Fournier / A. Verkhovski (Dir.)  

Lausanne, EPFL, 2011. 

Engineering of Signaling Microenvironments with Fibronectin Domains to Enhance Tissue Regeneration

M. Martino / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2011. 

2010

The Interplay between Cytidine Deaminases, HIV and Domesticated Genetic Parasites

Y. Bulliard / D. Trono (Dir.)  

Lausanne, EPFL, 2010. 

Biomechanics of Vascular Wall : the Role of Structural Organization of Elastin and Collagen

R. Saitta-Rezakhaniha / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2010. 

Dendritic cell chemotaxis in 3D : new tools and insights

U. Haessler / M. Swartz (Dir.)  

Lausanne, EPFL, 2010. 

Genomic Context and KRAB/KAP1-mediated Transcriptional Repression

S. Meylan / D. Trono (Dir.)  

Lausanne, EPFL, 2010. 

Rat bladder muscle regeneration induced by local delivery of an engineered insulin-like growth factor 1 in fibrin gels

L. Yang / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2010. 

Ambulatory Assessment of Foot Kinematics and Kinetics : Outcome Evaluation of Ankle Osteoarthritis Treatments

H. Rouhani / K. Aminian (Dir.)  

Lausanne, EPFL, 2010. 

Elucidating the Role of Quaternary Structure in Modulating Macrophage Migration Inhibitory Factor (MIF) Functions

F. El Turk / H. Lashuel (Dir.)  

Lausanne, EPFL, 2010. 

Biophysical Regulation of Lymphatic Vessel Function : Flow as a Mediator of Immune Cell and Fluid Transport

D. Miteva / M. Swartz (Dir.)  

Lausanne, EPFL, 2010. 

Identification of genetic insulator elements to increase the safety of viral gene therapy vectors

A. Gaussin / J. A. Hubbell; N. Mermod (Dir.)  

Lausanne, EPFL, 2010. 

Lentiviral Vector-Mediated Gene Delivery for the Generation of Chinese Hamster Ovary Cell Lines with Improved Productivity and Stability

A. Oberbek / F. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2010. 

Arterial remodeling using a constituent-based approach

A. Tsamis / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2010. 

Small Molecule Based Approaches to Inhibit Macrophage Migration Inhibitory Factor (MIF) Activities and Elucidate its Role in Health and Disease

H. Ouertatani-Sakouhi / H. Lashuel (Dir.)  

Lausanne, EPFL, 2010. 

Transient Gene Expression in HEK-293E Cells for Recombinant Protein Production : Process Characterization towards GMP Approval

S. Nallet / F. Wurm (Dir.)  

Lausanne, EPFL, 2010. 

Innate Barriers to Genome Invasion : how TRIM5a Restricts Retroelements

P. Maillard / D. Trono (Dir.)  

Lausanne, EPFL, 2010. 

2009

Tissue engineering of the bladder : exploiting a 3D hydrogel for modulation of the smooth muscle cell phenotype

C. Adelöw / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2009. 

The interplay between the VEGF-C/VEGFR-3 axis and CCL21/CCR7 axis in tumor cell invasion

A. Issa / M. Swartz (Dir.)  

Lausanne, EPFL, 2009. 

Investigation of novel calcium-related events as suspected contributors to neurodegeneration

N. Rudinskiy / R. Luthi-Carter (Dir.)  

Lausanne, EPFL, 2009. 

Transient recombinant protein expression in mammalian cells : the role of mRNA level and stability

S. Wulhfard / F. Wurm (Dir.)  

Lausanne, EPFL, 2009. 

The tissue reaction to neuroprostheses

A. Mercanzini / P. Renaud (Dir.)  

Lausanne, EPFL, 2009. 

Studies on lentiviral-mediated transgenesis

M-O. Sauvain / D. Trono (Dir.)  

Lausanne, EPFL, 2009. 

The role of TIF1 gamma during adult murine hematopoiesis

K. Shakhbazov / F. Radtke; A. Trumpp (Dir.)  

Lausanne, EPFL, 2009. 

Orbitally shaken bioreactors for mammalian cell culture : engineering characterization and bioprocess scale-up

X. Zhang / F. Wurm (Dir.)  

Lausanne, EPFL, 2009. 

Studies on scaffold design for tissue engineering applications : contribution of synthetic, natural and recombinant materials

E-M. Engelhardt / F. Wurm; P. Frey (Dir.)  

Lausanne, EPFL, 2009. 

Protein-binding microarray technology and ChIP-sequencing for the identification of novel targets of the human tumor suppressor AP2[alpha]

J. Kerschgens / J. A. Hubbell; N. Mermod (Dir.)  

Lausanne, EPFL, 2009. 

Differential effects of reduced cyclic stretch and perturbed shear stress within the arterial wall

T. Thacher / N. Stergiopulos; R. F. d. Silva (Dir.)  

Lausanne, EPFL, 2009. 

Fetal cells for intervertebral disc regeneration

A. Quintin / D. Pioletti; L. A. Laurent-Applegate (Dir.)  

Lausanne, EPFL, 2009. 

Immunoisolated cell implants for intracerebral delivery of anti-Aß single chain Fv antibodies in the APP23 Alzheimer’s mouse model

O. Marroquin Belaunzaran / P. Aebischer (Dir.)  

Lausanne, EPFL, 2009. 

Peptide ligands for targeting and retention of nanoparticles and protein therapeutics in articular cartilage

D. A. Rothenfluh / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2009. 

Stem cell-based cardiovascular tissue engineering

T. Krähenbühl / J. A. Hubbell; R. S. Langer (Dir.)  

Lausanne, EPFL, 2009. 

2008

Prevention of micromotion-related periprosthetic bone loss using local release of bisphosphonate : theoretical developments and experimental validations

V. Stadelmann / D. Pioletti (Dir.)  

Lausanne, EPFL, 2008. 

Development of an in vitro microenvironment for maturing oocytes

J. E. Ihm / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2008. 

Accelerating the development time of recombinant mammalian cell lines producing high titers of protein therapeutics

S. Chenuet / F. Wurm (Dir.)  

Lausanne, EPFL, 2008. 

A novel cell culture approach for tissue engineering based on surface expansion

H. Majd / B. Hinz (Dir.)  

Lausanne, EPFL, 2008. 

Role and mechanism of transient receptor potential (TRP) channels in gustatory and chemesthetic sensations associated with dietary molecules

C. Riera / H. Vogel (Dir.)  

Lausanne, EPFL, 2008. 

Novel applications of poly(ethylene glycol)-bl-poly(propylene sulfide) block copolymers

C. O’Neil / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2008. 

Effects of base-pair sequence, nicks and gaps on DNA minicircle shapes : analysis and experiment

A. Amzallag / J. H. Maddocks (Dir.)  

Lausanne, EPFL, 2008. 

Vascular physiology : effects of vascular smooth muscle alteration on arterial wall biomechanics

S. Roy / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2008. 

Development of high-titer transient gene expression processes for manufacturing recombinant proteins

G. Backliwal / F. Wurm (Dir.)  

Lausanne, EPFL, 2008. 

Tissue engineering complex and mechanically active microenvironments for studies in asthma and cancer

A. A. Tomei / M. Swartz (Dir.)  

Lausanne, EPFL, 2008. 

Polymeric carriers for therapeutic agents : drug and gene delivery systems by reversible addition-fragmentation transfer (RAFT) polymerization

Y. S. Jo / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2008. 

Exploiting immunofunctional nanoparticles as vaccines and synthetic pathogens

S. T. Reddy / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2008. 

Molecular and mechanical regulators of lymphatic biology

J. M. Rutkowski / M. Swartz (Dir.)  

Lausanne, EPFL, 2008. 

Mechanical orchestration of tissue remodeling

P-J. Wipff / B. Hinz (Dir.)  

Lausanne, EPFL, 2008. 

2007

Polynucleotide cytidine deaminases, innate immunity and hepatitis B infection

S. Jost / D. Trono (Dir.)  

Lausanne, EPFL, 2007. 

Effects of dynamic environments on extracellular morphogen gradients

M. E. Fleury / M. Swartz (Dir.)  

Lausanne, EPFL, 2007. 

Bioreactor processes based on disposable materials for the production of recombinant proteins from mammalian cells

M. Stettler / F. Wurm (Dir.)  

Lausanne, EPFL, 2007. 

2005

Development of a novel drug delivery system based on polymeric, thermoresponsive, hydrogel nanoparticles

D. Misirlis / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2005.