La Manno Lab – Laboratory of Neurodevelopmental Systems Biology

Our research focuses on understanding how the cell types in the nervous system are made. We are particularly interested in describing the sequence of states that embryonic stem cells go through during their differentiation towards mature neurons in the central nervous system and the retina.

Team

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The people in the lab

LATEST PUBLICATIONS

Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation

S. Petrus-Reurer; A. R. Lederer; L. Baque-Vidal; I. Douagi; B. Pannagel et al.

Stem Cell Reports. 2022-06-14. Vol. 17, num. 6, p. 1458-1475. DOI : 10.1016/j.stemcr.2022.05.005.

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Sphingolipids control dermal fibroblast heterogeneity

L. Capolupo; I. Khven; A. R. Lederer; L. Mazzeo; G. Glousker et al.

Science. 2022-04-15. Vol. 376, num. 6590, p. 262-+. DOI : 10.1126/science.abh1623.

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Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics

M. Ratz; L. von Berlin; L. Larsson; M. Martin; J. O. Westholm et al.

Nature Neuroscience. 2022-02-24. DOI : 10.1038/s41593-022-01011-x.

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Selected Publications

"Keep an open mind for all the new challenges"

Published:06.10.22 — Celebrating 20 years of the School of Life Sciences and the School of Computer and Communication Sciences, we talk to alumni about their career paths, memories of EPFL, and ask their advice to current students in a video series called “where are they now?”.

Nathalie Brandenberg et Sylke Hoehnel, the two founders of the EPFL Start-up SUN bioscience just got the 2022 Alumni Award. © Alain Herzog / 2022 EPFL

"Every step you take brings you ever closer to your goal"

Published:04.10.22 — SUN bioscience has developed a platform technology for growing organoids that doctors can use to determine the best treatment for a given patient. The company’s revolutionary approach has earned its two founders – EPFL graduates Nathalie Brandenberg and Sylke Hoehnel – a 2022 Alumni Award, which was given out at the Magistrale graduation ceremony.

Where Are They Now?

Published:27.09.22 — As different Schools across EPFL celebrate their 20th anniversary in 2022, the School of Computer and Communication Sciences (IC) and the School of Life Sciences (SV) have launched a new video series showcasing global alumni achievements.

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