La Manno Lab – Laboratory of Neurodevelopmental Systems Biology

Our research focuses on understanding how the cell types in the nervous system are made. We are particularly interested in describing the sequence of states that embryonic stem cells go through during their differentiation towards mature neurons in the central nervous system and the retina.

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LATEST PUBLICATIONS

Cell type prioritization in single-cell data

M. A. Skinnider; J. W. Squair; C. Kathe; M. A. Anderson; M. Gautier et al.

Nature Biotechnology. 2020-07-20. DOI : 10.1038/s41587-020-0605-1.

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The emergence and promise of single-cell temporal-omics approaches

A. R. Lederer; G. La Manno

Current Opinion In Biotechnology. 2020-06-01. Vol. 63, p. 70-78. DOI : 10.1016/j.copbio.2019.12.005.

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SINGLE-CELL ANALYSIS From single-cell RNA-seq to transcriptional regulation

G. La Manno

Nature Biotechnology. 2019-12-01. Vol. 37, num. 12, p. 1421-1422. DOI : 10.1038/s41587-019-0327-4.

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Selected Publications

Sylvie Roke, Head of Laboratory for fundamental BioPhotonics © 2020 Alain Herzog

Water influences the stickiness of Hyaluronan

Published:03.03.21 — Hyaluronic acid, also known as hyaluronan, is a polysaccharide that helps establish the viscosity of bodily fluids. According to a new study by EPFL scientists, it also influences the behavior of far more water molecules than previously thought. Their findings – just published in Science Advances – open new avenues of research on the role water plays in the human body.

Invasive Lobular Carcinoma Intraductal Xenograft Tissue Section Stained for Fibrillar Collagen. Credit: George Sflomos (EPFL)

Scientists model a peculiar type of breast cancer

Published:24.02.21 — Scientists led by EPFL have developed a breakthrough in vivo model for invasive lobular carcinoma, a serious yet understudied type of breast cancer. The work will open up previously inaccessible study of the tumor’s biology and help discover new therapies.

Tracing the activation mechanism of mitochondrial stress response and longevity in C. elegans. Credit: Terytty Yang Li and Arwen W. Gao, EPFL

Aging: What underlies the mitochondrial stress response

Published:16.02.21 — Scientists at EPFL have discovered certain enzymes that play a central role in the stress responses that defend mitochondria from stress, and promote health and longevity.

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