La Manno Lab – Laboratory of Neurodevelopmental Systems Biology

Our research focuses on understanding how the cell types in the nervous system are made. We are particularly interested in describing the sequence of states that embryonic stem cells go through during their differentiation towards mature neurons in the central nervous system and the retina.

Team

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The people in the lab

LATEST PUBLICATIONS

Cell type prioritization in single-cell data

M. A. Skinnider; J. W. Squair; C. Kathe; M. A. Anderson; M. Gautier et al.

Nature Biotechnology. 2020-07-20. DOI : 10.1038/s41587-020-0605-1.

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The emergence and promise of single-cell temporal-omics approaches

A. R. Lederer; G. La Manno

Current Opinion In Biotechnology. 2020-06-01. Vol. 63, p. 70-78. DOI : 10.1016/j.copbio.2019.12.005.

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SINGLE-CELL ANALYSIS From single-cell RNA-seq to transcriptional regulation

G. La Manno

Nature Biotechnology. 2019-12-01. Vol. 37, num. 12, p. 1421-1422. DOI : 10.1038/s41587-019-0327-4.

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Selected Publications

Foreign vs own DNA: How an innate immune sensor tells the difference

Published:26.11.20 — Scientists at EPFL and the Friedrich Miescher Institute have used cryo-electron microscopy to explain how a DNA-sensing biomolecule that is key to our innate immunity response is inactivated when it comes in contact with the cell’s own DNA.

Virtual reality helps measure vulnerability to stress

Published:23.11.20 — Behavioral scientists at EPFL have developed a virtual reality test that assesses a person’s vulnerability to stress while exploring immersive environments. The resulting model offers the field of stress research one of the first such tools that does not rely on subjective evaluations.