La Manno Lab – Laboratory of Neurodevelopmental Systems Biology

Our research focuses on understanding how the cell types in the nervous system are made. We are particularly interested in describing the sequence of states that embryonic stem cells go through during their differentiation towards mature neurons in the central nervous system and the retina.

Team

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LATEST PUBLICATIONS

SINGLE-CELL ANALYSIS From single-cell RNA-seq to transcriptional regulation

G. La Manno

Nature Biotechnology. 2019-12-01. Vol. 37, num. 12, p. 1421-1422. DOI : 10.1038/s41587-019-0327-4.

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A cell fitness selection model for neuronal survival during development

Y. Wang; H. Wu; P. Fontanet; S. Codeluppi; N. Akkuratova et al.

Nature Communications. 2019-09-12. Vol. 10, p. 4137. DOI : 10.1038/s41467-019-12119-3.

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Single-cell transcriptional logic of cell-fate specification and axon guidance in early-born retinal neurons

Q. Lo Giudice; M. Leleu; G. La Manno; P. J. Fabre

Development. 2019-09-01. Vol. 146, num. 17, p. dev178103. DOI : 10.1242/dev.178103.

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Selected Publications

New insights into the processes that cause Parkinson's disease

Published:20.02.20 — In a breakthrough for Parkinson’s disease, scientists at EPFL have reconstructed the process by which Lewy bodies form in the brain of patients. The study offers new insights into how Parkinson’s disease begins and evolves, and opens up a set of potential new treatment targets.

Fruit flies have a radical strategy for dealing with free radicals

Published:18.02.20 — Flies belonging to the genus Drosophila combat oxidative stress by removing excess fat from their blood. This remarkable mechanism proves that evolution has no shortage of answers to a problem that affects all life on Earth.

Bacteria under the microscope: a new growth model for tuberculosis

Published:11.02.20 — New research has shed light on how mycobacteria grow. This discovery could explain why some members of this family of single-celled organisms, which includes the bacillus that causes tuberculosis, can develop resistance to antibiotics

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Contact

Head of Laboratory : Gioele La Manno

Office : AAB 0 09

Phone : 41 21 69 38446

Mail : [email protected]

Administrative Assistant : Marie-France Radigois

Office : AI 2145

Phone : 41 21 69 30904

Mail : [email protected]

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