La Manno Lab – Laboratory of Neurodevelopmental Systems Biology

Our research focuses on understanding how the cell types in the nervous system are made. We are particularly interested in describing the sequence of states that embryonic stem cells go through during their differentiation towards mature neurons in the central nervous system and the retina.

Team

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LATEST PUBLICATIONS

SINGLE-CELL ANALYSIS From single-cell RNA-seq to transcriptional regulation

G. La Manno 

Nature Biotechnology. 2019-12-01. Vol. 37, num. 12, p. 1421-1422. DOI : 10.1038/s41587-019-0327-4.

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A cell fitness selection model for neuronal survival during development

Y. Wang; H. Wu; P. Fontanet; S. Codeluppi; N. Akkuratova et al. 

Nature Communications. 2019-09-12. Vol. 10, p. 4137. DOI : 10.1038/s41467-019-12119-3.

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Single-cell transcriptional logic of cell-fate specification and axon guidance in early-born retinal neurons

Q. Lo Giudice; M. Leleu; G. La Manno; P. J. Fabre 

Development. 2019-09-01. Vol. 146, num. 17, p. dev178103. DOI : 10.1242/dev.178103.

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Selected Publications

A new model of metabolism draws from thermodynamics and “omics”

— Scientists at EPFL have developed an algorithm that can model biochemical reactions from metabolism down to RNA synthesis with unprecedented accuracy.

Douglas Hanahan appointed Distinguished Scholar of Ludwig

— Ludwig Cancer Research is pleased to announce the appointment of Douglas Hanahan as a Distinguished Scholar at the Lausanne Branch of the Ludwig Institute for Cancer Research. A pioneering molecular biologist and renowned cancer researcher, Hanahan has made several seminal discoveries in cancer biology and immunology over the course of his career.

A porous and elastic biomaterial for transplantations

— Researchers from EPFL and UNIGE, in collaboration with the startup Volumina-Medical SA, have developed an innovative technique to allow for the direct transition from controllable in vitro cell culture to in vivo implantation. This technique uses chimeric particles: for in vitro cultures, these materials function like conventional microcarriers, but in part due to their surficial protection, they can come together to form an effective stem cell niche in vivo after subcutaneous injection.

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Contact

Head of Laboratory : Gioele La Manno

Office : AAB 0 09

Phone :  41 21 69 38446

Mail : [email protected]

Administrative Assistant : Marie-France Radigois

Office : AI 2145

Phone :  41 21 69 30904

Mail : [email protected]

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