La Manno Lab – Laboratory of Neurodevelopmental Systems Biology

Our research focuses on understanding how the cell types in the nervous system are made. We are particularly interested in describing the sequence of states that embryonic stem cells go through during their differentiation towards mature neurons in the central nervous system and the retina.

Team

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The people in the lab

LATEST PUBLICATIONS

Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation

S. Petrus-Reurer; A. R. Lederer; L. Baque-Vidal; I. Douagi; B. Pannagel et al.

Stem Cell Reports. 2022-06-14. Vol. 17, num. 6, p. 1458-1475. DOI : 10.1016/j.stemcr.2022.05.005.

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Sphingolipids control dermal fibroblast heterogeneity

L. Capolupo; I. Khven; A. R. Lederer; L. Mazzeo; G. Glousker et al.

Science. 2022-04-15. Vol. 376, num. 6590, p. 262-262. DOI : 10.1126/science.abh1623.

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Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics

M. Ratz; L. von Berlin; L. Larsson; M. Martin; J. O. Westholm et al.

Nature Neuroscience. 2022-02-24. DOI : 10.1038/s41593-022-01011-x.

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Selected Publications

EPFL's Highly Cited Researchers in 2022

Published:22.11.22 — Eleven EPFL researchers are among the most highly cited scientists in 2022. At SV, Andrea Ablasser and Johan Auwerx are among the nominees.

EPFL places in the top ten at the 2022 iGEM competition

Published:18.11.22 — With their biodegradable aerogel that can provide an alternative to conventional insulation materials, the EPFL team took home the gold along with four category nominations at this year’s iGEM synthetic biology competition, held in late October.

Tumor with FMRP-deficient cancer cells (in green) being infiltrated and attached by killer (CD8) T cells. Credit: Jeremy Guillot (Hanahan Lab – EPFL).

The protein behind immunotherapy resistance

Published:18.11.22 — Scientists at EPFL, Ludwig Institute of Cancer Research, and CHUV have identified a key protein that helps tumors evade attacks by the immune system, contributing to poor responses to immunotherapy in the clinic.

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