La Manno Lab – Laboratory of Neurodevelopmental Systems Biology

Our research focuses on understanding how the cell types in the nervous system are made. We are particularly interested in describing the sequence of states that embryonic stem cells go through during their differentiation towards mature neurons in the central nervous system and the retina.

Team

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LATEST PUBLICATIONS

Cell type prioritization in single-cell data

M. A. Skinnider; J. W. Squair; C. Kathe; M. A. Anderson; M. Gautier et al.

Nature Biotechnology. 2020-07-20. DOI : 10.1038/s41587-020-0605-1.

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The emergence and promise of single-cell temporal-omics approaches

A. R. Lederer; G. La Manno

Current Opinion In Biotechnology. 2020-06-01. Vol. 63, p. 70-78. DOI : 10.1016/j.copbio.2019.12.005.

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SINGLE-CELL ANALYSIS From single-cell RNA-seq to transcriptional regulation

G. La Manno

Nature Biotechnology. 2019-12-01. Vol. 37, num. 12, p. 1421-1422. DOI : 10.1038/s41587-019-0327-4.

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Selected Publications

Huntington's disease causes the death of neurons. @iStockphoto

Discovery shows promise for treating Huntington's Disease

Published:05.08.20 — Scientists at EPFL's Brain Mind Institute have identified an enzyme that can play a central role in developing a new route of treatment for Huntington's Disease.

Restoring mobility by identifying the neurons that make it possible

Published:20.07.20 — Partial mobility can be restored in rodents with impaired spinal cords. Using AI, scientists can now determine the cellular mechanisms responsible – a technique that may be applicable to many biomedical problems.