La Manno Lab – Laboratory of Neurodevelopmental Systems Biology

Our research focuses on understanding how the cell types in the nervous system are made. We are particularly interested in describing the sequence of states that embryonic stem cells go through during their differentiation towards mature neurons in the central nervous system and the retina.

Team

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The people in the lab

LATEST PUBLICATIONS

Oligodendroglia heterogeneity in the post-mortem human CNS with region, age and sex

L. A. Seeker; S. Jakel; N. B. Cuche; A. Kilpatrick; F. B. Pohl et al.

2021-07-01. p. E578-E580.

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Spatial tissue profiling by imaging-free molecular tomography

H. H. Schede; C. G. Schneider; J. Stergiadou; L. E. Borm; A. Ranjak et al.

Nature Biotechnology. 2021-04-19. DOI : 10.1038/s41587-021-00879-7.

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Cell type prioritization in single-cell data

M. A. Skinnider; J. W. Squair; C. Kathe; M. A. Anderson; M. Gautier et al.

Nature Biotechnology. 2020-07-20. DOI : 10.1038/s41587-020-0605-1.

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Selected Publications

Brian McCabe, Director of the Laboratory of Neural Genetics and Disease and a Professor in the EPFL Brain Mind Institute. © Alain Herzog / EPFL

Brain ‘noise' keeps nerve connections young

Published:22.07.21 — EPFL researchers have found that a form of neuron-to-neuron communication that has long been dismissed as ‘background noise’ is required to keep nerve junctions intact as animals age. The finding suggests that defects in this type of neural communication could contribute to neurodegenerative disorders and other brain conditions.

Priscilla Turelli (left) and Marlène Raclot analysing blood samples for SARS-CoV-2 antibodies. © EPFL / Alain Herzog 2021

New blood test measures immunity against SARS-CoV-2

Published:14.07.21 — The Lausanne University Hospital (CHUV) and EPFL teamed up to develop a new test that’s sensitive enough to measure the amount of SARS-CoV-2 neutralizing antibodies present in the bloodstream. The scientists’ discovery, published in the prestigious Science Translational Medicine, opens promising new avenues for tracking immunity acquired by infection or vaccination. With this test, experts can measure the level of protection against variants of the virus and monitor their prevalence over time.

Christian Iseli in his office © 2021 EPFL / Aurélien Tock

"Bioinformatics is a mix between services and research partnership"

Published:14.07.21 — Christian Iseli co-heads the Bioinformatics Competence Center, a research core facility shared between EPFL and UNIL. We spoke to him about his work, role, challenges and plans.

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