La Manno Lab - Laboratory of Neurodevelopmental Systems Biology

Our research focuses on understanding how the cell types in the nervous system are made. We are particularly interested in describing the sequence of states that embryonic stem cells go through during their differentiation towards mature neurons in the central nervous system and the retina.

Team

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The people in the lab

LATEST PUBLICATIONS

Spatial organization of the somatosensory cortex revealed by osmFISH

S. Codeluppi; L. E. Borm; A. Zeisel; G. La Manno; J. A. van Lunteren et al.

Nature Methods. 2018-11-01. Vol. 15, num. 11, p. 932-935. DOI : 10.1038/s41592-018-0175-z.

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Molecular Architecture of the Mouse Nervous System

A. Zeisel; H. Hochgerner; P. Lönnerberg; A. Johnsson; F. Memic et al.

Cell. 2018-08-09. Vol. 174, num. 4, p. 999-1014.e22. DOI : 10.1016/j.cell.2018.06.021.

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RNA velocity of single cells

G. La Manno; R. Soldatov; A. Zeisel; E. Braun; H. Hochgerner et al.

Nature. 2018-08-08. Vol. 560, num. 7719, p. 494-498. DOI : 10.1038/s41586-018-0414-6.

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Selected Publications

RNA velocity of single cells

Molecular architecture of the mouse nervous system

Molecular diversity of midbrain development in mouse, human, and stem cells

New cyclization reactions for synthesizing macrocyclic drug leads

Published:21.08.19 — Scientists at EPFL have developed a new method to synthesize and screen thousands of macrocyclic compounds, a family of chemicals that are of great interest in the pharmaceutical industry. The study is published in Science Advances.

How our biological clocks are locked in sync

Published:13.08.19 — Scientists from EPFL's Institute of Bioengineering have discovered that our circadian clock and our cell-cycle are in fact, synchronized.

School of Life Sciences welcomes students for Summer Research Program

Published:02.08.19 — Each summer, EPFL’s School of Life Sciences welcomes students from all over the world to participate in hands-on research projects and career-advancing workshops, in a unique, two-month science experience known as the Summer Research Program.

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Contact

Head of Laboratory : Gioele La Manno

Office : AAB 0 09

Phone : +41 21 69 38446

Mail : [email protected]

Administrative Assistant : Marie-France Radigois

Office : AI 2145

Phone : +41 21 69 30904

Mail : [email protected]

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