La Manno Lab – Laboratory of Neurodevelopmental Systems Biology

Our research focuses on understanding how the cell types in the nervous system are made. We are particularly interested in describing the sequence of states that embryonic stem cells go through during their differentiation towards mature neurons in the central nervous system and the retina.

Team

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LATEST PUBLICATIONS

The lipotype hypothesis

G. D’Angelo; G. La Manno

Nature Reviews Molecular Cell Biology. 2023. Vol. 24, p. 1–2. DOI : 10.1038/s41580-022-00556-w.

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Self-organizing in vitro mouse neural tube organoids mimic embryonic development

J. Park; H-A. Hsiung; I. Khven; G. La Manno; M. P. Lutolf

Development. 2022-10-01. Vol. 149, num. 20, p. dev. DOI : 10.1242/dev.201052.

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Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation

S. Petrus-Reurer; A. R. Lederer; L. Baque-Vidal; I. Douagi; B. Pannagel et al.

Stem Cell Reports. 2022-06-14. Vol. 17, num. 6, p. 1458-1475. DOI : 10.1016/j.stemcr.2022.05.005.

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Selected Publications

Johannes Gräff wins 2022 Robert Bing Prize

Published:17.01.23 — Professor Johannes Gräff, a neuroscientist at EPFL, is among the three winners of the 2022 Robert Bing Prize.

Drug combo breaks down cancer resistance to immunotherapy

Published:13.01.23 — By combining a checkpoint inhibitor with a new immunocytokine, scientists at EPFL, Ludwig Institute for Cancer Research, CHUV and Roche have made a breakthrough in fighting against immunotherapy-resistant cancers.

A robotic microsurgeon reveals how embryos grow

Published:09.01.23 — Combining biology and robotics, scientists at EPFL have built a robotic microsurgery platform that can perform high-precision, micrometer-resolution dissections to advance our understanding of how the vertebrate body forms during embryonic development.

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