La Manno Lab – Laboratory of Neurodevelopmental Systems Biology

Our research focuses on understanding how the cell types in the nervous system are made. We are particularly interested in describing the sequence of states that embryonic stem cells go through during their differentiation towards mature neurons in the central nervous system and the retina.

Team

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The people in the lab

LATEST PUBLICATIONS

Sphingolipids control dermal fibroblast heterogeneity

L. Capolupo; I. Khven; A. R. Lederer; L. Mazzeo; G. Glousker et al.

Science. 2022-04-15. Vol. 376, num. 6590, p. 262-+. DOI : 10.1126/science.abh1623.

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Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics

M. Ratz; L. von Berlin; L. Larsson; M. Martin; J. O. Westholm et al.

Nature Neuroscience. 2022-02-24. DOI : 10.1038/s41593-022-01011-x.

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Confronting false discoveries in single-cell differential expression

J. W. Squair; M. Gautier; C. Kathe; M. A. Anderson; N. D. James et al.

Nature Communications. 2021-09-28. Vol. 12, num. 1, p. 5692. DOI : 10.1038/s41467-021-25960-2.

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Selected Publications

Thamani Dahoun and Margaux Duchamp, cofounders of ArcoScreen © 2022 Arcoscreen

Turning drug discovery into speed dating

Published:24.05.22 — EPFL spin-off ArcoScreen has developed a platform that turns the discovery of new drugs for Alzheimer’s and Parkinson’s disease, diabetes and cancer from a marathon into a sprint. The firm’s microfluidic readout system assesses the response of G-protein-coupled receptors (GPCRs) to new substances, delivering significant time and financial gains for pharmaceutical companies.

Sophie Rivara, (in the center), winner of the Swis MT180 final 2022 © 2022 Alain Herzog

MT180: Sophie Rivara, an EPFL PhD student, wins the Swiss final

Published:20.05.22 — Sophie Rivara, a doctoral student in the Ablasser Lab of Innate immunity at EPFL, won the Swiss final of the My thesis in 180 seconds competitio. Congratulations! she will represent Switzerland at the international final in Montreal on October 6.

A digital model of Drosophila melanogaster called NeuroMechFly. Credit: Pavan Ramdya (EPFL)

NeuroMechFly: a digital twin of Drosophila

Published:16.05.22 — EPFL scientists have developed a digital model of the fruit fly, Drosophila melanogaster, which realistically simulates the movements of the animal. The twin is a big step towards reverse engineering the neuromechanical control of animal behavior, and developing bioinspired robots.

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