La Manno Lab – Laboratory of Neurodevelopmental Systems Biology

Our research focuses on understanding how the cell types in the nervous system are made. We are particularly interested in describing the sequence of states that embryonic stem cells go through during their differentiation towards mature neurons in the central nervous system and the retina.

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LATEST PUBLICATIONS

Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function

L. A. Seeker; N. Bestard-Cuche; S. Jaekel; N-L. Kazakou; S. M. K. Bostrand et al.

Acta Neuropathologica Communications. 2023-05-22. Vol. 11, num. 1, p. 84. DOI : 10.1186/s40478-023-01568-z.

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The lipotype hypothesis

G. D’Angelo; G. La Manno

Nature Reviews Molecular Cell Biology. 2023. Vol. 24, p. 1–2. DOI : 10.1038/s41580-022-00556-w.

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Self-organizing in vitro mouse neural tube organoids mimic embryonic development

J. Park; H-A. Hsiung; I. Khven; G. La Manno; M. P. Lutolf

Development. 2022-10-01. Vol. 149, num. 20, p. dev. DOI : 10.1242/dev.201052.

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Selected Publications

Credit: EPFL / Galina Limorenko. Illustration depicting how exposingTDP-43 fibril core enhances pathology formation in cell.

How a highly unstable protein may lead to neurodegeneration

Published:05.06.23 — EPFL scientists reproduce key features of pathological protein aggregates found in the brain of patients with Lou Gehrig's disease and other neurological diseases, providing insight into the underlying mechanism and offering promising avenues for new therapies.

Nominations of two professors at the School of Life Sciences

Published:26.05.23 — The Board of the Swiss Federal Institutes of Technology has announced the appointment of professors at EPFL, including two at the School of Life Sciences.

Gert-Jan et Andrea Galvez, doctorante, marchant au Lac de Sauvabelin à Lausanne. Photo Gilles Weber, CC-BY-SA

Thought-controlled walking again after spinal cord injury

Published:24.05.23 — Neuroscientists and neurosurgeons from EPFL/CHUV/UNIL and CEA/CHUGA/UGA report in the journal Nature that they have re-established the communication between the brain and spinal cord with a wireless digital bridge, allowing a paralyzed person to walk again naturally

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