Publications

2024

Journal Articles

Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells

L. Baque-Vidal; H. Main; S. Petrus-Reurer; A. R. Lederer; N-E. Beri et al. 

Cytotherapy. 2024-04-01. Vol. 26, num. 4, p. 340-350. DOI : 10.1016/j.jcyt.2024.01.014.

Theses

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

A. R. Lederer / G. La Manno (Dir.)  

Lausanne, EPFL, 2024. 

Meeting our Makers: Uncovering the cis-regulatory activity of transposable elements using statistical learning

C. D. S-T. Pulver / D. Trono (Dir.)  

Lausanne, EPFL, 2024. 

Deconvolution of ex-vivo drug screening data and bulk tissue expression predicts the abundance and viability of cancer cell subpopulations

A. Coudray / D. Trono; G. La Manno (Dir.)  

Lausanne, EPFL, 2024. 

2023

Journal Articles

Heterogeneity and developmental dynamics of mammalian neocortical progenitors

L. H. A. Alieh; A. Herrera; G. La Manno 

Current Opinion In Systems Biology. 2023-03-08. Vol. 32-33, p. 100444. DOI : 10.1016/j.coisb.2023.100444.

Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function

L. A. Seeker; N. Bestard-Cuche; S. Jaekel; N-L. Kazakou; S. M. K. Bostrand et al. 

Acta Neuropathologica Communications. 2023-05-22. Vol. 11, num. 1, p. 84. DOI : 10.1186/s40478-023-01568-z.

Conference Papers

The Key Players of CNS function: Exploring the Effects of Region, Age, and Sex on Human Glia Diversity

L. A. Seeker; N. Bestard-Cuche; S. Jaekel; N. -L. Kazakou; S. M. K. Bostrand et al. 

2023-07-01. 16th European Meeting on Glial Cells in Health and Disease, Berlin, GERMANY, JUL 08-11, 2023. p. E478-E479.

Profiling the chromatin landscape of adult human oligodendroglia using single-cell epigenomics

M. Kabbe; L. Seeker; E. Agirre; K. Carlstrom; F. B. Pohl et al. 

2023-07-01. 16th European Meeting on Glial Cells in Health and Disease, Berlin, GERMANY, JUL 08-11, 2023. p. E458-E458.

Reviews

The lipotype hypothesis

G. D’Angelo; G. La Manno 

Nature Reviews Molecular Cell Biology. 2023. Vol. 24, p. 1–2. DOI : 10.1038/s41580-022-00556-w.

2022

Journal Articles

Self-organizing in vitro mouse neural tube organoids mimic embryonic development

J. Park; H-A. Hsiung; I. Khven; G. La Manno; M. P. Lutolf 

Development. 2022-10-01. Vol. 149, num. 20, p. dev. DOI : 10.1242/dev.201052.

Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation

S. Petrus-Reurer; A. R. Lederer; L. Baque-Vidal; I. Douagi; B. Pannagel et al. 

Stem Cell Reports. 2022-06-14. Vol. 17, num. 6, p. 1458-1475. DOI : 10.1016/j.stemcr.2022.05.005.

Sphingolipids control dermal fibroblast heterogeneity

L. Capolupo; I. Khven; A. R. Lederer; L. Mazzeo; G. Glousker et al. 

Science. 2022-04-15. Vol. 376, num. 6590, p. 262-262. DOI : 10.1126/science.abh1623.

Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics

M. Ratz; L. von Berlin; L. Larsson; M. Martin; J. O. Westholm et al. 

Nature Neuroscience. 2022-02-24. DOI : 10.1038/s41593-022-01011-x.

2021

Journal Articles

Confronting false discoveries in single-cell differential expression

J. W. Squair; M. Gautier; C. Kathe; M. A. Anderson; N. D. James et al. 

Nature Communications. 2021-09-28. Vol. 12, num. 1, p. 5692. DOI : 10.1038/s41467-021-25960-2.

Molecular architecture of the developing mouse brain

G. La Manno; K. Siletti; A. Furlan; D. Gyllborg; E. Vinsland et al. 

Nature. 2021-07-28. Vol. 596, num. 7870, p. 92-96. DOI : 10.1038/s41586-021-03775-x.

Spatial tissue profiling by imaging-free molecular tomography

H. H. Schede; C. G. Schneider; J. Stergiadou; L. E. Borm; A. Ranjak et al. 

Nature Biotechnology. 2021-04-19. Vol. 39, p. 968–977. DOI : 10.1038/s41587-021-00879-7.

Cell type prioritization in single-cell data

M. A. Skinnider; J. W. Squair; C. Kathe; M. A. Anderson; M. Gautier et al. 

Nature Biotechnology. 2021. Vol. 39, p. 30–34. DOI : 10.1038/s41587-020-0605-1.

Conference Papers

Oligodendroglia heterogeneity in the post-mortem human CNS with region, age and sex

L. A. Seeker; S. Jakel; N. B. Cuche; A. Kilpatrick; F. B. Pohl et al. 

2021-07-01.  p. E578-E580.

2020

Reviews

The emergence and promise of single-cell temporal-omics approaches

A. R. Lederer; G. La Manno 

Current Opinion In Biotechnology. 2020-06-01. Vol. 63, p. 70-78. DOI : 10.1016/j.copbio.2019.12.005.

2019

Journal Articles

SINGLE-CELL ANALYSIS From single-cell RNA-seq to transcriptional regulation

G. La Manno 

Nature Biotechnology. 2019-12-01. Vol. 37, num. 12, p. 1421-1422. DOI : 10.1038/s41587-019-0327-4.

Single-cell transcriptional logic of cell-fate specification and axon guidance in early-born retinal neurons

Q. Lo Giudice; M. Leleu; G. La Manno; P. J. Fabre 

Development. 2019-09-01. Vol. 146, num. 17, p. dev178103. DOI : 10.1242/dev.178103.

A cell fitness selection model for neuronal survival during development

Y. Wang; H. Wu; P. Fontanet; S. Codeluppi; N. Akkuratova et al. 

Nature Communications. 2019-09-12. Vol. 10, p. 4137. DOI : 10.1038/s41467-019-12119-3.

2018

Journal Articles

Spatial organization of the somatosensory cortex revealed by osmFISH

S. Codeluppi; L. E. Borm; A. Zeisel; G. La Manno; J. A. van Lunteren et al. 

Nature Methods. 2018-11-01. Vol. 15, num. 11, p. 932-935. DOI : 10.1038/s41592-018-0175-z.

Molecular Architecture of the Mouse Nervous System

A. Zeisel; H. Hochgerner; P. Lönnerberg; A. Johnsson; F. Memic et al. 

Cell. 2018-08-09. Vol. 174, num. 4, p. 999-1014.e22. DOI : 10.1016/j.cell.2018.06.021.

RNA velocity of single cells

G. La Manno; R. Soldatov; A. Zeisel; E. Braun; H. Hochgerner et al. 

Nature. 2018-08-08. Vol. 560, num. 7719, p. 494-498. DOI : 10.1038/s41586-018-0414-6.

2017

Journal Articles

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson’s disease model

P. Rivetti di Val Cervo; R. A. Romanov; G. Spigolon; D. Masini; E. Martín-Montañez et al. 

Nature Biotechnology. 2017-04-10. Vol. 35, num. 5, p. 444-452. DOI : 10.1038/nbt.3835.

Molecular analysis of the midbrain dopaminergic niche during neurogenesis

E. M. Toledo; G. La Manno; P. Rivetti di Val Cervo; D. Gyllborg; S. Islam et al. 

bioRxiv. 2017-06-27. DOI : 10.1101/155846.

STRT-seq-2i: dual-index 5ʹ single cell and nucleus RNA-seq on an addressable microwell array

H. Hochgerner; P. Lönnerberg; R. Hodge; J. Mikes; A. Heskol et al. 

Scientific Reports. 2017-11-27. Vol. 7, p. 16327. DOI : 10.1038/s41598-017-16546-4.

2016

Journal Articles

Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity

S. Joost; A. Zeisel; T. Jacob; X. Sun; G. La Manno et al. 

Cell Systems. 2016-09-28. Vol. 3, num. 3, p. 221-237.e9. DOI : 10.1016/j.cels.2016.08.010.

Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control

A. Furlan; G. La Manno; M. Lübke; M. Häring; H. Abdo et al. 

Nature Neuroscience. 2016-08-29. Vol. 19, num. 10, p. 1331-1340. DOI : 10.1038/nn.4376.

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells

G. La Manno; D. Gyllborg; S. Codeluppi; K. Nishimura; C. Salto et al. 

Cell. 2016. Vol. 167, num. 2, p. 566-580. DOI : 10.1016/j.cell.2016.09.027.

2013

Journal Articles

Quantitative single-cell RNA-seq with unique molecular identifiers

S. Islam; A. Zeisel; S. Joost; G. La Manno; P. Zajac et al. 

Nature Methods. 2013-12-22. Vol. 11, num. 2, p. 163-166. DOI : 10.1038/nmeth.2772.