Journal Articles

Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion

J. Gao; S. Zhang; P. Deng; Z. Wu; B. Lemaitre et al. 

Nature Communications. 2024-04-25. Vol. 15, num. 1, p. 3514. DOI : 10.1038/s41467-024-47465-4.

The conceptual foundations of innate immunity: Taking stock 30 years later

Pradeu Thomas; Thomma Bart T.P.H.; Girarding Stephen; B. Lemaitre 

Immunity. 2024-04-09. Vol. 57, num. 4, p. 613-631. DOI : 10.1016/j.immuni.2024.03.007.

Cold stress-induced autophagy and apoptosis disorders are mainly mediated by AMPK/PPAR/PI3K/AKT/mTOR pathways

D. Wang; Y. Tian; Q. Wang; Y. Zhang; B. Ye et al. 

Aquaculture. 2024-03-30. Vol. 583, p. 740574. DOI : 10.1016/j.aquaculture.2024.740574.


Journal Articles

Toxic Effects of Koumine on the Early-Life Development Stage of Zebrafish

D. Wang; X. Leng; Y. Tian; J. Liu; J. Zou et al. 

Toxics. 2023-10-01. Vol. 11, num. 10, p. 853. DOI : 10.3390/toxics11100853.

Protein target highlights in CASP15: Analysis of models by structure providers

L. T. Alexander; J. Durairaj; A. Kryshtafovych; L. A. Abriata; Y. Bayo et al. 

Proteins-Structure Function And Bioinformatics. 2023-07-26. DOI : 10.1002/prot.26545.

Ecology-relevant bacteria drive the evolution of host antimicrobial peptides in Drosophila

M. A. Hanson; L. Grollmus; B. Lemaitre 

Science. 2023-07-21. Vol. 381, num. 6655, p. eadg5725. DOI : 10.1126/science.adg5725.

Antimicrobial peptides do not directly contribute to aging in Drosophila, but improve lifespan by preventing dysbiosis

M. A. Hanson; B. Lemaitre 

Disease Models & Mechanisms. 2023-04-01. Vol. 16, num. 4, p. dmm049965. DOI : 10.1242/dmm.049965.


Functional characterization of Drosophila melanogaster immune effectors

A. L. Carboni / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2023. 


Journal Articles

Compartmentalized PGRP expression along the dipteran Bactrocera dorsalis gut forms a zone of protection for symbiotic bacteria

Z. Yao; Z. Cai; Q. Ma; S. Bai; Y. Wang et al. 

Cell Reports. 2022-10-18. Vol. 41, num. 3, p. 111523. DOI : 10.1016/j.celrep.2022.111523.

Disproportionate investment in Spiralin B production limits in-host growth and favors the vertical transmission of Spiroplasma insect endosymbionts

F. Masson; S. Rommelaere; F. Schupfer; J-P. Boquete; B. Lemaitre 

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2022-07-26. Vol. 119, num. 30, p. e2208461119. DOI : 10.1073/pnas.2208461119.

Cecropins contribute to Drosophila host defense against a subset of fungal and Gram-negative bacterial infection

A. L. Carboni; M. A. Hanson; S. A. Lindsay; S. A. Wasserman; B. Lemaitre 

Genetics. 2022-01-01. Vol. 220, num. 1, p. iyab188. DOI : 10.1093/genetics/iyab188.


The role of the Nimrod proteins in the Drosophila immune system

B. M. Petrignani / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2022. 

A systematic CRISPR approach to understanding the role of Drosophila antimicrobial peptides in immunity in vivo

M. A. Hanson / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2022. 


Journal Articles

The wall-less bacterium Spiroplasma poulsonii builds a polymeric cytoskeleton composed of interacting MreB isoforms

F. Masson; X. Pierrat; B. Lemaitre; A. Persat 

Iscience. 2021-12-17. Vol. 24, num. 12, p. 103458. DOI : 10.1016/j.isci.2021.103458.

A secreted factor NimrodB4 promotes the elimination of apoptotic corpses by phagocytes in Drosophila

B. M. Petrignani; S. Rommelaere; K. Hakim‐Mishnaevski; F. F. Masson; E. J. V. Ramond et al. 

EMBO reports. 2021-08-09. Vol. 22, num. 9, p. e52262. DOI : 10.15252/embr.202052262.

The Drosophila Baramicin polypeptide gene protects against fungal infection

M. A. Hanson; L. B. Cohen; A. Marra; I. Iatsenko; S. A. Wasserman et al. 

Plos Pathogens. 2021-08-01. Vol. 17, num. 8, p. e1009846. DOI : 10.1371/journal.ppat.1009846.

Dual proteomics of Drosophila melanogaster hemolymph infected with the heritable endosymbiont Spiroplasma poulsonii

F. F. Masson; S. Rommelaere; A. Marra; F. Schüpfer; B. Lemaitre 

PLOS One. 2021-04-29. Vol. 16, num. 4, p. e0250524. DOI : 10.1371/journal.pone.0250524.

Rapid molecular evolution of Spiroplasma symbionts of Drosophila

M. Gerth; H. Martinez-Montoya; P. Ramirez; F. Masson; J. S. Griffin et al. 

Microbial Genomics. 2021-02-01. Vol. 7, num. 2, p. 000503. DOI : 10.1099/mgen.0.000503.

Autophagy as a Gatekeeper of Intestinal Homeostasis

X. Li; B. Lemaitre 

Developmental Cell. 2021-01-11. Vol. 56, num. 1, p. 5-6. DOI : 10.1016/j.devcel.2020.12.013.

The transposable element-rich genome of the cereal pest Sitophilus oryzae

N. Parisot; C. Vargas-Chavez; C. Goubert; P. Baa-Puyoulet; S. Balmand et al. 

Bmc Biology. 2021-11-09. Vol. 19, num. 1, p. 241. DOI : 10.1186/s12915-021-01158-2.

Alfalfa leaf curl virus is efficiently acquired by its aphid vector Aphis craccivora but inefficiently transmitted

F. Ryckebusch; M. Peterschmitt; M. Granier; N. Sauvion 

Journal Of General Virology. 2021-01-01. Vol. 102, num. 2, p. 001516. DOI : 10.1099/jgv.0.001516.


The role of immune effectors in controlling Drosophila-microbes interactions

A. Marra / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2021. 


Journal Articles

Transformation of the Drosophila Sex-Manipulative Endosymbiont Spiroplasma poulsonii and Persisting Hurdles for Functional Genetic Studies

F. Masson; F. Schuepfer; C. Jollivet; B. Lemaitre 

Applied And Environmental Microbiology. 2020-07-01. Vol. 86, num. 14, p. e00835-20. DOI : 10.1128/AEM.00835-20.

Comparative RNA-Seq analyses ofDrosophilaplasmatocytes reveal gene specific signatures in response to clean injury and septic injury

E. Ramond; J. P. Dudzic; B. Lemaitre 

Plos One. 2020-06-29. Vol. 15, num. 6, p. e0235294. DOI : 10.1371/journal.pone.0235294.

Machiavellian males with high emotional intelligence exhibit fewer depressive symptoms

R. Bianchi; N. Patthey; D. Mirkovic; B. Lemaitre; K. Schlegel 

Personality and Individual Differences. 2020-05-01. Vol. 158, p. 109867. DOI : 10.1016/j.paid.2020.109867.

Iron sequestration by transferrin 1 mediates nutritional immunity in Drosophila melanogaster

I. Iatsenko; A. Marra; J-P. Boquete; J. Pena; B. Lemaitre 

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2020-03-31. Vol. 117, num. 13, p. 7317-7325. DOI : 10.1073/pnas.1914830117.

Renal Purge of Hemolymphatic Lipids Prevents the Accumulation of ROS-Induced Inflammatory Oxidized Lipids and Protects Drosophila from Tissue Damage

X. Li; S. Rommelaere; S. Kondo; B. Lemaitre 

Immunity. 2020-02-18. Vol. 52, num. 2, p. 374-387.e6. DOI : 10.1016/j.immuni.2020.01.008.

The adipokine NimrodB5 regulates peripheral hematopoiesis in Drosophila

E. Ramond; B. Petrignani; J. P. Dudzic; J-P. Boquete; M. Poidevin et al. 

Febs Journal. 2020-02-17. Vol. 287, num. 16, p. 3399-3426. DOI : 10.1111/febs.15237.

Blind killing of both male and female Drosophila embryos by a natural variant of the endosymbiotic bacterium Spiroplasma poulsonii

F. Masson; S. Calderon-Copete; F. Schuepfer; A. Vigneron; S. Rommelaere et al. 

Cellular Microbiology. 2020-01-23.  p. e13156. DOI : 10.1111/cmi.13156.

Increasing heart vascularisation after myocardial infarction using brain natriuretic peptide stimulation of endothelial and WT1(+) epicardial cells

N. Li; S. Rignault-Clerc; C. Bielmann; A-C. Bon-Mathier; T. Deglise et al. 

Elife. 2020-11-27. Vol. 9, p. e61050. DOI : 10.7554/eLife.61050.

The DEAD-box RNA helicase CshA is required for fatty acid homeostasis inStaphylococcus aureus

V. Khemici; J. Prados; B. Petrignani; B. Di Nolfi; E. Berge et al. 

Plos Genetics. 2020-07-01. Vol. 16, num. 7, p. e1008779. DOI : 10.1371/journal.pgen.1008779.


Growing Ungrowable Bacteria: Overview and Perspectives on Insect Symbiont Culturability

F. Masson; B. Lemaitre 

Microbiology And Molecular Biology Reviews. 2020-12-01. Vol. 84, num. 4, p. e00089-20. DOI : 10.1128/MMBR.00089-20.


Role of Nimrod receptors in the Drosophila melanogaster cellular immune response

C. Melcarne / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2020. 


Journal Articles

Adult Drosophila Lack Hematopoiesis but Rely on a Blood Cell Reservoir at the Respiratory Epithelia to Relay Infection Signals to Surrounding Tissues

P. S. Bosch; K. Makhijani; L. Herboso; K. S. Gold; R. Baginsky et al. 

Developmental Cell. 2019-12-16. Vol. 51, num. 6, p. 787-803.e5. DOI : 10.1016/j.devcel.2019.10.017.

New insights on Drosophila antimicrobial peptide function in host defense and beyond

M. A. Hanson; B. Lemaitre 

Current Opinion in Immunology. 2019-12-11. Vol. 62, p. 22-30. DOI : 10.1016/j.coi.2019.11.008.

Dynamic Evolution of Antimicrobial Peptides Underscores Trade-Offs Between Immunity and Ecological Fitness

M. A. Hanson; B. Lemaitre; R. L. Unckless 

Frontiers In Immunology. 2019-11-08. Vol. 10, p. 2620. DOI : 10.3389/fimmu.2019.02620.

The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila

J-P. Parvy; Y. Yu; A. Dostalova; S. Kondo; A. Kurjan et al. 

Elife. 2019-07-30. Vol. 8, p. e45061. DOI : 10.7554/eLife.45061.

Two Nimrod receptors, NimC1 and Eater, synergistically contribute to bacterial phagocytosis in Drosophila melanogaster

C. Melcarne; E. Ramond; J. Dudzic; A. J. Bretscher; E. Kurucz et al. 

Febs Journal. 2019-07-01. Vol. 286, num. 14, p. 2670-2691. DOI : 10.1111/febs.14857.

More Than Black or White: Melanization and Toll Share Regulatory Serine Proteases in Drosophila

J. P. Dudzic; M. A. Hanson; I. Iatsenko; S. Kondo; B. Lemaitre 

Cell Reports. 2019-04-23. Vol. 27, num. 4, p. 1050-1061.e3. DOI : 10.1016/j.celrep.2019.03.101.

The Exchangeable Apolipoprotein Nplp2 Sustains Lipid Flow and Heat Acclimation in Drosophila

S. Rommelaere; J-P. Boquete; J. Piton; S. Kondo; B. Lemaitre 

Cell Reports. 2019-04-16. Vol. 27, num. 3, p. 886-899.e6. DOI : 10.1016/j.celrep.2019.03.074.

Functional analysis of RIP toxins from the Drosophila endosymbiont Spiroplasma poulsonii

M. G. Garcia-Arraez; F. Masson; J. C. P. Escobar; B. Lemaitre 

BMC Microbiology. 2019-02-20. Vol. 19, p. 46. DOI : 10.1186/s12866-019-1410-1.

Phagocytosis in Drosophila: From molecules and cellular machinery to physiology

C. Melcarne; B. Lemaitre; E. Kurant 

Insect Biochemistry And Molecular Biology. 2019-06-01. Vol. 109, p. 1-12. DOI : 10.1016/j.ibmb.2019.04.002.

Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach

M. A. Hanson; A. Dostálová; C. Ceroni; M. Poidevin; B. Lemaitre 

eLife. 2019. Vol. 8, p. e44341. DOI : 10.7554/eLife.44341.001.


Journal Articles

Evolution of longevity improves immunity in Drosophila

D. K. Fabian; K. Garschall; P. Klepsatel; G. Santos-Matos; E. Sucena et al. 

Evolution Letters. 2018-12-01. Vol. 2, num. 6, p. 567-579. DOI : 10.1002/evl3.89.

Microbiota-Derived Lactate Activates Production of Reactive Oxygen Species by the Intestinal NADPH Oxidase Nox and Shortens Drosophila Lifespan

I. Iatsenko; J-P. Boquete; B. Lemaitre; I. Iatsenko; J-P. Boquete et al. 

Immunity. 2018-11-20. Vol. 49, num. 5, p. 929-942.e5. DOI : 10.1016/j.immuni.2018.09.017.

An IMD-like pathway mediates both endosymbiont control and host immunity in the cereal weevil Sitophilus spp.

J. Maire; C. Vincent-Monegat; F. Masson; A. Zaidman-Remy; A. Heddi 

Microbiome. 2018. Vol. 6, p. 6. DOI : 10.1186/s40168-017-0397-9.

Male-killing toxin in a bacterial symbiont of Drosophila

T. Harumoto; B. Lemaitre 

Nature. 2018. Vol. 557, num. 7704, p. 252-255. DOI : 10.1038/s41586-018-0086-2.

Cell-Specific Imd-NF-κB Responses Enable Simultaneous Antibacterial Immunity and Intestinal Epithelial Cell Shedding upon Bacterial Infection

Z. Zhai; J-P. Boquete; B. Lemaitre; Z. Zhai; J-P. Boquete et al. 

Immunity. 2018. Vol. 48, num. 5, p. 897-910.e7. DOI : 10.1016/j.immuni.2018.04.010.

In Vitro Culture of the Insect Endosymbiont Spiroplasma poulsonii Highlights Bacterial Genes Involved in Host-Symbiont Interaction

F. Masson; S. Calderon Copete; F. Schüpfer; G. Garcia-Arraez; B. Lemaitre et al. 

mBio. 2018. Vol. 9, num. 2, p. e00024-18. DOI : 10.1128/mBio.00024-18.

Common and unique strategies of male killing evolved in two distinct Drosophila symbionts

T. Harumoto; T. Fukatsu; B. Lemaitre 

Proceedings of the Royal Society B: Biological Sciences. 2018. Vol. 285, num. 1875, p. 20172167. DOI : 10.1098/rspb.2017.2167.


Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster

I. Miguel-Aliaga; H. Jasper; B. Lemaitre 

Genetics. 2018-10-01. Vol. 210, num. 2, p. 357-396. DOI : 10.1534/genetics.118.300224.


The melanization reaction in Drosophila: More than black or white

J. P. Dudzic / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2018. 

The double-edged toxins

M. G. Garcia Arraez / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2018. 


Journal Articles

Transforming Growth Factor beta/Activin signaling in neurons increases susceptibility to starvation

W-B. A. Chng; R. Koch; X. Li; S. Kondo; E. Nagoshi et al. 

Plos One. 2017. Vol. 12, num. 10, p. e0187054. DOI : 10.1371/journal.pone.0187054.

The gram-negative sensing receptor PGRP-LC contributes to grooming induction in Drosophila

A. Yanagawa; C. Neyen; B. Lemaitre; F. Marion-Poll 

Plos One. 2017. Vol. 12, num. 11, p. e0185370. DOI : 10.1371/journal.pone.0185370.

Thioester-containing proteins regulate the Toll pathway and play a role in Drosophila defence against microbial pathogens and parasitoid wasps

A. Dostalova; S. Rommelaere; M. Poidevin; B. Lemaitre 

Bmc Biology. 2017. Vol. 15, p. 79. DOI : 10.1186/s12915-017-0408-0.

A genetic framework controlling the differentiation of intestinal stem cells during regeneration in Drosophila

Z. Zhai; J-P. Boquete; B. Lemaitre 

Plos Genetics. 2017. Vol. 13, num. 6, p. e1006854. DOI : 10.1371/journal.pgen.1006854.

Science, narcissism and the quest for visibility

B. Lemaitre 

Febs Journal. 2017. Vol. 284, num. 6, p. 875-882. DOI : 10.1111/febs.14032.

Protection from within

F. Masson; B. Lemaitre 

Elife. 2017. Vol. 6, p. e24111. DOI : 10.7554/eLife.24111.


Physiological Adaptations to Sugar Intake: New Paradigms from Drosophila melanogaster

W-B. A. Chng; V. Hietakangas; B. Lemaitre 

Trends In Endocrinology And Metabolism. 2017. Vol. 28, num. 2, p. 131-142. DOI : 10.1016/j.tem.2016.11.003.


Journal Articles

PGRP-SD, an Extracellular Pattern-Recognition Receptor, Enhances Peptidoglycan-Mediated Activation of the Drosophila Imd Pathway

I. Iatsenko; S. Kondo; D. Mengin-Lecreulx; B. Lemaitre 

Immunity. 2016. Vol. 45, num. 5, p. 1013-1023. DOI : 10.1016/j.immuni.2016.10.029.

Male-killing symbiont damages host’s dosage-compensated sex chromosome to induce embryonic apoptosis

T. Harumoto; H. Anbutsu; B. Lemaitre; T. Fukatsu 

Nature Communications. 2016. Vol. 7, p. 12781. DOI : 10.1038/ncomms12781.

Connecting the obesity and the narcissism epidemics

B. Lemaitre 

Medical Hypotheses. 2016. Vol. 95, p. 10-19. DOI : 10.1016/j.mehy.2016.08.001.

The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors

C. Neyen; C. Runchel; F. Schüpfer; P. Meier; B. Lemaitre 

Nature Immunology. 2016. Vol. 17, p. 1150–1158. DOI : 10.1038/ni.3536.

Chemometric Analysis of Bacterial Peptidoglycan Reveals Atypical Modifications That Empower the Cell Wall against Predatory Enzymes and Fly Innate Immunity

A. Espaillat; O. Forsmo; K. El Biari; R. Björk; B. Lemaitre et al. 

Journal of the American Chemical Society. 2016. Vol. 138, num. 29, p. 9193-9204. DOI : 10.1021/jacs.6b04430.

The Role of Lipid Competition for Endosymbiont-Mediated Protection against Parasitoid Wasps in Drosophila

J. C. Paredes; J. K. Herren; F. Schüpfer; B. Lemaitre 

mBio. 2016. Vol. 7, num. 4, p. e01006-16. DOI : 10.1128/mBio.01006-16.

Cell Division by Longitudinal Scission in the Insect Endosymbiont

E. Ramond; C. Maclachlan; S. Clerc-Rosset; G. W. Knott; B. Lemaitre 

mBio. 2016. Vol. 7, num. 4, p. e00881-16. DOI : 10.1128/mBio.00881-16.

The dual oxidase gene BdDuox regulates the intestinal bacterial community homeostasis of Bactrocera dorsalis

Z. Yao; A. Wang; Y. Li; Z. Cai; B. Lemaitre et al. 

Isme Journal. 2016. Vol. 10, num. 5, p. 1037-1050. DOI : 10.1038/ismej.2015.202.

Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila

S. Chakrabarti; J. P. Dudzic; X. Li; E. J. Collas; J-P. Boquete et al. 

PLOS Genetics. 2016. Vol. 12, num. 5, p. e1006089. DOI : 10.1371/journal.pgen.1006089.


Sensing Gram-negative bacteria: a phylogenetic perspective

C. Neyen; B. Lemaitre 

Current Opinion In Immunology. 2016. Vol. 38, p. 8-17. DOI : 10.1016/j.coi.2015.10.007.


The Drosophila gut response to infection

M. Bou Sleiman / B. Lemaitre; B. Deplancke (Dir.)  

Lausanne, EPFL, 2016. 


Journal Articles

Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis

Z. Zhai; S. Kondo; N. Ha; J-P. Boquete; M. Brunner et al. 

Nature Communications. 2015. Vol. 6, p. 10219. DOI : 10.1038/ncomms10219.

Infection Dynamics and Immune Response in a Newly Described Drosophila-Trypanosomatid Association

P. T. Hamilton; J. Votypka; A. Dostalova; V. Yurchenko; N. H. Bird et al. 

Mbio. 2015. Vol. 6, num. 5, p. e01356-15. DOI : 10.1128/mBio.01356-15.

Gut physiology mediates a trade-off between adaptation to malnutrition and susceptibility to food-borne pathogens

R. K. Vijendravarma; S. Narasimha; S. Chakrabarti; A. Babin; S. Kolly et al. 

Ecology Letters. 2015. Vol. 18, num. 10, p. 1078-1086. DOI : 10.1111/ele.12490.

Drosophila innate immunity: regional and functional specialization of prophenoloxidases

J. P. Dudzic; S. Kondo; R. Ueda; C. M. Bergman; B. Lemaitre 

BMC biology. 2015. Vol. 13, p. 81. DOI : 10.1186/s12915-015-0193-6.

X-ray and Cryo-electron Microscopy Structures of Monalysin Pore-forming Toxin Reveal Multimerization of the Pro-form

P. Leone; C. Bebeacua; O. Opota; C. Kellenberger; B. Klaholz et al. 

Journal Of Biological Chemistry. 2015. Vol. 290, num. 21, p. 13191-13201. DOI : 10.1074/jbc.M115.646109.

From Embryo to Adult: Hematopoiesis along the Drosophila Life Cycle

E. Ramond; M. Meister; B. Lemaitre 

Developmental Cell. 2015. Vol. 33, num. 4, p. 367-368. DOI : 10.1016/j.devcel.2015.05.002.

Genome Sequence of the Drosophila melanogaster Male-Killing Spiroplasma Strain MSRO Endosymbiont

J. C. Paredes; J. K. Herren; F. Schuepfer; R. Marin; S. Claverol et al. 

Mbio. 2015. Vol. 6, num. 2, p. e02437-14. DOI : 10.1128/mBio.02437-14.

Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence

M. S. B. Sleiman; D. Osman; A. Massouras; A. A. Hoffmann; B. Lemaitre et al. 

Nature Communications. 2015. Vol. 6, p. 7829. DOI : 10.1038/ncomms8829.

Different flavors of Toll guide olfaction

C. Neyen; B. Lemaitre 

Trends In Immunology. 2015. Vol. 36, num. 8, p. 439-441. DOI : 10.1016/

Determination of the structure of the O-antigen and the lipid A from the entomopathogenic bacterium Pseudomonas entomophila lipopolysaccharide along with its immunological properties

I. Speciale; I. Paciello; L. L. Fazio; L. Sturiale; A. Palmigiano et al. 

Carbohydrate Research. 2015. Vol. 412, p. 20-27. DOI : 10.1016/j.carres.2015.04.017.

The Black cells phenotype is caused by a point mutation in the Drosophila pro-phenoloxidase 1 gene that triggers melanization and hematopoietic defects

C. Neyen; O. Binggeli; P. Roversi; L. Bertin; M. B. Sleiman et al. 

Developmental And Comparative Immunology. 2015. Vol. 50, num. 2, p. 166-174. DOI : 10.1016/j.dci.2014.12.011.

The Nimrod transmembrane receptor Eater is required for hemocyte attachment to the sessile compartment in Drosophila melanogaster

A. J. Bretscher; V. Honti; O. Binggeli; O. Burri; M. Poidevin et al. 

Biology Open. 2015. Vol. 4, num. 3, p. 355-363. DOI : 10.1242/bio.201410595.


Redefining the metabolic landscape through TGF-beta/Activin signaling in Drosophila melanogaster

W. B. Chng / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2015. 


Journal Articles

Transforming Growth Factor beta/Activin Signaling Functions as a Sugar-Sensing Feedback Loop to Regulate Digestive Enzyme Expression

W-B. A. Chng; M. S. B. Sleiman; F. Schuepfer; B. Lemaitre 

Cell Reports. 2014. Vol. 9, num. 1, p. 336-348. DOI : 10.1016/j.celrep.2014.08.064.

The Drosophila MAPK p38c Regulates Oxidative Stress and Lipid Homeostasis in the Intestine

S. Chakrabarti; M. Poidevin; B. Lemaitre 

Plos Genetics. 2014. Vol. 10, num. 9, p. e1004659. DOI : 10.1371/journal.pgen.1004659.

Prophenoloxidase Activation Is Required for Survival to Microbial Infections in Drosophila

O. Binggeli; C. Neyen; M. Poidevin; B. Lemaitre 

Plos Pathogens. 2014. Vol. 10, num. 5, p. e1004067. DOI : 10.1371/journal.ppat.1004067.

The unsuspected complexity of the digestive tract of the fruitfly Towards a model of functional regionalization

D. Osman; N. Buchon 

M S-Medecine Sciences. 2014. Vol. 30, num. 5, p. 483-485. DOI : 10.1051/medsci/20143005003.

Microbiota-Induced Changes in Drosophila melanogaster Host Gene Expression and Gut Morphology

N. A. Broderick; N. Buchon; B. Lemaitre 

Mbio. 2014. Vol. 5, num. 3, p. e01117-14. DOI : 10.1128/mBio.01117-14.

Methods to study Drosophila immunity

C. Neyen; A. J. Bretscher; O. Binggeli; B. Lemaitre 

Methods. 2014. Vol. 68, num. 1, p. 116-128. DOI : 10.1016/j.ymeth.2014.02.023.

Insect endosymbiont proliferation is limited by lipid availability

J. K. Herren; J. C. Paredes; F. Schuepfer; K. Arafah; P. Bulet et al. 

Elife. 2014. Vol. 3, p. e02964. DOI : 10.7554/eLife.02964.


The useful gate-crasher

J. C. Paredes Escobar / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2014. 

The Effectual Hitchhiker

J. K. Herren / B. Lemaître (Dir.)  

Lausanne, EPFL, 2014. 

Book Chapters

Pseudomonas entomophila: A Versatile Bacterium with Entomopathogenic Properties

G. Dieppois; O. Opota; J. Lalucat; B. Lemaitre 

Pseudomonas; Dordrecht: Springer, 2014. p. 25-49.


Journal Articles

Functional Analysis of PGRP-LA in Drosophila Immunity

M. Gendrin; A. Zaidman-Remy; N. A. Broderick; J. Paredes; M. Poidevin et al. 

Plos One. 2013. Vol. 8, num. 7, p. e69742. DOI : 10.1371/journal.pone.0069742.

Crystallization and preliminary X-ray analysis of monalysin, a novel beta-pore-forming toxin from the entomopathogen Pseudomonas entomophila

M. Blemont; R. Vincentelli; C. Kellenberger; O. Opota; B. Lemaitre et al. 

Acta Crystallographica Section F-Structural Biology And Crystallization Communications. 2013. Vol. 69, num. 8, p. 930-933. DOI : 10.1107/S174430911301885X.

Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila

N. Buchon; D. Osman; F. P. A. David; H. Y. Fang; J-P. Boquete et al. 

Cell Reports. 2013. Vol. 3, num. 5, p. 1725-1738. DOI : 10.1016/j.celrep.2013.04.001.

Vertical transmission of a Drosophila endosymbiont via cooption of the yolk transport and internalization machinery

J. K. Herren; J. C. Paredes; F. Schüpfer; B. Lemaitre 

mBio. 2013. Vol. 4, num. 2, p. e00532-12. DOI : 10.1128/mBio.00532-12.

dRYBP Contributes to the Negative Regulation of the Drosophila Imd Pathway

R. Aparicio; C. Neyen; B. Lemaitre; A. Busturia 

PloS One. 2013. Vol. 8, num. 4, p. e62052. DOI : 10.1371/journal.pone.0062052.


The Digestive Tract of Drosophila melanogaster

B. Lemaitre; I. Miguel-Aliaga 

Annual review of genetics. 2013. Vol. 47, p. 377-404. DOI : 10.1146/annurev-genet-111212-133343.

Gut homeostasis in a microbial world: insights from Drosophila melanogaster

N. Buchon; N. A. Broderick; B. Lemaitre 

Nature Reviews Microbiology. 2013. Vol. 11, num. 9, p. 615-626. DOI : 10.1038/nrmicro3074.

Translation inhibition and metabolic stress pathways in the host response to bacterial pathogens

B. Lemaitre; S. E. Girardin 

Nature Reviews Microbiology. 2013. Vol. 11, num. 6, p. 365-369. DOI : 10.1038/nrmicro3029.


Role and regulation of the melanization reaction in Drosophila immune response

O. Binggeli / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2013. 

The contribution of the host stress response to the pathogenesis of Pseudomonas entomophila in the Drosophila intestine

S. Chakrabarti / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2013. 


Journal Articles

Gut-associated microbes of Drosophila melanogaster

N. A. Broderick; B. Lemaitre 

Gut microbes. 2012. Vol. 3, num. 4, p. 307-21. DOI : 10.4161/gmic.19896.

Insect-microbe interactions: the good, the bad and the others

J. Herren; B. Lemaitre 

Current opinion in microbiology. 2012. Vol. 15, num. 3, p. 217-9. DOI : 10.1016/j.mib.2012.05.014.

Tissue- and ligand-specific sensing of gram-negative infection in drosophila by PGRP-LC isoforms and PGRP-LE

C. Neyen; M. Poidevin; A. Roussel; B. Lemaitre 

Journal of immunology (Baltimore, Md. : 1950). 2012. Vol. 189, num. 4, p. 1886-97. DOI : 10.4049/jimmunol.1201022.

Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut

S. Chakrabarti; P. Liehl; N. Buchon; B. Lemaitre 

Cell host & microbe. 2012. Vol. 12, num. 1, p. 60-70. DOI : 10.1016/j.chom.2012.06.001.

Autocrine and paracrine unpaired signalling regulate intestinal stem cell maintenance and division

D. Osman; N. Buchon; S. Chakrabarti; Y-T. Huang; W-C. Su et al. 

Journal of cell science. 2012. Vol. 125, num. 24, p. 5944-5949. DOI : 10.1242/jcs.113100.

Taxonomic characterisation of Pseudomonas strain L48 and formal proposal of Pseudomonas entomophila sp nov.

M. Mulet; M. Gomila; B. Lemaitre; J. Lalucat; E. Garcia-Valdes 

Systematic And Applied Microbiology. 2012. Vol. 35, num. 3, p. 145-149. DOI : 10.1016/j.syapm.2011.12.003.

Conference Papers

The drosophila gut: A new paradigm for epithelial immune response

B. Lemaitre 

2012. 10th Joint Meeting of the International-Cytokine-Society (ICS) / Meeting of the International-Society-for-Interferon-and-Cytokine-Research (ISICR), Geneva, SWITZERLAND, SEP 11-14, 2012. p. 494-494. DOI : 10.1016/j.cyto.2012.06.305.

Distinguishing dead from alive – a novel intracellular receptor mediates ligand-specific regulation of Relish-dependent immune activation in Drosophila

C. Neyen; B. Lemaitre 

2012. European Congress of Immunology, Glasgow, SCOTLAND, SEP 05-08, 2012. p. 32-32.


Journal Articles

Drosophila immunity: analysis of PGRP-SB1 expression, enzymatic activity and function

A. Zaidman-Rémy; M. Poidevin; M. Hervé; D. P. Welchman; J. C. Paredes et al. 

PloS One. 2011. Vol. 6, num. 2, p. e17231. DOI : 10.1371/journal.pone.0017231.

Negative Regulation by Amidase PGRPs Shapes the Drosophila Antibacterial Response and Protects the Fly from Innocuous Infection

J. C. Paredes; D. P. Welchman; M. Poidevin; B. Lemaitre 

Immunity. 2011. Vol. 35, num. 5, p. 770-9. DOI : 10.1016/j.immuni.2011.09.018.

Genetic evidence for a protective role of the peritrophic matrix against intestinal bacterial infection in Drosophila melanogaster

T. Kuraishi; O. Binggeli; O. Opota; N. Buchon; B. Lemaitre 

Proceedings of the National Academy of Sciences of the United States of America. 2011. Vol. 108, num. 38, p. 15966-71. DOI : 10.1073/pnas.1105994108.

Spiroplasma and host immunity: activation of humoral immune responses increases endosymbiont load and susceptibility to certain Gram-negative bacterial pathogens in Drosophila melanogaster

J. K. Herren; B. Lemaitre 

Cellular microbiology. 2011. Vol. 13, num. 9, p. 1385-96. DOI : 10.1111/j.1462-5822.2011.01627.x.

Monalysin, a novel ß-pore-forming toxin from the Drosophila pathogen Pseudomonas entomophila, contributes to host intestinal damage and lethality

O. Opota; I. Vallet-Gély; R. Vincentelli; C. Kellenberger; I. Iacovache et al. 

PLoS pathogens. 2011. Vol. 7, num. 9, p. e1002259. DOI : 10.1371/journal.ppat.1002259.

Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila

J-R. Alattia; T. Kuraishi; M. Dimitrov; I. Chang; B. Lemaitre et al. 

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2011. Vol. 25, num. 7, p. 2287-95. DOI : 10.1096/fj.10-174078.


Journal Articles

Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection

N. Buchon; N. A. Broderick; T. Kuraishi; B. Lemaitre 

BMC biology. 2010. Vol. 8, num. 1, p. 152. DOI : 10.1186/1741-7007-8-152.

Association of hemolytic activity of Pseudomonas entomophila, a versatile soil bacterium, with cyclic lipopeptide production

I. Vallet-Gely; A. Novikov; L. Augusto; P. Liehl; G. Bolbach et al. 

Applied and environmental microbiology. 2010. Vol. 76, num. 3, p. 910-21. DOI : 10.1128/AEM.02112-09.

A secondary metabolite acting as a signalling molecule controls Pseudomonas entomophila virulence

I. Vallet-Gely; O. Opota; A. Boniface; A. Novikov; B. Lemaitre 

Cellular microbiology. 2010. Vol. 12, num. 11, p. 1666-79. DOI : 10.1111/j.1462-5822.2010.01501.x.

Conference Papers

Toll-like receptors – an evolutionary perspective

B. Lemaitre 

2010. Annual Congress of the British-Society-for-Immunology, Liverpool, ENGLAND, Dec 06-10, 2010. p. 19-19.


Journal Articles

Insect immunity: from pattern recognition to symbiont-mediated host defense

D. P. Welchman; S. Aksoy; F. Jiggins; B. Lemaitre 

Cell host & microbe. 2009. Vol. 6, num. 2, p. 107-14. DOI : 10.1016/j.chom.2009.07.008.

Genetic ablation of Drosophila phagocytes reveals their contribution to both development and resistance to bacterial infection

A. Defaye; I. Evans; M. Crozatier; W. Wood; B. Lemaitre et al. 

Journal of innate immunity. 2009. Vol. 1, num. 4, p. 322-34. DOI : 10.1159/000210264.

Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation

N. Buchon; N. A. Broderick; M. Poidevin; S. Pradervand; B. Lemaitre 

Cell host & microbe. 2009. Vol. 5, num. 2, p. 200-11. DOI : 10.1016/j.chom.2009.01.003.

Proteolytic cascade for the activation of the insect toll pathway induced by the fungal cell wall component

K-B. Roh; C-H. Kim; H. Lee; H-M. Kwon; J-W. Park et al. 

The Journal of biological chemistry. 2009. Vol. 284, num. 29, p. 19474-81. DOI : 10.1074/jbc.M109.007419.

A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway

N. Buchon; M. Poidevin; H-M. Kwon; A. Guillou; V. Sottas et al. 

Proceedings of the National Academy of Sciences of the United States of America. 2009. Vol. 106, num. 30, p. 12442-7. DOI : 10.1073/pnas.0901924106.

Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila

N. Buchon; N. A. Broderick; S. Chakrabarti; B. Lemaitre 

Genes & development. 2009. Vol. 23, num. 19, p. 2333-44. DOI : 10.1101/gad.1827009.

A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK

P. Geuking; R. Narasimamurthy; B. Lemaitre; K. Basler; F. Leulier 

PloS One. 2009. Vol. 4, num. 11, p. e7709. DOI : 10.1371/journal.pone.0007709.

Long-range activation of systemic immunity through peptidoglycan diffusion in Drosophila

M. Gendrin; D. P. Welchman; M. Poidevin; M. Hervé; B. Lemaitre 

PLoS pathogens. 2009. Vol. 5, num. 12, p. e1000694. DOI : 10.1371/journal.ppat.1000694.

Book Chapters

Recognition and response to microbial infection in Drosophila

N. A. Broderick; B. Lemaitre 

Insect Infection and Immunity: Evolution, Ecology, and Mechanisms; Oxford: Oxford University Press, 2009. p. 13-33.


Journal Articles

Drosophila immunity: methods for monitoring the activity of Toll and Imd signaling pathways

Y. Romeo; B. Lemaitre 

Methods in molecular biology (Clifton, N.J.). 2008. Vol. 415, p. 379-94. DOI : 10.1007/978-1-59745-570-1_22.

Animal models for host-pathogen interactions

B. Lemaitre; F. M. Ausubel 

Current opinion in microbiology. 2008. Vol. 11, num. 3, p. 249-50. DOI : 10.1016/j.mib.2008.05.002.

PIMS modulates immune tolerance by negatively regulating Drosophila innate immune signaling

N. Lhocine; P. S. Ribeiro; N. Buchon; A. Wepf; R. Wilson et al. 

Cell host & microbe. 2008. Vol. 4, num. 2, p. 147-58. DOI : 10.1016/j.chom.2008.07.004.

Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation

C. Scherfer; H. Tang; Z. Kambris; N. Lhocine; C. Hashimoto et al. 

Developmental biology. 2008. Vol. 323, num. 2, p. 189-96. DOI : 10.1016/j.ydbio.2008.08.030.

A serpin that regulates immune melanization in the respiratory system of Drosophila

H. Tang; Z. Kambris; B. Lemaitre; C. Hashimoto 

Developmental cell. 2008. Vol. 15, num. 4, p. 617-26. DOI : 10.1016/j.devcel.2008.08.017.

Evf, a virulence factor produced by the Drosophila pathogen Erwinia carotovora, is an S-palmitoylated protein with a new fold that binds to lipid vesicles

S. Quevillon-Cheruel; N. Leulliot; C. A. Muniz; M. Vincent; J. Gallay et al. 

The Journal of biological chemistry. 2008. Vol. 284, num. 6, p. 3552-62. DOI : 10.1074/jbc.M808334200.

Conference Papers

Cyanogenesis in Pseudomonas entomophila: an entomopathogenic bacterium

B. Ryall; H. Nasser; B. Lemaitre; D. Mossialos; H. D. Williams 

2008. Joint Conference of the 33rd FEBS Congress/11th IUBMB Conference, Athens, GREECE, Jun 28-Jul 03, 2008. p. 289-289.


Toll-like receptors–taking an evolutionary approach

F. Leulier; B. Lemaitre 

Nature reviews. Genetics. 2008. Vol. 9, num. 3, p. 165-78. DOI : 10.1038/nrg2303.

Bacterial strategies to overcome insect defences

I. Vallet-Gely; B. Lemaitre; F. Boccard 

Nature reviews. Microbiology. 2008. Vol. 6, num. 4, p. 302-13. DOI : 10.1038/nrmicro1870.



The host defense of Drosophila melanogaster

B. Lemaitre; J. Hoffmann 

Annual review of immunology. 2007. Vol. 25, p. 697-743. DOI : 10.1146/annurev.immunol.25.022106.141615.


Journal Articles

Insect immunity: the post-genomic era

J. Bangham; F. Jiggins; B. Lemaitre 

Immunity. 2006. Vol. 25, num. 1, p. 1-5. DOI : 10.1016/j.immuni.2006.07.002.

A Spätzle-processing enzyme required for toll signaling activation in Drosophila innate immunity

I-H. Jang; N. Chosa; S-H. Kim; H-J. Nam; B. Lemaitre et al. 

Developmental cell. 2006. Vol. 10, num. 1, p. 45-55. DOI : 10.1016/j.devcel.2005.11.013.

The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila

S. Brun; S. Vidal; P. Spellman; K. Takahashi; H. Tricoire et al. 

Genes to cells : devoted to molecular & cellular mechanisms. 2006. Vol. 11, num. 4, p. 397-407. DOI : 10.1111/j.1365-2443.2006.00953.x.

The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection

A. Zaidman-Rémy; M. Hervé; M. Poidevin; S. Pili-Floury; M-S. Kim et al. 

Immunity. 2006. Vol. 24, num. 4, p. 463-73. DOI : 10.1016/j.immuni.2006.02.012.

Drosophila immunity: a large-scale in vivo RNAi screen identifies five serine proteases required for Toll activation

Z. Kambris; S. Brun; I-H. Jang; H-J. Nam; Y. Romeo et al. 

Current biology : CB. 2006. Vol. 16, num. 8, p. 808-13. DOI : 10.1016/j.cub.2006.03.020.

The Toll immune-regulated Drosophila protein Fondue is involved in hemolymph clotting and puparium formation

C. Scherfer; M. R. Qazi; K. Takahashi; R. Ueda; M. S. Dushay et al. 

Developmental biology. 2006. Vol. 295, num. 1, p. 156-63. DOI : 10.1016/j.ydbio.2006.03.019.

Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila

N. Vodovar; D. Vallenet; S. Cruveiller; Z. Rouy; V. Barbe et al. 

Nature biotechnology. 2006. Vol. 24, num. 6, p. 673-9. DOI : 10.1038/nbt1212.

Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model

P. Liehl; M. Blight; N. Vodovar; F. Boccard; B. Lemaitre 

PLoS pathogens. 2006. Vol. 2, num. 6, p. e56. DOI : 10.1371/journal.ppat.0020056.

Two proteases defining a melanization cascade in the immune system of Drosophila

H. Tang; Z. Kambris; B. Lemaitre; C. Hashimoto 

The Journal of biological chemistry. 2006. Vol. 281, num. 38, p. 28097-104. DOI : 10.1074/jbc.M601642200.

The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection

F. Leulier; N. Lhocine; B. Lemaitre; P. Meier 

Molecular and cellular biology. 2006. Vol. 26, num. 21, p. 7821-31. DOI : 10.1128/MCB.00548-06.

Erwinia carotovora Evf antagonizes the elimination of bacteria in the gut of Drosophila larvae

C. Acosta Muniz; D. Jaillard; B. Lemaitre; F. Boccard 

Cellular microbiology. 2006. Vol. 9, num. 1, p. 106-19. DOI : 10.1111/j.1462-5822.2006.00771.x.


Journal Articles

Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species

N. Vodovar; M. Vinals; P. Liehl; A. Basset; J. Degrouard et al. 

Proceedings of the National Academy of Sciences of the United States of America. 2005. Vol. 102, num. 32, p. 11414-9. DOI : 10.1073/pnas.0502240102.

Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway

A. Kleino; S. Valanne; J. Ulvila; J. Kallio; H. Myllymäki et al. 

The EMBO journal. 2005. Vol. 24, num. 19, p. 3423-34. DOI : 10.1038/sj.emboj.7600807.


Structure and metabolism of peptidoglycan and molecular requirements allowing its detection by the Drosophila innate immune system

D. Mengin-Lecreulx; B. Lemaitre 

Journal of endotoxin research. 2005. Vol. 11, num. 2, p. 105-11. DOI : 10.1179/096805105X35233.


Journal Articles

In vivo RNA interference analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults

S. Pili-Floury; F. Leulier; K. Takahashi; K. Saigo; E. Samain et al. 

The Journal of biological chemistry. 2004. Vol. 279, num. 13, p. 12848-53. DOI : 10.1074/jbc.M313324200.

The road to Toll

B. Lemaitre 

Nature reviews. Immunology. 2004. Vol. 4, num. 7, p. 521-7. DOI : 10.1038/nri1390.

A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity

C-I. Chang; S. Pili-Floury; M. Hervé; C. Parquet; Y. Chelliah et al. 

PLoS biology. 2004. Vol. 2, num. 9, p. E277. DOI : 10.1371/journal.pbio.0020277.

Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway

C. R. Stenbak; J-H. Ryu; F. Leulier; S. Pili-Floury; C. Parquet et al. 

Journal of immunology. 2004. Vol. 173, num. 12, p. 7339-48. DOI : 10.4049/jimmunol.173.12.7339.


Drosophila: a polyvalent model to decipher host-pathogen interactions

N. Vodovar; C. Acosta; B. Lemaitre; F. Boccard 

Trends in microbiology. 2004. Vol. 12, num. 5, p. 235-42. DOI : 10.1016/j.tim.2004.03.007.


Journal Articles

A single gene that promotes interaction of a phytopathogenic bacterium with its insect vector, Drosophila melanogaster

A. Basset; P. Tzou; B. Lemaitre; F. Boccard 

EMBO reports. 2003. Vol. 4, num. 2, p. 205-9. DOI : 10.1038/sj.embor.embor730.

The Drosophila immune system detects bacteria through specific peptidoglycan recognition

F. Leulier; C. Parquet; S. Pili-Floury; J-H. Ryu; M. Caroff et al. 

Nature immunology. 2003. Vol. 4, num. 5, p. 478-84. DOI : 10.1038/ni922.

Directed expression of the HIV-1 accessory protein Vpu in Drosophila fat-body cells inhibits Toll-dependent immune responses

F. Leulier; C. Marchal; I. Miletich; B. Limbourg-Bouchon; R. Benarous et al. 

EMBO reports. 2003. Vol. 4, num. 10, p. 976-81. DOI : 10.1038/sj.embor.embor936.

Sensing microbes by diverse hosts. Workshop on pattern recognition proteins and receptors.

S. E. Girardin; D. J. Philpott; B. Lemaitre 

EMBO reports. 2003. Vol. 4, num. 10, p. 932-6. DOI : 10.1038/sj.embor.embor940.


Journal Articles

27 Methods for studying infection and immunity in Drosophila

P. Tzou; M. Meister; B. Lemaitre 

Methods in Microbiology. 2002. Vol. 31, p. 507-529. DOI : 10.1016/s0580-9517(02)31028-6.

Constitutive expression of a single antimicrobial peptide can restore wild-type resistance to infection in immunodeficient Drosophila mutants

P. Tzou; J-M. Reichhart; B. Lemaitre 

Proceedings of the National Academy of Sciences of the United States of America. 2002. Vol. 99, num. 4, p. 2152-7. DOI : 10.1073/pnas.042411999.

Immunology. Pathogen surveillance–the flies have it.

R. S. Khush; F. Leulier; B. Lemaitre 

Science (New York, N.Y.). 2002. Vol. 296, num. 5566, p. 273-5. DOI : 10.1126/science.1071208.

The mosquito genome: the post-genomic era opens

E. De Gregorio; B. Lemaitre 

Nature. 2002. Vol. 419, num. 6906, p. 496-7. DOI : 10.1038/419496a.

A ubiquitin-proteasome pathway represses the Drosophila immune deficiency signaling cascade

R. S. Khush; W. D. Cornwell; J. N. Uram; B. Lemaitre 

Current biology : CB. 2002. Vol. 12, num. 20, p. 1728-37. DOI : 10.1016/s0960-9822(02)01214-9.

The Toll and Imd pathways are the major regulators of the immune response in Drosophila

E. De Gregorio; P. T. Spellman; P. Tzou; G. M. Rubin; B. Lemaitre 

The EMBO journal. 2002. Vol. 21, num. 11, p. 2568-79. DOI : 10.1093/emboj/21.11.2568.

Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults

F. Leulier; S. Vidal; K. Saigo; R. Ueda; B. Lemaitre 

Current biology : CB. 2002. Vol. 12, num. 12, p. 996-1000. DOI : 10.1016/S0960-9822(02)00873-4.

An immune-responsive Serpin regulates the melanization cascade in Drosophila

E. De Gregorio; S-J. Han; W-J. Lee; M-J. Baek; T. Osaki et al. 

Developmental cell. 2002. Vol. 3, num. 4, p. 581-92. DOI : 10.1016/S1534-5807(02)00267-8.


How Drosophila combats microbial infection: a model to study innate immunity and host-pathogen interactions

P. Tzou; E. De Gregorio; B. Lemaitre 

Current opinion in microbiology. 2002. Vol. 5, num. 1, p. 102-10. DOI : 10.1016/S1369-5274(02)00294-1.


Journal Articles

Drosophila immunity: two paths to NF-kappaB

R. S. Khush; F. Leulier; B. Lemaitre 

Trends in immunology. 2001. Vol. 22, num. 5, p. 260-4. DOI : 10.1016/S1471-4906(01)01887-7.

Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses

S. Vidal; R. S. Khush; F. Leulier; P. Tzou; M. Nakamura et al. 

Genes & development. 2001. Vol. 15, num. 15, p. 1900-12. DOI : 10.1101/gad.203301.

Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays

E. De Gregorio; P. T. Spellman; G. M. Rubin; B. Lemaitre 

Proceedings of the National Academy of Sciences of the United States of America. 2001. Vol. 98, num. 22, p. 12590-5. DOI : 10.1073/pnas.221458698.


Journal Articles

The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response

A. Basset; R. S. Khush; A. Braun; L. Gardan; F. Boccard et al. 

Proceedings of the National Academy of Sciences of the United States of America. 2000. Vol. 97, num. 7, p. 3376-81. DOI : 10.1073/pnas.97.7.3376.

Comparative genomics of the eukaryotes

G. M. Rubin; M. D. Yandell; J. R. Wortman; G. L. Gabor Miklos; C. R. Nelson et al. 

Science (New York, N.Y.). 2000. Vol. 287, num. 5461, p. 2204-15. DOI : 10.1126/science.287.5461.2204.

Gram-negative bacteria-binding protein, a pattern recognition receptor for lipopolysaccharide and beta-1,3-glucan that mediates the signaling for the induction of innate immune genes in Drosophila melanogaster cells

Y. S. Kim; J. H. Ryu; S. J. Han; K. H. Choi; K. B. Nam et al. 

The Journal of biological chemistry. 2000. Vol. 275, num. 42, p. 32721-7. DOI : 10.1074/jbc.M003934200.

Stop press: genes that fight infections: what the drosophila genome says about animal immunity

R. Khush; B. Lemaitre 

Trends in genetics : TIG. 2000. Vol. 16, num. 10, p. 468. DOI : 10.1016/S0168-9525(00)02133-8.

Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia

P. Tzou; S. Ohresser; D. Ferrandon; M. Capovilla; J. M. Reichhart et al. 

Immunity. 2000. Vol. 13, num. 5, p. 737-48. DOI : 10.1016/S1074-7613(00)00072-8.

The Drosophila caspase Dredd is required to resist gram-negative bacterial infection

F. Leulier; A. Rodriguez; R. S. Khush; J. M. Abrams; B. Lemaitre 

EMBO reports. 2000. Vol. 1, num. 4, p. 353-8. DOI : 10.1093/embo-reports/kvd073.


Le génome de la mouche du vinaigre

B. Lemaitre 

Médecine/Sciences. 2000. Vol. 16, num. 5, p. 693-695. DOI : 10.4267/10608/1713.

Genes that fight infection: what the Drosophila genome says about animal immunity

R. S. Khush; B. Lemaitre 

Trends in genetics : TIG. 2000. Vol. 16, num. 10, p. 442-9. DOI : 10.1016/S0168-9525(00)02095-3.


Journal Articles

La drosophile : un modèle pour l’étude de la réponse immunitaire innée

B. Lemaitre 

Médecine/Sciences. 1999. Vol. 15, num. 1, p. 15-22. DOI : 10.4267/10608/1191.

A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF

P. Manfruelli; J. M. Reichhart; R. Steward; J. A. Hoffmann; B. Lemaitre 

The EMBO journal. 1999. Vol. 18, num. 12, p. 3380-91. DOI : 10.1093/emboj/18.12.3380.


Journal Articles

Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms

B. Lemaitre; J. M. Reichhart; J. A. Hoffmann 

Proceedings of the National Academy of Sciences of the United States of America. 1998. Vol. 94, num. 26, p. 14614-9. DOI : 10.1073/pnas.94.26.14614.

A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway

D. Ferrandon; A. C. Jung; M. Criqui; B. Lemaitre; S. Uttenweiler-Joseph et al. 

The EMBO journal. 1998. Vol. 17, num. 5, p. 1217-27. DOI : 10.1093/emboj/17.5.1217.

In vivo regulation of the IkappaB homologue cactus during the immune response of Drosophila

E. Nicolas; J. M. Reichhart; J. A. Hoffmann; B. Lemaitre 

The Journal of biological chemistry. 1998. Vol. 273, num. 17, p. 10463-9. DOI : 10.1074/jbc.273.17.10463.

Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin

E. A. Levashina; S. Ohresser; B. Lemaitre; J. L. Imler 

Journal of molecular biology. 1998. Vol. 278, num. 3, p. 515-27. DOI : 10.1006/jmbi.1998.1705.


Journal Articles

Drosophila immunity: analysis of larval hemocytes by P-element-mediated enhancer trap

A. Braun; B. Lemaitre; R. Lanot; D. Zachary; M. Meister 

Genetics. 1997. Vol. 147, num. 2, p. 623-34.


Antimicrobial peptide defense in Drosophila

M. Meister; B. Lemaitre; J. A. Hoffmann 

BioEssays : news and reviews in molecular, cellular and developmental biology. 1997. Vol. 19, num. 11, p. 1019-26. DOI : 10.1002/bies.950191112.


Journal Articles

Expression of antimicrobial peptide genes after infection by parasitoid wasps in Drosophila

E. Nicolas; A. J. Nappi; B. Lemaitre 

Developmental and comparative immunology. 1996. Vol. 20, num. 3, p. 175-81. DOI : 10.1016/0145-305X(96)00017-1.

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

B. Lemaitre; E. Nicolas; L. Michaut; J. M. Reichhart; J. A. Hoffmann 

Cell. 1996. Vol. 86, num. 6, p. 973-83. DOI : 10.1016/S0092-8674(00)80172-5.


Journal Articles

Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila

B. Lemaitre; M. Meister; S. Govind; P. Georgel; R. Steward et al. 

The EMBO journal. 1995. Vol. 14, num. 3, p. 536-45. DOI : 10.1002/j.1460-2075.1995.tb07029.x.

A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense

B. Lemaitre; E. Kromer-Metzger; L. Michaut; E. Nicolas; M. Meister et al. 

Proceedings of the National Academy of Sciences of the United States of America. 1995. Vol. 92, num. 21, p. 9465-9. DOI : 10.1073/pnas.92.21.9465.



Drosophila P element: transposition, regulation and evolution

D. Coen; B. Lemaitre; M. Delattre; H. Quesneville; S. Ronsseray et al. 

Genetica. 1994. Vol. 93, num. 1-3, p. 61-78. DOI : 10.1007/BF01435240.


Journal Articles

Maternal repression of the P element promoter in the germline of Drosophila melanogaster: a model for the P cytotype

B. Lemaitre; S. Ronsseray; D. Coen 

Genetics. 1993. Vol. 135, num. 1, p. 149-60.

Expression and nuclear translocation of the rel/NF-kappa B-related morphogen dorsal during the immune response of Drosophila

J. M. Reichhart; P. Georgel; M. Meister; B. Lemaitre; C. Kappler et al. 

Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie. 1993. Vol. 316, num. 10, p. 1218-24.

Maternal inheritance of P cytotype in Drosophila melanogaster: a “pre-P cytotype” is strictly extra-chromosomally transmitted

S. Ronsseray; B. Lemaitre; D. Coen 

Molecular & general genetics : MGG. 1993. Vol. 241, num. 1-2, p. 115-23. DOI : 10.1007/BF00280208.

Insect immunity: the diptericin promoter contains multiple functional regulatory sequences homologous to mammalian acute-phase response elements

P. Georgel; M. Meister; C. Kappler; B. Lemaitre; J. M. Reichhart et al. 

Biochemical and biophysical research communications. 1993. Vol. 197, num. 2, p. 508-17. DOI : 10.1006/bbrc.1993.2508.



L’element P de drosophila melanogaster : mecanismes controlant la transposition

B. Lemaitre / D. Coen; D. Anxolabemere (Dir.)  

Université de Paris 6, 1992. 


Journal Articles

P regulatory products repress in vivo the P promoter activity in P-lacZ fusion genes

B. Lemaitre; D. Coen 

Proceedings of the National Academy of Sciences of the United States of America. 1991. Vol. 88, num. 10, p. 4419-23. DOI : 10.1073/pnas.88.10.4419.