SenoTarg consortium

The SenoTarg consortium is an interdisciplinary network between four Swiss laboratories aimed at elucidating the role of senescent cells in different biological contexts of critical clinical relevance, including aging, cancer, acute and chronic tissue injury following pathological or iatrogenic insults. Within the consortium, the Auwerx lab studies the role of mitochondria in regulating senescence, and the potential of mitochondrial stress inducers to improve the clearance of senescent cells after an insult. The study will lead to the identification of novel elements of cellular senescence and potentially discover innovative pharmacological strategies to target senescence through mitochondria.

Experimental Tools

Movement Tracker

The Movement Tracker software package is a modification and update to the Parallel Worm Tracker by Ramot et al. (2008, PMID 18493300). Significant changes include: updates to the code for more recent MatLab versions (e.g. removing deprecated function calls), generalizing the software to different experimental setups, and increasing analytical throughput for measuring the movement of large quantities of worms and flies on a regular basis and in different experimental setups.

The package contains one module with three elements:

  1. a “MovementTracker” module for viewing and tracking;
  2. a “ObjectAnalyzer” module for analyzing tracks generated by the tracker software;
  3. a “TransferTracks” module for quickly synthesizing and analyzing all data from the tracks.

Citation: Mouchiroud L. et al. Curr Protoc Neurosci. 2016. DOI: 10.1002/cpns.17

The Movement Tracker software package and annexed manual can be downloaded using the link below:

Bioinformatics Resources is a web resource that makes use of the multilayered datasets from the BXD mouse population to expedite in silico gene function prediction through a series of integrative and complementary systems analytical approaches.

Citation: Li H. Cell Syst. 2018. DOI: 10.1016/j.cels.2017.10.016.