27/1/2020 Urolithin A, another product discovered in our lab, aka as “mitopure”, and developed by Amazentis and Timeline Nutrition will soon reach the US market. Read the story in today’s Le Temps.
4/12/2019 Hao Li and colleagues developed a systems toolkit to predict gene functions and module connections using big data. The story was published in Genome research and highlighted in the EPFL website.
14/11/2019 Adrienne Mottis and Sebastien Herzig covered the emerging field of mito-cellular communications in a landmark review published today in Science.
1/11/2019 We welcome Xiaoxu Li, a new Ph.D. student in our laboratory.
30/10/2019 We welcome Anna Nakamura, Naho Kitamura and Yoko Yokoyama from the Keio University (Japan) for a 2 months stay. They will work on new natural products.
28/10/2019 We welcome Tanes Imamura de Lima, a visiting scientist from University of Campinas, Brazil, strengthening our muscle team.
3/10/2019 A big congrats to Riekelt Houtkooper – a new and happy Professor at the University of Amsterdam.
20/8/2019 Our lab is being ranked in the top 0.01% related to impact. See detailed information and metrics here.
5/8/2019 We welcome Alexis Rapin, a new bioinformatician working on our SDSC project.
29/7/2019 Johan Auwerx comments on Nagi Biosciences, a spin-out from the laboratory led by Matteo Cornaglia and Laurent Mouchiroud.
28/6/2019 Congrats to Arwen who won the United Mitochondrial Disease Foundation (UMDF) Accelerator grant and gave a wonderful Ted-style talk in Washington DC.
1/5/2019 Welcome to Ludger Goeminne, a new post-doctoral scientist from Belgium.
4/4/2019 Our lab and Janssen started a research collaboration to discover interception targets and modifiers in the domain of aging-related diseases. ”Remarkable and significant partnering for EPFL” says Natalia Giovannini who negotiated the research agreement at EPFL’s TTO.
3/4/2019 Our work on Urolithin A makes a big step towards wide clinical use as it is being adapted by Nestle Health Sciences in anti-aging strategies. See news here.
7/3/2019 Several scientists from the Auwerx lab collaborated with the Naveiras lab and other EPFL teams to show an essential role of NAD in hematopoietic stem cell homeostasis. The work was published in Cell Stem Cell and covered on the EPFL website.
1/3/2019 We welcome Sebastien Herzig, a new post-doctoral scientist, to our team.
5/2/2019 Welcome to Jean-David Morel a new post-doctoral fellow and to Agathe Amouret a trainee from Université de Technologie de Compiègne (UTC).
4/2/2019 Our lab is proud to be amongst the 3 European founders of the Academy for Health and Lifespan Research (AHLR), a non-profit organisation which will support, promote and lobby for research in health and lifespan; more to follow on February 14th.
30/1/2019 Our lab was featured on Metabiolab. See the details here.
27/1/2019 Joe Nadeau and Johan Auwerx describe the fact that mouse experimentation will remain essential for human biology and in particular for drug discovery in a Nature Reviews Drug Discovery piece entitled “The virtuous cycle of human genetics (=observation) and mouse models (=experimentation) in drug discovery.
11/1/2019 Davide D’Amico published in Molecular Cell a novel pathway to control aging through the RNA-binding protein Pum2 and the mitochondrial fission factor Mff. The work has been highlighted on the EPFL website, as well as on ScienceDaily, EurekAlert, MedicalNewsToday, and an interview from Super Human Radio.
22/12/2018 Congrats to Laura Lukjanenko for the EPFL doctoral prize for 2018.
28/11/2018 Clarivate analytics, which runs the Web of Science, ranked Johan Auwerx in the top 1% by citations in the category of “Cross-Field”, thereby making him a “Highly Cited Researcher”. In an independent analysis by Google Scholar, he was also listed on position 438 out of the 3160 scientists with an h-index >100.
2/11/2018 Elena Katsyuba has been awarded the ‘EPFL Outstanding PhD Thesis Distinction in Biotechnology and Bioengineering’ for her PhD thesis defended during the past academic year. Congratulations on your outstanding work! It is awarded every year to the 8% best PhD theses of each EPFL Doctoral Program.
1/11/2018 Welcome to Wen Gao, a new postdoctoral researcher, and Fabiana Fraga, a trainee joining the lab.
25/4/2018 An interview with Johan Auwerx was published in the Journal of Cell Biology, providing some insight about the how and why of our research.
24/4/2018 Vera Lemos brilliantly passed her PhD thesis defence in Porto. Congratulations Dr. Lemos!
13/4/2018 A review from the lab in Development discusses mitochondrial function in stem cells.
22/2/2018 In new collaborative work published in eLife, Hao Li contributed to identify a new role of GRAM domain containing proteins in ER-plasma membrane contacts.
31/1/2018 It is with sadness that I announce that Arno Motulsky, one of my post-doctoral mentors at the University of Washington, has passed away. Dr. Motulsky ignited my interest in genetics and served as a role model during my career as a scientist.
24/1/2018 In a TV report, Johan Auwerx and Laurent Mouchiroud appeared in the popular Swiss program “A bonentendeur” broadcasted on RTS1. Click here to watch the video talking about the role of pomegranate as promising anti-aging fruit (Johan Auwerx and Laurent Mouchiroud interview are provided in French).
06/12/2017 Using a bioinformatics and experimental approach, Vincenzo Sorrentino and colleagues have found that rendering mitochondria resistant to damage can halt diseases caused by amyloid toxicity, such as Alzheimer’s disease. The study is published in Nature and has been covered in the front page of EPFL website as well as in Le Temps (here and here), 24 heures, Le Monde and La Vanguardia.
29/11/2017 An article by Hao Li and colleagues, published today in Cell Systems, describes a series of novel systems genetics tools (systems-genetics.org) to identify new links between genes and phenotypes. This paper was mentioned in the front page of EPFL website.
28/11/2017 A study from our laboratory by Olli and Maroun, published in Nature Communications, indicates that both chromatin and mitochondrial stress are monitored by chromatin remodeling and activate a cytosolic stress response.
2/11/2017 A warm welcome to Terytty Yang Li and Changmyung Oh, two postdoc scientists joining the lab.
2/11/2017 Xu WANG published today in Molecular Cell, that the mitochondrial unfolded protein response (UPRmt), a mitochondrial protein quality control pathway, is well conserved from animals to plants and that plant hormones play a central role in regulating mitochondrial proteotoxic stress. This study suggests that mitochondria are probable stress-sensors in plant response to biotic or abiotic stresses. See the EPFL news here.
2/11/2017 The spin-off project Nagi Bioscience co-delveopped in our lab is featured today in the Swiss newspaper Le Temps (in French). You can read the article online here or on the today’s paper version of the journal in the science section.
20/9/2017 Johan Auwerx was awarded on Sept 19, 2017 the 5th Helmholtz Diabetes Award in Munich. Thereby Johan joins the rank of the 4 previous prestigious awardee’s Jef Friedman, Ron Kahn, Bruce Spiegelman, and Steve O’Rahilly. Check the pictures taken during the lecture here and here, and the interview video here, as well the news in EPFL SV news.
10/9/2017 Davide D’Amico and Vincenzo Sorrentino review how mitochondrial and cytosolic proteostatic networks cross talk in Trends in Biochemical Sciences.
31/5/2017 A multi-omics study by Pedro Moral Quiros identifying ATF4 as a key mediator of mitochondrial stress in humans published today in Journal of Cell Biology.
19/5/2017 Frontiers in Metabolism 2017–”From systems physiology to precision medicine”, a symposium, co-organised by EPFL & EMBO Press, will be held from October 24 to October 26, 2017 (2.5 days) at the EPFL campus. It is chaired by Prof. Johan Auwerx.
3/4/2017 We welcome Dohyun Park, a new postdoc researcher, joining the lab.
27/3/2017 Laurent Mouchiroud received the FENRIV Prize from the president of the Egon-Naef Foundation, Marcel Naef, at a ceremony in Geneva on Saturday March 25th, 2017. This prize rewards Swiss researchers who develop alternative methods to limit the use of animal testing in scientific research. Click here to check the news from EPFL.
13/3/2017 Olli Matilainen and Pedro M. Quirós published a review on the intriguing link between Mitochondria and Epigenetics in Trends in Cell Biol.
13/3/2017 A warm welcome to Pirkka-Pekka Laurila, a new postdoc researcher from Finland.
1/3/2017 We welcome two PhD student to our lab: Alexis Bachmann will start working on systems genetics of metabolism, and Mario Romani will join the project of mitochondria and lipid metabolism.
28/2/2017 In a new TV report, Johan Auwerx and Laurent Mouchiroud appeared in the popular french program « Tout Compte Fait” broadcasted on France 2. Click here to watch the video talking about the role of pomegranate as promising anti-aging fruit (Johan Auwerx and Laurent Mouchiroud interview are provided in French, starting at 15’).
5/2/2017 Johan Auwerx and Laurent Mouchiroud appeared in the television programme broadcasted on Swiss TV tonight (RSI). Click here to watch the video talking about aging and pomegranate (Johan Auwerx and Laurent Mouchiroud interview are provided in Italian, starting at 21’).
1/2/2017 We welcome Ziari Naveed, a trainee from UCLA.
21/12/2016 In a collaborative paper published in the Journal of Cell Biology, Dongryeol Ryu from our group together with the group of Prof. Minho Shong, discovered a new myo-mitokine with important implications in metabolic control.
1/12/2016 In a joint study between the UNIL, NIHS, and Pooja Jha and Xu Wang (EPFL), published today in Cell Metabolism, we have shown that exercise enhances supercomplex formation in the mitochondria of human muscles. This work constitutes the human translation of an earlier study in mice and suggests that exercise can have major metabolic benefits. This study was covered on Swiss TV, Radio, as well as website of Unil, and Nestlé Institute of Health Sciences.
1/12/2016 A warm welcome to Francesca Potenza, who joined the lab as a master student.
31/10/2016 Johan Auwerx received the 2016 Marcel Benoist prize from the president of the Swiss Confederation, Johann Schneider-Amann at a ceremony at the Rolex Center. Check the pictures taken during the ceremony here and here.
20/10/2016 A landmark study by Dongryeol Ryu and colleagues, published today in Science Translational Medicine, demonstrates that NAD+ treatment can reverse the functional decline in degenerating muscles of worms and mouse models of Duchenne Muscular Dystrophy, offering some hope to patients. This paper has been covered in Medical Xpress, ScienceDaily, EurekAlert, Daily Mail, Health Medicine Network, Health Canal, La Côte, RTS, and also mentioned on the front page of the EPFL website. A radio interview of Laurent Mouchiroud for the RTS (in French) can be found here.
03/10/2016 Evan Williams is the awardee of the very competitive 2016 EPFL doctorate awards for his thesis work on systems genetics.
03/10/2016 A warm welcome to Maroun Bou Sleiman, who joined the lab as a postdoc scientist.
27/09/2016 Johan Auwerx is the Laureat of the Prix Marcel Benoist 2016. The president of the Swiss Confederation, Johann Schneider-Amman, who is the chairman of the Fondation Marcel Benoist, received Johan Auwerx in Berne to congratulate him for the award. The award ceremony will be on October 31st at the EPFL. Check the news on the website of Swiss government, as well as front page of EPFL.
31/08/2016 Our work was featured in the science section of Le Monde.
03/08/2016 Our laboratory is in the top 10 of the best performing EU Cell Biology laboratories. Click here to read the details.
13/07/2016 Congratulations to Karim Gariani who won the Hepatology prize of the Swiss Society of Gastroenterology and Hepatology!
11/07/2016 Our laboratory identified the pomegrenade compound Urolithin A as a powerful mitophagy inducer that extend lifespan in C.elegans and muscle function in rodents. This work was a collaboration with Amazentis, a biotech in the EPFL biotech park. This paper was published in Nature Medicine, and received coverage in popular press, including New Scientist, ScienceDaily, The Daily Telegraph, Daily Mail, Daily Express, The Local, Yahoo, Medical News Today, Medical Xpress, EurekAlert, Reuters, SBS, Financial Times, Business Wire, Daily Sabah, M2 Magazine (in English); 20 Minutes, Le Temps, 24 heures, Le Matin, Bilan, Sciences et Avenir, RTS (in French); Tages-Anzeiger, Der Bund, NZZ am Sonntag, Schweizer Bauer (in German); La Celosía, ABC.es, El Correo (in Spanish); as well as the front page of EPFL website.
25/06/2016 Johan Auwerx interviewed for ICI Radio-Canada on the development of reprogramming stem cells metabolism (in French).
16/06/2016 Johan Auwerx is the Swiss scientist of the month.
09/06/2016 A collaborative study from our team with the Aebersold lab, which showed the importance of a transomics approach to bridge the gap between gene (DNA) and phenotype (disease) in a mouse reference population, was published today in Science. This paper received a wide coverage in popular press, including ScienceDaily, News Detailansicht (German), El Economista (Spanish), Times of India, as well as the front page of EPFL and ETHZ website.
24/05/2016 Congratulations to Vincenzo Sorrentino who received the EPFL Fellowship co-funded by Marie Skłodowska-Curie.
23/05/2016 Welcome to Sophie You, and Aashima Goyal, two new summer students from the UC Berkeley and the IIT, New Dehli.
19/05/2016 Cell published today a collaboration between the Dillin laboratory (UC Berkeley) and Virginija Jovaisaite in our laboratory showing how 2 conserved histone demethylases epigenetically regulate mitochondrial stress induced longevity. This study was covered in a perspective in Cell, featured in the popular press, including in GEN, and was also mentioned on UC Berkeley website.
28/04/2016 An article by Hongbo Zhang and colleagues, published today in Science, demonstrates that NAD levels are reduced and that mitochondria are dysfunctional in aging stem cells (SC). Restoring NAD levels with the vitamin, nicotinamide riboside (NR), repairs the mitochondrial defects and prevents age-related SC decline, while increasing mouse lifespan, even when NR treatment is started late in life. This paper has been covered in Newsweek, Science Daily, 24 Heures (French), 20 minutes (French), Ouest-France (French), Yahoo (French), Le Matin (French), RTS (French), Sciences et Avenir (French), NetEase (Chinese), Montreal Gazette, Vancouver Sun, The Guardian Nigeria, and also mentioned on the front page of EPFL and U of Ottawa website. Johan Auwerx received radio interviews from the RTS (in French) and ICI Radio-Canada (in French), and a video interview from La Télé (in French).
23/04/2016 A warm welcome to Tao Lin, Lisa Vrijens, and Mario Romani who joined the laboratory as master students.
22/04/2016 We are co-organising a Latsis EPFL Symposium on “Multicellular organisms in microfluidic systems”, which will be held at EPFL November 14-16, 2016. Registrations are open: http://latsis2016.epfl.ch/.
21/04/2016 PNAS published a paper in which Dongryeol Ryu, together with a team at Cornell, showed that SIRT5 is having a major role in determining heart function. This paper received some interest in the lay press.
20/04/2016 Hongbo Zhang collaborated on a Cell Reports paper showing the importance of the acetyl transferase KAT2B in pancreatic beta-cell adaptation to ER stress.
24/03/2016 We published an important review defining the novel domain of “Mitonuclear Communication” in Nature Reviews in Molecular Cell Biology.
12/03/2016 Reproducible BN-PAGE analysis of mitochondrial complexes and supercomplexes made possible by a rigorous protocol published by Pooja Jha and Xu Wang.
15/02/2016 The EPFL website and the Swiss French Radio (RTS) announced the publication of a paper on an innovative microfluidic platform for the study of neurodegenerative diseases in C. elegans – the fruit of a collaboration between Laurent Mouchiroud and Matteo Cornaglia.
06/02/2016 Our lab contributed to the effort of Rob Williams to use the BXD genetic reference population for reverse genetic analysis at the systems level. Manuscript can be found here.
21/01/2016 Johan Auwerx appeared in the television programme broadcasted on norvegian TV tonight. Click here to watch the video “Exercise in a pill” (Johan Auwerx interview is provided in English).
23/11/2015 Johan Auwerx has joined the Journal of Cell Biology (JBC) editorial board. Click here to read the press release.
14/11/2015 Congratulations to Karim Gariani who won the Prize 2015 of the Fondation Romande pour la Recherche sur le Diabète! Click here to read the press release (in French).
10/11/2015 An artistic representation of a microfluidic device developped by Matteo Cornaglia of the Gijs lab and Laurent Mouchiroud published earlier in Scientific Reportswon the “Art in Science Award” at MicroTAS in South Korea.
27/10/2015 Congratulations to Keir Menzies, Hongbo Zhang and Elena Katsyuba whose review was published in Nature Reviews Endocrinology today! It discusses the role of reversible acetylation in metabolic control and different metabolites and cofactors governing this process via alteration of KATs/KDACs activity.
01/10/2015 A collaborative effort of our team and Professor S.Vatner group (Rutgers University, Newark, NJ, USA) has been published in Aging Cell today. This paper provides eidence that type 5 adenylate cyclase loss-of-function improves exercise capacity.
24/09/2015 Our new article by Karim Gariani et al. has been just published in Hepatology. It reports that replenishing liver NAD+ stocks can prevent and reverse the development ofnon-alcoholic fatty liver disease (NAFLD), the most common cause of chronic liver disease in western countries. The study was highlighted on nature.com. Congratulations to the whole team!
23/09/2015 A new review article co-authored by Xu Wang and Dongryeol Ryu and discussing the negative impacts of antibiotic use has been chosen as one of the highlights of the October issue of BioEssays. Click here to watch the video where Professor Auwerx disscusses why antibiotics should be used wisely.
20/08/2015 A slightly late but warm welcome to Gopal Krishnamani, a Master Student from STI, and Virginie Peter, a Master Student from Medicine, to our group!
07/07/2015 A new review article by our group was published in Cell Metabolism. It discusses the role of NAD+ in energy homeostasis control. Congratulations to the two first co-authors Keir Menzies and Carles Canto!
03/07/2015 The perspective of Johan Auwerx and Evan Williams on genetic research models and for a more efficient way forward in the combined analysis of population datasets and genetically-modified models has been published in the most recent issue of Cell (here; requires subscription until open access starts on 3 July 2016).
02/07/2015 The Auwerx laboratoryhas established a collaborationwith Prof. Roberto Pellicciari and TES Pharma (start-up from Perugia, Italy) aiming to test novel compounds to treat metabolic and aging-related diseases. Press releases in French (here), Italia (here) and Spanish (here).
17/06/2015 Congratulations to Laurent Mouchiroud and his collaborator Matteo Cornaglia from the Laboratoy of Microsystems for having being ranked in the “Top 10 Business Ideas” of the Venture.ch 2015 competition. Their project aims to build the first automated microfluidic-based platform for high-content screening on worms. “Venture” 2015 is an initiative of the ETH Zurich, Knecht Holding, the innovation promotion agency CTI and McKinsey & Company, Switzerland. The Swiss-wide business idea competition supports young entrepreneurs in founding a company.
22/05/2015 Another manuscript by our group has been published in Hepatology Journal. This study describes how Akt-mediatedNCoR1 phosphorylation orchestrates NCoR1 recruitment to different nuclear receptors and selectively modulates liver energy metabolism.
08/05/2015 We have published an article in Scientific Reports todayon examining C. elegansin microfluidic chambers, with implications for both drug development and examining fundamental questions in biology. This biotechnology collaboration between the laboratories of Johan Auwerx and Martin Gijs at the EPFL was headed by Laurent Mouchiroud and Matteo Cornaglia.
13/03/2015 An important paper by Norman Moullan, Laurent Mouchiroud et al. was published in Cell Reports today. This work, reporting the negative effects of antibiotics (tetracyclines) on mitochondrial function, received a wide coverage in popular press (e.g. The Scientist, Tribune de Genève, 24 heures). It has been also mentioned on the front page of the EPFL web-site. A radio interview of Laurent Mouchiroud for the RTS (in French)can be found here and here.
12/03/2015 Congratulations to Hongbo Zhang who was awarded a Carigest Doctoral Scholarship.
02/02/2015 A warm welcome to Davide D’Amico, a new post-doc researcher who joined our UPRmt team.
05/01/2015 We welcome Hao Li, a new graduate student who will begin his work in our group on population genetics and metabolic diseases.
29/11/2014 Congratulations to Johan Auwerx, who has been included on the list of 400 most influential biomedical researchers in a recent study based on several factors, including h-index and citation count. The paper and its methods can be read here.
14/11/2014 Congratulations to Evan Williams, who has completed the doctoral defense of his thesis today, entitled “A Systems Approach to Identify Genetic and Environmental Regulators of Metabolism.” We welcome Evan into the next stage of his career as a scientist.
4/11/2014 The Auwerx lab continues its work in sirtuin genes, with a paper on Sirt7 by Dongryeol Ryu et al. coming out today in Cell Metabolism.
3/11/2014 We welcome Vincenzo Sorrentino, a post-doctoral researcher, to our research team.
21/10/2014 The Auwerx laboratory welcomes Pooja Jha, a new post-doctoral researcher in our laboratory, coming from a background working on the metabolic health of the liver.
20/10/2014 The web site of the Lausanne Integrative Metabolism and Nutrition Alliance (LIMNA) was created at this address: www.limna.ch
You can check the agenda for all the upcoming events by clicking here.
5/10/2014 Our congratulations to Laurent Mouchiroud, a postdoc in our laboratory who has recieved the Fondation Latsis Internationale award for his work in aging in C. elegans (more details here). This prestigious award is given once yearly across all faculties at the EPFL for postdocs and other scientists beginning their careers (details here).
4/10/2014 Our congratulations to Amandine Nicolet who recieved the Prize from the Faculty of Life Sciences for the Best Master Project in Molecular Medicine. Click here to see the official photo of Amandine with the Dean of SV faculty Gisou Van Der Goot.
25/09/2014 A manuscript by Evan Williams and others in our research group has been published today at PLoS Genetics. In this manuscript, we located and validated that the gene Ahr plays a role in spontaneous movement activity in a tremendous range of organisms — all the way from C. elegans, to Drosophila, to mammals.
11/09/2014 A paper by Yibo Wu at ETHZ and Evan Williams in our laboratory is published today in Cell (link). This study makes use of advances in systems proteomics developed at ETHZ to identify new factors leading to metabolic diseases. Using this approach, a novel association was identified between the gene Dhtkd1 and diabetes, linked through the metabolite 2-aminoadipate. Strikingly, lower levels of this metabolite are also associated with diabetes in a human population study performed at CHUV. Several other leads between genetic variants and disease were also identified in the BXD mouse population that mirror human diseases, such as Maple Syrup Urinary Disease, an inborn error of amino acid metabolism. A press summary of this article can be found on the front page of the EPFL (link).
04/09/2014 A paper by Dongryeol Ryu et al. is published in Cell Metabolism. This study unravels the role of SIRT7 in regulation of mitochondrial homeostasis, which is fulfilled via deacetylation of GABPβ1, a master regulator of nuclear-encoded mitochondrial genes.
02/06/2014 Welcome to Tiffany Amariuta, a summer intern from MIT taking part in a new internship program at the EPFL for US and Canadian students.
15/05/2014 Together with the laboratory of Reuben Shaw, we have published a comprehensive review in Cell Metabolism detailing the gene and environmental interaction networks that influence metabolic homeostasis, and how these interactions affect the development of disease.
10/04/2014 Today, the hirsch-index of Professor Auwerx passed 100, a landmark number, according to the Thomson-Rueter’sWeb of Science. This h-index indicates that at least 100 papers have been cited at least 100 times, and we are all proud that our work is well appreciated by our peers.
11/02/2014Mitokyne, a start-up company co-founded by Johan Auwerx and focused on the treatment of mitochondrial diseases, isfeatured amongst the top 10 start-up companies of 2013by Nature Biotechnology (read highlight here).
01/01/2014 The New Year has started and we welcome two new people to our group: Olli Matilainen, a new postdoc joining C.elegans team and Karim Gariani who will start his PhD in our lab.
21/11/2013 We have activated an R01 grant from the NIH for continuing our work on aging in a genetically diverse population study, together with Robert Williams at the University of Tennessee. We have recently received some public coverage of this grant (e.g. Memphis Business Journal).
24/05/2013 Our congratulations to Pénélope Andreux, who has brilliantly passed her Ph.D. defense! We rewelcome Dr. Andreux into our laboratory in a new status of post-doc while she finishes up her work on mito-platform.
23/05/2013 A major publication by our laboratory, headed by L. Mouchiroud and R. Houtkooper, was published today in Nature. This paper reveals a new mechanism in the complex relationship between longevity and mitochondrial stress response and has already received some popular press (e.g. The Scientist, Huffington Post, Le Temps (French), La Parisienne (French), RTS (French), NOS (Dutch), NU (Dutch), C2W (Dutch), Volkskrant (Dutch)). The video is now on the front page of the EPFL website.
13/02/2013 We welcome two new collaborators to the lab: Alessia Perino and Carolina Hagberg, both of whom will work on TGR5.
21/01/2013 Many congratulations to Mitsunori Nomura, who has passed his Ph.D. defense! We welcome him into our laboratory now as a post-doc while he finishes up work on TGR5.
27/12/2012 Masters students interested in a position in the Auwerx/Schoonjans laboratory for their thesis project or semester project are invited to check our open positions page for details on potential projects. Interested bachelors students may also apply.
15/10/2012 The Journal of Cell Biology has published a review by Riekelt Houtkooper discussing different means of NAD+ modulation and how it can be translated into clinical applications.
30/08/2012 Cell has published a significant paper by Pénélope Andreux and Evan Williams on the new method involving murine genetic reference populations (GRPs) as a source for studying metabolic homeostasis. The paper illustrates how the use of this method reveals a bone-weakening mechanism.Seethe front page of the EPFL website for more details.
02/08/2012 Beginning a busy August, we welcome five new members to our lab: two doctoral students, Virginija Jovaisaite and Pan Xu, two postdocs, Young-Suk Jo and Géraldine Canny, and one short-term scientific collaborator, Dennis Dahlmans.
23/07/2012 Penelope Andreux has given a presentation (in French) last month to high school students interested in studying science about the functions of mitochondria and their relation to overall metabolism.
09/07/2012 The Journal of Clinical Investigation has published a paper by Maaike Oosterveer et al. on the role of Liver receptor homolog 1 (LRH-1) in hepatic intermediary metabolism.
20/06/2012 “Science! on tourne”: Prof. Auwerx participated in public debate (in French) about the future of performance-enhancing drugs in human sports. Watch the stream here.
15/06/2012 Congratulations to Evan Williams, who won the Best Presentation by a Graduate Student award at the CTC Meeting in Paris. His presentation illustrates the BXD mouse genetic reference population as a strong model for study of clinical and metabolic traits, such as alkaline phosphatase.
11/06/2012 Cell Metabolism has published a significant paper by Carles Canto et. al on the effects of nicotinamide riboside on sirtuin function and metabolism. This paper has been widely covered in the popular press (e.g. Huffington Post, Le Temps, Le Figaro, Nieuwsblad, Vilt, Femina, Huffington Post, Le Matin, Science Daily, Daily Mail, Swiss Info, 20 Minutes, De Morgen, Het Belang Van Limburg). Full explanation on youtube.
6/06/2012 Scientific Reports has published two papers by our group:one by Pablo Fernandez on Sirt3 showing the absence of an effect of Sirt3 on liver and muscle. The other paper, by Taoufiq Harach, shows that commonly-used bile acid binding resins affect metabolism through TGR5.
10/05/2012 Nature Reviews has published a review by Riekelt Houtkooper and Eija Pirinen on sirtuins as regulators of metabolism and health.
25/04/2012We welcome a new technician, Danielle Brandalise, to our team.
5/03/2012We welcome Jef Verbeek to the team, a guest PhD student who will work on bile acid homeostasis over the next six months.
1/02/2012 We welcome Julien Zaldivar and Hongbo Zhang to the team as PhD students.
7/12/2011Cell Metabolism has published a paper by Thijs Pols and Mitsunori Nomura from our laboratory on the positive effect of 10/01/2012 We received a short news segment in Television Suisse Romande on the Cell Metabolism paper published in December which can be watched here (French).
7/12/2011Cell Metabolism has published a paper by Thijs Pols and Mitsunori Nomura from our laboratory on the positive effect of TGR5 activation on macrophage inflammation and atherosclerosis. There has been quite some popular press on this article, including on Le Temps, Le Matin, and 20 Minutes.
11/11/2011 Cell has published a significant paper on NCoR1 by Hiroyasu Yamamoto in our group, as well as another collaborative work on NCoR1 in the same issue. The story has been widely covered in popular media (e.g. ABC News, Le Temps) as well as the front page of the EPFL website. The story has also been covered at Dailymail, The Telegraph, Fox News, CBC News, Medical Net, Gizmodo, TruthDive, Europa Press (Spanish), Nord Bayern (German), Blitz (Italian), Rianovosti (Russian), Pikiran Rakyat (Indonesian), Tribune de Geneve (French), 20 Minutes (German & French), Tages Anzeiger (German), Walliser Bote (German), 24 Heures (French), South CN (Chinese), Ziarul de iasi (Romanian), Bioscience Technology, and Le Monde (French).
02/11/2011 Cell Metabolism publishes a collaborative paper of the Schrauwen group in Maastricht with the Auwerx lab on the metabolic health effects of resveratrol supplementation on obese men. The paper is published as cover story and could have important implications for the treatment of metabolic diseases such as obesity and type 2 diabetes. See also coverage in The Guardian, Time, The Telegraph, The Washington Post, Daily Mail, USA Today.
31/10/2011Scientific Reports publishes an Auwerx lab paper on the characterization of aging mice, and the identification of metabolic aging biomarkers.
25/10/2011PNAS publishes a collaborative paper with the Milbrandt lab (Washington University, St. Louis) on the role of SIRT2 in myelination.
01/10/2011 We welcome Elena Katsyuba to the team as a PhD student.
22/09/2011 Nature publishes a commentary by Johan Auwerx and Carles Canto on the high-profile paper by David Gems and colleagues, who contest the lifespan extension by SIRT1 overexpression. See also the reply by the Guarente group and further discussion at Technology Review, Fierce Biotech, NZZ (in German).
14/08/2011Nature Cell Biology publishes a collaborative paper of Johan Auwerx with former Auwerx-lab fellow Lluis Fajas, on the role of E2F1 in regulating oxidative metabolism.
13/08/2011Physiology publishes a review by Carles Canto and Johan Auwerx on the role of AMPK as an energy sensor.
12/08/2011EMBO Reports publishes an Auwerx lab paper describing how CREB and ChREBP regulate SIRT1
25/07/2011 We welcome Adrienne Mottis to the team. Adrienne will do a master project on PARPs and mitochondrial function.
15/06/2011 We welcome Sylvie Timmers to our team. Sylvie will work as a guest PhD student for 6 months on the mitochondrial projects.
11/06/2011Science-Business eXchange publishes an interview with prof. Auwerx and others about the current LRH-1 research of Dr. David Moore.
01/05/2011 We welcome Matthias Stein to the team. Matthias will work on the LRH-1 projects.
06/04/2011 Cell Metabolism publishes two papers from the Auwerx lab —in collaboration with Peter Bai and colleagues in Hungary— on the role of PARP proteins in metabolism. Knockout mice for PARP1 or PARP2 have increased energy expenditure which is mediated through SIRT1. Both papers formed the subject of a Preview in Cell Metabolism and could have important implications for the treatment of mitochondrial diseases, diabetes, and cancer.
01/04/2011 We welcome Sooraj Ratnakumar to the lab. Sooraj will work on the acetyltransferase projects.
01/03/2011 We welcome Adriano Maida to the lab. Adriano will work as a postdoc on the TGR5 projects.
18/02/2011 The work of the Auwerx lab is discussed in “10vor10” on Swiss TV (SF, in German).
20/01/2011 Article in Outside magazine, mainly on the work of the Evans group on increasing exercise capacity. Prof. Auwerx is interviewed on the work on resveratrol.
05/01/2011Article on the first successful clinical development of a product discovered by our laboratory, by a company spun out of our lab (in French): a fat burner developed thanks to our studies on the bile acid activated GPCR, TGR5.
01/01/2011 We welcome Giuseppe Lo Sasso to the team. Giuseppe will work as a postdoc on both sirtuins and TGR5, especially in relation to the intestine
01/12/2010 We welcome Laurent Mouchiroud to the team. Laurent will work as a postdoc on the link between metabolism and lifespan.
01/11/2010 We welcome Thibaud Clerc to the team. Thibaud will work as a technician.
29/10/2010 On October 31st, prof Auwerx will give the Hans Popper Basic Science State-of-the-Art lecture at The Liver Meeting.
Update (11-10-2010): The full lecture can be viewed here.
09/10/2010 Carles Cantó is awarded the Latsis Prize for his groundbreaking work on the identification and characterization of the signaling pathways that connect AMPK and SIRT1 and that determine metabolic adaptation to energy stress.
07/10/2010 Johan Auwerx and Kristina Schoonjans are awarded the Windaus Prize from the Dr. Falk Foundation for their discovery of signaling/endocrine function of bile acids.
06/10/2010Cell Metabolism publishes an Auwerx-lab review on the link between histone methylation and metabolism.
01/10/2010 Prof. Auwerx interviewed for “La Télé” on the link between nutrition and metabolism (in French)
27/09/2010 A new review on AMPK by Carles Cantó and Johan Auwerx is published in CMLS.
16/09/2010Radio Suisse Romande interviews prof. Auwerx on the beneficial effects of resveratrol (in French; starts at 12min16).
01/09/2010 We welcome Dongryeol Ryu to the team. Dongryeol will work as a postdoc on both the sirtuin and the LRH-1 project.
16/08/2010 We welcome Amandine Signorino-Gelo to the team. Amadine will reinforce our technician team.
09/07/2010Cell publishes an Auwerx-lab Leading Edge essay by Riekelt Houtkooper and others on how metabolic pathways impact longevity
01/07/2010 We welcome Eija Pirinen to the team. Eija will work as a postdoc on PGC-1 acetylation
03/03/2010Cell Metabolism publishes a paper by Carles Canto and others from the Auwerx-team on the interdependence of AMPK and SIRT1 for metabolic adaptations.
03/03/2010Hebdo (in French) publishes a short portrait of the Nestlé chair at EPFL, which is headed by prof. Johan Auwerx
09/12/2009Endocrine Reviews publishes an Auwerx-lab review on the diverse roles of NAD+ in metabolism.
04/12/2009 A new Auwerx-lab study, identifying PPARg2 as a longevity gene, is published in PLoS Genetics.
12/11/2009 The Journal of Medicinal Chemistry publishes an Auwerx-lab publication describing the identification of a new potent, selective TGR5 agonist.
31/10/2009 Auwerx-lab team member Pénélope Andreux was awarded the “Prix de la Fondation Romande pour la recherchesur la diabète” for her project “A phenogenomic approach to identify novel mitochondrial function determinants”.
15/10/2009 We welcome Pablo Fernandez-Marcos to the lab. Pablo will work as a postdoc on the sirtuin project.
06/10/2009 Prof. Auwerx is awarded the prestiguous7th Danone International Prize for Nutrition. The prize is awarded for his discoveries concerning the mechanisms by which certain foods “communicate” with our cells by issuing them with orders in similar fashion to hormones. See also several press releases about the award
01/10/2009 The Auwerx-lab welcomes Taoufiq Harach to the team. Taoufiq will work as a postdoc on the role of bile acids and gut flora on metabolism.
11/09/2009 Jiujiu Yu and Johan Auwerx publish a review on sirtuins and metabolic homeostasis in the Annals of the New York Academy of Sciences.
01/09/2009 Cell Metabolism publishes the Auwerx-lab paper by Charles Thomas and others on the role of the bile acid sensor TGR5 in glucose homeostasis as the featured article of its most recent issue. The paper also receives a lot of attention in the lay press.
30/06/2009 The lab welcomes Mitsonura Nomura to the team. Mitsonura will work as a PhD student on the TGR5 project.