Journal Articles

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

T. Y. Li; Q. Wang; A. W. Gao; X. Li; Y. Sun et al. 

Cell Discovery. 2023-09-07. Vol. 9, num. 1, p. 92. DOI : 10.1038/s41421-023-00589-1.

Cyclo(His-Pro): A further step in the management of steatohepatitis

A. De Masi; X. Li; D. Lee; J. Jeon; Q. Wang et al. 

Jhep Reports. 2023-09-01. Vol. 5, num. 9, p. 100815. DOI : 10.1016/j.jhepr.2023.100815.

Gene network based analysis identifies a coexpression module involved in regulating plasma lipids with high-fat diet response

F. Xu; J. Ziebarth; L. J. E. Goeminne; J. Gao; E. G. Williams et al. 

Journal Of Nutritional Biochemistry. 2023-09-01. Vol. 119, p. 109398. DOI : 10.1016/j.jnutbio.2023.109398.

Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems

M. Girotra; Y-H. Chiang; M. Charmoy; P. Ginefra; H. C. Hope et al. 

Nature Aging. 2023-08-31. DOI : 10.1038/s43587-023-00473-3.

Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

A. Park; K-e. Kim; I. Park; S. H. Lee; K-Y. Park et al. 

Nature Communications. 2023-06-23. Vol. 14, num. 1, p. 3746. DOI : 10.1038/s41467-023-39106-z.

Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging

T. I. Lima; P-P. Laurila; M. Wohlwend; J. D. Morel; L. J. E. Goeminne et al. 

Science Translational Medicine. 2023-05-17. Vol. 15, num. 696, p. eade6509. DOI : 10.1126/scitranslmed.ade6509.

Upregulation of the ERR γ-VDAC1 axis underlies the molecular pathogenesis of pancreatitis

D. Chanda; T. Thoudam; I. S. Sinam; C. W. Lim; M. Kim et al. 

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2023-05-16. Vol. 120, num. 20, p. e2219644120. DOI : 10.1073/pnas.2219644120.

Mitochondria: A “pacemaker”for species-specific development

Y. J. Liu; J. Auwerx 

Molecular Cell. 2023-03-16. Vol. 83, num. 6, p. 824-826. DOI : 10.1016/j.molcel.2023.02.025.

Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

E. Yildiz; G. El Alam; A. Perino; A. Jalil; P-D. Denechaud et al. 

Elife. 2023-03-06. Vol. 12, p. e81926. DOI : 10.7554/eLife.81926.

Sodium ferrous citrate and 5-aminolevulinic acid improve type 2 diabetes by maintaining muscle and mitochondrial health

N. Kitamura; S. Zhang; J-D. Morel; U. Nagano; T. Taworntawat et al. 

Obesity. 2023-02-23. DOI : 10.1002/oby.23705.

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression

G. Benegiamo; G. V. G. von Alvensleben; S. Rodriguez-Lopez; L. J. E. Goeminne; A. M. Bachmann et al. 

Journal Of Experimental Medicine. 2023-02-14. Vol. 220, num. 4, p. e20221738. DOI : 10.1084/jem.20221738.

Mitochondrial and NAD plus metabolism predict recovery from acute kidney injury in a diverse mouse population

J. -D. Morel; M. B. Sleiman; T. Y. Li; G. von Alvensleben; A. M. Bachmann et al. 

Jci Insight. 2023-02-08. Vol. 8, num. 3, p. e164626. DOI : 10.1172/jci.insight.164626.

GPS2-mediated regulation of the adipocyte secretome modulates adipose tissue remodeling at the onset of diet-induced obesity

J. English; J. Orofino; C. T. Cederquist; I. Paul; H. Li et al. 

Molecular Metabolism. 2023-02-06. Vol. 69, p. 101682. DOI : 10.1016/j.molmet.2023.101682.


Identifying genetic and dietary modulators of metabolic disorders using systems genetics

X. Li / J. Auwerx (Dir.)  

Lausanne, EPFL, 2023. 

Characterization of Cyclo His-Pro for the prevention and treatment of liver disease and muscular dystrophy

A. De Masi / J. Auwerx (Dir.)  

Lausanne, EPFL, 2023. 

A single-cell-based characterization of mammalian adipose stem and progenitor cell heterogeneity and function

P. Y. Rainer / B. Deplancke (Dir.)  

Lausanne, EPFL, 2023. 


Tetracycline derivative induced mitohormesis mediates disease tolerance against viral infections

J. Auwerx; A. J. L. Mottis; M. Nelson 

WO2023274941; EP4112058.



Journal Articles

Machine learning-derived gut microbiome signature predicts fatty liver disease in the presence of insulin resistance

B. E. Kang; A. Park; H. Yang; Y. Jo; T. G. Oh et al. 

Scientific Reports. 2022-12-17. Vol. 12, num. 1. DOI : 10.1038/s41598-022-26102-4.

SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice

T. Yoshizawa; Y. Sato; S. U. Sobuz; T. Mizumoto; T. Tsuyama et al. 

Nature Communications. 2022-12-12. Vol. 13, num. 1, p. 7439. DOI : 10.1038/s41467-022-35219-z.

Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia

P-P. Laurila; M. Wohlwend; T. I. de Lima; P. Luan; S. Herzig et al. 

Nature Aging. 2022-12-01. Vol. 2, num. 12, p. 1159-+. DOI : 10.1038/s43587-022-00309-6.

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

T. Y. Li; A. W. Gao; X. Li; H. Li; Y. J. Liu et al. 

Journal of Cell Biology. 2022-10-31. Vol. 222, num. 1. DOI : 10.1083/jcb.202205045.

COX7A2L genetic variants determine cardiorespiratory fitness in mice and human

G. Benegiamo; M. B. Sleiman; M. Wohlwend; S. Rodriguez-Lopez; L. J. E. Goeminne et al. 

Nature Metabolism. 2022-10-17. Vol. 4, num. 10, p. 1336-1351. DOI : 10.1038/s42255-022-00655-0.

Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis

H. Li; A. Perino; Q. Huang; G. V. G. Von Alvensleben; A. Banaei-Esfahani et al. 

Cell Metabolism. 2022-10-04. Vol. 34, num. 10, p. 1594-+. DOI : 10.1016/j.cmet.2022.08.015.

Non-genomic activation of the AKT-mTOR pathway by the mitochondrial stress response in thyroid cancer

W. K. L. Doolittle; S. Park; S. G. Lee; S. Jeong; G. Lee et al. 

Oncogene. 2022-10-04. DOI : 10.1038/s41388-022-02484-7.

The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis

N. Bresciani; H. Demagny; V. Lemos; F. Pontanari; X. Li et al. 

Journal Of Hepatology. 2022-10-01. Vol. 77, num. 4, p. 1071-1082. DOI : 10.1016/j.jhep.2022.05.040.

Sex- and age-dependent genetics of longevity in a heterogeneous mouse population

M. Bou Sleiman; S. Roy; A. W. Gao; M. C. Sadler; G. V. G. von Alvensleben et al. 

Science. 2022-09-30. Vol. 377, num. 6614. DOI : 10.1126/science.abo3191.

Tetracycline-induced mitohormesis mediates disease tolerance against influenza

A. Mottis; T. Y. Li; G. El Alam; A. Rapin; E. Katsyuba et al. 

Journal Of Clinical Investigation. 2022-09-01. Vol. 132, num. 17, p. e151540. DOI : 10.1172/JCI151540.

Estrogen-related receptor gamma regulates mitochondrial and synaptic genes and modulates vulnerability to synucleinopathy

S. N. Fox; L. J. McMeekin; C. H. Savage; K. L. Joyce; S. M. Boas et al. 

Npj Parkinsons Disease. 2022-08-18. Vol. 8, num. 1, p. 106. DOI : 10.1038/s41531-022-00369-w.

Genetic background and sex control the outcome of high-fat diet feeding in mice

A. M. Bachmann; J-D. Morel; G. El Alam; S. Rodríguez-López; T. Imamura de lima et al. 

iScience. 2022-06-17. Vol. 25, num. 6, p. 104468. DOI : 10.1016/j.isci.2022.104468.

Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

A. Singh; D. D’Amico; P. A. Andreux; A. M. Fouassier; W. Blanco-Bose et al. 

Cell Reports Medicine. 2022-05-17. Vol. 3, num. 5, p. 100633. DOI : 10.1016/j.xcrm.2022.100633.

Sirtuin 7 Deficiency Reduces Inflammation and Tubular Damage Induced by an Episode of Acute Kidney Injury

A. Sanchez-Navarro; M. A. Martinez-Rojas; A. Albarran-Godinez; R. Perez-Villalva; J. Auwerx et al. 

International Journal Of Molecular Sciences. 2022-03-01. Vol. 23, num. 5, p. 2573. DOI : 10.3390/ijms23052573.

Article Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains

A. W. Gao; G. El Alam; A. Lalou; T. Y. Li; M. Molenaars et al. 

Iscience. 2022-02-18. Vol. 25, num. 2, p. 103734. DOI : 10.1016/j.isci.2022.103734.

The mouse metallomic landscape of aging and metabolism

J-D. Morel; L. Sauzeat; L. J. E. Goeminne; P. Jha; E. Williams et al. 

Nature Communications. 2022-02-01. Vol. 13, num. 1, p. 607. DOI : 10.1038/s41467-022-28060-x.

Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy

P-P. Laurila; P. Luan; M. Wohlwend; N. Zanou; B. Crisol et al. 

Science Advances. 2022-01-28. Vol. 8, num. 4. DOI : 10.1126/sciadv.abh4423.

eNAMPT actions through nucleus accumbens NAD + /SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress

L. Morató; S. Astori; I. Zalachoras; J. Rodrigues; S. Ghosal et al. 

Science Advances. 2022. Vol. 8, num. 9. DOI : 10.1126/sciadv.abj9109.

Conference Papers

The Genetic Background Shapes Disease Susceptibility And Reveals A Specific Role For Mitochondrial Dysfunction In The Progression From Nafld To Nash

G. Benegiamo; G. Von Alvensleben; Y. Liu; S. Rodriguez-Lopez; A. Bachmann et al. 

2022-10-01.  p. S633-S634.


Y. Liu; M. Kimura; A. Vijayakumar; E. Murakami; T. Takebe et al. 

2022-10-01.  p. S706-S706.

Cyclo (His-Pro) Prevents Diet-Induced Fatty Liver Disease

A. De Masi; Xiaoxu Li; Qi Wang; A. Mottis; A. Rapin et al. 

2022-10-01.  p. S627-S628.


Pleiotropic effects of mitochondria in aging

T. Lima; T. Y. Li; A. Mottis; J. Auwerx 

Nature Aging. 2022-03-01. Vol. 2, num. 3, p. 199-213. DOI : 10.1038/s43587-022-00191-2.


The role of nicotinamide riboside metabolism in pancreatic beta cells

A. S. Cercillieux / C. Canto Alvarez; J. Auwerx (Dir.)  

Lausanne, EPFL, 2022. 


Products and methods for promoting myogenesis

M. Wohlwend; J. Auwerx; U. Wisløff; J. B. Moreira 

WO2022171734; GB202101932.



Journal Articles

Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity

N. Zanou; H. Dridi; S. Reiken; T. I. de Lima; C. Donnelly et al. 

Nature Communications. 2021-12-10. Vol. 12, num. 1, p. 7219. DOI : 10.1038/s41467-021-27422-1.

GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression

G. C. Addicks; H. Zhang; D. Ryu; G. Vasam; A. E. Green et al. 

Journal Of Cell Biology. 2021-12-08. Vol. 221, num. 2, p. e202104022. DOI : 10.1083/jcb.202104022.

The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging

M. Wohlwend; P-P. Laurila; K. William; M. Romani; T. Lima et al. 

Science Translational Medicine. 2021-12-08. Vol. 13, num. 623, p. eabc7367. DOI : 10.1126/scitranslmed.abc7367.

Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression

T. Hu; S. K. Shukla; E. Vernucci; C. He; D. Wang et al. 

Gastroenterology. 2021-11-01. Vol. 161, num. 5, p. 1584-1600. DOI : 10.1053/j.gastro.2021.06.045.

Phalloidin Staining of Actin Filaments for Visualization of Muscle Fibers in Caenorhabditis elegans

M. Romani; J. Auwerx 

Bio-Protocol. 2021-10-05. Vol. 11, num. 19, p. e4183. DOI : 10.21769/BioProtoc.4183.

Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome

E. Porcu; M. C. Sadler; K. Lepik; C. Auwerx; A. R. Wood et al. 

Nature Communications. 2021-09-24. Vol. 12, num. 1, p. 5647. DOI : 10.1038/s41467-021-25805-y.

Gene-by-environment modulation of lifespan and weight gain in the murine BXD family

S. Roy; M. B. Sleiman; P. Jha; J. F. Ingels; C. J. Chapman et al. 

Nature Metabolism. 2021-09-01. Vol. 3, num. 9, p. 1217-1227. DOI : 10.1038/s42255-021-00449-w.

Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population

A. Singh; D. D’Amico; P. A. Andreux; G. Dunngalvin; T. Kern et al. 

European Journal Of Clinical Nutrition. 2021-06-11. Vol. 76, p. 297–308. DOI : 10.1038/s41430-021-00950-1.

Nicotinamide Riboside Enhances In Vitro Beta-adrenergic Brown Adipose Tissue Activity in Humans

E. B. M. Nascimento; M. P. B. Moonen; C. M. E. Remie; K. Gariani; J. A. Jorgensen et al. 

Journal Of Clinical Endocrinology & Metabolism. 2021-05-01. Vol. 106, num. 5, p. 1437-1447. DOI : 10.1210/clinem/dgaa960.

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

P. Luan; D. D’Amico; P. A. Andreux; P-P. Laurila; M. Wohlwend et al. 

Science Translational Medicine. 2021-04-07. Vol. 13, num. 588, p. eabb0319. DOI : 10.1126/scitranslmed.abb0319.

SIRT7 modulates the stability and activity of the renal K-Cl cotransporter KCC4 through deacetylation

L. G. Noriega; Z. Melo; R. D. Rajaram; A. Mercado; A. R. Tovar et al. 

Embo Reports. 2021-03-22.  p. e50766. DOI : 10.15252/embr.202050766.

Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response

S. G. Kang; M. J. Choi; S-B. Jung; H. K. Chung; J. Y. Chang et al. 

Iscience. 2021-03-19. Vol. 24, num. 3, p. 102181. DOI : 10.1016/j.isci.2021.102181.

A platform for experimental precision medicine: The extended BXD mouse family

D. G. Ashbrook; D. Arends; P. Prins; M. K. Mulligan; S. Roy et al. 

Cell Systems. 2021-03-17. Vol. 12, num. 3, p. 235-247.e9. DOI : 10.1016/j.cels.2020.12.002.

TGR5 Regulates Macrophage Inflammation in Nonalcoholic Steatohepatitis by Modulating NLRP3 Inflammasome Activation

Y. Shi; W. Su; L. Zhang; C. Shi; J. Zhou et al. 

Frontiers In Immunology. 2021-02-22. Vol. 11, p. 609060. DOI : 10.3389/fimmu.2020.609060.

Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer

Y. L. N. Abril; I. R. Fernandez; J. Y. Hong; Y-L. Chiang; D. A. Kutateladze et al. 

Oncogene. 2021-01-21. Vol. 40, num. 9, p. 1644-1658. DOI : 10.1038/s41388-020-01637-w.

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

M. Romani; V. Sorrentino; C. Oh; H. Li; T. Imamura de Lima et al. 

Cell Reports. 2021-01-19. Vol. 34, num. 3, p. 108660. DOI : 10.1016/j.celrep.2020.108660.

Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease

A. Faivre; E. Katsyuba; T. Verissimo; M. Lindenmeyer; R. D. Rajaram et al. 

Nephrology Dialysis Transplantation. 2021-01-01. Vol. 36, num. 1, p. 60-68. DOI : 10.1093/ndt/gfaa124.

Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity

X. Ming; A. C. K. Chung; D. Mao; H. Cao; B. Fan et al. 

Diabetes. 2021-01-01. Vol. 70, num. 1, p. 119-131. DOI : 10.2337/db20-0339.

TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury

H. Zhou; S. Zhou; Y. Shi; Q. Wang; S. Wei et al. 

American Journal Of Transplantation. 2021. Vol. 21, num. 4, p. 1453-1464. DOI : 10.1111/ajt.16327.


Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

D. D’Amico; P. A. Andreux; P. Valdes; A. Singh; C. Rinsch et al. 

Trends In Molecular Medicine. 2021-07-01. Vol. 27, num. 7, p. 687-699. DOI : 10.1016/j.molmed.2021.04.009.


Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in mouse

A. M. Bachmann / J. Auwerx (Dir.)  

Lausanne, EPFL, 2021. 

Organisation and dynamics of mitochondria and their RNA.

T. H. R. Rey / S. Manley (Dir.)  

Lausanne, EPFL, 2021. 

Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease

M. Romani / J. Auwerx (Dir.)  

Lausanne, EPFL, 2021. 


Treatment and prevention of aging related-disease and/or aging by the inhibition of sphingolipids

P-P. Laurila; J. Auwerx 

US2022288004; EP4034645; CN114746547; AU2020353222; WO2021058497.



Journal Articles

Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression

A. L. Rocha; T. I. de Lima; G. P. de Souza; R. O. Correa; D. L. Ferrucci et al. 

Science Advances. 2020-12-01. Vol. 6, num. 49, p. eabc6250. DOI : 10.1126/sciadv.abc6250.

Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis

D. Patoli; F. Mignotte; V. Deckert; A. Dusuel; A. Dumont et al. 

Journal Of Clinical Investigation. 2020-11-02. Vol. 130, num. 11, p. 5858-5874. DOI : 10.1172/JCI130996.

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators

M. B. Sleiman; P. Jha; R. Houtkooper; R. W. Williams; X. Wang et al. 

Cell Reports. 2020-09-29. Vol. 32, num. 13, p. 108203. DOI : 10.1016/j.celrep.2020.108203.

Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling

A. Nakamura; Y. Yokoyama; K. Tanaka; G. Benegiamo; A. Hirayama et al. 

Iscience. 2020-09-25. Vol. 23, num. 9, p. 101522. DOI : 10.1016/j.isci.2020.101522.

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington’s disease models

R. N. Hegde; A. Chiki; L. Petricca; P. Martufi; N. Arbez et al. 

The EMBO Journal. 2020-08-05.  p. e104671. DOI : 10.15252/embj.2020104671.

Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice

L-J. Du; J-Y. Sun; W-C. Zhang; Y-L. Wang; H. Zhu et al. 

Journal Of The American Heart Association. 2020-08-04. Vol. 9, num. 15, p. e015862. DOI : 10.1161/JAHA.120.015862.

PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle

H. Yoon; J. B. Spinelli; E. Zaganjor; S. J. Wong; N. J. German et al. 

Cell Metabolism. 2020-08-04. Vol. 32, num. 2, p. 215-+. DOI : 10.1016/j.cmet.2020.06.017.

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

C. M. E. Remie; K. H. M. Roumans; M. P. B. Moonen; N. J. Connell; B. Havekes et al. 

American Journal Of Clinical Nutrition. 2020-08-01. Vol. 112, num. 2, p. 413-426. DOI : 10.1093/ajcn/nqaa072.

Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age

D. Brigger; C. Riether; R. van Brummelen; K. I. Mosher; A. Shiu et al. 

Nature Metabolism. 2020-08-01. Vol. 2, num. 8, p. 688-702. DOI : 10.1038/s42255-020-0228-3.

Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice

J. S. Moon; L. J. E. Goeminne; J. T. Kim; J. W. Tian; S-H. Kim et al. 

Aging Cell. 2020-07-21.  p. e13195. DOI : 10.1111/acel.13195.

Confounding factors from inducible systems for spatiotemporal gene expression regulation

R. C. I. Wuest; R. H. Houtkooper; J. Auwerx 

Journal Of Cell Biology. 2020-07-06. Vol. 219, num. 7, p. e202003031. DOI : 10.1083/jcb.202003031.

Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

K. Williams; L. R. Ingerslev; J. Bork-Jensen; M. Wohlwend; A. N. Hansen et al. 

Nature Communications. 2020-06-01. Vol. 11, num. 1, p. 2695. DOI : 10.1038/s41467-020-16537-6.

Gene replacement therapy provides benefit in an adult mouse model of Leigh syndrome

R. Reynaud-Dulaurier; G. Benegiamo; E. Marrocco; R. Al-Tannir; E. M. Surace et al. 

Brain. 2020-06-01. Vol. 143, num. 6, p. 1686-1696. DOI : 10.1093/brain/awaa105.

Evaluation of the NAD(+) biosynthetic pathway in ALS patients and effect of modulating NAD(+) levels in hSOD1-linked ALS mouse models

B. A. Harlan; K. M. Killoy; M. Pehar; L. Liu; J. Auwerx et al. 

Experimental Neurology. 2020-05-01. Vol. 327, p. 113219. DOI : 10.1016/j.expneurol.2020.113219.

Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7

C. A. Stoyas; D. D. Bushart; P. M. Switonski; J. M. Ward; A. Alaghatta et al. 

Neuron. 2020-02-19. Vol. 105, num. 4, p. 630-644.e9. DOI : 10.1016/j.neuron.2019.11.019.

Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence

S. Haemmig; D. Yang; X. Sun; D. Das; S. Ghaffari et al. 

Science Translational Medicine. 2020-02-19. Vol. 12, num. 531, p. eaaw1868. DOI : 10.1126/scitranslmed.aaw1868.

Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress

A. E. Dikalova; A. Pandey; L. Xiao; L. Arslanbaeva; T. Sidorova et al. 

Circulation Research. 2020-02-14. Vol. 126, num. 4, p. 439-452. DOI : 10.1161/CIRCRESAHA.119.315767.

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis – Central role of macrophage scavenger receptor 1

T. Arsiwala; J. Pahla; L. J. van Tits; L. Bisceglie; D. S. Gaul et al. 

Journal Of Molecular And Cellular Cardiology. 2020-02-01. Vol. 139, p. 24-32. DOI : 10.1016/j.yjmcc.2020.01.002.

NCoR1 Protects Mice From Dextran Sodium Sulfate Induced Colitis by Guarding Colonic Crypt Cells From Luminal Insult

E. Mennillo; X. Yang; M. Paszek; J. Auwerx; C. Benner et al. 

Cellular And Molecular Gastroenterology And Hepatology. 2020-01-01. Vol. 10, num. 1, p. 133-147. DOI : 10.1016/j.jcmgh.2020.01.014.

Conference Papers

A conserved role of CBP/p300 in mitochondrial stress response and longevity

J. Auwerx; T. Li 

2020-04-01. Annual Meeting on Experimental Biology, San Diego, CA, Apr 04-07, 2020. DOI : 10.1096/fasebj.2020.34.s1.00128.


Mouse Systems Genetics as a Prelude to Precision Medicine

H. Li; J. Auwerx 

Trends In Genetics. 2020-04-01. Vol. 36, num. 4, p. 259-272. DOI : 10.1016/j.tig.2020.01.004.

NAD(+) homeostasis in health and disease

E. Katsyuba; M. Romani; D. Hofer; J. Auwerx 

Nature Metabolism. 2020-01-01. Vol. 2, num. 1, p. 9-31. DOI : 10.1038/s42255-019-0161-5.


Metabolic rescue of muscle and muscle stem cells in muscle disease

P. Luan / J. Auwerx (Dir.)  

Lausanne, EPFL, 2020. 


Journal Articles

The Detection of Early Epigenetic Inheritance of Mitochondrial Stress in C. Elegans with a Microfluidic Phenotyping Platform

H. B. Atakan; K. S. Hof; M. Cornaglia; J. Auwerx; M. A. M. Gijs 

Scientific Reports. 2019-12-17. Vol. 9, p. 19315. DOI : 10.1038/s41598-019-55979-x.

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

D. C. Hofer; G. Zirkovits; H. J. Pelzmann; K. Huber; A. R. Pessentheiner et al. 

Faseb Journal. 2019-12-01. Vol. 33, num. 12, p. 13808-13824. DOI : 10.1096/fj.201801323R.

A biosensor for measuring NAD(+) levels at the point of care

Q. Yu; N. Pourmandi; L. Xue; C. Gondrand; S. Fabritz et al. 

Nature Metabolism. 2019-12-01. Vol. 1, num. 12, p. 1219-1225. DOI : 10.1038/s42255-019-0151-7.

Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel

R. P. J. Bevers; M. Litovchenko; A. Kapopoulou; V. S. Braman; M. R. Robinson et al. 

Nature Metabolism. 2019-12-01. Vol. 1, num. 12, p. 1226-1242. DOI : 10.1038/s42255-019-0147-3.

Identifying gene function and module connections by the integration of multispecies expression compendia

H. Li; D. Rukina; F. P. A. David; T. Y. Li; C-M. Oh et al. 

Genome Research. 2019-12-01. Vol. 29, num. 12, p. 2034-2045. DOI : 10.1101/gr.251983.119.

Opposing action of NCoR1 and PGC-1 alpha in mitochondrial redox homeostasis

T. I. Lima; D. S. P. S. F. Guimaraes; A. G. Oliveira; H. Araujo; C. H. G. Sponton et al. 

Free Radical Biology And Medicine. 2019-11-01. Vol. 143, p. 203-208. DOI : 10.1016/j.freeradbiomed.2019.08.006.

Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population

M. E. Perez-Munoz; A. M. McKnite; E. G. Williams; J. Auwerx; R. W. Williams et al. 

Plos One. 2019-10-21. Vol. 14, num. 10, p. e0224100. DOI : 10.1371/journal.pone.0224100.

Automated Platform for Long-Term Culture and High-Content Phenotyping of Single C. elegans Worms

H. B. Atakan; R. Xiang; M. Cornaglia; L. Mouchiroud; E. Katsyuba et al. 

Scientific Reports. 2019-10-04. Vol. 9, p. 14340. DOI : 10.1038/s41598-019-50920-8.

Nuclear receptor corepressor 1 represses cardiac hypertrophy

C. Li; X-N. Sun; B-Y. Chen; M-R. Zeng; L-J. Du et al. 

EMBO Molecular Medicine. 2019-09-18.  p. e9127. DOI : 10.15252/emmm.201809127.

The gut microbiota influences skeletal muscle mass and function in mice

S. Lahiri; H. Kim; I. Garcia-Perez; M. M. Reza; K. A. Martin et al. 

Science Translational Medicine. 2019-07-24. Vol. 11, num. 502, p. eaan5662. DOI : 10.1126/scitranslmed.aan5662.

Cross-species functional modules link proteostasis to human normal aging

A. Komljenovic; H. Li; V. Sorrentino; Z. Kutalik; J. Auwerx et al. 

Plos Computational Biology. 2019-07-01. Vol. 15, num. 7, p. e1007162. DOI : 10.1371/journal.pcbi.1007162.

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

P. A. Andreux; W. Blanco-Bose; D. Ryu; F. Burdet; M. Ibberson et al. 

Nature Metabolism. 2019-06-01. Vol. 1, num. 6, p. 595-603. DOI : 10.1038/s42255-019-0073-4.

MicroRNA-382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells

D. Dahlmans; A. Houzelle; P. Andreux; X. Wang; J. A. Jorgensen et al. 

Journal Of Cellular Physiology. 2019-05-01. Vol. 234, num. 5, p. 6601-6610. DOI : 10.1002/jcp.27401.

Autophagy regulates lipid metabolism through selective turnover of NCoR1

T. Saito; A. Kuma; Y. Sugiura; Y. Ichimura; M. Obata et al. 

Nature Communications. 2019-04-05. Vol. 10, p. 1567. DOI : 10.1038/s41467-019-08829-3.

Mild inborn errors of metabolism in commonly used inbred mouse strains

J. Leandro; S. Violante; C. A. Argmann; J. Hagen; T. Dodatko et al. 

Molecular Genetics And Metabolism. 2019-04-01. Vol. 126, num. 4, p. 388-396. DOI : 10.1016/j.ymgme.2019.01.021.

Niacin: an old lipid drug in a new NAD(+) dress

M. Romani; D. C. Hofer; E. Katsyuba; J. Auwerx 

Journal Of Lipid Research. 2019-04-01. Vol. 60, num. 4, p. 741-746. DOI : 10.1194/jlr.S092007.

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

N. Vannini; V. Campos; M. Girotra; V. Trachsel; S. Rojas-Sutterlin et al. 

Cell Stem Cell. 2019-03-07. Vol. 24, num. 3, p. 405-418.e7. DOI : 10.1016/j.stem.2019.02.012.

The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo

X. Wan; L. Liu; P. Zhou; X. Hui; Q. He et al. 

Blood Advances. 2019-02-26. Vol. 3, num. 4, p. 644-657. DOI : 10.1182/bloodadvances.2018022756.

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

D. D’Amico; A. Mottis; F. Potenza; V. Sorrentino; H. Li et al. 

Molecular Cell. 2019-02-21. Vol. 73, num. 4, p. 775-787.e10. DOI : 10.1016/j.molcel.2018.11.034.

Multimodal imaging and high-throughput image-processing for drug screening on living organisms on-chip

D. Migliozzi; M. Cornaglia; L. Mouchiroud; V. Uhlmann; M. A. Unser et al. 

Journal of Biomedical Optics. 2019-02-01. Vol. 24, num. 2, p. 021205. DOI : 10.1117/1.JBO.24.2.021205.

Automated high-content phenotyping from the first larval stage till the onset of adulthood of the nematode Caenorhabditis elegans

H. B. Atakan; M. Cornaglia; L. Mouchiroud; J. Auwerx; M. A. M. Gijs 

Lab On A Chip. 2019-01-07. Vol. 19, num. 1, p. 120-135. DOI : 10.1039/c8lc00863a.

Conference Papers

Regulation of NAD plus biosynthesis pathway in chronic kidney disease

A. Faivre; A. Mottis; R. D. Rajaram; D. Legouis; M. Lindenmeyer et al. 

2019-12-04. 51st Annual meeting Swiss Society of Nephrology, Interlaken, Switzerland, 04 .- 06.12.2019. p. 4S-4S.

Inhibition of Mitophagy Triggers Classical Activation of Macrophages

D. Patoli; V. Deckert; A. Rieu; A. Dusuel; A. Jalil et al. 

2019-08-01. 87th Congress of the European-Atherosclerosis-Society (EAS), Maastricht, Netherlands, May 26-29, 2019. p. E26-E26. DOI : 10.1016/j.atherosclerosis.2019.06.075.

Automated High-Content Phenotyping Of The Nematode C. Elegans At Single Animal Resolution With A Microfluidic Platform

H. B. Atakan; R. Xiang; M. Cornaglia; L. Mouchiroud; J. Auwerx et al. 

2019-01-01. 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII (TRANSDUCERS and EUROSENSORS), Berlin, GERMANY, Jun 23-27, 2019. p. 2209-2212. DOI : 10.1109/TRANSDUCERS.2019.8808300.


Mitocellular communication: Shaping health and disease

A. Mottis; S. Herzig; J. Auwerx 

Science. 2019-11-15. Vol. 366, num. 6467, p. 827-832. DOI : 10.1126/science.aax3768.

The virtuous cycle of human genetics and mouse models in drug discovery

J. H. Nadeau; J. Auwerx 

Nature Reviews Drug Discovery. 2019-04-01. Vol. 18, num. 4, p. 255-272. DOI : 10.1038/s41573-018-0009-9.


Systems genetics approaches to probe gene function

H. Li / J. Auwerx (Dir.)  

Lausanne, EPFL, 2019. 


Methods of treating or preventing an aging-related disease

D. D’Amico; J. Auwerx 

WO2019229133; EP3575401.



Journal Articles

De novo NAD(+) synthesis enhances mitochondrial function and improves health

E. Katsyuba; A. Mottis; M. Zietak; F. De Franco; V. van der Velpen et al. 

Nature. 2018-11-15. Vol. 563, num. 7731, p. 354-359. DOI : 10.1038/s41586-018-0645-6.

Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease

M. Ruiz; M. Begou; N. Launay; P. Ranea-Robles; P. Bianchi et al. 

Brain Pathology. 2018-09-01. Vol. 28, num. 5, p. 611-30. DOI : 10.1111/bpa.12571.

Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population

E. G. Williams; Y. Wu; W. Wolski; J. Y. Kim; J. Lan et al. 

Molecular & Cellular Proteomics. 2018-09-01. Vol. 17, num. 9, p. 1766-1777. DOI : 10.1074/mcp.RA118.000554.

The role of mitochondria in stem cell fate and aging

H. Zhang; K. Menzies; J. Auwerx 

Development. 2018. Vol. 145, num. 8, p. dev143420. DOI : 10.1242/dev.143420.

Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species

P. Jha; M. McDevitt; R. Gupta; P. Quiros; E. Williams et al. 

Cell Systems. 2018. Vol. 6, num. 6, p. 722-733.e6. DOI : 10.1016/j.cels.2018.05.016.

Reversible and long-term immobilization in a hydrogel-microbead matrix for high-resolution imaging of Caenorhabditis elegans and other small organisms

L. Dong; M. Cornaglia; G. Krishnamani; J. Zhang; L. Mouchiroud et al. 

PLOS ONE. 2018. Vol. 13, num. 3, p. e0193989. DOI : 10.1371/journal.pone.0193989.

Repairing Mitochondrial Dysfunction in Disease

V. Sorrentino; K. Menzies; J. Auwerx 

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 2018. Vol. 58, p. 353-389. DOI : 10.1146/annurev-pharmtox-010716-104908.

Reduced oxidative capacity in macrophages results in systemic insulin resistance

S. Jung; M. Choi; D. Ryu; H. Yi; S. Lee et al. 

Nature Communications. 2018. Vol. 9, p. 1551. DOI : 10.1038/s41467-018-03998-z.

Mitochondria! function is impaired in the skeletal muscle of pre-frail elderly

P. Andreux; M. van Diemen; M. Heezen; J. Auwerx; C. Rinsch et al. 

Scientific Reports. 2018. Vol. 8, p. 8548. DOI : 10.1038/s41598-018-26944-x.

Microfluidics-enabled phenotyping of a whole population of C. elegans worms over their embryonic and post-embryonic development at single-organism resolution

M. Letizia; M. Cornaglia; R. Trouillon; V. Sorrentino; L. Mouchiroud et al. 

Microsystems & Nanoengineering. 2018. Vol. 4, p. 6. DOI : 10.1038/s41378-018-0003-8.

Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity

D. Gaul; J. Weber; L. van Tits; S. Sluka; L. Pasterk et al. 

CARDIOVASCULAR RESEARCH. 2018. Vol. 114, num. 8, p. 1178-1188. DOI : 10.1093/cvr/cvy036.

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes

A. Abderrahmani; L. Yengo; R. Caiazzo; M. Canouil; S. Cauchi et al. 

DIABETES. 2018. Vol. 67, num. 7, p. 1310-1321. DOI : 10.2337/db17-1539.

Increased cardiac fatty acid oxidation in a mousemodel with decreasedmalonyl-CoA sensitivity of CPT1B

M. van Weeghel; D. Abdurrachim; R. Nederlof; C. Argmann; R. Houtkooper et al. 

CARDIOVASCULAR RESEARCH. 2018. Vol. 114, num. 10, p. 1324-1334. DOI : 10.1093/cvr/cvy089.

GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells

M. Besprozvannaya; E. Dickson; H. Li; K. Ginburg; D. Bers et al. 

Elife. 2018. Vol. 7, p. e31019. DOI : 10.7554/eLife.31019.

Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes

P. Jha; M. McDevitt; E. Halilbasic; E. Williams; P. Quiros et al. 

Cell Systems. 2018. Vol. 6, num. 6, p. 709-721.e6. DOI : 10.1016/j.cels.2018.05.009.

Genetic cartography of longevity in humans and mice: Current landscape and horizons

M. Hook; S. Roy; E. Williams; M. Sleiman; K. Mozhui et al. 

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2018. Vol. 1864, num. 9, p. 2718-2732. DOI : 10.1016/j.bbadis.2018.01.026.

ERR gamma Preserves Brown Fat Innate Thermogenic Activity

M. Ahmadian; S. Liu; S. Reilly; N. Hah; W. Fan et al. 

CELL REPORTS. 2018. Vol. 22, num. 11, p. 2849-2859. DOI : 10.1016/j.celrep.2018.02.061.

Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14

D. Vatner; J. Zhang; M. Oydanich; J. Guers; E. Katsyuba et al. 

AGING CELL. 2018. Vol. 17, num. 4, p. e12751. DOI : 10.1111/acel.12751.

alpha-Amino-beta-carboxymuconate-epsilon-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD(+)) Biosynthesis

R. Pellicciari; P. Liscio; N. Giacche; F. De Franco; A. Carotti et al. 

JOURNAL OF MEDICINAL CHEMISTRY. 2018. Vol. 61, num. 3, p. 745-759. DOI : 10.1021/acs.jmedchem.7b01254.

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function

H. Li; X. Wang; D. Rukina; Q. Huang; T. Lin et al. 

Cell Systems. 2018. Vol. 6, num. 1, p. 90-102. DOI : 10.1016/j.cels.2017.10.016.

Conference Papers

A microfluidic array for high-content screening at whole-organism resolution

D. Migliozzi; M. Cornaglia; L. Mouchiroud; J. Auwerx; M. A. M. Gijs 

2018-01-01. Conference on Microfluidics, BioMEMS, and Medical Microsystems XVI, San Francisco, CA, Jan 27-29, 2018. p. 104910D. DOI : 10.1117/12.2285025.


Cofactor sensing proteins for metabolic assays at point-of-care

Q. Yu / K. Johnsson (Dir.)  

Lausanne, EPFL, 2018. 

Mitochondrial stress signalling and its impacts on physiology

A. J. L. Mottis / J. Auwerx (Dir.)  

Lausanne, EPFL, 2018. 

Microfluidic high-content phenotypic screening on a Caenorhabditis elegans model

M. C. Letizia / M. Gijs (Dir.)  

Lausanne, EPFL, 2018. 


Plasma and liver lipid species as biomarkers of fatty liver

P. Jha; J. Auwerx 

US2020096524; WO2018141965; WO2018141965.


Methods of treating amyloid-beta peptide diseases

J. Auwerx; V. Sorrentino; L. Mouchiroud 

US2022110902; US2019358184; WO2018108991; WO2018108991.



Journal Articles

The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress

O. Matilainen; M. S. B. Sleiman; P. M. Quiros; S. M. D. A. Garcia; J. Auwerx 

Nature Communications. 2017. Vol. 8, p. 1818. DOI : 10.1038/s41467-017-01903-8.

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis

K. Kim; D. Ryu; P. Dongiovanni; L. Ozcan; S. Nayak et al. 

Gastroenterology. 2017. Vol. 153, num. 6, p. 1568-1580.e10. DOI : 10.1053/j.gastro.2017.08.039.

Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity

V. Sorrentino; M. Romani; L. M. Ouchiroud; J. S. Beck; H. Zhang et al. 

Nature. 2017. Vol. 552, num. 7684, p. 187-193. DOI : 10.1038/nature25143.

An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondria! metabolism

D. Dahlmans; A. Houzelle; P. Andreux; J. A. Jorgensen; X. Wang et al. 

Molecular Metabolism. 2017. Vol. 6, num. 11, p. 1429-1442. DOI : 10.10161/j.molmet.2017.08.007.

Systems Phytohormone Responses to Mitochondrial Proteotoxic Stress

X. Wang; J. Auwerx 

Molecular Cell. 2017. Vol. 68, num. 3, p. 540-+. DOI : 10.1016/j.molcel.2017.10.006.

The corepressor NCOR1 regulates the survival of single-positive thymocytes

L. Mueller; D. Hainberger; V. Stolz; P. Hamminger; H. Hassan et al. 

Scientific Reports. 2017. Vol. 7, p. 15928. DOI : 10.1038/s41598-017-15918-0.

Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function

F. Item; S. Wueest; V. Lemos; S. Stein; F. C. Lucchini et al. 

Nature Communications. 2017. Vol. 8, p. 480. DOI : 10.1038/s41467-017-00566-9.

A multiscale study of the role of dynamin in the regulation of glucose uptake

R. Trouillon; M. C. Letizia; K. J. Menzies; L. Mouchiroud; J. Auwerx et al. 

Integrative Biology. 2017. Vol. 9, num. 10, p. 810-819. DOI : 10.1039/c7ib00015d.

Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain

S. Preston; P. K. Korhonen; L. Mouchiroud; M. Cornaglia; S. L. Mcgee et al. 

Faseb Journal. 2017. Vol. 31, num. 10, p. 4515-4532. DOI : 10.1096/fj.201700288R.

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection

J. Wang; N. He; N. Zhang; D. Quan; S. Zhang et al. 

Nature Communications. 2017. Vol. 8, p. 959. DOI : 10.1038/s41467-017-00931-8.

Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection

E. Ciarlo; T. Heinonen; C. Theroude; J. Herderschee; M. Mombelli et al. 

Frontiers In Immunology. 2017. Vol. 8, p. 1037. DOI : 10.3389/fimmu.2017.01037.

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections

E. Ciarlo; T. Heinonen; J. Lugrin; H. Acha-Orbea; D. Le Roy et al. 

Scientific Reports. 2017. Vol. 7, p. 3853. DOI : 10.1038/s41598-017-04263-x.

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

P. M. Quiros; M. A. Prado; N. Zamboni; D. D’Amico; R. W. Williams et al. 

Journal Of Cell Biology. 2017. Vol. 216, num. 7, p. 2027-2045. DOI : 10.1083/jcb.201702058.

Bayesian association scan reveals loci associated with human lifespan and linked biomarkers

A. F. Mcdaid; P. K. Joshi; E. Porcu; A. Komljenovic; H. Li et al. 

Nature Communications. 2017. Vol. 8, p. 15842. DOI : 10.1038/ncomms15842.

Label-free three-dimensional imaging of Caenorhabditis elegans with visible optical coherence microscopy

S. Coquoz; P. J. Marchand; A. Bouwens; L. Mouchiroud; V. Sorrentino et al. 

Plos One. 2017. Vol. 12, num. 7, p. e0181676. DOI : 10.1371/journal.pone.0181676.

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia (vol 114, pg E1432, 2017)

S. Chen; W. Lu; M-F. Yueh; E. Rettenmeier; M. Liu et al. 

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2017. Vol. 114, num. 20, p. E4115-E4115. DOI : 10.1073/pnas.1705671114.

A homozygous missense mutation in ERAL1, encoding a mitochondrial rRNA chaperone, causes Perrault syndrome

I. A. Chatzispyrou; M. Alders; S. Guerrero-Castillo; R. Z. Perez; M. A. Haagmans et al. 

Human Molecular Genetics. 2017. Vol. 26, num. 13, p. 2541-2550. DOI : 10.1093/hmg/ddx152.

PPAR delta Promotes Running Endurance by Preserving Glucose

W. Fan; W. Waizenegger; C. S. Lin; V. Sorrentino; M-X. He et al. 

Cell Metabolism. 2017. Vol. 25, num. 5, p. 1186-1193. DOI : 10.1016/j.cmet.2017.04.006.

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia

S. Chen; W. Lu; M-F. Yueh; E. Rettenmeier; M. Liu et al. 

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2017. Vol. 114, num. 8, p. E1432-E1440. DOI : 10.1073/pnas.1700232114.

PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis

P. Mukhopadhyay; B. Horvath; M. Rajesh; Z. V. Varga; K. Gariani et al. 

Journal Of Hepatology. 2017. Vol. 66, num. 3, p. 589-600. DOI : 10.1016/j.jhep.2016.10.023.

Plasma Membrane-bound G Protein-coupled Bile Acid Receptor Attenuates Liver Ischemia/Reperfusion Injury Via the Inhibition of Toll-like Receptor 4 Signaling in Mice

H. Yang; H. Zhou; L. Zhuang; J. Auwerx; K. Schoonjans et al. 

Liver Transplantation. 2017. Vol. 23, num. 1, p. 63-74. DOI : 10.1002/lt.24628.

Parkin functionally interacts with PGC-1 proportional to to preserve mitochondria and protect dopaminergic neurons

L. Zheng; N. Bernard-Marissal; N. Moullan; D. D’Amico; J. Auwerx et al. 

Human Molecular Genetics. 2017. Vol. 26, num. 3, p. 582-598. DOI : 10.1093/hmg/ddw418.

Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle

C. Greggio; P. Jha; S. S. Kulkarni; S. Lagarrigue; N. T. Broskey et al. 

Cell Metabolism. 2017. Vol. 25, num. 2, p. 301-311. DOI : 10.1016/j.cmet.2016.11.004.

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

H. K. Chung; D. Ryu; K. S. Kim; J. Y. Chang; Y. K. Kim et al. 

Journal Of Cell Biology. 2017. Vol. 216, num. 1, p. 149-165. DOI : 10.1083/jcb.201607110.

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

K. Gariani; D. Ryu; K. J. Menzies; H-S. Yi; S. Stein et al. 

Journal Of Hepatology. 2017. Vol. 66, num. 1, p. 132-141. DOI : 10.1016/j.jhep.2016.08.024.

Conference Papers

A microfluidic platform for automated phenotyping during full lifespan of Caenorhabditis elegans at high-throughput

H. B. Atakan; M. Cornaglia; L. Mouchiroud; J. Auwerx; M. Gijs 

2017. The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, Savannah, Georgia, USA, October 22-26, 2017.

Chromatin remodeling factor integrates responses against nuclear and mitochondrial stress

O. Matilainen; P. M. Quiros; J. Auwerx 

2017. 42nd Congress of the Federation-of-European-Biochemical-Societies (FEBS) on From Molecules to Cells and Back, Jerusalem, ISRAEL, SEP 10-14, 2017. p. 26-26.

Disease-Informed Bayesian Association Scan Reveals Novel Loci Associated with Human Lifespan and Linked Biomarkers

A. F. Mcdaid; P. K. Joshi; N. Mounier; E. Porcu; A. Komljenovic et al. 

2017. Annual Meeting of the International-Genetic-Epidemiology-Society (IGES), Queens Coll, Cambridge, ENGLAND, SEP 09-11, 2017. p. 648-649.


Cytosolic Proteostasis Networks of the Mitochondrial Stress Response

D. D’Amico; V. Sorrentino; J. Auwerx 

Trends In Biochemical Sciences. 2017. Vol. 42, num. 9, p. 712-725. DOI : 10.1016/j.tibs.2017.05.002.

Modulating NAD(+) metabolism, from bench to bedside

E. Katsyuba; J. Auwerx 

Embo Journal. 2017. Vol. 36, num. 18, p. 2670-2683. DOI : 10.15252/embj.201797135.

Mitochondria and Epigenetics Crosstalk in Homeostasis and Stress

O. Matilainen; P. M. Quiros; J. Auwerx 

Trends In Cell Biology. 2017. Vol. 27, num. 6, p. 453-463. DOI : 10.1016/j.tcb.2017.02.004.


Role of ACMSD in regulation of NAD+ metabolism and mitochondrial function

E. Katsyuba / J. Auwerx (Dir.)  

Lausanne, EPFL, 2017. 

The role of nicotinamide riboside kinases in mammalian NAD⁺ metabolism

J. Ratajczak / C. Canto Alvarez; J. Auwerx (Dir.)  

Lausanne, EPFL, 2017. 

The therapeutic role of NAD+ modulation in fatty liver disease

K. L. Gariani / J. Auwerx (Dir.)  

Lausanne, EPFL, 2017. 

Investigating the Biological Mechanisms underlying the Initiation of Autoimmunity against Beta Cell Antigens in Type 1 Diabetes

C. Cianciaruso / J. A. Hubbell; S. Baekkeskov Hanahan (Dir.)  

Lausanne, EPFL, 2017. 


Agents and methods using thereof for the prevention and treatment of stem cells senescence

H. Zhang; K. Menzies; J. Auwerx; D. Ryu 

US2019054098; EP3347023; WO2017042196; WO2017042196.


Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders

H. Zhang; K. Menzies; J. Auwerx; D. Ryu 

US2021137959; US10905704; US2018360862; EP3347024; WO2017042198; WO2017042198.



The effects of mitochondrial- and histone stress on the C. elegans transcriptome

O. J. Matilainen; M. Bou Sleiman; P. Moral Quiros; S. M. D. A. Garcia; J. Auwerx 



Journal Articles

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

J. Ratajczak; M. Joffraud; S. A. J. Trammell; R. Ras; N. Canela et al. 

Nature Communications. 2016-10-11. Vol. 7, p. 13103. DOI : 10.1038/ncomms13103.

LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer

P. Xu; M. H. Oosterveer; S. Stein; H. Demagny; D. Ryu et al. 

Genes & Development. 2016-06-01. Vol. 30, num. 11, p. 1255-1260. DOI : 10.1101/gad.277483.116.

Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: protective role of a novel C/EBP-β-dependent feedback regulation of SOD2

S. Winnik; D. S. Gaul; G. Siciliani; C. Lohmann; L. Pasterk et al. 

Basic Research in Cardiology. 2016-04-12. Vol. 111, num. 3, p. 33. DOI : 10.1007/s00395-016-0552-7.

Track C. Biomedical Instrumentation & Micro and Nano Systems

M. Cornaglia; L. Mouchiroud; G. Krishnamani; A. Marette; S. Narasimhan et al. 

Biomedical Engineering / Biomedizinische Technik. 2016. Vol. 61, num. s1, p. 24-29. DOI : 10.1515/bmt-2016-5002.

NAD(+) repletion improves muscle function in muscular dystrophy and counters global PARylation

D. Ryu; H. Zhang; E. R. Ropelle; V. Sorrentino; D. A. G. Mazala et al. 

Science Translational Medicine. 2016. Vol. 8, num. 361, p. 361ra139. DOI : 10.1126/scitranslmed.aaf5504.

Specification of haematopoietic stem cell fate via modulation of mitochondrial activity

N. Vannini; M. Girotra; O. Naveiras; G. Nikitin; V. Campos et al. 

Nature Communications. 2016. Vol. 7, p. 13125. DOI : 10.1038/ncomms13125.

A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans

M. Koopman; H. Michels; B. M. Dancy; R. Kamble; L. Mouchiroud et al. 

Nature Protocols. 2016. Vol. 11, num. 10, p. 1798-1816. DOI : 10.1038/nprot.2016.106.

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

D. Ryu; L. Mouchiroud; P. A. Andreux; E. Katsyuba; N. Moullan et al. 

Nat Med. 2016. Vol. 22, num. 8, p. 879-88. DOI : 10.1038/nm.4132.

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

S. Sadhukhan; X. Liu; D. Ryu; O. D. Nelson; J. A. Stupinski et al. 

Proceedings of the National Academy of Sciences of the United States of America. 2016. Vol. 113, num. 16, p. 4320-5. DOI : 10.1073/pnas.1519858113.

KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response

N. Rabhi; P-D. Denechaud; X. Gromada; S. A. Hannou; H. Zhang et al. 

Cell reports. 2016. Vol. 15, num. 5, p. 1051-61. DOI : 10.1016/j.celrep.2016.03.079.

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

H. Zhang; D. Ryu; Y. Wu; K. Gariani; X. Wang et al. 

Science (New York, N.Y.). 2016. Vol. 352, num. 6292, p. 1436-1443. DOI : 10.1126/science.aaf2693.

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

C. Merkwirth; V. Jovaisaite; J. Durieux; O. Matilainen; S. D. Jordan et al. 

Cell. 2016. Vol. 165, num. 5, p. 1209-23. DOI : 10.1016/j.cell.2016.04.012.

Systems proteomics of liver mitochondria function

E. G. Williams; Y. Wu; P. Jha; S. Dubuis; P. Blattmann et al. 

Science (New York, N.Y.). 2016. Vol. 352, num. 6291, p. aad0189. DOI : 10.1126/science.aad0189.

Joint mouse-human phenome-wide association to test gene function and disease risk

X. Wang; A. K. Pandey; M. K. Mulligan; E. G. Williams; K. Mozhui et al. 

Nature Communications. 2016. Vol. 7, p. 10464. DOI : 10.1038/ncomms10464.

Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models

M. Cornaglia; G. Krishnamani; L. Mouchiroud; V. Sorrentino; T. Lehnert et al. 

Molecular Neurodegeneration. 2016. Vol. 11, p. 17. DOI : 10.1186/s13024-016-0083-6.

Eliciting the mitochondrial unfolded protein response via NAD+ repletion reverses fatty liver disease

K. L. Gariani; K. J. Menzies; D. Ryu; C. J. Wenger; X. Wang et al. 

Hepatology. 2016. Vol. 63, num. 4, p. 1190-1204. DOI : 10.1002/hep.28245.

Conference Papers

Bone Marrow-Specific Sirt6 Deletion Increases Atherogenesis By Increasing Macrophage Scavenger Receptor 1

T. Arsiwala; L. J. Van Tits; M. Miranda; K. Nussbaum; J. Weber et al. 

2016. Congress of the European-Atherosclerosis-Society (EAS), Innsbruck, AUSTRIA, MAY 29-JUN 01, 2016. p. E247-E247. DOI : 10.1016/j.atherosclerosis.2016.07.049.

Mitochondrial Inhibition By Nicotinamide Riboside Potently Stimulates Hematopoiesis After Transplantation Via The Mitochondrial Unfolded Protein Response

N. Vannini; V. Campos; M. Girotra; E. Stefanidis; A. Semilietof et al. 

2016. 21st Congress of the European-Hematology-Association, Copenhagen, DENMARK, JUN 09-12, 2016. p. 106-106.

Integration Of Multi-Scale Datatypb In Mouse Genetic Reference Populations To Reveal Candidate Modifying Biology In Inborn Errors Of Metabolism

C. A. Argmann; E. G. Williams; S. Violante; J. Hagen; T. Dodatko et al. 

2016. 39th Annual Meeting of the Society-for-Inherited-Metabolic-Disorders (SIMD), Ponte Vedra Beach, FL, APR 03-06, 2016. p. 242-242.


Mitonuclear communication in homeostasis and stress

P. M. Quiros; A. Mottis; J. Auwerx 

Nature Reviews Molecular Cell Biology. 2016. Vol. 17, num. 4, p. 213-226. DOI : 10.1038/nrm.2016.23.

Protein acetylation in metabolism – metabolites and cofactors

K. J. Menzies; H. Zhang; E. Katsyuba; J. Auwerx 

Nature Reviews Endocrinology. 2016. Vol. 12, num. 1, p. 43-60. DOI : 10.1038/nrendo.2015.181.


Metabolic control of muscle and muscle stem cell function

H. Zhang / J. Auwerx (Dir.)  

Lausanne, EPFL, 2016. 

Novel interventions to recover the regenerative capacity of aged skeletal muscle by targeting the interactions in the stem cell niche

L. Lukjanenko / J. Feige; J. Auwerx (Dir.)  

Lausanne, EPFL, 2016. 

Mitochondrial unfolded protein response, its molecular mechanism and physiological impact

V. Jovaisaite / J. Auwerx (Dir.)  

Lausanne, EPFL, 2016. 

AMP-activated protein kinase

S. T. S. Ducommun / K. Sakamoto; J. Auwerx (Dir.)  

Lausanne, EPFL, 2016. 


Methods & compounds useful in hematopoietic stem cell medicine

N. Vannini; M. Lutolf; J. Auwerx; O. Naveiras; M. Girotra 

JP2017527572; US2017252362; CN107072975; EP3191837; KR20170045355; WO2016038011; EP2995948.



Journal Articles

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside

S. Winnik; J. Auwerx; D. A. Sinclair; C. M. Matter 

European Heart Journal. 2015. Vol. 36, num. 48, p. 3404-3412. DOI : 10.1093/eurheartj/ehv290.

Type 5 adenylyl cyclase disruption leads to enhanced exercise performance

D. E. Vatner; L. Yan; L. Lai; C. Yuan; L. Mouchiroud et al. 

Aging Cell. 2015. Vol. 14, num. 6, p. 1075-1084. DOI : 10.1111/acel.12401.

Miniaturized implantable sensors for in vivo localized temperature measurements in mice during cold exposure

R. Padovani; T. Lehnert; P. Cettour-Rose; R. Doenlen; J. Auwerx et al. 

Biomedical microdevices. 2015. Vol. 18, num. 1, p. 1. DOI : 10.1007/s10544-015-0028-9.

Intestinal steroidogenesis controls PPAR expression in the colon and is impaired during ulcerative colitis

G. Bouguen; A. Langlois; M. Djouina; J. Branche; D. Koriche et al. 

Gut. 2015. Vol. 64, num. 6, p. 901-910. DOI : 10.1136/gutjnl-2014-307618.

Gene expression mapping of histone deacetylases and co-factors, and correlation with survival time and 1H-HRMAS metabolomic profile in human gliomas

N. Dali-Youcef; S. Froelich; F-M. Moussallieh; S. Chibbaro; G. Noël et al. 

Scientific Reports. 2015. Vol. 5, p. 9087. DOI : 10.1038/srep09087.

An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging

M. Cornaglia; L. Mouchiroud; A. Marette; S. Narasimhan; T. Lehnert et al. 

Scientific Reports. 2015. Vol. 5, p. 10192. DOI : 10.1038/srep10192.

Phosphorylation of the nuclear receptor co-repressor 1 by protein kinase B (PKB/Akt) switches its co-repressor targets in the liver

Y. S. Jo; D. Ryu; A. Maida; X. Wang; R. M. Evans et al. 

Hepatology (Baltimore, Md.). 2015. Vol. 62, num. 5, p. 1606-1618. DOI : 10.1002/hep.27907.

Evidence for a Direct Effect of the NAD(+) Precursor Acipimox on Muscle Mitochondrial Function in Humans

T. Van De Weijer; E. Phielix; L. Bilet; E. G. Williams; E. R. Ropelle et al. 

Diabetes. 2015. Vol. 64, num. 4, p. 1193-1201. DOI : 10.2337/db14-0667.

The mitochondrial unfolded protein response – synchronizing genomes

V. Jovaisaite; J. Auwerx 

Current Opinion In Cell Biology. 2015. Vol. 33, p. 74-81. DOI : 10.1016/

Cell regulation: Cell biology, fueling a renaissance in metabolism

J. Nunnari; J. Auwerx 

Current Opinion In Cell Biology. 2015. Vol. 33, p. VI-VII. DOI : 10.1016/

PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis

D. M. Shih; J. M. Yu; L. Vergnes; N. Dali-Youcef; M. D. Champion et al. 

Faseb Journal. 2015. Vol. 29, num. 4, p. 1185-1197. DOI : 10.1096/fj.14-260570.

Dependence of Hippocampal Function on ERR gamma-Regulated Mitochondrial Metabolism

L. Pei; Y. Mu; M. Leblanc; W. Alaynick; G. D. Barish et al. 

Cell Metabolism. 2015. Vol. 21, num. 4, p. 628-636. DOI : 10.1016/j.cmet.2015.03.004.

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance

N. Bonhoure; A. Byrnes; R. D. Moir; W. Hodroj; F. Preitner et al. 

Genes & Development. 2015. Vol. 29, num. 9, p. 934-947. DOI : 10.1101/gad.258350.115.

ARTD1-induced poly-ADP-ribose formation enhances PPAR gamma ligand binding and co-factor exchange

M. Lehmann; E. Pirinen; A. Mirsaidi; F. A. Kunze; P. J. Richards et al. 

Nucleic Acids Research. 2015. Vol. 43, num. 1, p. 129-142. DOI : 10.1093/nar/gku1260.

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

N. Moullan; L. Mouchiroud; X. Wang; D. Ryu; E. G. Williams et al. 

Cell Reports. 2015. Vol. 10, num. 10, p. 1681-1691. DOI : 10.1016/j.celrep.2015.02.034.

The Sirt1 activator SRT3025 provides atheroprotection in Apoe(-/-) mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

M. X. Miranda; L. J. Van Tits; C. Lohmann; T. Arsiwala; S. Winnik et al. 

European Heart Journal. 2015. Vol. 36, num. 1, p. 51-59. DOI : 10.1093/eurheartj/ehu095.

Antiviral treatment of feline immunodeficiency virus-infected cats with (R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine

E. Taffin; D. Paepe; N. Goris; J. Auwerx; M. Debille et al. 

Journal of Feline Medicine and Surgery. 2015. Vol. 17, num. 2, p. 79-86. DOI : 10.1177/1098612X14532089.

Conference Papers

A microfluidic device for longitudinal studies of C.elegans neurodegenerative disease models

M. Cornaglia; G. N. Krishnamani; L. Mouchiroud; T. Lehnert; J. Auwerx et al. 

2015. 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Gyeongju, Korea, October 25-29, 2015. p. 689-691.

Multi-dimensional imaging and phenotyping of C. elegans embryos via an automated microfluidic device

M. Cornaglia; L. Mouchiroud; A. P. H. Marette; S. Narasimhan; T. Lehnert et al. 

2015. 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Gyeongju, Korea, October 25-29, 2015. p. 686-688.

Determination of sub-diffraction-limited organelles and biomolecules using microsphere lenses in combination with fluorescence microscopy

H. Yang; N. Moullan; J. Auwerx; M. Gijs 

2015. SPIE Photonics West 2015, San Francisco, USA, February 7-12, 2015. p. 932804. DOI : 10.1117/12.2078360.


Tetracycline Antibiotics Impair Mitochondrial Function and Its Experimental Use Confounds Research

I. A. Chatzispyrou; N. M. Held; L. Mouchiroud; J. Auwerx; R. H. Houtkooper 

Cancer Research. 2015. Vol. 75, num. 21, p. 4446-4449. DOI : 10.1158/0008-5472.Can-15-1626.

The Convergence of Systems and Reductionist Approaches in Complex Trait Analysis

E. G. Williams; J. Auwerx 

Cell. 2015. Vol. 162, num. 1, p. 23-32. DOI : 10.1016/j.cell.2015.06.024.

Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment

X. Wang; D. Ryu; R. H. Houtkooper; J. Auwerx 

Bioessays. 2015. Vol. 37, num. 10, p. 1045-1053. DOI : 10.1002/bies.201500071.

NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

C. Canto; K. J. Menzies; J. Auwerx 

Cell Metabolism. 2015. Vol. 22, num. 1, p. 31-53. DOI : 10.1016/j.cmet.2015.05.023.


Long-term culture and high-resolution imaging of C. elegans using an automated microfluidic platform

G. H. Krishnamani; M. Cornaglia; L. Mouchiroud; M. Gijs; J. Auwerx 

Third Lausanne Integrative Metabolism and Nutrition Alliance (LIMNA) Symposium, Lausanne, Switzerland, March 17.


Journal Articles

Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis

J. Verbeek; M. Lannoo; E. Pirinen; D. Ryu; P. Spincemaille et al. 

Gut. 2014. Vol. 64, num. 4, p. 673-83. DOI : 10.1136/gutjnl-2014-306748.

Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis

M. A. Lim; K. K. Bence; I. Sandesara; P. Andreux; J. Auwerx et al. 

Human Molecular Genetics. 2014. Vol. 23, num. 18, p. 4995-5008. DOI : 10.1093/hmg/ddu214.

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

D. Ryu; Y. S. Jo; G. Lo Sasso; S. Stein; H. Zhang et al. 

Cell metabolism. 2014. Vol. 20, num. 5, p. 856-869. DOI : 10.1016/j.cmet.2014.08.001.

An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement

E. G. Williams; L. Mouchiroud; M. Frochaux; P. Ashutosh; P. A. Andreux et al. 

PLoS genetics. 2014. Vol. 10, num. 9, p. e1004673. DOI : 10.1371/journal.pgen.1004673.

Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population

Y. Wu; E. G. Williams; S. Dubuis; A. Mottis; V. Jovaisaite et al. 

Cell. 2014. Vol. 158, num. 6, p. 1415-1430. DOI : 10.1016/j.cell.2014.07.039.

NAD(+)-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease

R. Cerutti; E. Pirinen; C. Lamperti; S. Marchet; A. A. Sauve et al. 

Cell Metabolism. 2014. Vol. 19, num. 6, p. 1042-1049. DOI : 10.1016/j.cmet.2014.04.001.

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

E. Pirinen; C. Canto; Y. S. Jo; L. Morato; H. Zhang et al. 

Cell Metabolism. 2014. Vol. 19, num. 6, p. 1034-1041. DOI : 10.1016/j.cmet.2014.04.002.

SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

G. Lo Sasso; K. J. Menzies; A. Mottis; A. Piersigilli; A. Perino et al. 

Plos One. 2014. Vol. 9, num. 7, p. e103573. DOI : 10.1371/journal.pone.0103573.

The mitochondrial unfolded protein response in mammalian physiology

A. Mottis; V. Jovaisaite; J. Auwerx 

Mammalian Genome. 2014. Vol. 25, num. 9-10, p. 424-433. DOI : 10.1007/s00335-014-9525-z.

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C-elegans

P. A. Andreux; L. Mouchiroud; X. Wang; V. Jovaisaite; A. Mottis et al. 

Scientific Reports. 2014. Vol. 4, p. 5285. DOI : 10.1038/srep05285.

PPAR beta/delta activation of CD300a controls intestinal immunity

T. Tanaka; S. Tahara-Hanaoka; T. Nabekura; K. Ikeda; S. Jiang et al. 

Scientific Reports. 2014. Vol. 4, p. 5412. DOI : 10.1038/srep05412.

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

G. Lo Sasso; D. Ryu; L. Mouchiroud; S. C. Fernando; C. L. Anderson et al. 

PloS One. 2014. Vol. 9, num. 7, p. e102495. DOI : 10.1371/journal.pone.0102495.

Super-Resolution Biological Microscopy Using Virtual Imaging by a Microsphere Nanoscope

H. Yang; N. Moullan; J. Auwerx; M. A. M. Gijs 

Small. 2014. Vol. 10, num. 9, p. 1712-1718. DOI : 10.1002/smll.201302942.

Estrogen-related receptor-alpha ( ERR alpha) deficiency in skeletal muscle impairs regeneration in response to injury

S. Labarge; M. Mcdonald; L. Smith-Powell; J. Auwerx; J. M. Huss 

Faseb Journal. 2014. Vol. 28, num. 3, p. 1082-1097. DOI : 10.1096/fj.13-229211.

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

N. Khan; M. Auranen; I. Paetau; E. R. Pirinen; L. Euro et al. 

EMBO Molecular Medicine. 2014. Vol. 6, num. 6, p. 721-731. DOI : 10.1002/emmm.201403943.

Is SIRT2 required for necroptosis?

K. Newton; J. M. Hildebrand; Z. Shen; D. Rodriguez; S. Alvarez-Diaz et al. 

Nature. 2014. Vol. 506, num. 7489, p. E4-E6. DOI : 10.1038/nature13024.

Impact of the apolipoprotein E polymorphism, age and sex on neurogenesis in mice: Pathophysiological relevance for Alzheimer’s disease?

A. Koutseff; C. Mittelhaeuser; K. Essabri; J. Auwerx; H. Meziane 

Brain Research. 2014. Vol. 1542, p. 32-40. DOI : 10.1016/j.brainres.2013.10.003.

Regulation of Steatohepatitis and PPARγ Signaling by Distinct AP-1 Dimers

S. C. Hasenfuss; L. Bakiri; M. K. Thomsen; E. G. Williams; J. Auwerx et al. 

Cell Metabolism. 2014. Vol. 19, num. 1, p. 84-95. DOI : 10.1016/j.cmet.2013.11.018.

Conference Papers

An automated microfluidic platform for reversible immobilization and imaging of C. elegans

M. Cornaglia; G. H. Krishnamani; M-P. Meurville; L. Mouchiroud; T. Lehnert et al. 

2014. Microfluidics 2014, Heidelberg, Germany, 23-25 July.

An automated microfluidic platform for long-term high-resolution imaging of C. elegans

M. Cornaglia; G. H. Krishnamani; M-P. Meurville; L. Mouchiroud; T. Lehnert et al. 

2014. The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014), San Antonio, TX, USA, 26-30 October. p. 709-711.

Mitochondrial Activity Determines Hematopoietic Stem Cell Fate Decisions

N. Vannini; M. Girotra; O. M. Naveiras; V. Campos; E. Williams et al. 



Transcriptional Coregulators: Fine-Tuning Metabolism

L. Mouchiroud; L. Eichner; R. Shaw; J. Auwerx 

Cell Metabolism. 2014. Vol. 20, num. 1, p. 26-40. DOI : 10.1016/j.cmet.2014.03.027.

Vitamin D and energy homeostasis-of mice and men

R. Bouillon; G. Carmeliet; L. Lieben; M. Watanabe; A. Perino et al. 

Nature Reviews Endocrinology. 2014. Vol. 10, num. 2, p. 79-87. DOI : 10.1038/nrendo.2013.226.

The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

V. Jovaisaite; L. Mouchiroud; J. Auwerx 

Journal Of Experimental Biology. 2014. Vol. 217, num. 1, p. 137-143. DOI : 10.1242/jeb.090738.


A Systems Approach to Identify Genetic and Environmental Regulators of Metabolism

E. G. Williams / J. Auwerx (Dir.)  

Lausanne, EPFL, 2014. 


Journal Articles

In vivo imaging reveals selective PPAR activity in the skin of peroxisome proliferator-activated receptor responsive element-luciferase reporter mice

N. El-Jamal; L. Dubuquoy; J. Auwerx; B. Bertin; P. Desreumaux 

Experimental dermatology. 2013. Vol. 22, num. 2, p. 137-40. DOI : 10.1111/exd.12082.

The C-type Lectin Receptors Dectin-1, MR, and SIGNR3 Contribute Both Positively and Negatively to the Macrophage Response to Leishmania infantum

L. Lefevre; G. Lugo-Villarino; E. Meunier; A. Valentin; D. Olagnier et al. 

Immunity. 2013. Vol. 38, num. 5, p. 1038-1049. DOI : 10.1016/j.immuni.2013.04.010.

Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development

S. Winnik; D. S. Gaul; F. Preitner; C. Lohmann; J. Weber et al. 

Basic Research In Cardiology. 2013. Vol. 109, num. 1, p. 399. DOI : 10.1007/s00395-013-0399-0.

Probing the Binding Site of Bile Acids in TGR5

A. Macchiarulo; A. Gioiello; C. Thomas; T. W. H. Pols; R. Nuti et al. 

Acs Medicinal Chemistry Letters. 2013. Vol. 4, num. 12, p. 1158-1162. DOI : 10.1021/ml400247k.

Bile Acids Increase Levels of MicroRNAs 221 and 222, Leading to Degradation of CDX2 During Esophageal Carcinogenesis

J. Matsuzaki; H. Suzuki; H. Tsugawa; M. Watanabe; S. Hossain et al. 

Gastroenterology. 2013. Vol. 145, num. 6, p. 1300-1311. DOI : 10.1053/j.gastro.2013.08.008.

Diet1 Functions in the FGF15/19 Enterohepatic Signaling Axis to Modulate Bile Acid and Lipid Levels

L. Vergnes; J. M. Lee; R. G. Chin; J. Auwerx; K. Reue 

Cell Metabolism. 2013. Vol. 17, num. 6, p. 916-928. DOI : 10.1016/j.cmet.2013.04.007.

Bioavailable copper modulates oxidative phosphorylation and growth of tumors

S. Ishida; P. Andreux; C. Poitry-Yamate; J. Auwerx; D. Hanahan 

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2013. Vol. 110, num. 48, p. 19507-12. DOI : 10.1073/pnas.1318431110.

Autophagy Defect Is Associated with Low Glucose-Induced Apoptosis in 661W Photoreceptor Cells

D. Balmer; M. Emery; P. Andreux; J. Auwerx; V. Ginet et al. 

Plos One. 2013. Vol. 8, num. 9, p. e74162. DOI : 10.1371/journal.pone.0074162.

NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids

P. Li; N. J. Spann; M. U. Kaikkonen; M. Lu; D. Y. Oh et al. 

Cell. 2013. Vol. 155, num. 1, p. 200-214. DOI : 10.1016/j.cell.2013.08.054.

Metabolic Characterization of a Sirt5 deficient mouse model

J. Yu; S. Sadhukhan; L. G. Noriega; N. Moullan; B. He et al. 

Scientific Reports. 2013. Vol. 3, p. 2806. DOI : 10.1038/srep02806.

Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of Manganese Superoxide Dismutase via the SIRT1/FoxO3a Pathway

L. Lai; L. Yan; S. Gao; C-L. Hu; H. Ge et al. 

Circulation. 2013. Vol. 127, num. 16, p. 1692-1701. DOI : 10.1161/Circulationaha.112.001212.

Hdac6 deletion delays disease progression in the SOD1(G93A) mouse model of ALS

I. Taes; M. Timmers; N. Hersmus; A. Bento-Abreu; L. Van Den Bosch et al. 

Human Molecular Genetics. 2013. Vol. 22, num. 9, p. 1783-1790. DOI : 10.1093/hmg/ddt028.

Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism

Z. Gan; J. Rumsey; B. C. Hazen; L. Lai; T. C. Leone et al. 

Journal Of Clinical Investigation. 2013. Vol. 123, num. 6, p. 2564-2575. DOI : 10.1172/Jci67652.

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

L. Mouchiroud; R. H. Houtkooper; N. Moullan; E. Katsyuba; D. Ryu et al. 

Cell. 2013. Vol. 154, num. 2, p. 430-41. DOI : 10.1016/j.cell.2013.06.016.

Mitonuclear protein imbalance as a conserved longevity mechanism

R. Houtkooper; L. Mouchiroud; D. Ryu; N. Moullan; E. Katsyuba et al. 

Nature. 2013. Vol. 497, num. 7450, p. 451-457. DOI : 10.1038/nature12188.

NR5A2 Regulates Lhb and Fshb Transcription in Gonadotrope-Like Cells In Vitro, but Is Dispensable for Gonadotropin Synthesis and Fertility In Vivo

J. Fortin; V. Kumar; X. Zhou; Y. Wang; J. Auwerx et al. 

Plos One. 2013. Vol. 8, num. 3, p. e59058. DOI : 10.1371/journal.pone.0059058.

Conference Papers

Copper chelation therapy suppresses tumor growth by inhibiting mitochondrial ATP production in tumors.

S. Ishida; P. Andreux; J. Auwerx; D. Hanahan 

2013. 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR). DOI : 10.1158/1538-7445.Am2013-Lb-301.

Deletion Of Sirt3 Does Not Affect Atherosclerosis But Accelerates Weight Gain And Impairs Rapid Metabolic Adaptation In Ldl Receptor Knockout Mice – Implications For Cardiovascular Risk Factor Development

D. Gaul; F. Preitner; M. X. Miranda; V. Tits; J. Lambertus et al. 

2013. 11th International Symposium on Mechanisms of Vasodilatation. p. 43-43.


An acetylation rheostat for the control of muscle energy homeostasis

K. Menzies; J. Auwerx 

Journal Of Molecular Endocrinology. 2013. Vol. 51, num. 3, p. T101-T113. DOI : 10.1530/Jme-13-0140.

Pharmacological approaches to restore mitochondrial function

P. Andreux; R. Houtkooper; J. Auwerx 

Nature Reviews Drug Discovery. 2013. Vol. 12, p. 465–483. DOI : 10.1038/nrd4023.

Emerging roles of the corepressors NCoR1 and SMRT in homeostasis

A. J. L. Mottis; L. Mouchiroud; J. Auwerx 

Genes and Development. 2013. Vol. 27, num. 8, p. 819-35. DOI : 10.1101/gad.214023.113.


In vivo metabolic studies in skeletal and cardiac muscle using ¹³C magnetic resonance spectroscopy

J. A. M. Bastiaansen / R. Gruetter; A. Comment (Dir.)  

Lausanne, EPFL, 2013. 

Identification of genetic determinants and pharmacological modulators of mitochondrial function

P. Andreux / J. Auwerx (Dir.)  

Lausanne, EPFL, 2013. 

Role of the bile acid membrane receptor TGR5 in macrophages and metabolism

M. Nomura / J. Auwerx; K. Schoonjans (Dir.)  

Lausanne, EPFL, 2013. 


Aging biomarkers

J. Auwerx; R. Houtkooper; S. Houten; C. Argmann 

WO2012164525; WO2012164525.


Mitochondrial ribosomal proteins as aging regulators

J. Auwerx; R. Houtkooper; L. Mouchiroud 

US9180134; US2014187611; WO2013024467; WO2013024467.


Methods of treating mitochondrial dysfunction

C. Alvarez; P. Bai; R. Houtkooper; J. Auwerx; L. Mouchiroud 

US10709724; US2019328758; US2017182076; US2014065099; WO2012114204; WO2012114204.



Journal Articles

Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass

M. Simonen; N. Dali-Youcef; D. Kaminska; S. Venesmaa; P. Kakela et al. 

Obesity Surgery. 2012. Vol. 22, num. 9, p. 1473-1480. DOI : 10.1007/s11695-012-0673-5.

Impaired myogenesis in estrogen-related receptor γ (ERRγ)-deficient skeletal myocytes due to oxidative stress

J. Murray; J. Auwerx; J. M. Huss 

FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012. Vol. 27, num. 1, p. 135-50. DOI : 10.1096/fj.12-212290.

Mitochondrial sirtuins and metabolic homeostasis

E. Pirinen; G. Lo Sasso; J. Auwerx 

Best practice & research. Clinical endocrinology & metabolism. 2012. Vol. 26, num. 6, p. 759-70. DOI : 10.1016/j.beem.2012.05.001.

The Corepressor NCoR1 Antagonizes PGC-1α and Estrogen-Related Receptor α in the Regulation of Skeletal Muscle Function and Oxidative Metabolism

J. Pérez-Schindler; S. Summermatter; S. Salatino; F. Zorzato; M. Beer et al. 

Molecular and cellular biology. 2012. Vol. 32, num. 24, p. 4913-4924. DOI : 10.1128/MCB.00877-12.

Common Mechanisms for Calorie Restriction and AC5 Knockout Models of Longevity

L. Yan; J. Y. Park; J-G. Dillinger; D. Lorenzo; S. Mariana et al. 

Aging cell. 2012. Vol. 11, num. 6, p. 1110-1120. DOI : 10.1111/acel.12013.

Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures

V. Hinard; C. Mikhail; S. Pradervand; T. Curie; R. H. Houtkooper et al. 

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012. Vol. 32, num. 36, p. 12506-17. DOI : 10.1523/JNEUROSCI.2306-12.2012.

Bile Acid Binding Resin Improves Metabolic Control through the Induction of Energy Expenditure

M. Watanabe; K. Morimoto; S. M. Houten; N. Kaneko-Iwasaki; T. Sugizaki et al. 

PloS One. 2012. Vol. 7, num. 8, p. e38286. DOI : 10.1371/journal.pone.0038286.

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

M. Janiszewska; M. L. Suvà; N. Riggi; R. H. Houtkooper; J. Auwerx et al. 

Genes & development. 2012. Vol. 26, num. 17, p. 1926-44. DOI : 10.1101/gad.188292.112.

Systems Genetics of Metabolism : The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits

P. Andreux; E. G. Williams; H. Koutnikova; R. Houtkooper; M-F. Champy et al. 

Cell. 2012. Vol. 150, num. 6, p. 1287-1299. DOI : 10.1016/j.cell.2012.08.012.

LRH-1-dependent glucose sensing determines intermediary metabolism in liver

M. H. Oosterveer; C. Mataki; H. Yamamoto; T. Harach; N. Moullan et al. 

Journal of Clinical Investigation. 2012. Vol. 122, num. 8, p. 2817-2826. DOI : 10.1172/JCI62368.

Murine Gut Microbiota Is Defined by Host Genetics and Modulates Variation of Metabolic Traits

A. M. McKnite; M. E. Perez-Munoz; L. Lu; E. G. Williams; S. Brewer et al. 

Plos One. 2012. Vol. 7, num. 6, p. e39191. DOI : 10.1371/journal.pone.0039191.

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

C. Cantó; R. Houtkooper; E. Pirinen; D. Youn; M. Oosterveer et al. 

Cell Metabolism. 2012. Vol. 15, num. 6, p. 838-847. DOI : 10.1016/j.cmet.2012.04.022.

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

T. Harach; T. W. H. Pols; M. Nomura; A. Maida; M. Watanabe et al. 

Scientific Reports. 2012. Vol. 2, p. 430. DOI : 10.1038/srep00430.

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

P. J. Fernandez-Marcos; E. H. Jeninga; C. Canto; T. Harach; V. C. J. de Boer et al. 

Scientific Reports. 2012. Vol. 2, p. 425. DOI : 10.1038/srep00425.

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

H. Cho; X. Zhao; M. Hatori; R. T. Yu; G. D. Barish et al. 

Nature. 2012. Vol. 485, num. 7396, p. 123-7. DOI : 10.1038/nature11048.

A guide to analysis of mouse energy metabolism

M. H. Tschoep; J. R. Speakman; J. R. S. Arch; J. Auwerx; J. C. Bruening et al. 

Nature Methods. 2012. Vol. 9, p. 57-63. DOI : 10.1038/NMETH.1806.

Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a ‘mitohormesis’ mechanism involving reactive oxygen species and PGC-1

J. Bouitbir; A-L. Charles; A. Echaniz-Laguna; M. Kindo; F. Daussin et al. 

European heart journal. 2012. Vol. 33, num. 11, p. 1397-1407. DOI : 10.1093/eurheartj/ehr224.

Conference Papers

In Vivo Modulation of Mitochondrial Activity Determines HSC Engraftment and Post-Transplant Survival in Mice

N. Vannini; O. M. Naveiras; V. Campos; E. Pirinen; R. Houtkooper et al. 

2012. 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta, GA, DEC 08-11, 2012.

Sleep In A Dish: Key Electrophysiological, Molecular, And Metabolic Signatures Of Sleep And Wakefulness Revealed In Primary Cortical Cultures

V. Hinard; C. Mikhail; S. Pradervand; T. Curie; R. Houtkooper et al. 

2012. Annual Meeting of the Associated-Professional-Sleep-Societies (APSS). p. A9-A9.

Key electrophysiological, molecular and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures

M. Tafti; V. Hinard; C. Mikhail; S. Pradervand; T. Curie et al. 

2012. 21st Congress of the European-Sleep-Research-Society. p. 89-89.

TGR5 in macrophages is protective against atherosclerosis and insulin resistance

T. Pols; M. Nomura; J. Auwerx; K. Schoonjans 

2012. 22nd IUBMB Congress/37th FEBS Congress. p. 157-158.

Impact of Sirtuin 2 knockout on innate immune responses

E. Ciarlo; J. Lugrin; I. Dos Santos Pinheiro; D. Le Roy; N. Moulan et al. 

2012. European Congress of Immunology. p. 271-271.


Exploring the therapeutic space around NAD+

R. Houtkooper; J. Auwerx 

Journal of Cell Biology. 2012. Vol. 199, num. 2, p. 205-209. DOI : 10.1083/jcb.201207019.

Cell biology. FGF21 takes a fat bite

C. Cantó; J. Auwerx 

Science (New York, N.Y.). 2012. Vol. 336, num. 6082, p. 675-6. DOI : 10.1126/science.1222646.

The journey of resveratrol from yeast to human

S. Timmers; J. Auwerx; P. Schrauwen 

Aging. 2012. Vol. 4, num. 3, p. 146-158. DOI : 10.18632/aging.100445.

Sirtuins as regulators of metabolism and healthspan

R. H. Houtkooper; E. Pirinen; J. Auwerx 

Nature reviews. Molecular cell biology. 2012. Vol. 13, num. 4, p. 225-38. DOI : 10.1038/nrm3293.

Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD(+)?

C. Cantó; J. Auwerx 

Pharmacological Reviews. 2012. Vol. 64, p. 166-187. DOI : 10.1124/pr.110.003905.


Ncor1 is a physiological modulator of muscle mass and oxidative function

J. Auwerx; H. Yamamoto; L. Mouchiroud 

US2014147434; WO2012153191.



Journal Articles

The metabolic footprint of aging in mice

R. H. Houtkooper; C. Argmann; S. M. Houten; C. Cantó; E. H. Jeninga et al. 

Scientific Reports. 2011. Vol. 1, p. 134. DOI : 10.1038/srep00134.

Regulation of PGC-1 alpha, a nodal regulator of mitochondrial biogenesis

P. J. Fernandez-Marcos; J. Auwerx 

American Journal Of Clinical Nutrition. 2011. Vol. 93, p. 884S-890S. DOI : 10.3945/ajcn.110.001917.

Don’t write sirtuins off

C. Canto; J. Auwerx 

Nature. 2011. Vol. 477, p. 411-411.

SRT1720 improves survival and healthspan of obese mice

R. K. Minor; J. A. Baur; A. P. Gomes; T. M. Ward; A. Csiszar et al. 

Scientific Reports. 2011. Vol. 1, p. 70. DOI : 10.1038/srep00070.

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

T. Pols; M. Nomura; T. Harach; G. Lo Sasso; M. H. Oosterveer et al. 

Cell Metabolism. 2011. Vol. 14, num. 6, p. 747-757. DOI : 10.1016/j.cmet.2011.11.006.

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

M. Watanabe; Y. Horai; S. M. Houten; K. Morimoto; T. Sugizaki et al. 

The Journal of biological chemistry. 2011. Vol. 286, num. 30, p. 26913-20. DOI : 10.1074/jbc.M111.248203.

The bile acid membrane receptor TGR5: a valuable metabolic target

T. W. H. Pols; L. G. Noriega; M. Nomura; J. Auwerx; K. Schoonjans 

Digestive diseases (Basel, Switzerland). 2011. Vol. 29, num. 1, p. 37-44. DOI : 10.1159/000324126.

CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability

L. G. Noriega; J. N. Feige; C. Canto; H. Yamamoto; J. Yu et al. 

EMBO reports. 2011. Vol. 12, num. 10, p. 1069-76. DOI : 10.1038/embor.2011.151.

E2F transcription factor-1 regulates oxidative metabolism

E. Blanchet; J-S. Annicotte; S. Lagarrigue; V. Aguilar; C. Clapé et al. 

Nature cell biology. 2011. Vol. 13, num. 9, p. 1146-52. DOI : 10.1038/ncb2309.

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

S. Timmers; E. Konings; L. Bilet; R. H. Houtkooper; T. van de Weijer et al. 

Cell metabolism. 2011. Vol. 14, num. 5, p. 612-22. DOI : 10.1016/j.cmet.2011.10.002.

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

J. Du; Y. Zhou; X. Su; J. J. Yu; S. Khan et al. 

Science (New York, N.Y.). 2011. Vol. 334, num. 6057, p. 806-9. DOI : 10.1126/science.1207861.

Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity

P. Li; W. Fan; J. Xu; M. Lu; H. Yamamoto et al. 

Cell. 2011. Vol. 147, num. 4, p. 815-26. DOI : 10.1016/j.cell.2011.09.050.

NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

H. Yamamoto; E. G. Williams; L. Mouchiroud; C. Canto Alvarez; W. Fan et al. 

Cell. 2011. Vol. 147, num. 4, p. 827-839. DOI : 10.1016/j.cell.2011.10.017.

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling

B. Beirowski; J. Gustin; S. M. Armour; H. Yamamoto; A. Viader et al. 

Proceedings of the National Academy of Sciences of the United States of America. 2011. Vol. 108, num. 43, p. E952-61. DOI : 10.1073/pnas.1104969108.

Lack of IL-2 in PPAR-alpha deficient mice triggers allergic contact dermatitis by affecting regulatory T cells

S. Dubrac; A. Elentner; K. Schoonjans; J. Auwerx; M. Schmuth 

European journal of immunology. 2011. Vol. 41, num. 7, p. 1980-1991. DOI : 10.1002/eji.201041357.

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

P. Bai; C. Canto Alvarez; H. Oudart; A. Brunyánszki; Y. Cen et al. 

Cell Metabolism. 2011. Vol. 13, num. 4, p. 461-468. DOI : 10.1016/j.cmet.2011.03.004.

PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure

P. Bai; C. Canto Alvarez; A. Brunyánszki; A. Huber; M. Szanto et al. 

Cell Metabolism. 2011. Vol. 13, num. 4, p. 450-460. DOI : 10.1016/j.cmet.2011.03.013.

Conference Papers

Deconstructing bile acid signaling pathways

R. Pellicciari; A. Macchiarulo; A. Gioiello; C. Thomas; E. Rosatelli et al. 

2011. 241st National Meeting and Exposition of the American-Chemical-Society (ACS), Anaheim, CA, Mar 27-31, 2011. p. 334-MEDI.

Bile acid signaling and control of metabolism

J. H. Auwerx 

2011. 241st National Meeting and Exposition of the American-Chemical-Society (ACS), Anaheim, CA, Mar 27-31, 2011. p. 331-MEDI.

Transcriptional cofactors and NAD(+) in the control of metabolism

J. Auwerx 

2011. 36th FEBS Congress of the Biochemistry for Tomorrows Medicine, Torino, ITALY, Jun 25-30, 2011. p. 37-37.


The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

T. W. H. Pols; L. G. Noriega; M. Nomura; J. Auwerx; K. Schoonjans 

Journal of hepatology. 2011. Vol. 54, num. 6, p. 1263-1272. DOI : 10.1016/j.jhep.2010.12.004.

Interference between PARPs and SIRT1: a novel approach to healthy ageing?

C. Cantó; J. Auwerx 

Aging. 2011. Vol. 3, num. 5, p. 543-547. DOI : 10.18632/aging.100326.

Calorie restriction: is AMPK a key sensor and effector?

C. Cantó; J. Auwerx 

Physiology (Bethesda, Md.). 2011. Vol. 26, num. 4, p. 214-24. DOI : 10.1152/physiol.00010.2011.

Ageing: longevity hits a roadblock

D. B. Lombard; S. D. Pletcher; C. Cantó; J. Auwerx 

Nature. 2011. Vol. 477, num. 7365, p. 410-1. DOI : 10.1038/477410a.

Emerging actions of the nuclear receptor LRH-1 in the gut

F. Marcos; P. Jose; J. Auwerx; K. Schoonjans 

Biochimica et Biophysica Acta. 2011. Vol. 1812, num. 8, p. 947-955. DOI : 10.1016/j.bbadis.2010.12.010.


Upstream binding protein 1 polymorphisms and their use for prognosing or diagnosing arterial blood pressure

J. Auwerx; R. Williams; M. Laakso; H. Koutnikova-rousselin 



Student Projects

Investigating the role of AS160/TBC1D4 in controlling glucose homeostasis

S. T. S. Ducommun 



Journal Articles

The Intestinal Nuclear Receptor Signature With Epithelial Localization Patterns and Expression Modulation in Tumors

S. Modica; F. Gofflot; S. Murzilli; A. D’Orazio; L. Salvatore et al. 

Gastroenterology. 2010. Vol. 138, p. 636-U295. DOI : 10.1053/j.gastro.2009.09.060.

The Pollutant Diethylhexyl Phthalate Regulates Hepatic Energy Metabolism via Species-Specific PPAR alpha-Dependent Mechanisms

J. N. Feige; A. Gerber; C. Casals-Casas; Q. Yang; C. Winkler et al. 

Environmental Health Perspectives. 2010. Vol. 118, p. 234-241. DOI : 10.1289/ehp.0901217.

PPAR gamma Ligands Switched High Fat Diet-Induced Macrophage M2b Polarization toward M2a Thereby Improving Intestinal Candida Elimination

L. Lefevre; A. Gales; D. Olagnier; J. Bernad; L. Perez et al. 

Plos One. 2010. Vol. 5, num. 9, p. e12828. DOI : 10.1371/journal.pone.0012828.

Redefining the TGR5 triterpenoid binding pocket at the C-3 position

C. Genet; C. Schmidt; A. Strehle; K. Schoonjans; J. Auwerx et al. 

Chemmedchem. 2010. Vol. 5, num. 12, p. 1983-1988. DOI : 10.1002/cmdc.201000329.

SIRT1 mRNA Expression May Be Associated with Energy Expenditure and Insulin Sensitivity

J. Rutanen; N. Yaluri; S. Modi; J. Pihlajamäki; M. Vänttinen et al. 

Diabetes. 2010. Vol. 59, num. 4, p. 829-835. DOI : 10.2337/db09-1191.

PPARgamma controls dectin-1 expression required for host antifungal defense against Candida albicans

A. Galès; A. Conduché; J. Bernad; L. Lefevre; D. Olagnier et al. 

Plos Pathogens. 2010. Vol. 6, num. 1, p. e1000714. DOI : 10.1371/journal.ppat.1000714.

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

C. Cantó; L. Q. Jiang; A. S. Deshmukh; C. Mataki; A. Coste et al. 

Cell Metabolism. 2010. Vol. 11, num. 3, p. 213-219. DOI : 10.1016/j.cmet.2010.02.006.

Conference Papers

Targeting TGR5 in diabesity: Focus on S-EMCA (INT-777) a potent and selective bile acid mimetic agonist

R. Pellicciari; A. Macchiarulo; A. Gioiello; C. Thomas; E. Rosatelli et al. 

2010.  p. 314-MEDI.

Increased skin contact hypersensitivity correlates with altered number and function of regulatory T cells in PPAR-alpha mice.

S. Dubrac; A. Elentner; K. Schoonjans; J. Auwerx; M. Schmuth 

2010. 37th Annual Meeting of the Arbeitsgemeinschaft-Dermatologishche-Forschung, Luebeck, GERMANY, Feb 18-20, 2010. p. 183-183.

Cofactor network to control metabolism

J. Auwerx 

2010.  p. 1-1.

PPAR-alpha deficiency triggers allergic contact dermatitis by affecting regulatory T cells through lack of IL-2

S. Dubrac; A. Elentner; K. Schoonjans; J. Auwerx; M. Schmuth 

2010. 40th Annual Meeting of the European-Society-for-Dermatological-Research (ESDR 2010), Helsinki, FINLAND, Sep 08-11, 2010. p. S38-S38.


Histone methyl transferases and demethylases; can they link metabolism and transcription?

R. Teperino; K. Schoonjans; J. Auwerx 

Cell Metabolism. 2010. Vol. 12, num. 4, p. 321-327. DOI : 10.1016/j.cmet.2010.09.004.

pRb, a switch between bone and brown fat

P. Fernandez-Marcos; J. Auwerx 

Developmental Cell. 2010. Vol. 19, num. 3, p. 360-2. DOI : 10.1016/j.devcel.2010.08.018.

Obesity: New life for antidiabetic drugs

R. H. Houtkooper; J. Auwerx 

Nature. 2010. Vol. 466, num. 7305, p. 443-4. DOI : 10.1038/466443a.

AMP-activated protein kinase and its downstream transcriptional pathways

C. Canto Alvarez; J. Auwerx 

Cellular and Molecular Life Sciences. 2010. Vol. 67, num. 20, p. 3407-2. DOI : 10.1007/s00018-010-0454-z.

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

E. H. Jeninga; K. Schoonjans; J. Auwerx 

Oncogene. 2010. Vol. 29, num. 33, p. 4617-24. DOI : 10.1038/onc.2010.206.

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

T. W. Pols; J. Auwerx; K. Schoonjans 

Gastroenterol Clin Biol. 2010. Vol. 34, num. 4-5, p. 270-3. DOI : 10.1016/j.gcb.2010.03.009.

Metabolic Networks of Longevity

R. H. Houtkooper; R. W. Williams; J. Auwerx 

Cell. 2010. Vol. 142, num. 1, p. 9-14. DOI : 10.1016/j.cell.2010.06.029.

Clking on PGC-1alpha to inhibit gluconeogenesis

C. Cantó; J. Auwerx 

Cell Metabolism. 2010. Vol. 11, num. 1, p. 6-7. DOI : 10.1016/j.cmet.2009.12.003.

Protein deacetylation by SIRT1: An emerging key post- translational modification in metabolic regulation

J. Yu; J. Auwerx 

Pharmacological Research. 2010. Vol. 62, num. 1, p. 35-41. DOI : 10.1016/j.phrs.2009.12.006.

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

R. H. Houtkooper; C. Cantó; R. J. Wanders; J. Auwerx 

Endocrine Reviews. 2010. Vol. 31, num. 2, p. 194-223. DOI : 10.1210/er.2009-0026.

Student Projects

Findings and approach for development of a TGR5 agonist used to treat diabetes

G. Rydlo 


Effect of carbonated and still beverages containing same dose of caffeine and green tea catechins on energy expenditure

M. Trousseau 



Journal Articles

Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes

C. Genet; A. Strehle; C. Schmidt; G. Boudjelal; A. Lobstein et al. 

Journal of medicinal chemistry. 2009. Vol. 53, num. 1, p. 178-90. DOI : 10.1021/jm900872z.

The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice

D. H. Volle; M. Decourteix; E. Garo; J. McNeilly; P. Fenichel et al. 

Journal Of Clinical Investigation. 2009. Vol. 119, num. 12, p. 3752-3764. DOI : 10.1172/JCI38521.

Discovery of 6alpha-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity

R. Pellicciari; A. Gioiello; A. Macchiarulo; C. Thomas; E. Rosatelli et al. 

Journal of Medicinal Chemistry. 2009. Vol. 52, num. 24, p. 7958-7961. DOI : 10.1021/jm901390p.

Ppargamma2 is a key driver of longevity in the mouse

C. Argmann; R. Dobrin; S. Heikkinen; A. Auburtin; L. Pouilly et al. 

PLoS Genetics. 2009. Vol. 5, num. 12, p. e1000752. DOI : 10.1371/journal.pgen.1000752.

TGR5-mediated bile acid sensing controls glucose homeostasis

C. Thomas; A. Gioiello; L. Noriega; A. Strehle; J. Oury et al. 

Cell Metabolism. 2009. Vol. 10, num. 3, p. 167-177. DOI : 10.1016/j.cmet.2009.08.001.

Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics

H. Koutnikova; M. Laakso; L. Lu; R. Combe; J. Paananen et al. 

PLoS Genetics. 2009. Vol. 5, num. 8, p. e1000591. DOI : 10.1371/journal.pgen.1000591.

mTOR complex 2 in adipose tissue negatively controls whole- body growth

N. Cybulski; P. Polak; J. Auwerx; M. A. Rüegg; M. N. Hall 

Proceedings of the National Academy of Sciences of the United States of America. 2009. Vol. 106, num. 24, p. 9902-9907. DOI : 10.1073/pnas.0811321106.

Serum Bile Acids Are Higher in Humans With Prior Gastric Bypass: Potential Contribution to Improved Glucose and Lipid Metabolism

M-E. Patti; S. M. Houten; A. C. Bianco; R. Bernier; P. R. Larsen et al. 

Obesity. 2009. Vol. 17, num. 9, p. 1671-1677. DOI : 10.1038/oby.2009.102.

The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface

S. Heikkinen; C. Argmann; J. N. Feige; H. Koutnikova; M-F. Champy et al. 

Cell metabolism. 2009. Vol. 9, num. 1, p. 88-98. DOI : 10.1016/j.cmet.2008.11.007.

AMPK regulates energy expenditure by modulating NAD(+) metabolism and SIRT1 activity

C. Cantó; Z. Gerhart-Hines; J. N. Feige; M. Lagouge; L. Noriega et al. 

Nature. 2009. Vol. 458, num. 7241, p. 1056-1060. DOI : 10.1038/nature07813.

Conference Papers

Lack of PPAR-alpha aggravates skin contact hypersensitivity by triggering regulatory T cells

S. Dubrac; A. Elentner; K. Schoonjans; J. Auwerx; M. Schmuth 

2009. 39th Annual European-Society-for-Dermatological-Research, Budapest, HUNGARY, Sep 10, 2009. p. S9-S9.


The role of sirtuins in the control of metabolic homeostasis

J. Yu; J. Auwerx 

Annals of the New York Academy of Sciences. 2009. Vol. 1173, num. Suppl 1, p. E10-19.

Caloric restriction, SIRT1 and longevity

C. Cantó; J. Auwerx 

Trends in Endocrinology & Metabolism. 2009. Vol. 20, num. 7, p. 325-331. DOI : 10.1016/j.tem.2009.03.008.

PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

C. Cantó; J. Auwerx 

Current opinion in lipidology. 2009. Vol. 20, num. 2, p. 98-105. DOI : 10.1097/MOL.0b013e328328d0a4.


Journal Articles

LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling

J. Terrand; V. Bruban; L. Zhou; W. Gong; Z. El Asmar et al. 

The Journal of biological chemistry. 2008. Vol. 284, num. 1, p. 381-8. DOI : 10.1074/jbc.M806538200.

Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies

H. Sato; A. Macchiarulo; C. Thomas; A. Gioiello; M. Une et al. 

Journal of medicinal chemistry. 2008. Vol. 51, num. 6, p. 1831-41. DOI : 10.1021/jm7015864.

Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration

P. Polak; N. Cybulski; J. N. Feige; J. Auwerx; M. A. Rüegg et al. 

Cell metabolism. 2008. Vol. 8, num. 5, p. 399-410. DOI : 10.1016/j.cmet.2008.09.003.

Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study

S. Mandillo; V. Tucci; S. M. Hölter; H. Meziane; M. A. Banchaabouchi et al. 

Physiological genomics. 2008. Vol. 34, num. 3, p. 243-55. DOI : 10.1152/physiolgenomics.90207.2008.

Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5

A. Macchiarulo; A. Gioiello; C. Thomas; A. Massarotti; R. Nuti et al. 

Journal of chemical information and modeling. 2008. Vol. 48, num. 9, p. 1792-801. DOI : 10.1021/ci800196h.

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

J. N. Feige; M. Lagouge; C. Canto; A. Strehle; S. M. Houten et al. 

Cell metabolism. 2008. Vol. 8, num. 5, p. 347-58. DOI : 10.1016/j.cmet.2008.08.017.

Liver receptor homolog 1 is essential for ovulation

R. Duggavathi; D. H. Volle; C. Mataki; M. C. Antal; N. Messaddeq et al. 

Genes & development. 2008. Vol. 22, num. 14, p. 1871-6. DOI : 10.1101/gad.472008.

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}

A. Coste; J-F. Louet; M. Lagouge; C. Lerin; M. C. Antal et al. 

Proceedings of the National Academy of Sciences of the United States of America. 2008. Vol. 105, num. 44, p. 17187-92. DOI : 10.1073/pnas.0808207105.

IL-13 attenuates gastrointestinal candidiasis in normal and immunodeficient RAG-2(-/-) mice via peroxisome proliferator-activated receptor-gamma activation

A. Coste; C. Lagane; C. Filipe; H. Authier; A. Galès et al. 

Journal of immunology (Baltimore, Md. : 1950). 2008. Vol. 180, num. 7, p. 4939-47.

Genetic background determines metabolic phenotypes in the mouse

M-F. Champy; M. Selloum; V. Zeitler; C. Caradec; B. Jung et al. 

Mammalian genome : official journal of the International Mammalian Genome Society. 2008. Vol. 19, num. 5, p. 318-31. DOI : 10.1007/s00335-008-9107-z.


Targeting bile-acid signalling for metabolic diseases

C. Thomas; R. Pellicciari; M. Pruzanski; J. Auwerx; K. Schoonjans 

Nature reviews. Drug discovery. 2008. Vol. 7, num. 8, p. 678-93. DOI : 10.1038/nrd2619.

Transcriptional targets of sirtuins in the coordination of mammalian physiology

J. N. Feige; J. Auwerx 

Current opinion in cell biology. 2008. Vol. 20, num. 3, p. 303-9. DOI : 10.1016/

Glucose restriction: longevity SIRTainly, but without building muscle?

C. Cantó; J. Auwerx 

Developmental cell. 2008. Vol. 14, num. 5, p. 642-4. DOI : 10.1016/j.devcel.2008.04.012.

Book Chapters

Dietary manipulation of mouse metabolism

J. Feige; M. Lagouge; J. Auwerx 

Current Protocols in Molecular Biology; Wiley, 2008. p. 29B.5.


Methods for increasing cellular energy expenditure

A. Bianco; J. Auwerx; M. Christoffolete; S. Houten; B. Kim et al. 



Sirtuin polymorphisms and methods of use thereof

M. Laakso; T. Kuulasmaa; J. Auwerx; C. Westphal; P. Elliott et al. 

EP2094868; WO2008060400; US2008249103; WO2008060400.



Journal Articles

The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice

D. H. Volle; R. Duggavathi; B. C. Magnier; S. M. Houten; C. L. Cummins et al. 

Genes & development. 2007. Vol. 21, num. 3, p. 303-15. DOI : 10.1101/gad.409307.

Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea

H. Sato; C. Genet; A. Strehle; C. Thomas; A. Lobstein et al. 

Biochemical and biophysical research communications. 2007. Vol. 362, num. 4, p. 793-8. DOI : 10.1016/j.bbrc.2007.06.130.

Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5

R. Pellicciari; H. Sato; A. Gioiello; G. Costantino; A. Macchiarulo et al. 

Journal of medicinal chemistry. 2007. Vol. 50, num. 18, p. 4265-8. DOI : 10.1021/jm070633p.

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1

C. Mataki; B. C. Magnier; S. M. Houten; J-S. Annicotte; C. Argmann et al. 

Molecular and cellular biology. 2007. Vol. 27, num. 23, p. 8330-9. DOI : 10.1128/MCB.00852-07.

In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue

S. M. Houten; D. H. Volle; C. L. Cummins; D. J. Mangelsdorf; J. Auwerx 

Molecular endocrinology (Baltimore, Md.). 2007. Vol. 21, num. 6, p. 1312-23. DOI : 10.1210/me.2007-0113.

Systematic gene expression mapping clusters nuclear receptors according to their function in the brain

F. Gofflot; N. Chartoire; L. Vasseur; S. Heikkinen; D. Dembele et al. 

Cell. 2007. Vol. 131, num. 2, p. 405-18. DOI : 10.1016/j.cell.2007.09.012.

Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function

S. Dubrac; P. Stoitzner; D. Pirkebner; A. Elentner; K. Schoonjans et al. 

Journal of immunology (Baltimore, Md. : 1950). 2007. Vol. 178, num. 7, p. 4362-72. DOI : 10.4049/​jimmunol.178.7.4362.

Suppression of allergen-induced airway inflammation and immune response by the peroxisome proliferator-activated receptor-alpha agonist fenofibrate

C. Delayre-Orthez; J. Becker; J. Auwerx; N. Frossard; F. Pons 

European journal of pharmacology. 2007. Vol. 581, num. 1-2, p. 177-84. DOI : 10.1016/j.ejphar.2007.11.040.

Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure

N. Dali-Youcef; C. Mataki; A. Coste; N. Messaddeq; S. Giroud et al. 

Proceedings of the National Academy of Sciences of the United States of America. 2007. Vol. 104, num. 25, p. 10703-8. DOI : 10.1073/pnas.0611568104.

LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease

A. Coste; L. Dubuquoy; R. Barnouin; J-S. Annicotte; B. Magnier et al. 

Proceedings of the National Academy of Sciences of the United States of America. 2007. Vol. 104, num. 32, p. 13098-103. DOI : 10.1073/pnas.0702440104.

LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome

P. Boucher; W-P. Li; R. L. Matz; Y. Takayama; J. Auwerx et al. 

PLoS ONE. 2007. Vol. 2, num. 5, p. e448. DOI : 10.1371/journal.pone.0000448.

IL-13 induces expression of CD36 in human monocytes through PPARgamma activation

A. Berry; P. Balard; A. Coste; D. Olagnier; C. Lagane et al. 

European journal of immunology. 2007. Vol. 37, num. 6, p. 1642-52. DOI : 10.1002/eji.200636625.

Poly(ADP-ribose) polymerase-2 [corrected] controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid X receptor/peroxisome proliferator-activated receptor-gamma [corrected] heterodimer

P. Bai; S. M. Houten; A. Huber; V. Schreiber; M. Watanabe et al. 

The Journal of biological chemistry. 2007. Vol. 282, num. 52, p. 37738-46. DOI : 10.1074/jbc.M701021200.


SIRT1/PGC-1: A neuroprotective axis? [SIRT1/PGC-1: Un axe neuroprotecteur?]

S. Rasouri; M. Lagouge; J. Auwerx 

Medecine/Sciences. 2007. Vol. 23, num. 10, p. 840-844. DOI : 10.1051/medsci/20072310840.

Sirtuin functions in health and disease

H. Yamamoto; K. Schoonjans; J. Auwerx 

Molecular endocrinology (Baltimore, Md.). 2007. Vol. 21, num. 8, p. 1745-55. DOI : 10.1210/me.2007-0079.

PPARgamma in human and mouse physiology

S. Heikkinen; J. Auwerx; C. A. Argmann 

Biochimica et biophysica acta. 2007. Vol. 1771, num. 8, p. 999-1013. DOI : 10.1016/j.bbalip.2007.03.006.

DisSIRTing on LXR and cholesterol metabolism

J. N. Feige; J. Auwerx 

Cell metabolism. 2007. Vol. 6, num. 5, p. 343-5. DOI : 10.1016/j.cmet.2007.10.003.

Transcriptional coregulators in the control of energy homeostasis

J. N. Feige; J. Auwerx 

Trends in cell biology. 2007. Vol. 17, num. 6, p. 292-301. DOI : 10.1016/j.tcb.2007.04.001.

Sirtuins: the ‘magnificent seven’, function, metabolism and longevity

N. Dali-Youcef; M. Lagouge; S. Froelich; C. Koehl; K. Schoonjans et al. 

Annals of medicine. 2007. Vol. 39, num. 5, p. 335-45. DOI : 10.1080/07853890701408194.

Book Chapters

Tissue collection for systematic phenotyping in the mouse

C. Antal; M. Teletin; O. Wendling; M. Dgheem; J. Auwerx et al. 

Current Protocols in Molecular Biology; Wiley, 2007. p. 29A.4.

Histopathology in mouse metabolic investigations

M. Mark; M. Teletin; C. Antal; O. Wendling; J. Auwerx et al. 

Current Protocols in Molecular Biology; Wiley, 2007. p. 29B.4.

Evaluation of glucose homeostasis

S. Heikkinen; C. Argmann; M-A. Champy; J. Auwerx 

Current Protocols in Molecular Biology; Wiley, 2007. p. 29B.3.


Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders

M. Milburn; J. Milne; J. Auwerx; C. Argmann; M. Lagouge et al. 

US2015175645; EP2805719; JP2013082723; CN103055313; AU2006269459; AU2006204699; AU2006230478; JP2009500357; JP2008542296; JP2008538215; CN101257897; JP2008527002; EP1928440; WO2006127987; EP1898897; EP1877054; EP1863462; EP1850840; WO2007008548; WO2006076681; US2007149466; WO2006105440; WO2006105403; US2007014833; AU2006269459; CA2613141; WO2007008548; US2006292099; US2006276393; AU2006249816; CA2609549; WO2006127987; US2006229265; CA2610854; WO2006105440; AU2006230478; CA2603009; WO2006105403; AU2006204699; CA2595159; WO2006076681.



Journal Articles

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

M. Watanabe; S. M. Houten; C. Mataki; M. A. Christoffolete; B. W. Kim et al. 

Nature. 2006. Vol. 439, num. 7075, p. 484-9. DOI : 10.1038/nature04330.

Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62

A. Rodriguez; A. Durán; M. Selloum; M-F. Champy; F. J. Diez-Guerra et al. 

Cell metabolism. 2006. Vol. 3, num. 3, p. 211-22. DOI : 10.1016/j.cmet.2006.01.011.

Visceral obesity is associated with high levels of serum squalene

P. Peltola; J. Pihlajamäki; H. Koutnikova; E. Ruotsalainen; U. Salmenniemi et al. 

Obesity. 2006. Vol. 14, num. 7, p. 1155-63. DOI : 10.1038/oby.2006.132.

Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program

J-F. Louet; A. Coste; L. Amazit; M. Tannour-Louet; R-C. Wu et al. 

Proceedings of the National Academy of Sciences of the United States of America. 2006. Vol. 103, num. 47, p. 17868-73. DOI : 10.1073/pnas.0608711103.

Deletion of peroxisome proliferator-activated receptor-alpha induces an alteration of cardiac functions

C. Loichot; L. Jesel; A. Tesse; A. Tabernero; K. Schoonjans et al. 

American journal of physiology. Heart and circulatory physiology. 2006. Vol. 291, num. 1, p. H161-6. DOI : 10.1152/ajpheart.01065.2004.

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

M. Lagouge; C. Argmann; Z. Gerhart-Hines; H. Meziane; C. Lerin et al. 

Cell. 2006. Vol. 127, num. 6, p. 1109-22. DOI : 10.1016/j.cell.2006.11.013.

Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects

N. Grarup; M. K. Andersen; C. H. Andreasen; A. Albrechtsen; K. Borch-Johnsen et al. 

The Journal of clinical endocrinology and metabolism. 2006. Vol. 92, num. 1, p. 363-6. DOI : 10.1210/jc.2006-1958.

Absence of the steroid receptor coactivator-3 induces B-cell lymphoma

A. Coste; M. C. Antal; S. Chan; P. Kastner; M. Mark et al. 

The EMBO journal. 2006. Vol. 25, num. 11, p. 2453-64. DOI : 10.1038/sj.emboj.7601106.


International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors.

L. Michalik; J. Auwerx; J. P. Berger; V. K. Chatterjee; C. K. Glass et al. 

Pharmacological reviews. 2006. Vol. 58, num. 4, p. 726-41. DOI : 10.1124/pr.58.4.5.

Endocrine functions of bile acids

S. M. Houten; M. Watanabe; J. Auwerx 

The EMBO journal. 2006. Vol. 25, num. 7, p. 1419-25. DOI : 10.1038/sj.emboj.7601049.

Improving metabolism by increasing energy expenditure

J. Auwerx 

Nature medicine. 2006. Vol. 12, num. 1, p. 44-5; discussion 45. DOI : 10.1038/nm0106-44.

Insulin secretion: SIRT4 gets in on the act

C. Argmann; J. Auwerx 

Cell. 2006. Vol. 126, num. 5, p. 837-9. DOI : 10.1016/j.cell.2006.08.031.

Book Chapters

Collection of blood and plasma from the mouse

C. Argmann; J. Auwerx 

Current Protocols in Molecular Biology; Wiley, 2006. p. 29A.3.

Minimizing variation due to genotype and environment

C. Argmann; J. Auwerx 

Current Protocols in Molecular Biology; Wiley, 2006. p. 29A.2.

Uses of forward and reverse genetics in mice to study gene function

C. Argmann; A. Dierich; J. Auwerx 

Current Protocols in Molecular Biology; Wiley, 2006. p. 29A.1.

Evaluation of energy homeostasis

C. Argmann; M-A. Champy; J. Auwerx 

Current Protocols in Molecular Biology; Wiley, 2006. p. 29B.1.

Lipid and bile acid analysis

C. Argmann; S. Houten; M-F. Champy; J. Auwerx 

Current Protocols in Molecular Biology; Wiley, 2006. p. 29B.2.

Exploration of metabolic and endocrine function in the mouse

M. Champy; C. Argmann; P. Chambon; J. Auwerx 

Standards of mouse model phenotyping; Weinheim: Wiley, 2006. p. 109-134.


Preventive and/or therapeutic agents for diabetes

K. Suzuki; K. Sakai; S. Ishii; K. Sugimoto; J. Auwerx et al. 

US2010055066; EP1810689; JPWO2006041150; CN101039697; EP1810689; WO2006041150.



Journal Articles

Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation

K. Schoonjans; L. Dubuquoy; J. Mebis; E. Fayard; O. Wendling et al. 

Proceedings of the National Academy of Sciences of the United States of America. 2005. Vol. 102, num. 6, p. 2058-62. DOI : 10.1073/pnas.0409756102.

Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma

C. Rousseaux; B. Lefebvre; L. Dubuquoy; P. Lefebvre; O. Romano et al. 

The Journal of experimental medicine. 2005. Vol. 201, num. 8, p. 1205-15. DOI : 10.1084/jem.20041948.

Study of a new PPARgamma2 promoter polymorphism and haplotype analysis in a French population

A. Meirhaeghe; M. W. T. Tanck; L. Fajas; C. Janot; N. Helbecque et al. 

Molecular genetics and metabolism. 2005. Vol. 85, num. 2, p. 140-8. DOI : 10.1016/j.ymgme.2005.02.004.

Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection

S. Dharancy; M. Malapel; G. Perlemuter; T. Roskams; Y. Cheng et al. 

Gastroenterology. 2005. Vol. 128, num. 2, p. 334-42. DOI : 10.1053/j.gastro.2004.11.016.

PPARalpha downregulates airway inflammation induced by lipopolysaccharide in the mouse

C. Delayre-Orthez; J. Becker; I. Guenon; V. Lagente; J. Auwerx et al. 

Respiratory research. 2005. Vol. 6, p. 91. DOI : 10.1186/1465-9921-6-91.

Scaffold attachment factor B1 directly interacts with nuclear receptors in living cells and represses transcriptional activity

Debril; L. Dubuquoy; Feige; W. Wahli; B. Desvergne et al. 

Journal of molecular endocrinology. 2005. Vol. 35, num. 3, p. 503-17. DOI : 10.1677/jme.1.01856.

The optomotor response: a robust first-line visual screening method for mice

J. Abdeljalil; M. Hamid; O. Abdel-Mouttalib; R. Stéphane; R. Raymond et al. 

Vision research. 2005. Vol. 45, num. 11, p. 1439-46. DOI : 10.1016/j.visres.2004.12.015.


Peroxisome proliferator-activated receptor gamma: the more the merrier?

C. A. Argmann; Cock; J. Auwerx 

European journal of clinical investigation. 2005. Vol. 35, num. 2, p. 82-92; discussion 80. DOI : 10.1111/j.1365-2362.2005.01456.x.

Mouse phenogenomics: the fast track to “systems metabolism”

C. A. Argmann; P. Chambon; J. Auwerx 

Cell metabolism. 2005. Vol. 2, num. 6, p. 349-60. DOI : 10.1016/j.cmet.2005.11.002.


Inhibition of S6 Kinase activity for the treatment of insulin resistance

J. Auwerx; F. Frigerio; S. Fumagalli; S. Kozma; F. Picard et al. 

ES2331006; DE602004022423; AT438859; EP1658504; US2007191259; JP2007503203; EP1658504; WO2005019829.



Journal Articles

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

M. Watanabe; S. M. Houten; L. Wang; A. Moschetta; D. J. Mangelsdorf et al. 

The Journal of clinical investigation. 2004. Vol. 113, num. 10, p. 1408-18. DOI : 10.1172/JCI21025.

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

S. H. Um; F. Frigerio; M. Watanabe; F. Picard; M. Joaquin et al. 

Nature. 2004. Vol. 431, num. 7005, p. 200-5. DOI : 10.1038/nature02866.

Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes

M. Schmuth; C. M. Haqq; W. J. Cairns; J. C. Holder; S. Dorsam et al. 

The Journal of investigative dermatology. 2004. Vol. 122, num. 4, p. 971-83. DOI : 10.1111/j.0022-202X.2004.22412.x.

Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells

B. Mascrez; N. B. Ghyselinck; M. Watanabe; J-S. Annicotte; P. Chambon et al. 

EMBO reports. 2004. Vol. 5, num. 3, p. 285-90. DOI : 10.1038/sj.embor.7400094.

Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/-) mice

L. Fajas; J-S. Annicotte; S. Miard; D. Sarruf; M. Watanabe et al. 

The Journal of clinical investigation. 2004. Vol. 113, num. 9, p. 1288-95. DOI : 10.1172/JCI18555.

Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit

M-B. Debril; L. Gelman; E. Fayard; J-S. Annicotte; S. Rocchi et al. 

The Journal of biological chemistry. 2004. Vol. 279, num. 16, p. 16677-86. DOI : 10.1074/jbc.M312288200.

Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma

K. T. Dalen; K. Schoonjans; S. M. Ulven; M. S. Weedon-Fekjaer; T. G. Bentzen et al. 

Diabetes. 2004. Vol. 53, num. 5, p. 1243-52. DOI : 10.2337/diabetes.53.5.1243.

Enhanced bone formation in lipodystrophic PPARgamma(hyp/hyp) mice relocates haematopoiesis to the spleen

T-A. Cock; J. Back; F. Elefteriou; G. Karsenty; P. Kastner et al. 

EMBO reports. 2004. Vol. 5, num. 10, p. 1007-12. DOI : 10.1038/sj.embor.7400254.

Mouse functional genomics requires standardization of mouse handling and housing conditions

M-F. Champy; M. Selloum; L. Piard; V. Zeitler; C. Caradec et al. 

Mammalian genome : official journal of the International Mammalian Genome Society. 2004. Vol. 15, num. 10, p. 768-83. DOI : 10.1007/s00335-004-2393-1.

Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation

O. A. Botrugno; E. Fayard; J-S. Annicotte; C. Haby; T. Brennan et al. 

Molecular cell. 2004. Vol. 15, num. 4, p. 499-509. DOI : 10.1016/j.molcel.2004.07.009.

The European dimension for the mouse genome mutagenesis program

J. Auwerx; P. Avner; R. Baldock; A. Ballabio; R. Balling et al. 

Nature genetics. 2004. Vol. 36, num. 9, p. 925-7. DOI : 10.1038/ng0904-925.

Expression of the liver X receptor alpha and beta in embryonic and adult mice

J-S. Annicotte; K. Schoonjans; J. Auwerx 

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. 2004. Vol. 277, num. 2, p. 312-6. DOI : 10.1002/ar.a.20015.

Conference Papers

PPAR-gamma’s fundamental role in adipogenesis

T-A. Cock; J. Auwerx 

2004. 13th International Atherosclerosis Symposium, Kyoto, September 28 – October 2, 2003.


Adipose tissue: New therapeutic targets from molecular and genetic studies – IASO Stock Conference 2003 report

S. Farmer; J. Auwerx 

Obesity Reviews. 2004. Vol. 5, num. 4, p. 189-196. DOI : 10.1111/j.1467-789X.2004.00157.x.

Cholesterol metabolism modulators and the future of atherosclerosis therapy [Modulateurs du métabolisme du cholestérol et avenir du traitement de l’athérosclérose]

S. Morozova; I. Suc-Royer; J. Auwerx 

Médecine sciences : M/S. 2004. Vol. 20, num. 6-7, p. 685-690. DOI : 10.1051/medsci/2004206-7685.

Peroxisome proliferator-activated receptor-gamma calls for activation in moderation: lessons from genetics and pharmacology

C. Knouff; J. Auwerx 

Endocrine reviews. 2004. Vol. 25, num. 6, p. 899-918. DOI : 10.1210/er.2003-0036.

PGC-1alpha: turbocharging mitochondria

S. M. Houten; J. Auwerx 

Cell. 2004. Vol. 119, num. 1, p. 5-7. DOI : 10.1016/j.cell.2004.09.016.

The enterohepatic nuclear receptors are major regulators of the enterohepatic circulation of bile salts

S. M. Houten; J. Auwerx 

Annals of medicine. 2004. Vol. 36, num. 7, p. 482-91. DOI : 10.1080/07853890410018790.

LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis

E. Fayard; J. Auwerx; K. Schoonjans 

Trends in cell biology. 2004. Vol. 14, num. 5, p. 250-60. DOI : 10.1016/j.tcb.2004.03.008.

Peroxisome proliferator-activated receptor-gamma: too much of a good thing causes harm

T-A. Cock; S. M. Houten; J. Auwerx 

EMBO reports. 2004. Vol. 5, num. 2, p. 142-7. DOI : 10.1038/sj.embor.7400082.

Book Chapters

Peroxisome proliferator-activated receptor gamma and the transcriptional control of adipogenesis and metabolism

L. Fajas; J. Auwerx 

Handbook of obesity: etiology and pathophysiology; New York: Marcel Dekker, 2004. p. 559-587.


Journal Articles

Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation

G. Woerly; K. Honda; M. Loyens; J-P. Papin; J. Auwerx et al. 

The Journal of experimental medicine. 2003. Vol. 198, num. 3, p. 411-21. DOI : 10.1084/jem.20021384.

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome

T. Tanaka; J. Yamamoto; S. Iwasaki; H. Asaba; H. Hamura et al. 

Proceedings of the National Academy of Sciences of the United States of America. 2003. Vol. 100, num. 26, p. 15924-9. DOI : 10.1073/pnas.0306981100.

SRC-1 and TIF2 control energy balance between white and brown adipose tissues

F. Picard; M. Géhin; J-S. Annicotte; S. Rocchi; M-F. Champy et al. 

Cell. 2003. Vol. 111, num. 7, p. 931-41. DOI : 10.1016/S0092-8674(02)01169-8.

A functional polymorphism in a STAT5B site of the human PPAR gamma 3 gene promoter affects height and lipid metabolism in a French population

A. Meirhaeghe; L. Fajas; F. Gouilleux; D. Cottel; N. Helbecque et al. 

Arteriosclerosis, thrombosis, and vascular biology. 2003. Vol. 23, num. 2, p. 289-94. DOI : 10.1161/01.ATV.0000051382.28752.FE.

Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice

H. Koutnikova; T-A. Cock; M. Watanabe; S. M. Houten; M-F. Champy et al. 

Proceedings of the National Academy of Sciences of the United States of America. 2003. Vol. 100, num. 24, p. 14457-62. DOI : 10.1073/pnas.2336090100.

Liver receptor homolog 1 controls the expression of carboxyl ester lipase

E. Fayard; K. Schoonjans; J-S. Annicotte; J. Auwerx 

The Journal of biological chemistry. 2003. Vol. 278, num. 37, p. 35725-31. DOI : 10.1074/jbc.M302370200.

Selective cyclo-oxygenase-2 inhibitors impair adipocyte differentiation through inhibition of the clonal expansion phase

L. Fajas; S. Miard; M. R. Briggs; J. Auwerx 

Journal of lipid research. 2003. Vol. 44, num. 9, p. 1652-9. DOI : 10.1194/jlr.M300248-JLR200.

PPARgamma controls cell proliferation and apoptosis in an RB-dependent manner

L. Fajas; V. Egler; R. Reiter; S. Miard; A-M. Lefebvre et al. 

Oncogene. 2003. Vol. 22, num. 27, p. 4186-93. DOI : 10.1038/sj.onc.1206530.

Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis

L. Dubuquoy; E. A. Jansson; S. Deeb; S. Rakotobe; M. Karoui et al. 

Gastroenterology. 2003. Vol. 124, num. 5, p. 1265-76. DOI : 10.1016/S0016-5085(03)00271-3.

Induction of plasminogen activator inhibitor I by the PPARalpha ligand, Wy-14,643, is dependent on ERK1/2 signaling pathway

C. Banfi; J. Auwerx; F. Poma; E. Tremoli; L. Mussoni 

Thrombosis and haemostasis. 2003. Vol. 90, num. 4, p. 611-9. DOI : 10.1267/THRO03040611.

Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development

J-S. Annicotte; E. Fayard; G. H. Swift; L. Selander; H. Edlund et al. 

Molecular and cellular biology. 2003. Vol. 23, num. 19, p. 6713-24. DOI : 10.1128/MCB.23.19.6713-6724.2003.


Nuclear receptors and the control of metabolism

G. A. Francis; E. Fayard; F. Picard; J. Auwerx 

Annual review of physiology. 2003. Vol. 65, p. 261-311. DOI : 10.1146/annurev.physiol.65.092101.142528.

PPAR-alpha effects on the heart and other vascular tissues

G. A. Francis; J-S. Annicotte; J. Auwerx 

American journal of physiology. Heart and circulatory physiology. 2003. Vol. 285, num. 1, p. H1-9. DOI : 10.1152/ajpheart.01118.2002.

PPAR agonists in the treatment of atherosclerosis

G. A. Francis; J-S. Annicotte; J. Auwerx 

Current opinion in pharmacology. 2003. Vol. 3, num. 2, p. 186-91. DOI : 10.1016/S1471-4892(03)00014-6.

Leptin: cutting the fat off the bone

T-A. Cock; J. Auwerx 

Lancet. 2003. Vol. 362, num. 9395, p. 1572-4. DOI : 10.1016/S0140-6736(03)14747-2.

Récepteurs à la Provençale. EMBO workshop on the biology of nuclear receptors.

J. Auwerx; J. Drouin; V. Laudet 

EMBO reports. 2003. Vol. 4, num. 12, p. 1122-6. DOI : 10.1038/sj.embor.7400031.

Book Chapters

Serial analysis of gene expression and gene trapping to identify nuclear receptor target genes

H. Koutnikova; E. Fayard; J. Lehmann; J. Auwerx 

Nuclear receptors; San Diego: Elsevier, 2003. p. 297-322.


Cofactor-based screening method for nuclear receptor modulators and related modulators

J. Auwerx; P. Chambon; F. Picard 

US2003104975; JP2003125773; AU4755502; EP1267171; CA2390686.



Journal Articles

C3, hormone-sensitive lipase, and peroxisome proliferator-activated receptor gamma expression in adipose tissue of familial combined hyperlipidemia patients

K. Ylitalo; I. Nuotio; J. Viikari; J. Auwerx; H. Vidal et al. 

Metabolism: clinical and experimental. 2002. Vol. 51, num. 5, p. 664-70. DOI : 10.1053/meta.2002.32032.

The generation of monoclonal antibodies against human peroxisome proliferator-activated receptors (PPARs)

T. Tanaka; T. Takeno; Y. Watanabe; Y. Uchiyama; T. Murakami et al. 

Journal of atherosclerosis and thrombosis. 2002. Vol. 9, num. 5, p. 233-42.

Activation of the peroxisome proliferator-activated receptor alpha protects against myocardial ischaemic injury and improves endothelial vasodilatation

A. Tabernero; K. Schoonjans; L. Jesel; I. Carpusca; J. Auwerx et al. 

BMC pharmacology. 2002. Vol. 2, p. 1-10. DOI : 10.1186/1471-2210-2-10.

Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models

M. Y. Sheu; A. J. Fowler; J. Kao; M. Schmuth; K. Schoonjans et al. 

The Journal of investigative dermatology. 2002. Vol. 118, num. 1, p. 94-101. DOI : 10.1046/j.0022-202x.2001.01626.x.

Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I

K. Schoonjans; J-S. Annicotte; T. Huby; O. A. Botrugno; E. Fayard et al. 

EMBO reports. 2002. Vol. 3, num. 12, p. 1181-7. DOI : 10.1093/embo-reports/kvf238.

Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero

M. Schmuth; K. Schoonjans; Q-C. Yu; J. W. Fluhr; D. Crumrine et al. 

The Journal of investigative dermatology. 2002. Vol. 119, num. 6, p. 1298-303. DOI : 10.1046/j.1523-1747.2002.19605.x.

Progesterone receptor knockout mice have an improved glucose homeostasis secondary to beta-cell proliferation

F. Picard; M. Wanatabe; K. Schoonjans; J. Lydon; B. W. O’Malley et al. 

Proceedings of the National Academy of Sciences of the United States of America. 2002. Vol. 99, num. 24, p. 15644-8. DOI : 10.1073/pnas.202612199.

E2Fs regulate adipocyte differentiation

L. Fajas; R. L. Landsberg; Y. Huss-Garcia; C. Sardet; J. A. Lees et al. 

Developmental cell. 2002. Vol. 3, num. 1, p. 39-49. DOI : 10.1016/S1534-5807(02)00190-9.

The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation

L. Fajas; V. Egler; R. Reiter; J. Hansen; K. Kristiansen et al. 

Developmental cell. 2002. Vol. 3, num. 6, p. 903-10. DOI : 10.1016/S1534-5807(02)00360-X.

Oxidized phospholipids inhibit cyclooxygenase-2 in human macrophages via nuclear factor-kappaB/IkappaB- and ERK2-dependent mechanisms

S. Eligini; M. Brambilla; C. Banfi; M. Camera; L. Sironi et al. 

Cardiovascular research. 2002. Vol. 55, num. 2, p. 406-15. DOI : 10.1016/S0008-6363(02)00437-6.

The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity

C. Brendel; K. Schoonjans; O. A. Botrugno; E. Treuter; J. Auwerx 

Molecular endocrinology (Baltimore, Md.). 2002. Vol. 16, num. 9, p. 2065-76. DOI : 10.1210/me.2001-0194.

Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism

C. Brendel; L. Gelman; J. Auwerx 

Molecular endocrinology (Baltimore, Md.). 2002. Vol. 16, num. 6, p. 1367-77. DOI : 10.1210/me.16.6.1367.


A sharper image of SHP

K. Schoonjans; J. Auwerx 

Nature medicine. 2002. Vol. 8, num. 8, p. 789-91. DOI : 10.1038/nm0802-789.

PPAR(gamma) and glucose homeostasis

F. Picard; J. Auwerx 

Annual review of nutrition. 2002. Vol. 22, p. 167-97. DOI : 10.1146/annurev.nutr.22.010402.102808.

Liver X receptors: Xcreting Xol to combat atherosclerosis

G. A. Francis; J-S. Annicotte; J. Auwerx 

Trends in molecular medicine. 2002. Vol. 8, num. 10, p. 455-8. DOI : 10.1016/S1471-4914(02)02400-0.

The role of PPAR-gamma/RXR-alpha heterodimers in the regulation of human trophoblast invasion

T. Fournier; L. Pavan; A. Tarrade; K. Schoonjans; J. Auwerx et al. 

Annals of the New York Academy of Sciences. 2002. Vol. 973, p. 26-30. DOI : 10.1111/j.1749-6632.2002.tb04601.x.

Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases

L. Dubuquoy; S. Dharancy; S. Nutten; S. Pettersson; J. Auwerx et al. 

Lancet. 2002. Vol. 360, num. 9343, p. 1410-8. DOI : 10.1016/S0140-6736(02)11395-X.

Nuclear receptors. I. PPAR gamma in the gastrointestinal tract: gain or pain?

J. Auwerx 

American journal of physiology. Gastrointestinal and liver physiology. 2002. Vol. 282, num. 4, p. G581-5. DOI : 10.1152/ajpgi.00508.2001.


Novel constructs and vectors for the targeted and inducible expression of genes

A. Mohfoudi; P. Benoit; D. Branellec; P. Denefle; N. Duverger et al. 

HU9904235; US2002144302; JP2001503279; KR20000053163; BR9713981; HU9904235; SK61499; EP0946740; CZ163399; NO992153; NO992153; FR2755699; ZA9710114; AU5057898; CA2269864; WO9821349; FR2755699.



Journal Articles

PPARgamma/RXRalpha heterodimers control human trophoblast invasion

A. Tarrade; K. Schoonjans; L. Pavan; J. Auwerx; C. Rochette-Egly et al. 

The Journal of clinical endocrinology and metabolism. 2001. Vol. 86, num. 10, p. 5017-24. DOI : 10.1210/jc.86.10.5017.

PPAR gamma/RXR alpha heterodimers are involved in human CG beta synthesis and human trophoblast differentiation

A. Tarrade; K. Schoonjans; J. Guibourdenche; J. M. Bidart; M. Vidaud et al. 

Endocrinology. 2001. Vol. 142, num. 10, p. 4504-14. DOI : 10.1210/en.142.10.4504.

A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity

S. Rocchi; F. Picard; J. Vamecq; L. Gelman; N. Potier et al. 

Molecular cell. 2001. Vol. 8, num. 4, p. 737-47. DOI : 10.1016/S1097-2765(01)00353-7.

The expression of the p85alpha subunit of phosphatidylinositol 3-kinase is induced by activation of the peroxisome proliferator-activated receptor gamma in human adipocytes

J. Rieusset; C. Chambrier; K. Bouzakri; E. Dusserre; J. Auwerx et al. 

Diabetologia. 2001. Vol. 44, num. 5, p. 544-54. DOI : 10.1007/s001250051660.

Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha

K. Hanley; L. G. Kömüves; D. C. Ng; K. Schoonjans; S. S. He et al. 

The Journal of biological chemistry. 2001. Vol. 275, num. 15, p. 11484-91. DOI : 10.1074/jbc.275.15.11484.

Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer: A basis for new therapeutic strategies

P. Desreumaux; L. Dubuquoy; S. Nutten; M. Peuchmaur; W. Englaro et al. 

The Journal of experimental medicine. 2001. Vol. 193, num. 7, p. 827-38. DOI : 10.1084/jem.193.7.827.

Metabolic effects of rexinoids: tissue-specific regulation of lipoprotein lipase activity

P. J. Davies; S. A. Berry; G. L. Shipley; R. H. Eckel; N. Hennuyer et al. 

Molecular pharmacology. 2001. Vol. 59, num. 2, p. 170-6.

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor

T. Claudel; M. D. Leibowitz; C. Fiévet; A. Tailleux; B. Wagner et al. 

Proceedings of the National Academy of Sciences of the United States of America. 2001. Vol. 98, num. 5, p. 2610-5. DOI : 10.1073/pnas.041609298.

Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines

T. E. Akiyama; C. J. Nicol; C. Fievet; B. Staels; J. M. Ward et al. 

The Journal of biological chemistry. 2001. Vol. 276, num. 42, p. 39088-93. DOI : 10.1074/jbc.M107073200.


The role of PPARs in inflammation and cancer [Rôle des PPARs dans l’inflammation et le cancer]

C. Brendel; L. Gelman; J. Auwerx; S. Rocchi 

Medecine Therapeutique Endocrinologie. 2001. Vol. 3, num. Spec. Iss., p. 19-25.

Peroxisome proliferator-activated receptor gamma, the ultimate liaison between fat and transcription

S. Rocchi; J. Auwerx 

The British journal of nutrition. 2001. Vol. 84, num. Suppl 2, p. S223-S227. DOI : 10.1079/09658219738858.

Regulation of adipocyte differentiation

H. Koutnikova; J. Auwerx 

Annals of medicine. 2001. Vol. 33, num. 8, p. 556-61. DOI : 10.3109/07853890108995966.

Xol INXS: role of the liver X and the farnesol X receptors

E. Fayard; K. Schoonjans; J. Auwerx 

Current opinion in lipidology. 2001. Vol. 12, num. 2, p. 113-20. DOI : 10.1097/00041433-200104000-00004.

PPAR gamma: an essential role in metabolic control

L. Fajas; M. B. Debril; J. Auwerx 

Nutrition, metabolism, and cardiovascular diseases : NMCD. 2001. Vol. 11, num. 1, p. 64-9.

Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis

L. Fajas; M. B. Debril; J. Auwerx 

Journal of molecular endocrinology. 2001. Vol. 27, num. 1, p. 1-9. DOI : 10.1677/jme.0.0270001.

The pleiotropic functions of peroxisome proliferator-activated receptor gamma

M. B. Debril; J. P. Renaud; L. Fajas; J. Auwerx 

Journal of molecular medicine (Berlin, Germany). 2001. Vol. 79, num. 1, p. 30-47. DOI : 10.1007/s001090000145.


Journal Articles

Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha

K. A. Tobin; H. H. Steineger; S. Alberti; O. Spydevold; J. Auwerx et al. 

Molecular endocrinology (Baltimore, Md.). 2000. Vol. 14, num. 5, p. 741-52. DOI : 10.1210/me.14.5.741.

Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes

K. Schoonjans; L. Gelman; C. Haby; M. Briggs; J. Auwerx 

Journal of molecular biology. 2000. Vol. 304, num. 3, p. 323-34. DOI : 10.1006/jmbi.2000.4218.

The Pro12A1a substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia

J. Pihlajamäki; R. Miettinen; R. Valve; L. Karjalainen; L. Mykkänen et al. 

Atherosclerosis. 2000. Vol. 151, num. 2, p. 567-74. DOI : 10.1016/S0021-9150(99)00433-5.

Intronic polymorphism in the fatty acid transport protein 1 gene is associated with increased plasma triglyceride levels in a French population

A. Meirhaeghe; G. Martin; M. Nemoto; S. Deeb; D. Cottel et al. 

Arteriosclerosis, thrombosis, and vascular biology. 2000. Vol. 20, num. 5, p. 1330-1334. DOI : 10.1161/01.ATV.20.5.1330.

Impact of the Peroxisome Proliferator Activated Receptor gamma2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus

A. Meirhaeghe; L. Fajas; N. Helbecque; D. Cottel; J. Auwerx et al. 

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 2000. Vol. 24, num. 2, p. 195-9. DOI : 10.1038/sj.ijo.0801112.

Induction of the fatty acid transport protein 1 and acyl-CoA synthase genes by dimer-selective rexinoids suggests that the peroxisome proliferator-activated receptor-retinoid X receptor heterodimer is their molecular target

G. Martin; H. Poirier; N. Hennuyer; D. Crombie; J. C. Fruchart et al. 

The Journal of biological chemistry. 2000. Vol. 275, num. 17, p. 12612-8. DOI : 10.1074/jbc.275.17.12612.

The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression

G. Martin; M. Nemoto; L. Gelman; S. Geffroy; J. Najib et al. 

Genomics. 2000. Vol. 66, num. 3, p. 296-304. DOI : 10.1006/geno.2000.6191.

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

T. T. Lu; M. Makishima; J. J. Repa; K. Schoonjans; T. A. Kerr et al. 

Molecular cell. 2000. Vol. 6, num. 3, p. 507-15. DOI : 10.1016/S1097-2765(00)00050-2.

Activation of PPARdelta alters lipid metabolism in db/db mice

M. D. Leibowitz; C. Fiévet; N. Hennuyer; J. Peinado-Onsurbe; H. Duez et al. 

FEBS letters. 2000. Vol. 473, num. 3, p. 333-6. DOI : 10.1016/S0014-5793(00)01554-4.

Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo

L. G. Kömüves; K. Hanley; A. M. Lefebvre; M. Q. Man; D. C. Ng et al. 

The Journal of investigative dermatology. 2000. Vol. 115, num. 3, p. 353-60. DOI : 10.1046/j.1523-1747.2000.00073.x.

Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in normal human pancreatic islet cells

M. Dubois; F. Pattou; J. Kerr-Conte; V. Gmyr; B. Vandewalle et al. 

Diabetologia. 2000. Vol. 43, num. 9, p. 1165-9. DOI : 10.1007/s001250051508.

Fatty acid transport protein-1 mRNA expression in skeletal muscle and in adipose tissue in humans

C. Binnert; H. A. Koistinen; G. Martin; F. Andreelli; P. Ebeling et al. 

American journal of physiology. Endocrinology and metabolism. 2000. Vol. 279, num. 5, p. E1072-E1079. DOI : 10.1152/ajpendo.2000.279.5.E1072.

Conference Papers

Insulinerésistance, le PPAR-gamma: un maître contrôleur

C. Brendel; J. Auwerx 

2000. Congrès de nutrition et santé, Louvain, Belgique, p. 119-124.

X-ceptors, nuclear receptors for metabolism

J. Auwerx; D. Mangelsdorf 

2000. XIIth International Symposium on Atheros clerosis, Stockholm, Sweden, June 25-29, 2000. p. 21-39.


Sterols and gene expression: control of affluence

K. Schoonjans; C. Brendel; D. Mangelsdorf; J. Auwerx 

Biochimica et Biophysica Acta. 2000. Vol. 1529, p. 114-125. DOI : 10.1016/S1388-1981(00)00141-4.

Thiazolidinediones: an update

K. Schoonjans; J. Auwerx 

Lancet. 2000. Vol. 355, num. 9208, p. 1008-10. DOI : 10.1016/S0140-6736(00)90002-3.


Journal Articles

Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women

R. Valve; K. Sivenius; R. Miettinen; J. Pihlajamäki; A. Rissanen et al. 

The Journal of clinical endocrinology and metabolism. 1999. Vol. 84, num. 10, p. 3708-12. DOI : 10.1210/jc.84.10.3708.

3-Hydroxy-3-methylglutaryl CoA reductase inhibitors reduce serum triglyceride levels through modulation of apolipoprotein C-III and lipoprotein lipase

K. Schoonjans; J. Peinado-Onsurbe; J. C. Fruchart; A. Tailleux; C. Fiévet et al. 

FEBS letters. 1999. Vol. 452, num. 3, p. 160-4. DOI : 10.1016/S0014-5793(99)00632-8.

Differential regulation of peroxisome proliferator activated receptor gamma1 (PPARgamma1) and PPARgamma2 messenger RNA expression in the early stages of adipogenesis

R. Saladin; L. Fajas; S. Dana; Y. D. Halvorsen; J. Auwerx et al. 

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 1999. Vol. 10, num. 1, p. 43-8.

Regulation of gene expression by activation of the peroxisome proliferator-activated receptor gamma with rosiglitazone (BRL 49653) in human adipocytes

J. Rieusset; J. Auwerx; H. Vidal 

Biochemical and biophysical research communications. 1999. Vol. 265, num. 1, p. 265-71. DOI : 10.1006/bbrc.1999.1657.

Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-gamma in human adipocytes

J. Rieusset; F. Andreelli; D. Auboeuf; M. Roques; P. Vallier et al. 

Diabetes. 1999. Vol. 48, num. 4, p. 699-705. DOI : 10.2337/diabetes.48.4.699.

Peroxisome proliferator-activated receptor gamma is induced during differentiation of colon epithelium cells

M. Lefebvre; B. Paulweber; L. Fajas; J. Woods; C. McCrary et al. 

The Journal of endocrinology. 1999. Vol. 162, num. 3, p. 331-40. DOI : 10.1677/joe.0.1620331.

p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively

L. Gelman; G. Zhou; L. Fajas; E. Raspé; J. C. Fruchart et al. 

The Journal of biological chemistry. 1999. Vol. 274, num. 12, p. 7681-8. DOI : 10.1074/jbc.274.12.7681.

Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism

L. Fajas; K. Schoonjans; L. Gelman; J. B. Kim; J. Najib et al. 

Molecular and cellular biology. 1999. Vol. 19, num. 8, p. 5495-503. DOI : 10.1128/MCB.19.8.5495.

Homozygosity of the Pro12Ala variant of the peroxisome proliferation-activated receptor-gamma2 (PPAR-gamma2): divergent modulating effects on body mass index in obese and lean Caucasian men

J. Ek; S. A. Urhammer; T. I. Sørensen; T. Andersen; J. Auwerx et al. 

Diabetologia. 1999. Vol. 42, num. 7, p. 892-5. DOI : 10.1007/s001250051243.

Inflammatory alterations in mesenteric adipose tissue in Crohn’s disease

P. Desreumaux; O. Ernst; K. Geboes; L. Gambiez; D. Berrebi et al. 

Gastroenterology. 1999. Vol. 117, num. 1, p. 73-81. DOI : 10.1016/S0016-5085(99)70552-4.

Conference Papers

Peroxisome proliferator-activated receptor gamma, the ultimate liaison between fat and transcription

S. Rocchi; J. Auwerx; H. Imura; M. Kasuga; K. Nakao 

1999. Uehara Memorial Foundation Symposium on Common Disease, Tokyo, June 30-July 2, 1999. p. 169-179.

Altered fatty acid partitioning by PPAR activators improves glucose homeostasis: a case for PPAR-gamma and alpha-coagonists

J. Auwerx; G. Crepaldi; A. Tiengo; S. Del Prato 

1999. European Symposium on Metabolism, Padova, September 30-October 3, 1998. p. 167-172.


Transcriptional regulation of cholesterol metabolism [Regulation transcriptionnelle du metabolisme du cholesterol]

C. Brendel; J-C. Fruchart; J. Auwerx; K. Schoonjans 

Medecine/Sciences. 1999. Vol. 15, num. 1, p. 56-62.

Peroxisome proliferator-activated receptor-gamma: a versatile metabolic regulator

S. Rocchi; J. Auwerx 

Annals of medicine. 1999. Vol. 31, num. 5, p. 342-351. DOI : 10.3109/07853899908995901.

The mitochondrion is the principal target for nutritional and pharmacological control of plasma triglyceride

L. Madsen; L. Frøyland; H. Kryvi; J. Auwerx; B. Staels et al. 

Lipids. 1999. Vol. 34 Suppl, p. S167. DOI : 10.1007/BF02562277.

An update on the mechanisms of action of the peroxisome proliferator-activated receptors (PPARs) and their roles in inflammation and cancer

L. Gelman; J. C. Fruchart; J. Auwerx 

Cellular and molecular life sciences : CMLS. 1999. Vol. 55, num. 6-7, p. 932-43. DOI : 10.1007/s000180050345.

Peroxisome proliferator-activated receptors: mediators of a fast food impact on gene regulation

L. Gelman; J. Auwerx 

Current opinion in clinical nutrition and metabolic care. 1999. Vol. 2, num. 4, p. 307-12. DOI : 10.1097/00075197-199907000-00010.

Leptin, a pleiotropic hormone: physiology, pharmacology, and strategies for discovery of leptin modulators

J. Dallongeville; J. C. Fruchart; J. Auwerx 

Journal of medicinal chemistry. 1999. Vol. 41, num. 27, p. 5337-52. DOI : 10.1021/jm9802867.

PPARgamma, the ultimate thrifty gene

J. Auwerx 

Diabetologia. 1999. Vol. 42, num. 9, p. 1033-49. DOI : 10.1007/s001250051268.

Book Chapters

Les dyslipidémies

L. Gelman; C. Brendel; J. Fruchart; J. Auwerx 

Biologie moléculaire en biologie clinique; Amsterdam: Elsevier, 1999. p. 185-196.


Human peroxisome proliferator activated receptor gamma (ppar gamma ) gene regulatory sequences and uses therefor

M. Briggs; R. Saladin; J. Auwerx; L. Fajas 

US2006276426; US7098025; AU8588798; WO9905161.


Nucleotide sequence expressing human fatty acid transport protein and corresponding aminoacid sequence. Use for the regulation of fatty acids metabolism

G. Martin; M. Nemoto; S. Deeb; J. Auwerx 

WO9951740; AU3333399; WO9951740.



Journal Articles

Human peroxisome proliferator-activated receptor-gamma2: genetic mapping, identification of a variant in the coding sequence, and exclusion as the gene responsible for lipoatrophic diabetes

C. Vigouroux; L. Fajas; E. Khallouf; M. Meier; G. Gyapay et al. 

Diabetes. 1998. Vol. 47, num. 3, p. 490-2. DOI : 10.2337/diabetes.47.3.490.

Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein

M. Ricote; J. Huang; L. Fajas; A. Li; J. Welch et al. 

Proceedings of the National Academy of Sciences of the United States of America. 1998. Vol. 95, num. 13, p. 7614-9. DOI : 10.1073/pnas.95.13.7614.

A genetic polymorphism of the peroxisome proliferator-activated receptor gamma gene influences plasma leptin levels in obese humans

A. Meirhaeghe; L. Fajas; N. Helbecque; D. Cottel; P. Lebel et al. 

Human molecular genetics. 1998. Vol. 7, num. 3, p. 435-40. DOI : 10.1093/hmg/7.3.435.

Overexpression of placental leptin in diabetic pregnancy: a critical role for insulin

J. Lepercq; M. Cauzac; N. Lahlou; J. Timsit; J. Girard et al. 

Diabetes. 1998. Vol. 47, num. 5, p. 847-50. DOI : 10.2337/diabetes.47.5.847.

Depot-specific differences in adipose tissue gene expression in lean and obese subjects

A. M. Lefebvre; M. Laville; N. Vega; J. P. Riou; L. van Gaal et al. 

Diabetes. 1998. Vol. 47, num. 1, p. 98-103.

Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

A. M. Lefebvre; I. Chen; P. Desreumaux; J. Najib; J. C. Fruchart et al. 

Nature medicine. 1998. Vol. 4, num. 9, p. 1053-7. DOI : 10.1038/2036.

Cycle sequencing on large DNA templates

L. Fajas; B. Staels; J. Auwerx 

BioTechniques. 1998. Vol. 23, num. 6, p. 1034-1036. DOI : 10.2144/97236bm14.

PPARgamma3 mRNA: a distinct PPARgamma mRNA subtype transcribed from an independent promoter

L. Fajas; J. C. Fruchart; J. Auwerx 

FEBS letters. 1998. Vol. 438, num. 1-2, p. 55-60. DOI : 10.1016/S0014-5793(98)01273-3.

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

S. S. Deeb; L. Fajas; M. Nemoto; J. Pihlajamäki; L. Mykkänen et al. 

Nature genetics. 1998. Vol. 20, num. 3, p. 284-7. DOI : 10.1038/3099.

Glucocorticoids induce the expression of the leptin gene through a non-classical mechanism of transcriptional activation

P. De Vos; A. M. Lefebvre; I. Shrivo; J. C. Fruchart; J. Auwerx 

European journal of biochemistry / FEBS. 1998. Vol. 253, num. 3, p. 619-26. DOI : 10.1046/j.1432-1327.1998.2530619.x.

Short term response of circulating leptin to feeding and fasting in man: influence of circadian cycle

J. Dallongeville; B. Hecquet; P. Lebel; J. L. Edmé; C. Le Fur et al. 

International journal of obesity and related metabolic disorders. 1998. Vol. 22, num. 8, p. 728-33. DOI : 10.1038/sj.ijo.0800648.

The carboxy-terminal region of human lipoprotein lipase is necessary for its exit from the endoplasmic reticulum

R. Buscà; M. Martínez; E. Vilella; J. Peinado; J. L. Gelpi et al. 

Journal of lipid research. 1998. Vol. 39, num. 4, p. 821-833. DOI : 10.1016/S0022-2275(20)32569-4.

Conference Papers

Mechanisms of the hypolipidemic action of fibrates

J. Auwerx; J. Dallongeville; J. Fruchart; B. Staels; A. Gotto 

1998. 4th International Symposium on Multiple Risk Factors and Cardiovascular Disease. p. 9-15. DOI : 10.1007/978-94-011-5022-4_2.

PPAR activators improve glucose homeostasis by changing fatty acid partitioning

G. Martin; K. Schoonjans; B. Staels; J. Auwerx; B. Jacotot et al. 

1998. XIth International Symposium on Atherosclerosis, Paris, France, October 5-9, 1997. p. 35-47.

Molecular mechanisms of action of fenofibrate

B. Staels; J. Auwerx; J. Fruchart; B. Jacotot; D. Mathé et al. 

1998. XIth International Symposium on Atherosclerosis, Paris, France, October 5-9, 1997. p. 249-257.


Reduction of serum cholesterol by soy proteins: Clinical experience and potential molecular mechanisms

C. Sirtori; M. Lovati; C. Manzoni; E. Gianazza; A. Bondioli et al. 

Nutrition, Metabolism and Cardiovascular Diseases. 1998. Vol. 8, num. 5, p. 334-340.

Mechanism of action of fibrates on lipid and lipoprotein metabolism

B. Staels; J. Dallongeville; J. Auwerx; K. Schoonjans; E. Leitersdorf et al. 

Circulation. 1998. Vol. 98, num. 19, p. 2088-2093. DOI : 10.1161/01.CIR.98.19.2088.

PPARgamma activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes

G. Martin; K. Schoonjans; B. Staels; J. Auwerx 

Atherosclerosis. 1998. Vol. 137 Suppl, p. S75-80. DOI : 10.1016/S0021-9150(97)00315-8.

Transcriptional control of adipogenesis

L. Fajas; J. C. Fruchart; J. Auwerx 

Current opinion in cell biology. 1998. Vol. 10, num. 2, p. 165-73. DOI : 10.1016/S0955-0674(98)80138-5.