Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

T. Y. Li; Q. Wang; A. W. Gao; X. Li; Y. Sun et al. 

Cyclo(His-Pro): A further step in the management of steatohepatitis

A. De Masi; X. Li; D. Lee; J. Jeon; Q. Wang et al. 

Gene network based analysis identifies a coexpression module involved in regulating plasma lipids with high-fat diet response

F. Xu; J. Ziebarth; L. J. E. Goeminne; J. Gao; E. G. Williams et al. 

Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems

M. Girotra; Y-H. Chiang; M. Charmoy; P. Ginefra; H. C. Hope et al. 

Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

A. Park; K-e. Kim; I. Park; S. H. Lee; K-Y. Park et al. 

Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging

T. I. Lima; P-P. Laurila; M. Wohlwend; J. D. Morel; L. J. E. Goeminne et al. 

Upregulation of the ERR γ-VDAC1 axis underlies the molecular pathogenesis of pancreatitis

D. Chanda; T. Thoudam; I. S. Sinam; C. W. Lim; M. Kim et al. 

Mitochondria: A “pacemaker”for species-specific development

Y. J. Liu; J. Auwerx 

Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

E. Yildiz; G. El Alam; A. Perino; A. Jalil; P-D. Denechaud et al. 

Sodium ferrous citrate and 5-aminolevulinic acid improve type 2 diabetes by maintaining muscle and mitochondrial health

N. Kitamura; S. Zhang; J-D. Morel; U. Nagano; T. Taworntawat et al. 

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression

G. Benegiamo; G. V. G. von Alvensleben; S. Rodriguez-Lopez; L. J. E. Goeminne; A. M. Bachmann et al. 

Mitochondrial and NAD plus metabolism predict recovery from acute kidney injury in a diverse mouse population

J. -D. Morel; M. B. Sleiman; T. Y. Li; G. von Alvensleben; A. M. Bachmann et al. 

GPS2-mediated regulation of the adipocyte secretome modulates adipose tissue remodeling at the onset of diet-induced obesity

J. English; J. Orofino; C. T. Cederquist; I. Paul; H. Li et al. 

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

Characterization of Cyclo His-Pro for the prevention and treatment of liver disease and muscular dystrophy

A single-cell-based characterization of mammalian adipose stem and progenitor cell heterogeneity and function

Tetracycline derivative induced mitohormesis mediates disease tolerance against viral infections

J. Auwerx; A. J. L. Mottis; M. Nelson 

Machine learning-derived gut microbiome signature predicts fatty liver disease in the presence of insulin resistance

B. E. Kang; A. Park; H. Yang; Y. Jo; T. G. Oh et al. 

SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice

T. Yoshizawa; Y. Sato; S. U. Sobuz; T. Mizumoto; T. Tsuyama et al. 

Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia

P-P. Laurila; M. Wohlwend; T. I. de Lima; P. Luan; S. Herzig et al. 

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

T. Y. Li; A. W. Gao; X. Li; H. Li; Y. J. Liu et al. 

COX7A2L genetic variants determine cardiorespiratory fitness in mice and human

G. Benegiamo; M. B. Sleiman; M. Wohlwend; S. Rodriguez-Lopez; L. J. E. Goeminne et al. 

Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis

H. Li; A. Perino; Q. Huang; G. V. G. Von Alvensleben; A. Banaei-Esfahani et al. 

Non-genomic activation of the AKT-mTOR pathway by the mitochondrial stress response in thyroid cancer

W. K. L. Doolittle; S. Park; S. G. Lee; S. Jeong; G. Lee et al. 

The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis

N. Bresciani; H. Demagny; V. Lemos; F. Pontanari; X. Li et al. 

Sex- and age-dependent genetics of longevity in a heterogeneous mouse population

M. Bou Sleiman; S. Roy; A. W. Gao; M. C. Sadler; G. V. G. von Alvensleben et al. 

Tetracycline-induced mitohormesis mediates disease tolerance against influenza

A. Mottis; T. Y. Li; G. El Alam; A. Rapin; E. Katsyuba et al. 

Estrogen-related receptor gamma regulates mitochondrial and synaptic genes and modulates vulnerability to synucleinopathy

S. N. Fox; L. J. McMeekin; C. H. Savage; K. L. Joyce; S. M. Boas et al. 

Genetic background and sex control the outcome of high-fat diet feeding in mice

A. M. Bachmann; J-D. Morel; G. El Alam; S. Rodríguez-López; T. Imamura de lima et al. 

Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

A. Singh; D. D’Amico; P. A. Andreux; A. M. Fouassier; W. Blanco-Bose et al. 

Sirtuin 7 Deficiency Reduces Inflammation and Tubular Damage Induced by an Episode of Acute Kidney Injury

A. Sanchez-Navarro; M. A. Martinez-Rojas; A. Albarran-Godinez; R. Perez-Villalva; J. Auwerx et al. 

Article Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains

A. W. Gao; G. El Alam; A. Lalou; T. Y. Li; M. Molenaars et al. 

The mouse metallomic landscape of aging and metabolism

J-D. Morel; L. Sauzeat; L. J. E. Goeminne; P. Jha; E. Williams et al. 

Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy

P-P. Laurila; P. Luan; M. Wohlwend; N. Zanou; B. Crisol et al. 

eNAMPT actions through nucleus accumbens NAD + /SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress

L. Morató; S. Astori; I. Zalachoras; J. Rodrigues; S. Ghosal et al. 

The Genetic Background Shapes Disease Susceptibility And Reveals A Specific Role For Mitochondrial Dysfunction In The Progression From Nafld To Nash

G. Benegiamo; G. Von Alvensleben; Y. Liu; S. Rodriguez-Lopez; A. Bachmann et al. 

ENHANCEMENT OF DE NOVO NAD plus BIOSYNTHESIS BY NOVEL ACMSD INHIBITORS IMPROVES MITOCHONDRIAL FUNCTION IN iPSC-DERIVED HUMAN LIVER ORGANOID MODELS OF STEATOHEPATITIS

Y. Liu; M. Kimura; A. Vijayakumar; E. Murakami; T. Takebe et al. 

Cyclo (His-Pro) Prevents Diet-Induced Fatty Liver Disease

A. De Masi; Xiaoxu Li; Qi Wang; A. Mottis; A. Rapin et al. 

Pleiotropic effects of mitochondria in aging

T. Lima; T. Y. Li; A. Mottis; J. Auwerx 

The role of nicotinamide riboside metabolism in pancreatic beta cells

Products and methods for promoting myogenesis

M. Wohlwend; J. Auwerx; U. Wisløff; J. B. Moreira 

Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity

N. Zanou; H. Dridi; S. Reiken; T. I. de Lima; C. Donnelly et al. 

GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression

G. C. Addicks; H. Zhang; D. Ryu; G. Vasam; A. E. Green et al. 

The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging

M. Wohlwend; P-P. Laurila; K. William; M. Romani; T. Lima et al. 

Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression

T. Hu; S. K. Shukla; E. Vernucci; C. He; D. Wang et al. 

Phalloidin Staining of Actin Filaments for Visualization of Muscle Fibers in Caenorhabditis elegans

M. Romani; J. Auwerx 

Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome

E. Porcu; M. C. Sadler; K. Lepik; C. Auwerx; A. R. Wood et al. 

Gene-by-environment modulation of lifespan and weight gain in the murine BXD family

S. Roy; M. B. Sleiman; P. Jha; J. F. Ingels; C. J. Chapman et al. 

Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population

A. Singh; D. D’Amico; P. A. Andreux; G. Dunngalvin; T. Kern et al. 

Nicotinamide Riboside Enhances In Vitro Beta-adrenergic Brown Adipose Tissue Activity in Humans

E. B. M. Nascimento; M. P. B. Moonen; C. M. E. Remie; K. Gariani; J. A. Jorgensen et al. 

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

P. Luan; D. D’Amico; P. A. Andreux; P-P. Laurila; M. Wohlwend et al. 

SIRT7 modulates the stability and activity of the renal K-Cl cotransporter KCC4 through deacetylation

L. G. Noriega; Z. Melo; R. D. Rajaram; A. Mercado; A. R. Tovar et al. 

Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response

S. G. Kang; M. J. Choi; S-B. Jung; H. K. Chung; J. Y. Chang et al. 

A platform for experimental precision medicine: The extended BXD mouse family

D. G. Ashbrook; D. Arends; P. Prins; M. K. Mulligan; S. Roy et al. 

TGR5 Regulates Macrophage Inflammation in Nonalcoholic Steatohepatitis by Modulating NLRP3 Inflammasome Activation

Y. Shi; W. Su; L. Zhang; C. Shi; J. Zhou et al. 

Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer

Y. L. N. Abril; I. R. Fernandez; J. Y. Hong; Y-L. Chiang; D. A. Kutateladze et al. 

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

M. Romani; V. Sorrentino; C. Oh; H. Li; T. Imamura de Lima et al. 

Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease

A. Faivre; E. Katsyuba; T. Verissimo; M. Lindenmeyer; R. D. Rajaram et al. 

Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity

X. Ming; A. C. K. Chung; D. Mao; H. Cao; B. Fan et al. 

TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury

H. Zhou; S. Zhou; Y. Shi; Q. Wang; S. Wei et al. 

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

D. D’Amico; P. A. Andreux; P. Valdes; A. Singh; C. Rinsch et al. 

Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in mouse

Organisation and dynamics of mitochondria and their RNA.

Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease

Treatment and prevention of aging related-disease and/or aging by the inhibition of sphingolipids

P-P. Laurila; J. Auwerx 

Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression

A. L. Rocha; T. I. de Lima; G. P. de Souza; R. O. Correa; D. L. Ferrucci et al. 

Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis

D. Patoli; F. Mignotte; V. Deckert; A. Dusuel; A. Dumont et al. 

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators

M. B. Sleiman; P. Jha; R. Houtkooper; R. W. Williams; X. Wang et al. 

Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling

A. Nakamura; Y. Yokoyama; K. Tanaka; G. Benegiamo; A. Hirayama et al. 

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington’s disease models

R. N. Hegde; A. Chiki; L. Petricca; P. Martufi; N. Arbez et al. 

Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice

L-J. Du; J-Y. Sun; W-C. Zhang; Y-L. Wang; H. Zhu et al. 

PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle

H. Yoon; J. B. Spinelli; E. Zaganjor; S. J. Wong; N. J. German et al. 

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

C. M. E. Remie; K. H. M. Roumans; M. P. B. Moonen; N. J. Connell; B. Havekes et al. 

Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age

D. Brigger; C. Riether; R. van Brummelen; K. I. Mosher; A. Shiu et al. 

Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice

J. S. Moon; L. J. E. Goeminne; J. T. Kim; J. W. Tian; S-H. Kim et al. 

Confounding factors from inducible systems for spatiotemporal gene expression regulation

R. C. I. Wuest; R. H. Houtkooper; J. Auwerx 

Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

K. Williams; L. R. Ingerslev; J. Bork-Jensen; M. Wohlwend; A. N. Hansen et al. 

Gene replacement therapy provides benefit in an adult mouse model of Leigh syndrome

R. Reynaud-Dulaurier; G. Benegiamo; E. Marrocco; R. Al-Tannir; E. M. Surace et al. 

Evaluation of the NAD(+) biosynthetic pathway in ALS patients and effect of modulating NAD(+) levels in hSOD1-linked ALS mouse models

B. A. Harlan; K. M. Killoy; M. Pehar; L. Liu; J. Auwerx et al. 

Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7

C. A. Stoyas; D. D. Bushart; P. M. Switonski; J. M. Ward; A. Alaghatta et al. 

Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence

S. Haemmig; D. Yang; X. Sun; D. Das; S. Ghaffari et al. 

Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress

A. E. Dikalova; A. Pandey; L. Xiao; L. Arslanbaeva; T. Sidorova et al. 

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis – Central role of macrophage scavenger receptor 1

T. Arsiwala; J. Pahla; L. J. van Tits; L. Bisceglie; D. S. Gaul et al. 

NCoR1 Protects Mice From Dextran Sodium Sulfate Induced Colitis by Guarding Colonic Crypt Cells From Luminal Insult

E. Mennillo; X. Yang; M. Paszek; J. Auwerx; C. Benner et al. 

A conserved role of CBP/p300 in mitochondrial stress response and longevity

J. Auwerx; T. Li 

Mouse Systems Genetics as a Prelude to Precision Medicine

H. Li; J. Auwerx 

NAD(+) homeostasis in health and disease

E. Katsyuba; M. Romani; D. Hofer; J. Auwerx 

Metabolic rescue of muscle and muscle stem cells in muscle disease

The Detection of Early Epigenetic Inheritance of Mitochondrial Stress in C. Elegans with a Microfluidic Phenotyping Platform

H. B. Atakan; K. S. Hof; M. Cornaglia; J. Auwerx; M. A. M. Gijs 

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

D. C. Hofer; G. Zirkovits; H. J. Pelzmann; K. Huber; A. R. Pessentheiner et al. 

A biosensor for measuring NAD(+) levels at the point of care

Q. Yu; N. Pourmandi; L. Xue; C. Gondrand; S. Fabritz et al. 

Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel

R. P. J. Bevers; M. Litovchenko; A. Kapopoulou; V. S. Braman; M. R. Robinson et al. 

Identifying gene function and module connections by the integration of multispecies expression compendia

H. Li; D. Rukina; F. P. A. David; T. Y. Li; C-M. Oh et al. 

Opposing action of NCoR1 and PGC-1 alpha in mitochondrial redox homeostasis

T. I. Lima; D. S. P. S. F. Guimaraes; A. G. Oliveira; H. Araujo; C. H. G. Sponton et al. 

Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population

M. E. Perez-Munoz; A. M. McKnite; E. G. Williams; J. Auwerx; R. W. Williams et al. 

Automated Platform for Long-Term Culture and High-Content Phenotyping of Single C. elegans Worms

H. B. Atakan; R. Xiang; M. Cornaglia; L. Mouchiroud; E. Katsyuba et al. 

Nuclear receptor corepressor 1 represses cardiac hypertrophy

C. Li; X-N. Sun; B-Y. Chen; M-R. Zeng; L-J. Du et al. 

The gut microbiota influences skeletal muscle mass and function in mice

S. Lahiri; H. Kim; I. Garcia-Perez; M. M. Reza; K. A. Martin et al. 

Cross-species functional modules link proteostasis to human normal aging

A. Komljenovic; H. Li; V. Sorrentino; Z. Kutalik; J. Auwerx et al. 

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

P. A. Andreux; W. Blanco-Bose; D. Ryu; F. Burdet; M. Ibberson et al. 

MicroRNA-382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells

D. Dahlmans; A. Houzelle; P. Andreux; X. Wang; J. A. Jorgensen et al. 

Autophagy regulates lipid metabolism through selective turnover of NCoR1

T. Saito; A. Kuma; Y. Sugiura; Y. Ichimura; M. Obata et al. 

Mild inborn errors of metabolism in commonly used inbred mouse strains

J. Leandro; S. Violante; C. A. Argmann; J. Hagen; T. Dodatko et al. 

Niacin: an old lipid drug in a new NAD(+) dress

M. Romani; D. C. Hofer; E. Katsyuba; J. Auwerx 

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

N. Vannini; V. Campos; M. Girotra; V. Trachsel; S. Rojas-Sutterlin et al. 

The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo

X. Wan; L. Liu; P. Zhou; X. Hui; Q. He et al. 

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

D. D’Amico; A. Mottis; F. Potenza; V. Sorrentino; H. Li et al. 

Multimodal imaging and high-throughput image-processing for drug screening on living organisms on-chip

D. Migliozzi; M. Cornaglia; L. Mouchiroud; V. Uhlmann; M. A. Unser et al. 

Automated high-content phenotyping from the first larval stage till the onset of adulthood of the nematode Caenorhabditis elegans

H. B. Atakan; M. Cornaglia; L. Mouchiroud; J. Auwerx; M. A. M. Gijs 

Regulation of NAD plus biosynthesis pathway in chronic kidney disease

A. Faivre; A. Mottis; R. D. Rajaram; D. Legouis; M. Lindenmeyer et al. 

Inhibition of Mitophagy Triggers Classical Activation of Macrophages

D. Patoli; V. Deckert; A. Rieu; A. Dusuel; A. Jalil et al. 

Automated High-Content Phenotyping Of The Nematode C. Elegans At Single Animal Resolution With A Microfluidic Platform

H. B. Atakan; R. Xiang; M. Cornaglia; L. Mouchiroud; J. Auwerx et al. 

Mitocellular communication: Shaping health and disease

A. Mottis; S. Herzig; J. Auwerx 

The virtuous cycle of human genetics and mouse models in drug discovery

J. H. Nadeau; J. Auwerx 

Systems genetics approaches to probe gene function

Methods of treating or preventing an aging-related disease

D. D’Amico; J. Auwerx 

De novo NAD(+) synthesis enhances mitochondrial function and improves health

E. Katsyuba; A. Mottis; M. Zietak; F. De Franco; V. van der Velpen et al. 

Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease

M. Ruiz; M. Begou; N. Launay; P. Ranea-Robles; P. Bianchi et al. 

Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population

E. G. Williams; Y. Wu; W. Wolski; J. Y. Kim; J. Lan et al. 

The role of mitochondria in stem cell fate and aging

H. Zhang; K. Menzies; J. Auwerx 

Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species

P. Jha; M. McDevitt; R. Gupta; P. Quiros; E. Williams et al. 

Reversible and long-term immobilization in a hydrogel-microbead matrix for high-resolution imaging of Caenorhabditis elegans and other small organisms

L. Dong; M. Cornaglia; G. Krishnamani; J. Zhang; L. Mouchiroud et al. 

Repairing Mitochondrial Dysfunction in Disease

V. Sorrentino; K. Menzies; J. Auwerx 

Reduced oxidative capacity in macrophages results in systemic insulin resistance

S. Jung; M. Choi; D. Ryu; H. Yi; S. Lee et al. 

Mitochondria! function is impaired in the skeletal muscle of pre-frail elderly

P. Andreux; M. van Diemen; M. Heezen; J. Auwerx; C. Rinsch et al. 

Microfluidics-enabled phenotyping of a whole population of C. elegans worms over their embryonic and post-embryonic development at single-organism resolution

M. Letizia; M. Cornaglia; R. Trouillon; V. Sorrentino; L. Mouchiroud et al. 

Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity

D. Gaul; J. Weber; L. van Tits; S. Sluka; L. Pasterk et al. 

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes

A. Abderrahmani; L. Yengo; R. Caiazzo; M. Canouil; S. Cauchi et al. 

Increased cardiac fatty acid oxidation in a mousemodel with decreasedmalonyl-CoA sensitivity of CPT1B

M. van Weeghel; D. Abdurrachim; R. Nederlof; C. Argmann; R. Houtkooper et al. 

GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells

M. Besprozvannaya; E. Dickson; H. Li; K. Ginburg; D. Bers et al. 

Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes

P. Jha; M. McDevitt; E. Halilbasic; E. Williams; P. Quiros et al. 

Genetic cartography of longevity in humans and mice: Current landscape and horizons

M. Hook; S. Roy; E. Williams; M. Sleiman; K. Mozhui et al. 

ERR gamma Preserves Brown Fat Innate Thermogenic Activity

M. Ahmadian; S. Liu; S. Reilly; N. Hah; W. Fan et al. 

Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14

D. Vatner; J. Zhang; M. Oydanich; J. Guers; E. Katsyuba et al. 

alpha-Amino-beta-carboxymuconate-epsilon-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD(+)) Biosynthesis

R. Pellicciari; P. Liscio; N. Giacche; F. De Franco; A. Carotti et al. 

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function

H. Li; X. Wang; D. Rukina; Q. Huang; T. Lin et al. 

A microfluidic array for high-content screening at whole-organism resolution

D. Migliozzi; M. Cornaglia; L. Mouchiroud; J. Auwerx; M. A. M. Gijs 

Cofactor sensing proteins for metabolic assays at point-of-care

Mitochondrial stress signalling and its impacts on physiology

Microfluidic high-content phenotypic screening on a Caenorhabditis elegans model

Plasma and liver lipid species as biomarkers of fatty liver

P. Jha; J. Auwerx 

Methods of treating amyloid-beta peptide diseases

J. Auwerx; V. Sorrentino; L. Mouchiroud 

The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress

O. Matilainen; M. S. B. Sleiman; P. M. Quiros; S. M. D. A. Garcia; J. Auwerx 

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis

K. Kim; D. Ryu; P. Dongiovanni; L. Ozcan; S. Nayak et al. 

Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity

V. Sorrentino; M. Romani; L. M. Ouchiroud; J. S. Beck; H. Zhang et al. 

An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondria! metabolism

D. Dahlmans; A. Houzelle; P. Andreux; J. A. Jorgensen; X. Wang et al. 

Systems Phytohormone Responses to Mitochondrial Proteotoxic Stress

X. Wang; J. Auwerx 

The corepressor NCOR1 regulates the survival of single-positive thymocytes

L. Mueller; D. Hainberger; V. Stolz; P. Hamminger; H. Hassan et al. 

Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function

F. Item; S. Wueest; V. Lemos; S. Stein; F. C. Lucchini et al. 

A multiscale study of the role of dynamin in the regulation of glucose uptake

R. Trouillon; M. C. Letizia; K. J. Menzies; L. Mouchiroud; J. Auwerx et al. 

Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain

S. Preston; P. K. Korhonen; L. Mouchiroud; M. Cornaglia; S. L. Mcgee et al. 

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection

J. Wang; N. He; N. Zhang; D. Quan; S. Zhang et al. 

Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection

E. Ciarlo; T. Heinonen; C. Theroude; J. Herderschee; M. Mombelli et al. 

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections

E. Ciarlo; T. Heinonen; J. Lugrin; H. Acha-Orbea; D. Le Roy et al. 

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

P. M. Quiros; M. A. Prado; N. Zamboni; D. D’Amico; R. W. Williams et al. 

Bayesian association scan reveals loci associated with human lifespan and linked biomarkers

A. F. Mcdaid; P. K. Joshi; E. Porcu; A. Komljenovic; H. Li et al. 

Label-free three-dimensional imaging of Caenorhabditis elegans with visible optical coherence microscopy

S. Coquoz; P. J. Marchand; A. Bouwens; L. Mouchiroud; V. Sorrentino et al. 

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia (vol 114, pg E1432, 2017)

S. Chen; W. Lu; M-F. Yueh; E. Rettenmeier; M. Liu et al. 

A homozygous missense mutation in ERAL1, encoding a mitochondrial rRNA chaperone, causes Perrault syndrome

I. A. Chatzispyrou; M. Alders; S. Guerrero-Castillo; R. Z. Perez; M. A. Haagmans et al. 

PPAR delta Promotes Running Endurance by Preserving Glucose

W. Fan; W. Waizenegger; C. S. Lin; V. Sorrentino; M-X. He et al. 

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia

S. Chen; W. Lu; M-F. Yueh; E. Rettenmeier; M. Liu et al. 

PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis

P. Mukhopadhyay; B. Horvath; M. Rajesh; Z. V. Varga; K. Gariani et al. 

Plasma Membrane-bound G Protein-coupled Bile Acid Receptor Attenuates Liver Ischemia/Reperfusion Injury Via the Inhibition of Toll-like Receptor 4 Signaling in Mice

H. Yang; H. Zhou; L. Zhuang; J. Auwerx; K. Schoonjans et al. 

Parkin functionally interacts with PGC-1 proportional to to preserve mitochondria and protect dopaminergic neurons

L. Zheng; N. Bernard-Marissal; N. Moullan; D. D’Amico; J. Auwerx et al. 

Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle

C. Greggio; P. Jha; S. S. Kulkarni; S. Lagarrigue; N. T. Broskey et al. 

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

H. K. Chung; D. Ryu; K. S. Kim; J. Y. Chang; Y. K. Kim et al. 

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

K. Gariani; D. Ryu; K. J. Menzies; H-S. Yi; S. Stein et al. 

A microfluidic platform for automated phenotyping during full lifespan of Caenorhabditis elegans at high-throughput

H. B. Atakan; M. Cornaglia; L. Mouchiroud; J. Auwerx; M. Gijs 

Chromatin remodeling factor integrates responses against nuclear and mitochondrial stress

O. Matilainen; P. M. Quiros; J. Auwerx 

Disease-Informed Bayesian Association Scan Reveals Novel Loci Associated with Human Lifespan and Linked Biomarkers

A. F. Mcdaid; P. K. Joshi; N. Mounier; E. Porcu; A. Komljenovic et al. 

Cytosolic Proteostasis Networks of the Mitochondrial Stress Response

D. D’Amico; V. Sorrentino; J. Auwerx 

Modulating NAD(+) metabolism, from bench to bedside

E. Katsyuba; J. Auwerx 

Mitochondria and Epigenetics Crosstalk in Homeostasis and Stress

O. Matilainen; P. M. Quiros; J. Auwerx 

Role of ACMSD in regulation of NAD+ metabolism and mitochondrial function

The role of nicotinamide riboside kinases in mammalian NAD⁺ metabolism

The therapeutic role of NAD+ modulation in fatty liver disease

Investigating the Biological Mechanisms underlying the Initiation of Autoimmunity against Beta Cell Antigens in Type 1 Diabetes

Agents and methods using thereof for the prevention and treatment of stem cells senescence

H. Zhang; K. Menzies; J. Auwerx; D. Ryu 

Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders

H. Zhang; K. Menzies; J. Auwerx; D. Ryu 

The effects of mitochondrial- and histone stress on the C. elegans transcriptome

O. J. Matilainen; M. Bou Sleiman; P. Moral Quiros; S. M. D. A. Garcia; J. Auwerx 

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

J. Ratajczak; M. Joffraud; S. A. J. Trammell; R. Ras; N. Canela et al. 

LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer

P. Xu; M. H. Oosterveer; S. Stein; H. Demagny; D. Ryu et al. 

Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: protective role of a novel C/EBP-β-dependent feedback regulation of SOD2

S. Winnik; D. S. Gaul; G. Siciliani; C. Lohmann; L. Pasterk et al. 

Track C. Biomedical Instrumentation & Micro and Nano Systems

M. Cornaglia; L. Mouchiroud; G. Krishnamani; A. Marette; S. Narasimhan et al. 

NAD(+) repletion improves muscle function in muscular dystrophy and counters global PARylation

D. Ryu; H. Zhang; E. R. Ropelle; V. Sorrentino; D. A. G. Mazala et al. 

Specification of haematopoietic stem cell fate via modulation of mitochondrial activity

N. Vannini; M. Girotra; O. Naveiras; G. Nikitin; V. Campos et al. 

A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans

M. Koopman; H. Michels; B. M. Dancy; R. Kamble; L. Mouchiroud et al. 

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

D. Ryu; L. Mouchiroud; P. A. Andreux; E. Katsyuba; N. Moullan et al. 

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

S. Sadhukhan; X. Liu; D. Ryu; O. D. Nelson; J. A. Stupinski et al. 

KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response

N. Rabhi; P-D. Denechaud; X. Gromada; S. A. Hannou; H. Zhang et al. 

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

H. Zhang; D. Ryu; Y. Wu; K. Gariani; X. Wang et al. 

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

C. Merkwirth; V. Jovaisaite; J. Durieux; O. Matilainen; S. D. Jordan et al. 

Systems proteomics of liver mitochondria function

E. G. Williams; Y. Wu; P. Jha; S. Dubuis; P. Blattmann et al. 

Joint mouse-human phenome-wide association to test gene function and disease risk

X. Wang; A. K. Pandey; M. K. Mulligan; E. G. Williams; K. Mozhui et al. 

Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models

M. Cornaglia; G. Krishnamani; L. Mouchiroud; V. Sorrentino; T. Lehnert et al. 

Eliciting the mitochondrial unfolded protein response via NAD+ repletion reverses fatty liver disease

K. L. Gariani; K. J. Menzies; D. Ryu; C. J. Wenger; X. Wang et al. 

Bone Marrow-Specific Sirt6 Deletion Increases Atherogenesis By Increasing Macrophage Scavenger Receptor 1

T. Arsiwala; L. J. Van Tits; M. Miranda; K. Nussbaum; J. Weber et al. 

Mitochondrial Inhibition By Nicotinamide Riboside Potently Stimulates Hematopoiesis After Transplantation Via The Mitochondrial Unfolded Protein Response

N. Vannini; V. Campos; M. Girotra; E. Stefanidis; A. Semilietof et al. 

Integration Of Multi-Scale Datatypb In Mouse Genetic Reference Populations To Reveal Candidate Modifying Biology In Inborn Errors Of Metabolism

C. A. Argmann; E. G. Williams; S. Violante; J. Hagen; T. Dodatko et al. 

Mitonuclear communication in homeostasis and stress

P. M. Quiros; A. Mottis; J. Auwerx 

Protein acetylation in metabolism – metabolites and cofactors

K. J. Menzies; H. Zhang; E. Katsyuba; J. Auwerx 

Metabolic control of muscle and muscle stem cell function

Novel interventions to recover the regenerative capacity of aged skeletal muscle by targeting the interactions in the stem cell niche

Mitochondrial unfolded protein response, its molecular mechanism and physiological impact

AMP-activated protein kinase

Methods & compounds useful in hematopoietic stem cell medicine

N. Vannini; M. Lutolf; J. Auwerx; O. Naveiras; M. Girotra 

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside

S. Winnik; J. Auwerx; D. A. Sinclair; C. M. Matter 

Type 5 adenylyl cyclase disruption leads to enhanced exercise performance

D. E. Vatner; L. Yan; L. Lai; C. Yuan; L. Mouchiroud et al. 

Miniaturized implantable sensors for in vivo localized temperature measurements in mice during cold exposure

R. Padovani; T. Lehnert; P. Cettour-Rose; R. Doenlen; J. Auwerx et al. 

Intestinal steroidogenesis controls PPAR expression in the colon and is impaired during ulcerative colitis

G. Bouguen; A. Langlois; M. Djouina; J. Branche; D. Koriche et al. 

Gene expression mapping of histone deacetylases and co-factors, and correlation with survival time and 1H-HRMAS metabolomic profile in human gliomas

N. Dali-Youcef; S. Froelich; F-M. Moussallieh; S. Chibbaro; G. Noël et al. 

An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging

M. Cornaglia; L. Mouchiroud; A. Marette; S. Narasimhan; T. Lehnert et al. 

Phosphorylation of the nuclear receptor co-repressor 1 by protein kinase B (PKB/Akt) switches its co-repressor targets in the liver

Y. S. Jo; D. Ryu; A. Maida; X. Wang; R. M. Evans et al. 

Evidence for a Direct Effect of the NAD(+) Precursor Acipimox on Muscle Mitochondrial Function in Humans

T. Van De Weijer; E. Phielix; L. Bilet; E. G. Williams; E. R. Ropelle et al. 

The mitochondrial unfolded protein response – synchronizing genomes

V. Jovaisaite; J. Auwerx 

Cell regulation: Cell biology, fueling a renaissance in metabolism

J. Nunnari; J. Auwerx 

PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis

D. M. Shih; J. M. Yu; L. Vergnes; N. Dali-Youcef; M. D. Champion et al. 

Dependence of Hippocampal Function on ERR gamma-Regulated Mitochondrial Metabolism

L. Pei; Y. Mu; M. Leblanc; W. Alaynick; G. D. Barish et al. 

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance

N. Bonhoure; A. Byrnes; R. D. Moir; W. Hodroj; F. Preitner et al. 

ARTD1-induced poly-ADP-ribose formation enhances PPAR gamma ligand binding and co-factor exchange

M. Lehmann; E. Pirinen; A. Mirsaidi; F. A. Kunze; P. J. Richards et al. 

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

N. Moullan; L. Mouchiroud; X. Wang; D. Ryu; E. G. Williams et al. 

The Sirt1 activator SRT3025 provides atheroprotection in Apoe(-/-) mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

M. X. Miranda; L. J. Van Tits; C. Lohmann; T. Arsiwala; S. Winnik et al. 

Antiviral treatment of feline immunodeficiency virus-infected cats with (R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine

E. Taffin; D. Paepe; N. Goris; J. Auwerx; M. Debille et al. 

A microfluidic device for longitudinal studies of C.elegans neurodegenerative disease models

M. Cornaglia; G. N. Krishnamani; L. Mouchiroud; T. Lehnert; J. Auwerx et al. 

Multi-dimensional imaging and phenotyping of C. elegans embryos via an automated microfluidic device

M. Cornaglia; L. Mouchiroud; A. P. H. Marette; S. Narasimhan; T. Lehnert et al. 

Determination of sub-diffraction-limited organelles and biomolecules using microsphere lenses in combination with fluorescence microscopy

H. Yang; N. Moullan; J. Auwerx; M. Gijs 

Tetracycline Antibiotics Impair Mitochondrial Function and Its Experimental Use Confounds Research

I. A. Chatzispyrou; N. M. Held; L. Mouchiroud; J. Auwerx; R. H. Houtkooper 

The Convergence of Systems and Reductionist Approaches in Complex Trait Analysis

E. G. Williams; J. Auwerx 

Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment

X. Wang; D. Ryu; R. H. Houtkooper; J. Auwerx 

NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

C. Canto; K. J. Menzies; J. Auwerx 

Long-term culture and high-resolution imaging of C. elegans using an automated microfluidic platform

G. H. Krishnamani; M. Cornaglia; L. Mouchiroud; M. Gijs; J. Auwerx 

Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis

J. Verbeek; M. Lannoo; E. Pirinen; D. Ryu; P. Spincemaille et al. 

Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis

M. A. Lim; K. K. Bence; I. Sandesara; P. Andreux; J. Auwerx et al. 

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

D. Ryu; Y. S. Jo; G. Lo Sasso; S. Stein; H. Zhang et al. 

An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement

E. G. Williams; L. Mouchiroud; M. Frochaux; P. Ashutosh; P. A. Andreux et al. 

Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population

Y. Wu; E. G. Williams; S. Dubuis; A. Mottis; V. Jovaisaite et al. 

NAD(+)-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease

R. Cerutti; E. Pirinen; C. Lamperti; S. Marchet; A. A. Sauve et al. 

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

E. Pirinen; C. Canto; Y. S. Jo; L. Morato; H. Zhang et al. 

SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

G. Lo Sasso; K. J. Menzies; A. Mottis; A. Piersigilli; A. Perino et al. 

The mitochondrial unfolded protein response in mammalian physiology

A. Mottis; V. Jovaisaite; J. Auwerx 

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C-elegans

P. A. Andreux; L. Mouchiroud; X. Wang; V. Jovaisaite; A. Mottis et al. 

PPAR beta/delta activation of CD300a controls intestinal immunity

T. Tanaka; S. Tahara-Hanaoka; T. Nabekura; K. Ikeda; S. Jiang et al. 

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

G. Lo Sasso; D. Ryu; L. Mouchiroud; S. C. Fernando; C. L. Anderson et al. 

Super-Resolution Biological Microscopy Using Virtual Imaging by a Microsphere Nanoscope

H. Yang; N. Moullan; J. Auwerx; M. A. M. Gijs 

Estrogen-related receptor-alpha ( ERR alpha) deficiency in skeletal muscle impairs regeneration in response to injury

S. Labarge; M. Mcdonald; L. Smith-Powell; J. Auwerx; J. M. Huss 

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

N. Khan; M. Auranen; I. Paetau; E. R. Pirinen; L. Euro et al. 

Is SIRT2 required for necroptosis?

K. Newton; J. M. Hildebrand; Z. Shen; D. Rodriguez; S. Alvarez-Diaz et al. 

Impact of the apolipoprotein E polymorphism, age and sex on neurogenesis in mice: Pathophysiological relevance for Alzheimer’s disease?

A. Koutseff; C. Mittelhaeuser; K. Essabri; J. Auwerx; H. Meziane 

Regulation of Steatohepatitis and PPARγ Signaling by Distinct AP-1 Dimers

S. C. Hasenfuss; L. Bakiri; M. K. Thomsen; E. G. Williams; J. Auwerx et al. 

An automated microfluidic platform for reversible immobilization and imaging of C. elegans

M. Cornaglia; G. H. Krishnamani; M-P. Meurville; L. Mouchiroud; T. Lehnert et al. 

An automated microfluidic platform for long-term high-resolution imaging of C. elegans

M. Cornaglia; G. H. Krishnamani; M-P. Meurville; L. Mouchiroud; T. Lehnert et al. 

Mitochondrial Activity Determines Hematopoietic Stem Cell Fate Decisions

N. Vannini; M. Girotra; O. M. Naveiras; V. Campos; E. Williams et al. 

Transcriptional Coregulators: Fine-Tuning Metabolism

L. Mouchiroud; L. Eichner; R. Shaw; J. Auwerx 

Vitamin D and energy homeostasis-of mice and men

R. Bouillon; G. Carmeliet; L. Lieben; M. Watanabe; A. Perino et al. 

The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

V. Jovaisaite; L. Mouchiroud; J. Auwerx 

A Systems Approach to Identify Genetic and Environmental Regulators of Metabolism

In vivo imaging reveals selective PPAR activity in the skin of peroxisome proliferator-activated receptor responsive element-luciferase reporter mice

N. El-Jamal; L. Dubuquoy; J. Auwerx; B. Bertin; P. Desreumaux 

The C-type Lectin Receptors Dectin-1, MR, and SIGNR3 Contribute Both Positively and Negatively to the Macrophage Response to Leishmania infantum

L. Lefevre; G. Lugo-Villarino; E. Meunier; A. Valentin; D. Olagnier et al. 

Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development

S. Winnik; D. S. Gaul; F. Preitner; C. Lohmann; J. Weber et al. 

Probing the Binding Site of Bile Acids in TGR5

A. Macchiarulo; A. Gioiello; C. Thomas; T. W. H. Pols; R. Nuti et al. 

Bile Acids Increase Levels of MicroRNAs 221 and 222, Leading to Degradation of CDX2 During Esophageal Carcinogenesis

J. Matsuzaki; H. Suzuki; H. Tsugawa; M. Watanabe; S. Hossain et al. 

Diet1 Functions in the FGF15/19 Enterohepatic Signaling Axis to Modulate Bile Acid and Lipid Levels

L. Vergnes; J. M. Lee; R. G. Chin; J. Auwerx; K. Reue 

Bioavailable copper modulates oxidative phosphorylation and growth of tumors

S. Ishida; P. Andreux; C. Poitry-Yamate; J. Auwerx; D. Hanahan 

Autophagy Defect Is Associated with Low Glucose-Induced Apoptosis in 661W Photoreceptor Cells

D. Balmer; M. Emery; P. Andreux; J. Auwerx; V. Ginet et al. 

NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids

P. Li; N. J. Spann; M. U. Kaikkonen; M. Lu; D. Y. Oh et al. 

Metabolic Characterization of a Sirt5 deficient mouse model

J. Yu; S. Sadhukhan; L. G. Noriega; N. Moullan; B. He et al. 

Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of Manganese Superoxide Dismutase via the SIRT1/FoxO3a Pathway

L. Lai; L. Yan; S. Gao; C-L. Hu; H. Ge et al. 

Hdac6 deletion delays disease progression in the SOD1(G93A) mouse model of ALS

I. Taes; M. Timmers; N. Hersmus; A. Bento-Abreu; L. Van Den Bosch et al. 

Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism

Z. Gan; J. Rumsey; B. C. Hazen; L. Lai; T. C. Leone et al. 

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

L. Mouchiroud; R. H. Houtkooper; N. Moullan; E. Katsyuba; D. Ryu et al. 

Mitonuclear protein imbalance as a conserved longevity mechanism

R. Houtkooper; L. Mouchiroud; D. Ryu; N. Moullan; E. Katsyuba et al. 

NR5A2 Regulates Lhb and Fshb Transcription in Gonadotrope-Like Cells In Vitro, but Is Dispensable for Gonadotropin Synthesis and Fertility In Vivo

J. Fortin; V. Kumar; X. Zhou; Y. Wang; J. Auwerx et al. 

Copper chelation therapy suppresses tumor growth by inhibiting mitochondrial ATP production in tumors.

S. Ishida; P. Andreux; J. Auwerx; D. Hanahan 

Deletion Of Sirt3 Does Not Affect Atherosclerosis But Accelerates Weight Gain And Impairs Rapid Metabolic Adaptation In Ldl Receptor Knockout Mice – Implications For Cardiovascular Risk Factor Development

D. Gaul; F. Preitner; M. X. Miranda; V. Tits; J. Lambertus et al. 

An acetylation rheostat for the control of muscle energy homeostasis

K. Menzies; J. Auwerx 

Pharmacological approaches to restore mitochondrial function

P. Andreux; R. Houtkooper; J. Auwerx 

Emerging roles of the corepressors NCoR1 and SMRT in homeostasis

A. J. L. Mottis; L. Mouchiroud; J. Auwerx 

In vivo metabolic studies in skeletal and cardiac muscle using ¹³C magnetic resonance spectroscopy

Identification of genetic determinants and pharmacological modulators of mitochondrial function

Role of the bile acid membrane receptor TGR5 in macrophages and metabolism

Aging biomarkers

J. Auwerx; R. Houtkooper; S. Houten; C. Argmann 

Mitochondrial ribosomal proteins as aging regulators

J. Auwerx; R. Houtkooper; L. Mouchiroud 

Methods of treating mitochondrial dysfunction

C. Alvarez; P. Bai; R. Houtkooper; J. Auwerx; L. Mouchiroud 

Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass

M. Simonen; N. Dali-Youcef; D. Kaminska; S. Venesmaa; P. Kakela et al. 

Impaired myogenesis in estrogen-related receptor γ (ERRγ)-deficient skeletal myocytes due to oxidative stress

J. Murray; J. Auwerx; J. M. Huss 

Mitochondrial sirtuins and metabolic homeostasis

E. Pirinen; G. Lo Sasso; J. Auwerx 

The Corepressor NCoR1 Antagonizes PGC-1α and Estrogen-Related Receptor α in the Regulation of Skeletal Muscle Function and Oxidative Metabolism

J. Pérez-Schindler; S. Summermatter; S. Salatino; F. Zorzato; M. Beer et al. 

Common Mechanisms for Calorie Restriction and AC5 Knockout Models of Longevity

L. Yan; J. Y. Park; J-G. Dillinger; D. Lorenzo; S. Mariana et al. 

Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures

V. Hinard; C. Mikhail; S. Pradervand; T. Curie; R. H. Houtkooper et al. 

Bile Acid Binding Resin Improves Metabolic Control through the Induction of Energy Expenditure

M. Watanabe; K. Morimoto; S. M. Houten; N. Kaneko-Iwasaki; T. Sugizaki et al. 

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

M. Janiszewska; M. L. Suvà; N. Riggi; R. H. Houtkooper; J. Auwerx et al. 

Systems Genetics of Metabolism : The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits

P. Andreux; E. G. Williams; H. Koutnikova; R. Houtkooper; M-F. Champy et al. 

LRH-1-dependent glucose sensing determines intermediary metabolism in liver

M. H. Oosterveer; C. Mataki; H. Yamamoto; T. Harach; N. Moullan et al. 

Murine Gut Microbiota Is Defined by Host Genetics and Modulates Variation of Metabolic Traits

A. M. McKnite; M. E. Perez-Munoz; L. Lu; E. G. Williams; S. Brewer et al. 

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

C. Cantó; R. Houtkooper; E. Pirinen; D. Youn; M. Oosterveer et al. 

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

T. Harach; T. W. H. Pols; M. Nomura; A. Maida; M. Watanabe et al. 

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

P. J. Fernandez-Marcos; E. H. Jeninga; C. Canto; T. Harach; V. C. J. de Boer et al. 

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

H. Cho; X. Zhao; M. Hatori; R. T. Yu; G. D. Barish et al. 

A guide to analysis of mouse energy metabolism

M. H. Tschoep; J. R. Speakman; J. R. S. Arch; J. Auwerx; J. C. Bruening et al. 

Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a ‘mitohormesis’ mechanism involving reactive oxygen species and PGC-1

J. Bouitbir; A-L. Charles; A. Echaniz-Laguna; M. Kindo; F. Daussin et al. 

In Vivo Modulation of Mitochondrial Activity Determines HSC Engraftment and Post-Transplant Survival in Mice

N. Vannini; O. M. Naveiras; V. Campos; E. Pirinen; R. Houtkooper et al. 

Sleep In A Dish: Key Electrophysiological, Molecular, And Metabolic Signatures Of Sleep And Wakefulness Revealed In Primary Cortical Cultures

V. Hinard; C. Mikhail; S. Pradervand; T. Curie; R. Houtkooper et al. 

Key electrophysiological, molecular and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures

M. Tafti; V. Hinard; C. Mikhail; S. Pradervand; T. Curie et al. 

TGR5 in macrophages is protective against atherosclerosis and insulin resistance

T. Pols; M. Nomura; J. Auwerx; K. Schoonjans 

Impact of Sirtuin 2 knockout on innate immune responses

E. Ciarlo; J. Lugrin; I. Dos Santos Pinheiro; D. Le Roy; N. Moulan et al. 

Exploring the therapeutic space around NAD+

R. Houtkooper; J. Auwerx 

Cell biology. FGF21 takes a fat bite

C. Cantó; J. Auwerx 

The journey of resveratrol from yeast to human

S. Timmers; J. Auwerx; P. Schrauwen 

Sirtuins as regulators of metabolism and healthspan

R. H. Houtkooper; E. Pirinen; J. Auwerx 

Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD(+)?

C. Cantó; J. Auwerx 

Ncor1 is a physiological modulator of muscle mass and oxidative function

J. Auwerx; H. Yamamoto; L. Mouchiroud 

The metabolic footprint of aging in mice

R. H. Houtkooper; C. Argmann; S. M. Houten; C. Cantó; E. H. Jeninga et al. 

Regulation of PGC-1 alpha, a nodal regulator of mitochondrial biogenesis

P. J. Fernandez-Marcos; J. Auwerx 

Don’t write sirtuins off

C. Canto; J. Auwerx 

SRT1720 improves survival and healthspan of obese mice

R. K. Minor; J. A. Baur; A. P. Gomes; T. M. Ward; A. Csiszar et al. 

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

T. Pols; M. Nomura; T. Harach; G. Lo Sasso; M. H. Oosterveer et al. 

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

M. Watanabe; Y. Horai; S. M. Houten; K. Morimoto; T. Sugizaki et al. 

The bile acid membrane receptor TGR5: a valuable metabolic target

T. W. H. Pols; L. G. Noriega; M. Nomura; J. Auwerx; K. Schoonjans 

CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability

L. G. Noriega; J. N. Feige; C. Canto; H. Yamamoto; J. Yu et al. 

E2F transcription factor-1 regulates oxidative metabolism

E. Blanchet; J-S. Annicotte; S. Lagarrigue; V. Aguilar; C. Clapé et al. 

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

S. Timmers; E. Konings; L. Bilet; R. H. Houtkooper; T. van de Weijer et al. 

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

J. Du; Y. Zhou; X. Su; J. J. Yu; S. Khan et al. 

Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity

P. Li; W. Fan; J. Xu; M. Lu; H. Yamamoto et al. 

NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

H. Yamamoto; E. G. Williams; L. Mouchiroud; C. Canto Alvarez; W. Fan et al. 

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling

B. Beirowski; J. Gustin; S. M. Armour; H. Yamamoto; A. Viader et al. 

Lack of IL-2 in PPAR-alpha deficient mice triggers allergic contact dermatitis by affecting regulatory T cells

S. Dubrac; A. Elentner; K. Schoonjans; J. Auwerx; M. Schmuth 

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

P. Bai; C. Canto Alvarez; H. Oudart; A. Brunyánszki; Y. Cen et al. 

PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure

P. Bai; C. Canto Alvarez; A. Brunyánszki; A. Huber; M. Szanto et al. 

Deconstructing bile acid signaling pathways

R. Pellicciari; A. Macchiarulo; A. Gioiello; C. Thomas; E. Rosatelli et al. 

Bile acid signaling and control of metabolism

J. H. Auwerx 

Transcriptional cofactors and NAD(+) in the control of metabolism

J. Auwerx 

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

T. W. H. Pols; L. G. Noriega; M. Nomura; J. Auwerx; K. Schoonjans 

Interference between PARPs and SIRT1: a novel approach to healthy ageing?

C. Cantó; J. Auwerx 

Calorie restriction: is AMPK a key sensor and effector?

C. Cantó; J. Auwerx 

Ageing: longevity hits a roadblock

D. B. Lombard; S. D. Pletcher; C. Cantó; J. Auwerx 

Emerging actions of the nuclear receptor LRH-1 in the gut

F. Marcos; P. Jose; J. Auwerx; K. Schoonjans 

Upstream binding protein 1 polymorphisms and their use for prognosing or diagnosing arterial blood pressure

J. Auwerx; R. Williams; M. Laakso; H. Koutnikova-rousselin 

Investigating the role of AS160/TBC1D4 in controlling glucose homeostasis

S. T. S. Ducommun 

The Intestinal Nuclear Receptor Signature With Epithelial Localization Patterns and Expression Modulation in Tumors

S. Modica; F. Gofflot; S. Murzilli; A. D’Orazio; L. Salvatore et al. 

The Pollutant Diethylhexyl Phthalate Regulates Hepatic Energy Metabolism via Species-Specific PPAR alpha-Dependent Mechanisms

J. N. Feige; A. Gerber; C. Casals-Casas; Q. Yang; C. Winkler et al. 

PPAR gamma Ligands Switched High Fat Diet-Induced Macrophage M2b Polarization toward M2a Thereby Improving Intestinal Candida Elimination

L. Lefevre; A. Gales; D. Olagnier; J. Bernad; L. Perez et al. 

Redefining the TGR5 triterpenoid binding pocket at the C-3 position

C. Genet; C. Schmidt; A. Strehle; K. Schoonjans; J. Auwerx et al. 

SIRT1 mRNA Expression May Be Associated with Energy Expenditure and Insulin Sensitivity

J. Rutanen; N. Yaluri; S. Modi; J. Pihlajamäki; M. Vänttinen et al. 

PPARgamma controls dectin-1 expression required for host antifungal defense against Candida albicans

A. Galès; A. Conduché; J. Bernad; L. Lefevre; D. Olagnier et al. 

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

C. Cantó; L. Q. Jiang; A. S. Deshmukh; C. Mataki; A. Coste et al. 

Targeting TGR5 in diabesity: Focus on S-EMCA (INT-777) a potent and selective bile acid mimetic agonist

R. Pellicciari; A. Macchiarulo; A. Gioiello; C. Thomas; E. Rosatelli et al. 

Increased skin contact hypersensitivity correlates with altered number and function of regulatory T cells in PPAR-alpha mice.

S. Dubrac; A. Elentner; K. Schoonjans; J. Auwerx; M. Schmuth 

Cofactor network to control metabolism

J. Auwerx 

PPAR-alpha deficiency triggers allergic contact dermatitis by affecting regulatory T cells through lack of IL-2

S. Dubrac; A. Elentner; K. Schoonjans; J. Auwerx; M. Schmuth 

Histone methyl transferases and demethylases; can they link metabolism and transcription?

R. Teperino; K. Schoonjans; J. Auwerx 

pRb, a switch between bone and brown fat

P. Fernandez-Marcos; J. Auwerx 

Obesity: New life for antidiabetic drugs

R. H. Houtkooper; J. Auwerx 

AMP-activated protein kinase and its downstream transcriptional pathways

C. Canto Alvarez; J. Auwerx 

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

E. H. Jeninga; K. Schoonjans; J. Auwerx 

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

T. W. Pols; J. Auwerx; K. Schoonjans 

Metabolic Networks of Longevity

R. H. Houtkooper; R. W. Williams; J. Auwerx