Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia

Regulation and impact of TERRA R-loops at human telomeres

Whole genome doubling promotes tumorigenesis through loss of chromatin segregation and compartment repositioning

Coordination of protein synthesis and degradation in mammalian cells

New roles of Bicc1 in cilia formation, cell adhesion, and in adult kidneys

Generalisable Methods for Early Prediction in Interactive Simulations for Education

J. M. L. Cock; M. Marras; C. Giang; T. Käser 

The role of eosinophils in breast cancer

AMP-activated Protein Kinase (AMPK): New molecular insights and novel downstream targets

Metabolic regulation of cytokinesis in Schizosaccharomyces pombe

Role of the androgen receptor in the human breast epithelium

Dissecting centriole fate in C. elegans development

Identification and characterization of proteins that protect human telomeres from fragility

Exploring the mechanisms governing nuclear cGAS localization and activity

Dissecting the role of the mitochondrial carrier SLC25A47

How Vibrio cholerae adapts to the environment: from cell shape transitions to antagonistic behavior

FATED 2022: Fairness, Accountability, and Transparency in Educational Data

C. Lynch; M. Marras; M. Pechenizkiy; A. Rafferty; S. Ritter et al. 

KRAB zinc-finger proteins and their transposable element targets: between antagonism and cooperation

Natural competence of the pathogen Acinetobacter baumannii: an elusive phenomenon

Immunosuppressive roles of Activin-A in melanoma and characterization of its precursor cleavage

The role of nicotinamide riboside metabolism in pancreatic beta cells

The role of the Nimrod proteins in the Drosophila immune system

Mitochondrial respiratory chain dysfunction disrupts intracellular cholesterol homeostasis

Estrogen receptor signaling in the human breast epithelium

New approaches to uncover the minimally functional hematopoietic niche using the adipocytic differentiation axis: pharmacological modulation and adrenal niche induction

A systematic CRISPR approach to understanding the role of Drosophila antimicrobial peptides in immunity in vivo

Can Feature Predictive Power Generalize? Benchmarking Early Predictors of Student Success across Flipped and Online Courses

M. Marras; T. Tu; J. Vignoud; T. Käser 

Intestinal stem cells differentiation and its application in cancer therapy

Notch1-driven T-ALL chromatin landscape is regulated by Tcf1 in hematopoietic progenitors

The molecular treasure box of environmental Vibrio cholerae strains

Intraductal xenografts model estrogen receptor-positive (ER+) breast cancer dormancy and reveal a critical role for epithelial-mesenchymal transition (EMT) in its establishment

Investigation of physiological roles of AMPK-activated protein kinase y3

The role and transcriptional regulation of FAM46A in adipocyte differentiation

The role of immune effectors in controlling Drosophila-microbes interactions

Unequal cleavage of the C. elegans zygote ensures robust embryogenesis

Crosstalk between Drp1 phosphorylation sites during mitochondrial dynamics and metabolic adaptation

Notch Signaling – a Booster of Chronic Lymphocytic Leukemia During Initiation and Disease Progression

cGAS regulation and activity during genotoxic stress

Allosteric regulation and targeting of Bruton’s tyrosine kinase (Btk) in B-cell lymphoma

Molecular profiling and functional analysis of macrophage-derived tumour extracellular vesicles

Coordinate Difference Matrices

G. Baechler; F. Duembgen; G. Elhami; M. Krekovic; M. Vetterli 

A single-cell-based identification and characterisation of Aregs, an inhibitory subpopulation of adipose stem and precursor cells

Flexure-based mecano-optical multi-degree-of-freedom transducers dedicated to medical force sensing instruments

Roles of Epigenetic Dysregulation in Cancer Progression and Metastasis

Targeting the oncogenic signaling of the transcription factor STAT3 with potent and selective monobody inhibitors

Metabolic plasticity and glucose transporter redundancy dictate lung adenocarcinoma growth

HIV host genomics in the era of effective antiretroviral therapy

Kinetic Euclidean Distance Matrices

P. Tabaghi; I. Dokmanic; M. Vetterli 

Role of Nimrod receptors in the Drosophila melanogaster cellular immune response

Role of Activin-A signaling in melanoma

Two nanomachines drive evolution in diverse Vibrio species

RADX: A novel single-stranded DNA-binding protein regulating telomere recombination

Targeting mitochondrial bioenergetics and NAD+ metabolism during sarcopenia and regeneration of skeletal muscle

The role of the transcriptional regulator BCL6 in adipose tissue development and remodeling

Hormone receptor signaling in estrogen receptor positive breast cancer

A Tale of Two Tumors: Unraveling the Complexities of Epigenetic Dysregulation in Cancer

Novel therapeutic strategies targeting the B-cell receptor signaling and antigen presentation pathways in non-Hodgkin lymphoma

Beyond silence : a functional and evolutionary study of KRAB zinc finger proteins

Analysis of long-range gene regulation at the HoxD locus

Functional analysis of the telomeric long non-coding RNA TERRA

Role of metabolism and mitochondria during glucose sensing and glucose-induced dysfunction in human pancreatic beta-cells

Innovative Tools and in vivo Methods for Tuberculosis Drug Discovery and Development

Mechanistic insights into AMP-activated protein kinase-dependent gene expression

Bacterial cell cycle dynamics: size regulation during exponential growth and role of polyphosphate during starvation response

Identification and characterisation of small-molecule inhibitors targeting STING

Adamts18 Function in Mammary Gland Development

Mitotic chromosome binding predicts transcription factor properties in interphase

An Exploratory Study On The Functional Significance Of Eosinophil Residency In The Small Intestine Under Homeostatic Conditions

The melanization reaction in Drosophila: More than black or white

Functional characterization of the virulence determinant ESX-1 from Mycobacterium tuberculosis

Development of topological tools for the analysis of biological data

Combinatorial targeting of angiogenesis with inducers of autophagy in the treatment of glioblastoma multiforme

The telomeric DNA damage response: Insights into telomere compaction and identification of novel damage signaling factors

Cytosolic delivery and characterization of monobodies interfering with SH2 domain-phosphotyrosine interactions

Probing the distribution of cortical components, including PtdIns(4,5)P2, during asymmetric division of C. elegans embryos

Coordinated Hoxd genes expression during embryogenesis is dependent on a strict disposition of genes and polarized regulators within the HoxD cluster

Single live cell monitoring of protein turnover reveals intercellular variability and cell cycle dependence of degradation rates

The double-edged toxins

Progestins used for hormonal contraception in Switzerland: study of their effects on the breast epithelium

Integrative approach to analyze the proximal region of the Trichonympha agilis centriole

Intestinal helminths modulate the gut microbiome

Genomics: a Swiss army knife to fight leprosy

Telomeric states in cancer development

The role of Snail in non-small cell lung cancer

Novel compartment-specific biosensors reveal a complementary subcellular distribution of bioactive Furin and PC7

Functional analysis of Bicc1 and novel interacting proteins in renal tubule cell metabolism and polycystic kidneys

Role of myeloid cells in mediating protection against parasitic helminth larvae

Functional Characterization of Nucleoid Associated Proteins Acting as Global Transcription Factors in Mycobacterium tuberculosis

KRAB’n’KAP, DNA methylation and epigenetic memory

Rhythmic modulation of transcriptional burst frequency in circadian gene promoters

Targeting cancer stem cells by T cell engineering

The role of nicotinamide riboside kinases in mammalian NAD⁺ metabolism

The microbiota provides colonisation resistance against intestinal helminths by regulating intestinal physiology

Physiological regulation of the CDK16/PCTAIRE-1 protein kinase and its proposed role in the brain

Rhythmic and clock-dependent chromatin loops regulate circadian gene expression

Genomic targets and molecular partners of the chromatin regulator KAP1

Capturing epidermal stemness

Phase specific transcriptional regulation of circadian clock and metabolism in mouse liver

Circadian rhythm and cell cycle

The Drosophila gut response to infection

AMP-activated protein kinase

Structural and functional characterization of the mycobacterial ESX-1 secretion system

Identification of genetic interactors of ypa2 in Schizosaccharomyces pombe

Role of RIP4 in lung adenocarcinoma differentiation

Development of microfluidic devices for chemotaxis of primary stem cells

Semi-Markov model for simulating MOOC students

L. Faucon; L. Kidzinski; P. Dillenbourg 

A balancing act between stratification and EMT in cultured human thymic epithelial cells

Wiki-LDA: A Mixed-Method Approach for Effective Interest Mining on Twitter Data

X. Pu; M. A. Chatti; H. Th ̈us; U. Schroeder 

Mechanisms of centrosome separation in C. elegans

Simultaneous Acoustic Localization of Multiple Smartphones with Euclidean Distance Matrices

S. M. Moosavi Dezfooli; Y-A. Pignolet-Oswald; D. Dzung 

Identification and functional characterization of protein kinases that modulate Notch signaling under physiological conditions and in cancer

Folding and Endocytosis of Anthrax Toxin Receptors

On the Performance Characteristics of Latent-Factor and Knowledge Tracing Models

S. Klingler; T. Käser; B. Solenthaler; M. Gross 

Lead Optimisation of a Novel Small Molecule Notch Inhibitor

GLUT1 and GLUT3 in non-small cell lung cancer

Unraveling the Physiological Role of Capillary Morphogenesis Gene 2 in Health and Disease

Redefining the metabolic landscape through TGF-beta/Activin signaling in Drosophila melanogaster

Relax and Unfold: Microphone Localization with Euclidean Distance Matrices

I. Dokmanic; J. Ranieri; M. Vetterli 

Development of a system for part quality prediction and process parameters adjustment in wire electrical discharge machining

Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

The chromatin remodeller Chd7 and the calcium ATPase Serca2 – adding new facets to the role of Notch in Hematopoiesis and T-ALL

Regulation of the mRNA silencing activity of Bicaudal-C

Mechanisms underlying cell-fate determination in the mammary gland development

Evolutionally dynamic control of LINE-1 elements in embryonic stem cells

Different parameters – same prediction. An analysis of learning curves

T. Käser; K. R. Koedinger; M. Gross 

MicroRNA 21 is a novel oncogene in Notch1-driven acute lymphoblastic T cell leukemia

The Bcl9-beta-catenin interface as a potential therapeutic target for colorectal cancer

Mechanisms of differential centriole inheritance in C. elegans

Characterizing the localization and role of lin-5 and era-1 mRNAs in early C. elegans embryos

Spatio-temporal synchronization of biological oscillators

Context-specific regulation of BMAL1 target genes during the circadian rhythm in mouse

Benzothiazinones: from a new lead to new combination therapies against Mycobacterium tuberculosis

In-Depth Analysis of Mutations in Hyaline Fibromatosis Syndrome (HFS)

The useful gate-crasher

The role of recruited bone-marrow derived mesenchymal stem cells in the establishment of the tumor stroma and a growth-supportive environment

Assessing the role of Hes1 and identification of target genes in human and murine T-ALL

Mechanistic aspects of DNA uptake in naturally competent Vibrio cholerae

Regulatory T cells modulate the intestinal immune response in homeostasis and infection

Human telomerase oligomerization and activity of hTERT mutants

Identification of tumor-stroma interactions crucial for the establishment of liver metastasis

Antibiotic-Induced Killing and Persistence of Mycobacteria

NMDAR signaling in cancer

Towards uncovering novel functions of Aurora A kinase in C. elegans embryos

c-Myc is essential for melanoma formation and metastasis

Mechanism and Function of S-palmitoylation in Capillary Morphogenesis Gene 2

Distributed Particle Swarm Optimization for Limited Time Adaptation in Autonomous Robots

E. Di Mario; A. Martinoli 

Euclidean Distance Matrices

An ancestral regulatory mechanism underlies Hoxd gene expression in both developing genitals and digits

Notch Signaling in Pigment Cells and Generation of Mouse Models for Ocular Diseases

A Quantitative Telomeric Chromatin Isolation Protocol (Q-TIP) to Characterize Telomere Composition Changes

Kinetic Analysis of Transcriptional and Post-Transcriptional Processes During Circadian Cycles

Role and regulation of the melanization reaction in Drosophila immune response

The contribution of the host stress response to the pathogenesis of Pseudomonas entomophila in the Drosophila intestine

Quantitative analysis and mathematical modeling of polarity establishment in C. elegans embryos

Novel strategies for the development of anti-tuberculosis compounds

RNA-Protein interactions at AU-rich elements

Involvement of the THO complex subunit Thp2 in telomere stability

Regulatory Switches Underlie Hoxd Gene Activation in Tetrapod Limbs

Polycomb Recruitment and Targeting in Mammals

Mechanisms of Hoxd gene regulation during the development and evolution of the intestinal caecum

Identification of a Novel Wnt Inhibitor

Isolation and Analysis of Regulators Coordinating the Nuclear Cycle with Cytokinesis in Schizosaccharomyces Pombe

Towards understanding HsSAS-6, a key player in centriole duplication

Planar Cell Polarity Controls Pancreatic Endocrine Differentiation

Experimental proposal Test of radiation protection instrumentation in HiRadMat

N. Charitonidis; M. Silari; P. G. Manessi 

Radiological assessment of the Collimator Materials tests at HiRadMat in 2012

N. Charitonidis; C. Theis; S. Roesler 

Telomeric Repeat Containing RNAs and the Response to Telomere Deprotection in Saccharomyces Cerevisiae

Isolation and Characterisation of Regulators of the Septation Initiation Network Regulators in Fission Yeast

Activin Signalling in Human Melanoma Cells

Asymmetric Cell Division in the Skin

A Combined Structural and Electromechanical FE Approach for Industrial Ultrasonic Devices Design

A. Schorderet; A. Prenleloup; E. Colla 

Identification and Preclinical Validation of Novel Inhibitors of the Notch Pathway

Mutual Inhibition Between the Anaphase-promoting Complex and the Spindle Assembly Checkpoint in C. Elegans Embryos

Role of Bcl9 and Bcl9l in Homeostasis, Regeneration and Tumorigenesis of the Gastrointestinal Epithelium

The Role of Nodal Processing in Pluripotent Progenitors

On the Relationship Between Protein-DNA Interactions and Circadian Gene Expression in Mouse Liver

The Intestinal Epithelium

Asymmetric Spindle Positioning and Intracellular Trafficking in C. Elegans Embryos

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

The Cell Differentiation Status Influences the Outcome of Notch-Induced Malignancy

Insight into the Regulation of Telomerase Access to Telomeres by Shelterin Proteins

Design of hybrid-kinematic mechanisms for machine tools

Characterization of electrical discharge machining plasmas

Contribution à l’accroissement des performances du processus de µEDM par l’utilisation d’un robot à dynamique élevée et de haute précision

Extension d’algorithmes d’ordre zéro pour l’optimisation stochastique

Temperature measurements and numerical analysis of the heat transfer in samples submitted to electron discharge machining (EDM)

B. Revaz; R. Flukiger; J. Carron; M. Rappaz