EPFL | École polytechnique fédérale de Lausanne
EPFL is ranked 12th in the world in QS 2017 – World University Ranking. EPFL offers an exceptional research and training environment with state-of-the-art facilities. The working language at EPFL is English. Laboratory of Biomaterials for Immunoengineering (Tang lab @ EPFL) is located on the 2nd floor of the new MED building (east side). We are actively looking for highly motivated and talented students and postdocs to join our laboratory.
Highly motivated students (bachelor or master) with excellent academic achievements in a major field of Immunology, Cancer Biology, Chemistry, Polymer Science&Engineering, Bioengineering, Materials Science&Engineering, Chemical Engineering, or a closely related discipline, are encouraged to apply for EPFL doctoral programs (EDBB or EDMX or EDMS, see http://phd.epfl.ch/programs for details). Preference will be given to candidates with a strong research background in immunology/chemical synthesis and published scientific papers.
If you are interested in joining Tang Lab, please forward your CV, research statement (including experience and interest, max. 3 pages), and the contact information of 3 references to Prof. Tang ( [email protected]). If you are interested in getting Prof. Tang’s support to apply for graduate fellowships that can sponsor your graduate study at EPFL, including European or international scholarships (e.g., Swiss Government Excellence Scholarships for Foreign Scholars, Chinese Scholarship Council (CSC)), please contact Prof. Tang directly.
Candidates with only a four-year Bachelor Degree are also considered (depending on the undergraduate institution and study/research performance there).
Training projects for master and bachelor students
We welcome master and bachelor students to join our lab for semester projects, internship, and theses. Students who like to join as a lab member and conduct a relatively long-term project will be considered with preference. Interested candidates should email Prof. Tang ([email protected]) their CVs containing completed courses, GPA, and research experience (if any), and schedule a meeting with Prof. Tang or a mentor to discuss their potential research interest and time commitment for conducting research in Tang lab.
There are several training projects available for semester projects, summer internship, or master theses depending on the time commitment of the student:
Nanogel synthesis and interaction with immune cells
The goal of this project is to synthesize biomacromolecule nanogels with responsive linkers and study their interaction with immune cells. The students will investigate how to control the composition, size, and surface properties of nanogels, and characterize the chemical and physical properties of the nanomaterials. They will next explore the interaction of various nanogels with T-cells, B-cells, dendritic cells, and macrophages and the dependence of their chemo-physical properties.
Chemical syntheses of responsive linkers and nanovaccines
The goal of this project is to design, conduct, and scale up the organic syntheses of small molecule responsive linkers and prepare nanovaccines. The students will learn the basic organic syntheses techniques and use NMR, MS, and HPLC to characterize the molecules. They will next prepare vaccines by linking antigens and adjuvant molecules using the synthesized linkers and study how the nanovaccines interact with antigen presenting cells.
Selective antibody modification and engineering
The goal of this project is to develop novel bioconjugation techniques to selectively modify antibodies. The students will investigate how to control the binding and dissociation of antibodies by varying chemical, physical or biological conditions, and learn how to modify antibodies through bioconjugation with polymers and responsive linkers. They will then study and characterize the binding specificity of the modified antibodies and their responsive activation.
Chemotaxis of immune cells
The goal of this project is to investigate the chemotaxis of immune cells, in particular, T cells, macrophages, and dendritic cells. The students will use transwell, cell monolayer, or tissue sections to establish reliable assays to study the chemotaxis behavior of immunes cells induced by single or combination of chemokines.