Journal Articles

Google Scholar profile;   ORCID ID

*: corresponding author; #: equal contribution

Donor-Cell Engineering with GSK3 Inhibitor-Loaded Nanoparticles Enhances Engraftment Following in Utero Transplantation

Loukogeorgakis, S.P.; Fachin, C.G.; Dias, A.S.; Li, H.; Tang, L.; im, A.G.; Vrecenak, J.D.; Stratigis, J.; Ahn, N.J.; Nissim, I.; Nissim, I.; Moron, A.F.; Martins, J.L.; Peranteau, W.H.; Coppi, P.D.; Irvine, D.L.; Flake, A.W.

Blood. 2019, in press.

A Magnetic Nanovaccine Enhances Cancer Immunotherapy

Guo, Y.; Tang, L.*

ACS Central Science. 2019, 5, 747-749. DOI: 10.1021/acscentsci.9b00325.

Redox-Responsive Interleukin-2 Nanogel Specifically and Safely Promotes the Proliferation and Memory Precursor Differentiation of Tumor-Reactive T-Cells

Xie, Y-Q.; Arik, H.; Wei, L.; Zheng, Y.; Suh, H.; Irvine, D.J.; Tang, L.*

Biomaterials Science2019, 7, 1345-1357. DOI: 10.1039/c8bm01556b. Invited contribution as Biomaterials Science Emerging Investigator

Surgery-free injectable macroscale biomaterials for local cancer immunotherapy

Lei, K.; Tang, L.*

Biomaterials Science. 2019, 7, 733-749. DOI : 10.1039/c8bm01470a. Invited review.

Engineering Cancer Vaccines Using Stimuli-Responsive Biomaterials

Zhao, Y.; Guo, Y.; Tang, L.*

Nano Research. 2018, 11, 5355–5371. DOI : 10.1007/s12274-018-2162-1. Invited review. Special issue: 2018 Nano Research Young Innovators (NR45) Award in nanobiotechnology

Enhancing T-cell Therapy Through TCR Signaling-Responsive Nanoparticle Drug Delivery

Tang, L.*; Zheng, Y.; Melo, M.B.; Mabardi, L.; Castaño, A.P.; Xie, Y.-Q.; Li, N.; Kudchodkar, S.B.; Wong, H.C.; Jeng, E.K.; Maus, M.V. and Irvine, D.J.*

Nature Biotechnology. 2018, 36, 707-716. DOI : 10.1038/nbt.4181. Cover story of Nature Biotechnology, Volume 36 Issue 8, August 2018. News & Views “A backpack revs up T-cell activity” in Nat. Biotech. Highlighted: MIT NewsEPFL News, EurekAlert!,, Nanowerk, My Science, eCancer, Health Canal, Medindia, Madrid,, Science and Enterprise, Brinkwire, Sina, BioArt

Neoantigen Vaccine Delivery for Personalized Anticancer Immunotherapy

Guo, Y.; Lei, K.; Tang, L.*

Frontiers in Immunology. 2018, 9, 1499. DOI : 10.3389/fimmu.2018.01499. Invited review, total views 13,925.

Albumin as a “Trojan Horse” for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting

Yin, Q.; Tang, L.; Cai, K.; Yang, X.; Yin, L.; Zhang, Y.; Dobrucki, L.W.; Helferich, W.G.; Fan, T.M. and Cheng, J.

Biomaterials Science. 2018, 6, 1189-1200. DOI : 10.1039/c8bm00149a.

Immunoengineering with Biomaterials for Enhanced Cancer Immunotherapy

Xie, Y-Q.; Wei, L.; Tang, L.*

WIREs Nanomed. Nanobiotechnol. 2018, 10, e1506. DOI : 10.1002/wnan.1506. Invited review.

Enhancing Adoptive Cell Therapy of Cancer through Targeted Delivery of Small-Molecule Immunomodulators to Internalizing or Noninternalizing Receptors

Zheng, Y.; Tang, L.; Sudha Kumari, S.; and Irvine, D.J.

ACS Nano. 2017, 11, 3089-3100. DOI : 10.1021/acsnano.7b00078.

High-Throughput Quantitation of Inorganic Nanoparticle Biodistribution at the Single-Cell Level Using Mass Cytometry

Yang, Y.S.; Atukorale, P.; Moynihan, K.; Bekdemir, A.; Rakhra, K.; Tang, L.; Stellacci, F. and Irvine, D.J.

Nature Communications. 20178, 14069. DOI : 10.1038/ncomms14069.

Selective in vivo Metabolic Cell-Labeling-Mediated Cancer Targeting

Wang, H.; Wang, R.; Cai, K.; He, H.; Liu, Y.; Yen, J.; Wang, Z.; Xu, M.; Sun, Y.; Zhou, X.; Yin, Q.; Tang, L.; Dobrucki, I.T.; Dobrucki, L.W.; Chaney, E.J.; Boppart, S.A.; Fan, T.M.; Lezmi, S.; Chen, X.; Yin, L.; Cheng, J.

Nature Chemical Biology. 201713, 415-424. DOI : 10.1038/nchembio.2297.

Pamidronate Functionalized Nanoconjugates for Targeted Therapy of Focal Skeletal Malignant Osteolysis

Yin, Q.#; Tang, L.#; Tong, R.; Sternberg, R.; Yang, X.; Dobrucki, L.W.; Borst, L.B.; Kamstock, D.A.; Cai, K.; Song, Z.; Helferich, W.G.; Cheng, J. and Fan T.M.

Proc. Natl. Acad. Sci. 2016113, E4601-4609. DOI : 10.1073/pnas.1603316113Highlighted: NIH Director’ Blog, FierceBiotech, Noodles, EurekAlert!,, Nanotechnology Now, Drug Discovery & Development, Bioscience technology, Azonano, Science Daily, Laboratory Journal,, Nanowerk, Engineering at Illinois.

In Vivo Targeting of Metabolically Labeled Cancers with Ultra-Small Silica Nanoconjugates

Wang, H.; Tang, L.; Liu, Y.; Dobrucka, I.T.; Dobrucki, L.W.; Yin, L. and Cheng, J

Theranostics. 2016, 6, 1467-1476. DOI : 10.7150/thno.16003.

Targeted Delivery of Immunomodulators to Lymph Nodes

Azzi, J., Yin, Q., Uehara, M., Ohori, S., Tang, L., Cai, K., Ichimura, T., McGrath, M., Maarouf, O., Kefaloyianni, E., Loughhead, S., Petr, J., Sun, Q., Kwon, M., Tullius, S., von Andrian, U.H., Cheng, J. and Abdi, R.

Cell Reports. 2016, 15, 1202-1213. DOI : 10.1016/j.celrep.2016.04.007.


Prior to EPFL

Targeting Tumor Vasculature with Aptamer Functionalized Doxorubicin-Polylactide Nanoconjugates for Enhanced Cancer Therapy

Tang, L.; Coyle, V.J.; Tong, R.; Yin, Q.; Pondenis, H.; Shor, S.; Borst, L.; Cheng, J.; Fan T.M.

ACS Nano. 2015, 9, 5072-5081. DOI : 10.1021/acsnano.5b00166.

Biomaterial Strategies for Immunomodulation

Hotaling, N.A.#Tang, L.#; Irvine, D.J.; Babensee, J.E.

Annu. Rev. Biomed. Eng. 2015, 17, 317-349. DOI : 10.1146/annurev-bioeng-071813-104814.

Bioorthogonal Oxime Ligation Mediated In Vivo Cancer Targeting

Tang, L.#; Yin, Q.#; Xu, Y.; Zhou, Q.; Cai, K.; Yen, J.; Dobrucki, L.W. and Cheng, J.

Chemical Science. 2015, 6, 2182-2186. DOI : 10.1039/C5SC00063G.

Investigating the Optimal Size of Anticancer Nanomedicine

Tang, L.; Yang, X.; Yin, Q.; Cai, K.; Wang, H.; Chaudhury, I.; Yao, C.; Zhou, Q.; Kwon, M.; Hartman, J.A.; Dobrucki, L.W.; Dobrucki, I.T.; Borst, L.B.; Lezmi, S.; Helferich, W.G.; Ferguson, A.L.; Fan, T.M. and Cheng, J.

Proc. Natl. Acad. Sci. 2014, 111, 15344-15349. DOI : 10.1073/pnas.1411499111Highlighted: Engineering at Illinois, Nanowerk, MedicalXpress, Science Daily, Nanotechnology Now, Daily News, EurekAlert!, Azonano, Health Canal, Bionity, Controlled Environments, Technology Org., Nature Science-Business eXchange 7(43); doi:10.1038/scibx.2014.1275.

Smart Chemistry in Polymeric Nanomedicines

Tong, R.; Tang, L.; Ma, L.; Tu, C.; Baumgartner, R. and Cheng, J.

Chem. Soc. Rev. 2014, 43, 6982-7012. DOI : 10.1039/C4CS00133H.

Nonporous Silica Nanoparticles for Nanomedicine Applications

Tang, L.; Cheng, J.

Nano Today. 2013, 8, 290-312. DOI : 10.1016/j.nantod.2013.04.007.

Size-Dependent Tumor Penetration and In Vivo Efficacy of Monodisperse Drug-silica Nanoconjugates

Tang, L.; Gabrielson, N.P.; Uckun, F. M.; Fan, T.M. and Cheng, J.

Mol. Pharm. 2013, 10, 883-892. DOI : 10.1021/mp300684a.

Selective Delivery of an Anticancer Drug with Aptamer-Functionalized Liposomes to Breast Cancer Cells in Vitro and in Vivo.

Xing, H.#Tang, L.#; Yang, X.#; Hwang, K.; Wang, W.; Yin, Q.; Dobrucki, W.L.; Yasui, N.; Katzenellenbogen, J.A.; Helferich, W.G.; Cheng, J. and Lu, Y.

J. Mater. Chem. B. 2013, 1, 5288-5297. DOI : 10.1039/C3TB20412J.

Redox-Responsive, Core-Cross-Linked Micelles Capable of On-Demand, Concurrent Drug Release and Structure Disassembly

Wang, H.; Tang, L.; Tu, C.; Song, Z.; Yin, Q.; Yin, L.; Zhang, Z.; Cheng, J.

Biomacromolecules. 2013, 14, 3706-3712. DOI : 10.1021/bm401086d.

Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability

Zhang, Y.; Yin, Q.; Yin, L.; Ma, L.; Tang, L.; Cheng, J.

Angew. Chem. Int. Ed. 2013, 52, 6435-6439. DOI : 10.1002/anie.201300497.

Aptamer-Functionalized, Ultra-Small, Monodisperse Silica Nanoconjugates for Targeted Dual-Modal Imaging of Lymph Nodes with Metastatic Tumors

Tang, L.; Yang, X.; Dobrucki, W.L.; Chaudhury, I.; Yin, Q.; Yao, C.; Lezmi, S.; Helferich, W.G.; Fan, T.M. and Cheng, J.

Angew. Chem. Int. Ed. 2015, 51, 12721-12726. DOI : 10.1002/anie.201205271. Highlighted: Nature Science-Business eXchange 5(45); doi:10.1038/scibx.2012.1193.

Synthesis and Biological Response of Size-Specific, Monodisperse Drug-Silica Nanoconjugates

Tang, L.; Fan, T.M.; Borst, L.B. and Cheng, J.

ACS Nano. 20126, 3954-3966. DOI : 10.1021/nn300149c

Immunosuppressive Activity of Size-Controlled PEG-PLGA Nanoparticles Containing Encapsulated Cyclosporine A

Tang, L.; Azzi, J.; Kwon, M.; Mounayar, M.; Tong, R.; Yin, Q.; Moore, R.; Skartsis, N.; Fan, T.M.; Abdi, R.; Cheng, J.

JTransplant. 2012, Article ID 896141. DOI :10.1155/2012/896141.

Targeting Mantle Cell Lymphoma with Anti-SYK Nanoparticles

Cely, I.; Yiv, S.; Yin, Q.; Shahidzadeh, A.; Tang, L.; Cheng, J.

J. Analy. Oncol. 2012, 1, 1-9. DOI : 10.6000/1927-7229.2012.01.01.1.

The Therapeutic Efficacy of Camptothecin-Encapsulated Supramolecular Nanoparticles

Chen, K.J.#Tang, L.#; Garcia, M.A.; Wang, H.; Lu, H.; Lin, W.Y.; Hou, S.; Yin., Q.; Shen, C.K.F.; Cheng, J.; Tseng, H.R.

Biomaterials. 2011, 33, 1162-1169. DOI : 10.1016/j.biomaterials.2011.10.044.

Translocation of HIV TAT Peptide and Analogues Induced by Multiplexed Membrane and Cytoskeletal Interactions

Mishra, A.; Lai, G.H.; Schmidt, N.W.; Sun, V.Z.; Rodriguez, A.R., Tong, R.; Tang, L.; Cheng, J.; Deming, T.J.; Kamei, D.T.; Wong, G.C.L.

Proc. Natl. Acad. Sci. 2011, 108, 16883-16888. DOI : 10.1073/pnas.1108795108.

Polylactide-Cyclosporin A Nanoparticles for Targeted Immunosuppression

Azzi, J.#Tang, L.#; Moore, R.; Tong, R.; El, Haddad N.; Akiyoshi, T.; Mfarrej, B.; Yang, S.; Jurewicz, M.; Ichimura, T.; Lindeman, N.; Cheng, J.; Abdi, R.

FASEB J. 2010, 24, 3927-3938. DOI : 10.1096/fj.10-154690.

Lymphatic Biodistribution of Polylactide Nanoparticles

Chaney, E. J.; Tang, L.; Tong, R.; Rezaeipoor, R.; Cheng, J.; Boppart, S.

Mol. Imag. 2010, 9, 153-162.

Polylactide Nanoparticles Containing Stably-Incorporated Cyanine Dyes for In Vitro and In Vivo Imaging Applications

Tong, R.; Coyle, V.J; Tang, L.; Barger, A.M., Fan, T.M.; Cheng, J.

Microsc. Res. Tech. 2010, 73, 901-909. DOI : 10.1002/jemt.20824.

Nanopolymeric Therapeutics

Tong, R.; Christian, D.A.; Tang, L.; Cabral, H.; Baker, J.R. Jr.; Kataoka, K.; Discher, D.; Cheng, J.

MRS Bulletin. 2009, 34, 422-431. DOI : 10.1557/mrs2009.118.

Immune control of tuberculosis by IFN-gamma-inducible LRG-47Hydrothermal Growth of Large-scale Micropatterned Arrays of Ultralong ZnO Nanowires and Nanobelts on Zinc Substrate

Lu, C.; Qi, L.; Yang J.; Tang, L., Zhang, D.; Ma, J.

Chem. Commun. 2006, 3551-3553. DOI : 10.1039/B608151G.


Efficient and Stable Cell Surface Coupling of Nanoparticles

Irvine, D.J.; Zheng, Y.; Tang, L.

U.S. provisional patent application, 2015.

Carrier-Free Biologically-Active Protein Nanogels

Tang, L. ; Irvine, D.J.

US Patent 20150110740, 2015.

Silica Nanoparticle Agent Conjugates

Cheng, J; Tang, L.

US 61/418,230, 2010, WO PCT/US2011/062548, 2011 (TF09149).