Tang Lab

Laboratory of Biomaterials for Immunoengineering

Our new paper is now out on the cover of Nature Immunology

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EPFL scientists have discovered that an engineered interleukin-10-Fc fusion protein can boost the effectiveness of exhausted T lymphocytes – our body’s immune cells for fighting cancer, by reprograming their metabolism. Their findings have been recently published in Nature Immunology as a cover story.

Our research

Our immune system is constantly defending us from many diseases through profound interactions with invaders or diseased cells. Such interactions are multi-dimensional involving substantial biological, chemical, and physical exchanges. The overarching goal of Tang laboratory is to develop novel strategies to engineer the multi-dimensional immune-disease interactions, an emerging field called ‘immunoengineering’, to create safe and effective therapies against cancer and infectious diseases. We leverage the power of metabolic and cellular bioengineering, synthetic chemistry and material engineering, and mechanical engineering to achieve controllable modulation of the immune system through metabolic, chemical, and mechanical means. There are three interconnected themes in our research program:

1) to reprogram immune cell metabolism with engineered proteins, cells, and molecules for enhanced proliferation, function, and longevity (Metabolic immunoengineering)

2) to achieve tissue-/cell-specific immune modulation using responsive chemistry and smart biomaterials (Chemical immunoengineering)

3) to manipulate the mechanical properties and interactions at cellular and tissue levels for enhanced immunotherapy (Mechanical immunoengineering)

Contact

Head of Laboratory : Li Tang
EPFL-STI-IBI/IMX-LBI
MED 1 2826, Station 9
CH-1015 Lausanne, Switzerland
Phone : +41 21 693 0937
Email: [email protected]


Administrative Assistant : Monica Navarro Suarez
EPFL-STI-IBI/IMX-LBI
MED 1 2726, Station 9
CH-1015 Lausanne, Switzerland
Phone : +41 21 693 0756
Email: [email protected]