Our laboratory offers projects for master students. Depending on the student’s interest and background, projects are designed together with the laboratory head and/or project supervisor.
Master’s Project Opportunity: Metabolic Regulation of Liver Cell Function and Stress Response
Join our research team to investigate how specific metabolites influence hepatic energy metabolism, oxidative stress resilience, and mitochondrial function. This project will provide hands-on experience with cutting-edge techniques in cellular metabolism and functional genomics.
Key Techniques & Approaches:
- Metabolomics (LC-MS/MS, GC-MS) – Profile intracellular and extracellular metabolites to track metabolic fluxes.
- Transcriptomics (RNA-seq, qPCR, RT-qPCR) – Analyze gene expression changes in metabolic and stress response pathways.
- Mitochondrial Functional Assays (Seahorse XF, Oroboros O2k) – Assess mitochondrial respiration, ATP production, and metabolic flexibility.
- Oxidative Stress and Redox Biology (ROS detection, GSH/GSSG assays, NADPH measurements) – Investigate how cells manage oxidative stress.
- Advanced Cell Culture (Primary hepatocytes, 3D hepatic spheroids) – Study metabolic adaptations in physiologically relevant liver models.
What You’ll Gain:
- Hands-on training in state-of-the-art bioanalytical techniques used in metabolic research.
- Experience in multi-omics data integration to understand metabolic regulation.
- The opportunity to contribute to a high-impact research project on liver metabolism.