Publications

2025

Journal Articles

Bile acid 7α-dehydroxylating bacteria accelerate injury-induced mucosal healing in the colon

A. Jalil; A. Perino; Y. Dong; J. Imbach; C. Volet et al. 

EMBO MOLECULAR MEDICINE. 2025. DOI : 10.1038/s44321-025-00202-w.

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Wars1 downregulation in hepatocytes induces mitochondrial stress and disrupts metabolic homeostasis

F. Pontanari; H. Demagny; A. Faure; X. Li; G. Benegiamo et al. 

Metabolism: clinical and experimental. 2025. Vol. 162. DOI : 10.1016/j.metabol.2024.156061.

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TGR5 receptors in SF1-expressing neurons of the ventromedial hypothalamus regulate glucose homeostasis

P. Zizzari; A. Castellanos-Jankiewicz; S. Yagoub; V. Simon; S. Clark et al. 

Molecular Metabolism. 2025. Vol. 91, p. 102071. DOI : 10.1016/j.molmet.2024.102071.

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2024

Journal Articles

Protecting liver health with microbial-derived succinylated bile acids

H. C. E. Demagny; A. Perino; K. Schoonjans 

LIFE METABOLISM. 2024. Vol. 3, num. 5. DOI : 10.1093/lifemeta/loae023.

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Loss of hepatic Sirt7 accelerates diethylnitrosamine (DEN)-induced formation of hepatocellular carcinoma by impairing DNA damage repair

Y. Kim; B. E. Kang; K. Gariani; J. Gariani; J. Lee et al. 

BMB reports. 2024. Vol. 57, num. 2, p. 98 – 103. DOI : 10.5483/BMBRep.2023-0187.

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2023

Journal Articles

Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

X. Li; J-D. H. Morel; G. Benegiamo; J. G. A. Poisson; A. Bachmann et al. 

Elife. 2023. Vol. 12, p. RP87569. DOI : 10.7554/eLife.87569.

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Asparagine protects pericentral hepatocytes during acute liver injury

Y. Sun; H. Demagny; A. Faure; F. Pontanari; A. Jalil et al. 

Journal Of Clinical Investigation. 2023. Vol. 133, num. 7, p. e163508. DOI : 10.1172/JCI163508.

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Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

E. Yildiz; G. El Alam; A. Perino; A. Jalil; P-D. Denechaud et al. 

Elife. 2023. Vol. 12, p. e81926. DOI : 10.7554/eLife.81926.

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2022

Journal Articles

Trans-anethole Induces Thermogenesis via Activating SERCA/SLN Axis in C2C12 Muscle Cells

S. Mukherjee; M. Choi; J. W. Yun 

Biotechnology And Bioprocess Engineering. 2022. Vol. 27, p. 938 – 948. DOI : 10.1007/s12257-022-0242-2.

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Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis

H. Li; A. Perino; Q. Huang; G. V. G. Von Alvensleben; A. Banaei-Esfahani et al. 

Cell Metabolism. 2022. Vol. 34, num. 10, p. 1594 – +. DOI : 10.1016/j.cmet.2022.08.015.

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Non-genomic activation of the AKT-mTOR pathway by the mitochondrial stress response in thyroid cancer

W. K. L. Doolittle; S. Park; S. G. Lee; S. Jeong; G. Lee et al. 

Oncogene. 2022. DOI : 10.1038/s41388-022-02484-7.

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The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis

N. Bresciani; H. Demagny; V. Lemos; F. Pontanari; X. Li et al. 

Journal Of Hepatology. 2022. Vol. 77, num. 4, p. 1071 – 1082. DOI : 10.1016/j.jhep.2022.05.040.

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Colchicine stimulates browning via antagonism of GABA receptor B and agonism of? 3-adrenergic receptor in 3T3-L1 white adipocytes

M. Choi; S. Mukherjee; J. W. Yun 

Molecular And Cellular Endocrinology. 2022. Vol. 552, p. 111677. DOI : 10.1016/j.mce.2022.111677.

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Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance

T. Laura; H. Helene; M. Melusine; G. Manon; D. H. Angelique et al. 

Advanced Science. 2022.  p. 2200626. DOI : 10.1002/advs.202200626.

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Metabolic Messengers: bile acids

A. Perino; K. Schoonjans 

Nature Metabolism. 2022. DOI : 10.1038/s42255-022-00559-z.

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Engineering Modular 3D Liver Culture Microenvironments In Vitro to Parse the Interplay between Biophysical and Biochemical Microenvironment Cues on Hepatic Phenotypes

A. J. Wang; A. Allen; M. Sofman; P. Sphabmixay; E. Yildiz et al. 

Advanced Nanobiomed Research. 2022. Vol. 2, num. 1, p. 2100049. DOI : 10.1002/anbr.202100049.

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2021

Journal Articles

Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis

M. Reich; L. Spomer; C. Klindt; K. Fuchs; J. Stindt et al. 

Journal Of Hepatology. 2021. Vol. 75, num. 3, p. 634 – 646. DOI : 10.1016/j.jhep.2021.03.029.

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Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity

A. Castellanos-Jankiewicz; O. Guzman-Quevedo; V. S. Fenelon; P. Zizzari; C. Quarta et al. 

Cell Metabolism. 2021. Vol. 33, num. 7, p. 1483 – 1492.e10. DOI : 10.1016/j.cmet.2021.04.009.

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Central anorexigenic actions of bile acids are mediated by TGR5

A. Perino; L. A. Velazquez-Villegas; N. Bresciani; Y. Sun; Q. Huang et al. 

Nature Metabolism. 2021. Vol. 3, num. 5, p. 595 – 603. DOI : 10.1038/s42255-021-00398-4.

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Emerging functions of the nuclear receptor LRH-1 in liver physiology and pathology

Y. Sun; H. C. E. Demagny; K. Schoonjans 

Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease. 2021. Vol. 1867, num. 8, p. 166145. DOI : 10.1016/j.bbadis.2021.166145.

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TGR5 Regulates Macrophage Inflammation in Nonalcoholic Steatohepatitis by Modulating NLRP3 Inflammasome Activation

Y. Shi; W. Su; L. Zhang; C. Shi; J. Zhou et al. 

Frontiers In Immunology. 2021. Vol. 11, p. 609060. DOI : 10.3389/fimmu.2020.609060.

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TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury

H. Zhou; S. Zhou; Y. Shi; Q. Wang; S. Wei et al. 

American Journal Of Transplantation. 2021. Vol. 21, num. 4, p. 1453 – 1464. DOI : 10.1111/ajt.16327.

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Molecular physiology of bile acid signaling in health, disease, and aging

A. Perino; H. C. E. Demagny; L. A. Velazquez Villegas; K. Schoonjans 

Physiological Reviews. 2021. Vol. 101, num. 2, p. 683 – 731. DOI : 10.1152/physrev.00049.2019.

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2020

Journal Articles

Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

G. Sorrentino; A. Perino; E. Yildiz; G. El Alam; M. B. Sleiman et al. 

Gastroenterology. 2020. Vol. 159, num. 3, p. 956 – 968.e8. DOI : 10.1053/j.gastro.2020.05.067.

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Compound 18 Improves Glucose Tolerance in a Hepatocyte TGR5-dependent Manner in Mice

M. M. Holter; M. K. Chirikjian; D. A. Briere; A. Maida; K. W. Sloop et al. 

Nutrients. 2020. Vol. 12, num. 7, p. 2124. DOI : 10.3390/nu12072124.

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Mechano-modulatory synthetic niches for liver organoid derivation

G. Sorrentino; S. Rezakhani; E. Yildiz; S. Nuciforo; M. H. Heim et al. 

Nature Communications. 2020. Vol. 11, num. 1, p. 3416. DOI : 10.1038/s41467-020-17161-0.

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L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

M. L. Lund; G. Sorrentino; K. L. Egerod; C. Kroone; B. Mortensen et al. 

Diabetes. 2020. Vol. 69, num. 4, p. 614 – 623. DOI : 10.2337/db19-0764.

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2019

Journal Articles

Genistein increases the thermogenic program of subcutaneous WAT and increases energy expenditure in mice

B. Palacios-Gonzalez; A. Vargas-Castillo; L. Alejandra Velazquez-Villegas; S. Vasquez-Reyes; P. Lopez et al. 

Journal Of Nutritional Biochemistry. 2019. Vol. 68, p. 59 – 68. DOI : 10.1016/j.jnutbio.2019.03.012.

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A new class of protein biomarkers based on subcellular distribution: application to a mouse liver cancer model

T. Sajic; R. Ciuffa; V. Lemos; P. Xu; V. Leone et al. 

Scientific Reports. 2019. Vol. 9, p. 6913. DOI : 10.1038/s41598-019-43091-z.

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Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

R. Bertolio; F. Napoletano; M. Mano; S. Maurer-Stroh; M. Fantuz et al. 

Nature Communications. 2019. Vol. 10, p. 1326. DOI : 10.1038/s41467-019-09152-7.

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Manganese-mediated reductive amidation of esters with nitroarenes

C. W. Cheung; N. Shen; S-P. Wang; A. Ullah; X. Hu et al. 

Organic Chemistry Frontiers. 2019. Vol. 6, num. 6, p. 756 – 761. DOI : 10.1039/c8qo01405a.

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The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

D. D’Amico; A. Mottis; F. Potenza; V. Sorrentino; H. Li et al. 

Molecular Cell. 2019. Vol. 73, num. 4, p. 775 – 787.e10. DOI : 10.1016/j.molcel.2018.11.034.

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2018

Journal Articles

De novo NAD(+) synthesis enhances mitochondrial function and improves health

E. Katsyuba; A. Mottis; M. Zietak; F. De Franco; V. van der Velpen et al. 

Nature. 2018. Vol. 563, num. 7731, p. 354 – 359. DOI : 10.1038/s41586-018-0645-6.

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GDA, a web-based tool for Genomics and Drugs integrated analysis

J. Caroli; G. Sorrentino; M. Forcato; G. Del Sal; S. Bicciato 

NUCLEIC ACIDS RESEARCH. 2018. Vol. 46, num. W1, p. W148 – W156. DOI : 10.1093/nar/gky434.

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The stiff RhoAd from mevalonate to mutant p53

G. Sorrentino; F. Mantovani; G. Del Sal 

CELL DEATH AND DIFFERENTIATION. 2018. Vol. 25, num. 4, p. 643 – 645. DOI : 10.1038/s41418-018-0091-x.

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Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas

R. Kuhre; N. Albrechtsen; O. Larsen; S. Jepsen; E. Balk-Moller et al. 

MOLECULAR METABOLISM. 2018. Vol. 11, p. 84 – 95. DOI : 10.1016/j.molmet.2018.03.007.

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Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas

I. Cobo; P. Martinelli; M. Flandez; L. Bakiri; M. Zhang et al. 

Nature. 2018. Vol. 554, num. 7693, p. 533 – 537. DOI : 10.1038/nature25751.

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TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue

L. Velazquez-Villegas; A. Perino; V. Lemos; M. Zietak; M. Nomura et al. 

Nature Communications. 2018. Vol. 9, p. 245. DOI : 10.1038/s41467-017-02068-0.

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LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus

N. Cobo-Vuilleumier; P. Lorenzo; N. Rodriguez; I. Gomez; E. Fuente-Martin et al. 

Nature Communications. 2018. Vol. 9, p. 162. DOI : 10.1038/s41467-018-03943-0.

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The Orphan Nuclear Receptor Liver Homolog Receptor-1 (Nr5a2) Regulates Ovarian Granulosa Cell Proliferation

M. Meinsohn; F. Morin; K. Bertolin; R. Duggavathi; K. Schoonjans et al. 

JOURNAL OF THE ENDOCRINE SOCIETY. 2018. Vol. 2, num. 1, p. 24 – 41. DOI : 10.1210/js.2017-00329.

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Long-Term Genistein Consumption Modifies Gut Microbiota, Improving Glucose Metabolism, Metabolic Endotoxemia, and Cognitive Function in Mice Fed a High-Fat Diet

P. Lopez; M. Sanchez; C. Perez-Cruz; L. Velazquez-Villegas; T. Syeda et al. 

Molecular Nutrition & Food Research. 2018. Vol. 62, num. 16, p. 1800313. DOI : 10.1002/mnfr.201800313.

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Mechanical cues control mutant p53 stability through a mevalonate-RhoA axis

E. Ingallina; G. Sorrentino; R. Bertolio; K. Lisek; A. Zannini et al. 

Nature Cell Biology. 2018. Vol. 20, num. 1, p. 28 – 35. DOI : 10.1038/s41556-017-0009-8.

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2017

Journal Articles

beta-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue

E. Somm; H. Henry; S. J. Bruce; S. Aeby; M. Rosikiewicz et al. 

Jci Insight. 2017. Vol. 2, num. 8, p. e91809. DOI : 10.1172/jci.insight.91809.

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Plasma Membrane-bound G Protein-coupled Bile Acid Receptor Attenuates Liver Ischemia/Reperfusion Injury Via the Inhibition of Toll-like Receptor 4 Signaling in Mice

H. Yang; H. Zhou; L. Zhuang; J. Auwerx; K. Schoonjans et al. 

Liver Transplantation. 2017. Vol. 23, num. 1, p. 63 – 74. DOI : 10.1002/lt.24628.

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Small Heterodimer Partner Deletion Prevents Hepatic Steatosis and When Combined With Farnesoid X Receptor Loss Protects Against Type 2 Diabetes in Mice

O. Akinrotimi; R. Riessen; P. Vanduyne; J. E. Park; Y. K. Lee et al. 

Hepatology. 2017. Vol. 66, num. 6, p. 1854 – 1865. DOI : 10.1002/hep.29305.

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Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

K. Gariani; D. Ryu; K. J. Menzies; H-S. Yi; S. Stein et al. 

Journal Of Hepatology. 2017. Vol. 66, num. 1, p. 132 – 141. DOI : 10.1016/j.jhep.2016.08.024.

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Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human beta-defensin-1 and-2 secretion by colonic epithelial cells

N. K. Lajczak; V. Saint-Criq; A. M. O’Dwyer; A. Perino; L. Adorini et al. 

Faseb Journal. 2017. Vol. 31, num. 9, p. 3848 – 3857. DOI : 10.1096/fj.201601365R.

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A multiscale study of the role of dynamin in the regulation of glucose uptake

R. Trouillon; M. C. Letizia; K. J. Menzies; L. Mouchiroud; J. Auwerx et al. 

Integrative Biology. 2017. Vol. 9, num. 10, p. 810 – 819. DOI : 10.1039/c7ib00015d.

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Ovary-specific depletion of the nuclear receptor Nr5a2 compromises expansion of the cumulus oophorus but not fertilization by intracytoplasmic sperm injection

K. Bertolin; M-C. Meinsohn; J. Suzuki; J. Gossen; K. Schoonjans et al. 

Biology Of Reproduction. 2017. Vol. 96, num. 6, p. 1231 – 1243. DOI : 10.1093/biolre/iox045.

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Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease

S. Stein; V. Lemos; P. Xu; H. Demagny; X. Wang et al. 

Journal Of Clinical Investigation. 2017. Vol. 127, num. 2, p. 583 – 592. DOI : 10.1172/Jci85499.

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2016

Journal Articles

LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer

P. Xu; M. H. Oosterveer; S. Stein; H. Demagny; D. Ryu et al. 

Genes & Development. 2016. Vol. 30, num. 11, p. 1255 – 1260. DOI : 10.1101/gad.277483.116.

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Eliciting the mitochondrial unfolded protein response via NAD+ repletion reverses fatty liver disease

K. L. Gariani; K. J. Menzies; D. Ryu; C. J. Wenger; X. Wang et al. 

Hepatology. 2016. Vol. 63, num. 4, p. 1190 – 1204. DOI : 10.1002/hep.28245.

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Bile acid-FXR alpha pathways regulate male sexual maturation in mice

M. Baptissart; E. Martinot; A. Vega; L. Sedes; B. Rouaisnel et al. 

Oncotarget. 2016. Vol. 7, num. 15, p. 19468 – 19482. DOI : 10.18632/oncotarget.7153.

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2015

Journal Articles

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors

C. A. Brighton; J. Rievaj; R. E. Kuhre; L. L. Glass; K. Schoonjans et al. 

Endocrinology. 2015. Vol. 156, num. 11, p. 3961 – 3970. DOI : 10.1210/en.2015-1321.

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Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

S. Fang; J. M. Suh; S. M. Reilly; E. Yu; O. Osborn et al. 

Nature Medicine. 2015. Vol. 21, num. 2, p. 71 – 77. DOI : 10.1038/nm.3760.

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The Sirt1 activator SRT3025 provides atheroprotection in Apoe(-/-) mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

M. X. Miranda; L. J. Van Tits; C. Lohmann; T. Arsiwala; S. Winnik et al. 

European Heart Journal. 2015. Vol. 36, num. 1, p. 51 – 59. DOI : 10.1093/eurheartj/ehu095.

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Women in Metabolism: Part I

B. Kahn; M. C. Simon; B. B. Zhang; J. R. Zierath; D. M. Muoio et al. 

Cell Metabolism. 2015. Vol. 21, num. 5, p. 654 – 657. DOI : 10.1016/j.cmet.2015.04.017.

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LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPAR gamma ligand synthesis

L. Lefevre; H. Authier; S. Stein; C. Majorel; B. Couderc et al. 

Nature Communications. 2015. Vol. 6, p. 6801. DOI : 10.1038/ncomms7801.

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Phosphorylation of the nuclear receptor co-repressor 1 by protein kinase B (PKB/Akt) switches its co-repressor targets in the liver

Y. S. Jo; D. Ryu; A. Maida; X. Wang; R. M. Evans et al. 

Hepatology (Baltimore, Md.). 2015. Vol. 62, num. 5, p. 1606 – 1618. DOI : 10.1002/hep.27907.

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Molecular basis for the regulation of the nuclear receptor LRH-1

S. Stein; K. Schoonjans 

Current Opinion In Cell Biology. 2015. Vol. 33, p. 26 – 34. DOI : 10.1016/j.ceb.2014.10.007.

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Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

M-S. Trabelsi; M. Daoudi; J. Prawitt; S. Ducastel; V. Touche et al. 

Nature Communications. 2015. Vol. 6, p. 7629. DOI : 10.1038/ncomms8629.

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Identification of the Link Between the Hypothalamo-Pituitary Axis and the Testicular Orphan Nuclear Receptor NR0B2 in Adult Male Mice

A. Vega; E. Martinot; M. Baptissart; A. De Haze; J-P. Saru et al. 

Endocrinology. 2015. Vol. 156, num. 2, p. 660 – 669. DOI : 10.1210/en.2014-1418.

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2014

Journal Articles

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

E. Pirinen; C. Canto; Y. S. Jo; L. Morato; H. Zhang et al. 

Cell Metabolism. 2014. Vol. 19, num. 6, p. 1034 – 1041. DOI : 10.1016/j.cmet.2014.04.002.

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Another Shp on the Horizon for Bile Acids

A. Perino; K. Schoonjans 

Cell Metabolism. 2014. Vol. 20, num. 2, p. 203 – 205. DOI : 10.1016/j.cmet.2014.07.019.

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Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP

A. Vega; M. Baptissart; E. Martinot; J-P. Saru; S. Baron et al. 

Expert Opinion On Therapeutic Targets. 2014. Vol. 18, num. 12, p. 1367 – 1376. DOI : 10.1517/14728222.2014.964209.

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Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

G. Lo Sasso; D. Ryu; L. Mouchiroud; S. C. Fernando; C. L. Anderson et al. 

PloS One. 2014. Vol. 9, num. 7, p. e102495. DOI : 10.1371/journal.pone.0102495.

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The Orphan Nuclear Receptor Nr5a2 Is Essential for Luteinization in the Female Mouse Ovary

K. Bertolin; J. Gossen; K. Schoonjans; B. D. Murphy 

Endocrinology. 2014. Vol. 155, num. 5, p. 1931 – 1943. DOI : 10.1210/en.2013-1765.

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SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport

S. Stein; M. H. Oosterveer; C. Mataki; P. Xu; V. Lemos et al. 

Cell metabolism. 2014. Vol. 20, num. 4, p. 603 – 13. DOI : 10.1016/j.cmet.2014.07.023.

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TGR5 reduces macrophage migration through mTOR-induced C/EBP beta differential translation

A. Perino; T. W. H. Pols; M. Nomura; S. Stein; R. Pellicciari et al. 

Journal Of Clinical Investigation. 2014. Vol. 124, num. 12, p. 5424 – 5436. DOI : 10.1172/JCI76289.

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Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas(G12V)-driven pancreatic tumourigenesis

M. Flandez; J. Cendrowski; M. Canamero; A. Salas; N. Del Pozo et al. 

Gut. 2014. Vol. 63, num. 4, p. 647 – 655. DOI : 10.1136/gutjnl-2012-304381.

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A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

D. Ryu; Y. S. Jo; G. Lo Sasso; S. Stein; H. Zhang et al. 

Cell metabolism. 2014. Vol. 20, num. 5, p. 856 – 869. DOI : 10.1016/j.cmet.2014.08.001.

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Bile Acids Alter Male Fertility Through G-Protein-Coupled Bile Acid Receptor 1 Signaling Pathways in Mice

M. Baptissart; A. Vega; E. Martinot; A. J. Pommier; S. M. Houten et al. 

Hepatology. 2014. Vol. 60, num. 3, p. 1054 – 1065. DOI : 10.1002/hep.27204.

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SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

G. Lo Sasso; K. J. Menzies; A. Mottis; A. Piersigilli; A. Perino et al. 

Plos One. 2014. Vol. 9, num. 7, p. e103573. DOI : 10.1371/journal.pone.0103573.

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Reviews

Vitamin D and energy homeostasis-of mice and men

R. Bouillon; G. Carmeliet; L. Lieben; M. Watanabe; A. Perino et al. 

Nature Reviews Endocrinology. 2014. Vol. 10, num. 2, p. 79 – 87. DOI : 10.1038/nrendo.2013.226.

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Hepatic glucose sensing and integrative pathways in the liver

M. H. Oosterveer; K. Schoonjans 

Cellular And Molecular Life Sciences. 2014. Vol. 71, num. 8, p. 1453 – 1467. DOI : 10.1007/s00018-013-1505-z.

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2013

Journal Articles

NR5A2 Regulates Lhb and Fshb Transcription in Gonadotrope-Like Cells In Vitro, but Is Dispensable for Gonadotropin Synthesis and Fertility In Vivo

J. Fortin; V. Kumar; X. Zhou; Y. Wang; J. Auwerx et al. 

Plos One. 2013. Vol. 8, num. 3, p. e59058. DOI : 10.1371/journal.pone.0059058.

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Probing the Binding Site of Bile Acids in TGR5

A. Macchiarulo; A. Gioiello; C. Thomas; T. W. H. Pols; R. Nuti et al. 

Acs Medicinal Chemistry Letters. 2013. Vol. 4, num. 12, p. 1158 – 1162. DOI : 10.1021/ml400247k.

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The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

L. Mouchiroud; R. H. Houtkooper; N. Moullan; E. Katsyuba; D. Ryu et al. 

Cell. 2013. Vol. 154, num. 2, p. 430 – 41. DOI : 10.1016/j.cell.2013.06.016.

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Metabolic Characterization of a Sirt5 deficient mouse model

J. Yu; S. Sadhukhan; L. G. Noriega; N. Moullan; B. He et al. 

Scientific Reports. 2013. Vol. 3, p. 2806. DOI : 10.1038/srep02806.

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Liver receptor homolog-1 is essential for pregnancy

C. Zhang; M. J. Large; R. Duggavathi; F. J. Demayo; J. P. Lydon et al. 

Nature Medicine. 2013. Vol. 19, num. 8, p. 1061 – 1066. DOI : 10.1038/nm.3192.

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The Receptor TGR5 Protects the Liver From Bile Acid Overload During Liver Regeneration in Mice

N. Pean; I. Doignon; I. Garcin; A. Besnard; B. Julien et al. 

Hepatology. 2013. Vol. 58, num. 4, p. 1451 – 1460. DOI : 10.1002/hep.26463.

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The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice

F. Alemi; D. P. Poole; J. Chiu; K. Schoonjans; F. Cattaruzza et al. 

Gastroenterology. 2013. Vol. 144, num. 1, p. 145 – 154. DOI : 10.1053/j.gastro.2012.09.055.

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2012

Journal Articles

LRH-1-dependent glucose sensing determines intermediary metabolism in liver

M. H. Oosterveer; C. Mataki; H. Yamamoto; T. Harach; N. Moullan et al. 

Journal of Clinical Investigation. 2012. Vol. 122, num. 8, p. 2817 – 2826. DOI : 10.1172/JCI62368.

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Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

P. J. Fernandez-Marcos; E. H. Jeninga; C. Canto; T. Harach; V. C. J. de Boer et al. 

Scientific Reports. 2012. Vol. 2, p. 425. DOI : 10.1038/srep00425.

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Bile Acid Binding Resin Improves Metabolic Control through the Induction of Energy Expenditure

M. Watanabe; K. Morimoto; S. M. Houten; N. Kaneko-Iwasaki; T. Sugizaki et al. 

PloS One. 2012. Vol. 7, num. 8, p. e38286. DOI : 10.1371/journal.pone.0038286.

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The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

C. Cantó; R. Houtkooper; E. Pirinen; D. Youn; M. Oosterveer et al. 

Cell Metabolism. 2012. Vol. 15, num. 6, p. 838 – 847. DOI : 10.1016/j.cmet.2012.04.022.

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Systems Genetics of Metabolism : The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits

P. Andreux; E. G. Williams; H. Koutnikova; R. Houtkooper; M-F. Champy et al. 

Cell. 2012. Vol. 150, num. 6, p. 1287 – 1299. DOI : 10.1016/j.cell.2012.08.012.

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TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

T. Harach; T. W. H. Pols; M. Nomura; A. Maida; M. Watanabe et al. 

Scientific Reports. 2012. Vol. 2, p. 430. DOI : 10.1038/srep00430.

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2011

Journal Articles

The bile acid membrane receptor TGR5: a valuable metabolic target

T. W. H. Pols; L. G. Noriega; M. Nomura; J. Auwerx; K. Schoonjans 

Digestive diseases (Basel, Switzerland). 2011. Vol. 29, num. 1, p. 37 – 44. DOI : 10.1159/000324126.

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Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion

A. Wiederkehr; S. Gergo; D. Akhmedov; C. Mataki; C. W. Heizmann et al. 

Cell Metabolism. 2011. Vol. 13, p. 601 – 611. DOI : 10.1016/j.cmet.2011.03.015.

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TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

T. Pols; M. Nomura; T. Harach; G. Lo Sasso; M. H. Oosterveer et al. 

Cell Metabolism. 2011. Vol. 14, num. 6, p. 747 – 757. DOI : 10.1016/j.cmet.2011.11.006.

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Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

M. Watanabe; Y. Horai; S. M. Houten; K. Morimoto; T. Sugizaki et al. 

Journal of Biological Chemistry. 2011. Vol. 286, num. 30, p. 26913 – 20. DOI : 10.1074/jbc.M111.248203.

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NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

H. Yamamoto; E. G. Williams; L. Mouchiroud; C. Canto Alvarez; W. Fan et al. 

Cell. 2011. Vol. 147, num. 4, p. 827 – 839. DOI : 10.1016/j.cell.2011.10.017.

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Local glucocorticoid production in the mouse lung is induced by immune cell stimulation

N. Hostettler; P. Bianchi; C. Gennari-Moser; D. Kassahn; K. Schoonjans et al. 

Allergy. 2011. Vol. 67, num. 2, p. 227 – 234. DOI : 10.1111/j.1398-9995.2011.02749.x.

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PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

P. Bai; C. Canto Alvarez; H. Oudart; A. Brunyánszki; Y. Cen et al. 

Cell Metabolism. 2011. Vol. 13, num. 4, p. 461 – 468. DOI : 10.1016/j.cmet.2011.03.004.

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The metabolic footprint of aging in mice

R. H. Houtkooper; C. Argmann; S. M. Houten; C. Cantó; E. H. Jeninga et al. 

Scientific Reports. 2011. Vol. 1, p. 134. DOI : 10.1038/srep00134.

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Lack of IL-2 in PPAR-alpha deficient mice triggers allergic contact dermatitis by affecting regulatory T cells

S. Dubrac; A. Elentner; K. Schoonjans; J. Auwerx; M. Schmuth 

European journal of immunology. 2011. Vol. 41, num. 7, p. 1980 – 1991. DOI : 10.1002/eji.201041357.

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Reviews

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

T. W. H. Pols; L. G. Noriega; M. Nomura; J. Auwerx; K. Schoonjans 

Journal of hepatology. 2011. Vol. 54, num. 6, p. 1263 – 1272. DOI : 10.1016/j.jhep.2010.12.004.

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Emerging actions of the nuclear receptor LRH-1 in the gut

F. Marcos; P. Jose; J. Auwerx; K. Schoonjans 

Biochimica et Biophysica Acta. 2011. Vol. 1812, num. 8, p. 947 – 955. DOI : 10.1016/j.bbadis.2010.12.010.

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2010

Journal Articles

The Intestinal Nuclear Receptor Signature With Epithelial Localization Patterns and Expression Modulation in Tumors

S. Modica; F. Gofflot; S. Murzilli; A. D’Orazio; L. Salvatore et al. 

Gastroenterology. 2010. Vol. 138, p. 636 – U295. DOI : 10.1053/j.gastro.2009.09.060.

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The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr

A. Milona; B. M. Owen; S. van Mil; D. Dormann; C. Mataki et al. 

American Journal Of Physiology-Gastrointestinal And Liver Physiology. 2010. Vol. 298, p. G151 – G158. DOI : 10.1152/ajpgi.00336.2009.

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Redefining the TGR5 triterpenoid binding pocket at the C-3 position

C. Genet; C. Schmidt; A. Strehle; K. Schoonjans; J. Auwerx et al. 

Chemmedchem. 2010. Vol. 5, num. 12, p. 1983 – 1988. DOI : 10.1002/cmdc.201000329.

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Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

T. W. Pols; J. Auwerx; K. Schoonjans 

Gastroenterol Clin Biol. 2010. Vol. 34, num. 4-5, p. 270 – 3. DOI : 10.1016/j.gcb.2010.03.009.

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Histone methyl transferases and demethylases; can they link metabolism and transcription?

R. Teperino; K. Schoonjans; J. Auwerx 

Cell Metabolism. 2010. Vol. 12, num. 4, p. 321 – 327. DOI : 10.1016/j.cmet.2010.09.004.

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Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

E. H. Jeninga; K. Schoonjans; J. Auwerx 

Oncogene. 2010. Vol. 29, num. 33, p. 4617 – 24. DOI : 10.1038/onc.2010.206.

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2009

Journal Articles

The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice

D. H. Volle; M. Decourteix; E. Garo; J. McNeilly; P. Fenichel et al. 

Journal Of Clinical Investigation. 2009. Vol. 119, num. 12, p. 3752 – 3764. DOI : 10.1172/JCI38521.

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Discovery of 6alpha-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity

R. Pellicciari; A. Gioiello; A. Macchiarulo; C. Thomas; E. Rosatelli et al. 

Journal of Medicinal Chemistry. 2009. Vol. 52, num. 24, p. 7958 – 7961. DOI : 10.1021/jm901390p.

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Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes

C. Genet; A. Strehle; C. Schmidt; G. Boudjelal; A. Lobstein et al. 

Journal of medicinal chemistry. 2009. Vol. 53, num. 1, p. 178 – 90. DOI : 10.1021/jm900872z.

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TGR5-mediated bile acid sensing controls glucose homeostasis

C. Thomas; A. Gioiello; L. Noriega; A. Strehle; J. Oury et al. 

Cell Metabolism. 2009. Vol. 10, num. 3, p. 167 – 177. DOI : 10.1016/j.cmet.2009.08.001.

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2008

Journal Articles

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}

A. Coste; J-F. Louet; M. Lagouge; C. Lerin; M. C. Antal et al. 

Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2008. Vol. 105, num. 44, p. 17187 – 92. DOI : 10.1073/pnas.0808207105.

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Liver receptor homolog 1 is essential for ovulation

R. Duggavathi; D. H. Volle; C. Mataki; M. C. Antal; N. Messaddeq et al. 

Genes & development. 2008. Vol. 22, num. 14, p. 1871 – 6. DOI : 10.1101/gad.472008.

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Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5

A. Macchiarulo; A. Gioiello; C. Thomas; A. Massarotti; R. Nuti et al. 

Journal of chemical information and modeling. 2008. Vol. 48, num. 9, p. 1792 – 801. DOI : 10.1021/ci800196h.

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Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies

H. Sato; A. Macchiarulo; C. Thomas; A. Gioiello; M. Une et al. 

Journal of medicinal chemistry. 2008. Vol. 51, num. 6, p. 1831 – 41. DOI : 10.1021/jm7015864.

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Reviews

Targeting bile-acid signalling for metabolic diseases

C. Thomas; R. Pellicciari; M. Pruzanski; J. Auwerx; K. Schoonjans 

Nature reviews. Drug discovery. 2008. Vol. 7, num. 8, p. 678 – 93. DOI : 10.1038/nrd2619.

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2007

Journal Articles

Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure

N. Dali-Youcef; C. Mataki; A. Coste; N. Messaddeq; S. Giroud et al. 

Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2007. Vol. 104, num. 25, p. 10703 – 8. DOI : 10.1073/pnas.0611568104.

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The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice

D. H. Volle; R. Duggavathi; B. C. Magnier; S. M. Houten; C. L. Cummins et al. 

Genes & development. 2007. Vol. 21, num. 3, p. 303 – 15. DOI : 10.1101/gad.409307.

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Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5

R. Pellicciari; H. Sato; A. Gioiello; G. Costantino; A. Macchiarulo et al. 

Journal of medicinal chemistry. 2007. Vol. 50, num. 18, p. 4265 – 8. DOI : 10.1021/jm070633p.

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LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease

A. Coste; L. Dubuquoy; R. Barnouin; J-S. Annicotte; B. Magnier et al. 

Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2007. Vol. 104, num. 32, p. 13098 – 103. DOI : 10.1073/pnas.0702440104.

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Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1

C. Mataki; B. C. Magnier; S. M. Houten; J-S. Annicotte; C. Argmann et al. 

Molecular and cellular biology. 2007. Vol. 27, num. 23, p. 8330 – 9. DOI : 10.1128/MCB.00852-07.

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Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function

S. Dubrac; P. Stoitzner; D. Pirkebner; A. Elentner; K. Schoonjans et al. 

Journal of immunology (Baltimore, Md. : 1950). 2007. Vol. 178, num. 7, p. 4362 – 72. DOI : 10.4049/​jimmunol.178.7.4362.

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Sirtuins: the ‘magnificent seven’, function, metabolism and longevity

N. Dali-Youcef; M. Lagouge; S. Froelich; C. Koehl; K. Schoonjans et al. 

Annals of medicine. 2007. Vol. 39, num. 5, p. 335 – 45. DOI : 10.1080/07853890701408194.

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Sirtuin functions in health and disease

H. Yamamoto; K. Schoonjans; J. Auwerx 

Molecular endocrinology (Baltimore, Md.). 2007. Vol. 21, num. 8, p. 1745 – 55. DOI : 10.1210/me.2007-0079.

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2006

Journal Articles

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

M. Watanabe; S. M. Houten; C. Mataki; M. A. Christoffolete; B. W. Kim et al. 

Nature. 2006. Vol. 439, num. 7075, p. 484 – 9. DOI : 10.1038/nature04330.

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Deletion of peroxisome proliferator-activated receptor-alpha induces an alteration of cardiac functions

C. Loichot; L. Jesel; A. Tesse; A. Tabernero; K. Schoonjans et al. 

American journal of physiology. Heart and circulatory physiology. 2006. Vol. 291, num. 1, p. H161 – 6. DOI : 10.1152/ajpheart.01065.2004.

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2005

Journal Articles

Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation

K. Schoonjans; L. Dubuquoy; J. Mebis; E. Fayard; O. Wendling et al. 

Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2005. Vol. 102, num. 6, p. 2058 – 62. DOI : 10.1073/pnas.0409756102.

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Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection

S. Dharancy; M. Malapel; G. Perlemuter; T. Roskams; Y. Cheng et al. 

Gastroenterology. 2005. Vol. 128, num. 2, p. 334 – 42. DOI : 10.1053/j.gastro.2004.11.016.

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2004

Journal Articles

Expression of the liver X receptor alpha and beta in embryonic and adult mice

J-S. Annicotte; K. Schoonjans; J. Auwerx 

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. 2004. Vol. 277, num. 2, p. 312 – 6. DOI : 10.1002/ar.a.20015.

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Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes

M. Schmuth; C. M. Haqq; W. J. Cairns; J. C. Holder; S. Dorsam et al. 

The Journal of investigative dermatology. 2004. Vol. 122, num. 4, p. 971 – 83. DOI : 10.1111/j.0022-202X.2004.22412.x.

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Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma

K. T. Dalen; K. Schoonjans; S. M. Ulven; M. S. Weedon-Fekjaer; T. G. Bentzen et al. 

Diabetes. 2004. Vol. 53, num. 5, p. 1243 – 52. DOI : 10.2337/diabetes.53.5.1243.

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Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation

O. A. Botrugno; E. Fayard; J-S. Annicotte; C. Haby; T. Brennan et al. 

Molecular cell. 2004. Vol. 15, num. 4, p. 499 – 509. DOI : 10.1016/j.molcel.2004.07.009.

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LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis

E. Fayard; J. Auwerx; K. Schoonjans 

Trends in cell biology. 2004. Vol. 14, num. 5, p. 250 – 60. DOI : 10.1016/j.tcb.2004.03.008.

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2003

Journal Articles

Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development

J-S. Annicotte; E. Fayard; G. H. Swift; L. Selander; H. Edlund et al. 

Molecular and cellular biology. 2003. Vol. 23, num. 19, p. 6713 – 24. DOI : 10.1128/MCB.23.19.6713-6724.2003.

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Liver receptor homolog 1 controls the expression of carboxyl ester lipase

E. Fayard; K. Schoonjans; J-S. Annicotte; J. Auwerx 

Journal of Biological Chemistry. 2003. Vol. 278, num. 37, p. 35725 – 31. DOI : 10.1074/jbc.M302370200.

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2002

Journal Articles

The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity

C. Brendel; K. Schoonjans; O. A. Botrugno; E. Treuter; J. Auwerx 

Molecular endocrinology (Baltimore, Md.). 2002. Vol. 16, num. 9, p. 2065 – 76. DOI : 10.1210/me.2001-0194.

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Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero

M. Schmuth; K. Schoonjans; Q-C. Yu; J. W. Fluhr; D. Crumrine et al. 

The Journal of investigative dermatology. 2002. Vol. 119, num. 6, p. 1298 – 303. DOI : 10.1046/j.1523-1747.2002.19605.x.

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Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I

K. Schoonjans; J-S. Annicotte; T. Huby; O. A. Botrugno; E. Fayard et al. 

EMBO reports. 2002. Vol. 3, num. 12, p. 1181 – 7. DOI : 10.1093/embo-reports/kvf238.

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Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models

M. Y. Sheu; A. J. Fowler; J. Kao; M. Schmuth; K. Schoonjans et al. 

The Journal of investigative dermatology. 2002. Vol. 118, num. 1, p. 94 – 101. DOI : 10.1046/j.0022-202x.2001.01626.x.

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Activation of the peroxisome proliferator-activated receptor alpha protects against myocardial ischaemic injury and improves endothelial vasodilatation

A. Tabernero; K. Schoonjans; L. Jesel; I. Carpusca; J. Auwerx et al. 

BMC pharmacology. 2002. Vol. 2, p. 1 – 10. DOI : 10.1186/1471-2210-2-10.

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Progesterone receptor knockout mice have an improved glucose homeostasis secondary to beta-cell proliferation

F. Picard; M. Wanatabe; K. Schoonjans; J. Lydon; B. W. O’Malley et al. 

Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2002. Vol. 99, num. 24, p. 15644 – 8. DOI : 10.1073/pnas.202612199.

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A sharper image of SHP

K. Schoonjans; J. Auwerx 

Nature medicine. 2002. Vol. 8, num. 8, p. 789 – 91. DOI : 10.1038/nm0802-789.

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The role of PPAR-gamma/RXR-alpha heterodimers in the regulation of human trophoblast invasion

T. Fournier; L. Pavan; A. Tarrade; K. Schoonjans; J. Auwerx et al. 

Annals of the New York Academy of Sciences. 2002. Vol. 973, p. 26 – 30. DOI : 10.1111/j.1749-6632.2002.tb04601.x.

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2001

Journal Articles

PPAR gamma/RXR alpha heterodimers are involved in human CG beta synthesis and human trophoblast differentiation

A. Tarrade; K. Schoonjans; J. Guibourdenche; J. M. Bidart; M. Vidaud et al. 

Endocrinology. 2001. Vol. 142, num. 10, p. 4504 – 14. DOI : 10.1210/en.142.10.4504.

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PPARgamma/RXRalpha heterodimers control human trophoblast invasion

A. Tarrade; K. Schoonjans; L. Pavan; J. Auwerx; C. Rochette-Egly et al. 

The Journal of clinical endocrinology and metabolism. 2001. Vol. 86, num. 10, p. 5017 – 24. DOI : 10.1210/jc.86.10.5017.

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Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer: A basis for new therapeutic strategies

P. Desreumaux; L. Dubuquoy; S. Nutten; M. Peuchmaur; W. Englaro et al. 

The Journal of experimental medicine. 2001. Vol. 193, num. 7, p. 827 – 38. DOI : 10.1084/jem.193.7.827.

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Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha

K. Hanley; L. G. Kömüves; D. C. Ng; K. Schoonjans; S. S. He et al. 

Journal of Biological Chemistry. 2001. Vol. 275, num. 15, p. 11484 – 91. DOI : 10.1074/jbc.275.15.11484.

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Xol INXS: role of the liver X and the farnesol X receptors

E. Fayard; K. Schoonjans; J. Auwerx 

Current opinion in lipidology. 2001. Vol. 12, num. 2, p. 113 – 20. DOI : 10.1097/00041433-200104000-00004.

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2000

Journal Articles

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

T. T. Lu; M. Makishima; J. J. Repa; K. Schoonjans; T. A. Kerr et al. 

Molecular cell. 2000. Vol. 6, num. 3, p. 507 – 15. DOI : 10.1016/S1097-2765(00)00050-2.

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Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes

K. Schoonjans; L. Gelman; C. Haby; M. Briggs; J. Auwerx 

Journal of molecular biology. 2000. Vol. 304, num. 3, p. 323 – 34. DOI : 10.1006/jmbi.2000.4218.

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Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in normal human pancreatic islet cells

M. Dubois; F. Pattou; J. Kerr-Conte; V. Gmyr; B. Vandewalle et al. 

Diabetologia. 2000. Vol. 43, num. 9, p. 1165 – 9. DOI : 10.1007/s001250051508.

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Thiazolidinediones: an update

K. Schoonjans; J. Auwerx 

Lancet. 2000. Vol. 355, num. 9208, p. 1008 – 10. DOI : 10.1016/S0140-6736(00)90002-3.

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Sterols and gene expression: control of affluence

K. Schoonjans; C. Brendel; D. Mangelsdorf; J. Auwerx 

Biochimica et Biophysica Acta. 2000. Vol. 1529, p. 114 – 125. DOI : 10.1016/S1388-1981(00)00141-4.

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1999

Journal Articles

Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism

L. Fajas; K. Schoonjans; L. Gelman; J. B. Kim; J. Najib et al. 

Molecular and cellular biology. 1999. Vol. 19, num. 8, p. 5495 – 503. DOI : 10.1128/MCB.19.8.5495.

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3-Hydroxy-3-methylglutaryl CoA reductase inhibitors reduce serum triglyceride levels through modulation of apolipoprotein C-III and lipoprotein lipase

K. Schoonjans; J. Peinado-Onsurbe; J. C. Fruchart; A. Tailleux; C. Fiévet et al. 

FEBS letters. 1999. Vol. 452, num. 3, p. 160 – 4. DOI : 10.1016/S0014-5793(99)00632-8.

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Reviews

Transcriptional regulation of cholesterol metabolism [Regulation transcriptionnelle du metabolisme du cholesterol]

C. Brendel; J-C. Fruchart; J. Auwerx; K. Schoonjans 

Medecine/Sciences. 1999. Vol. 15, num. 1, p. 56 – 62.

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1998

Reviews

Mechanism of action of fibrates on lipid and lipoprotein metabolism

B. Staels; J. Dallongeville; J. Auwerx; K. Schoonjans; E. Leitersdorf et al. 

Circulation. 1998. Vol. 98, num. 19, p. 2088 – 2093. DOI : 10.1161/01.CIR.98.19.2088.

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PPARgamma activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes

G. Martin; K. Schoonjans; B. Staels; J. Auwerx 

Atherosclerosis. 1998. Vol. 137 Suppl, p. S75 – 80. DOI : 10.1016/S0021-9150(97)00315-8.

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1997

Journal Articles

The organization, promoter analysis, and expression of the human PPARgamma gene

L. Fajas; D. Auboeuf; E. Raspé; K. Schoonjans; A. M. Lefebvre et al. 

Journal of Biological Chemistry. 1997. Vol. 272, num. 30, p. 18779 – 89. DOI : 10.1074/jbc.272.30.18779.

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Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators

G. Martin; K. Schoonjans; A. M. Lefebvre; B. Staels; J. Auwerx 

Journal of Biological Chemistry. 1997. Vol. 272, num. 45, p. 28210 – 7. DOI : 10.1074/jbc.272.45.28210.

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Reviews

Peroxisome proliferator-activated receptors, orphans with ligands and functions

K. Schoonjans; G. Martin; B. Staels; J. Auwerx 

Current opinion in lipidology. 1997. Vol. 8, num. 3, p. 159 – 66. DOI : 10.1097/00041433-199706000-00006.

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The effects of fibrates and thiazolidinediones on plasma triglyceride metabolism are mediated by distinct peroxisome proliferator activated receptors (PPARs)

B. Staels; K. Schoonjans; J. C. Fruchart; J. Auwerx 

Biochimie. 1997. Vol. 79, num. 2-3, p. 95 – 9. DOI : 10.1016/S0300-9084(97)81497-6.

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1996

Journal Articles

Retinoids increase human apolipoprotein A-11 expression through activation of the retinoid X receptor but not the retinoic acid receptor

N. Vu-Dac; K. Schoonjans; V. Kosykh; J. Dallongeville; R. A. Heyman et al. 

Molecular and cellular biology. 1996. Vol. 16, num. 7, p. 3350 – 3360. DOI : 10.1128/mcb.16.7.3350.

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PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene

K. Schoonjans; J. Peinado-Onsurbe; A. M. Lefebvre; R. A. Heyman; M. Briggs et al. 

The EMBO journal. 1996. Vol. 15, num. 19, p. 5336 – 5548. DOI : 10.1002/j.1460-2075.1996.tb00918.x.

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Reviews

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

K. Schoonjans; B. Staels; J. Auwerx 

Journal of lipid research. 1996. Vol. 37, num. 5, p. 907 – 925. DOI : 10.1016/S0022-2275(20)42003-6.

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The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation

K. Schoonjans; B. Staels; J. Auwerx 

Biochimica et biophysica acta. 1996. Vol. 1302, num. 2, p. 93 – 109. DOI : 10.1016/0005-2760(96)00066-5.

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Transcriptional control of triglyceride metabolism: fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR

J. Auwerx; K. Schoonjans; J. C. Fruchart; B. Staels 

Atherosclerosis. 1996. Vol. 124 Suppl, p. S29 – 37. DOI : 10.1016/0021-9150(96)05854-6.

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Regulation of triglyceride metabolism by PPARs: fibrates and thiazolidinediones have distinct effects

J. Auwerx; K. Schoonjans; J. C. Fruchart; B. Staels 

Journal of atherosclerosis and thrombosis. 1996. Vol. 3, num. 2, p. 81 – 89. DOI : 10.5551/jat1994.3.81.

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1995

Journal Articles

Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter

K. Schoonjans; M. Watanabe; H. Suzuki; A. Mahfoudi; G. Krey et al. 

Journal of Biological Chemistry. 1995. Vol. 270, num. 33, p. 19269 – 76. DOI : 10.1074/jbc.270.33.19269.

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Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor

N. Vu-Dac; K. Schoonjans; V. Kosykh; J. Dallongeville; J. C. Fruchart et al. 

The Journal of clinical investigation. 1995. Vol. 96, num. 2, p. 741 – 50. DOI : 10.1172/JCI118118.

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1994

Journal Articles

Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element

N. Vu-Dac; K. Schoonjans; B. Laine; J. C. Fruchart; J. Auwerx et al. 

Journal of Biological Chemistry. 1994. Vol. 269, num. 49, p. 31012 – 31018. DOI : 10.1016/S0021-9258(18)47383-8.

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1993

Journal Articles

A Fos-Jun element in the first intron of an alpha 2u-globulin gene

P. van Dijck; K. Schoonjans; P. Sassone-Corsi; J. Auwerx; G. Verhoeven 

Molecular and cellular biochemistry. 1993. Vol. 125, num. 2, p. 127 – 36. DOI : 10.1007/BF00936441.

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Developmental extinction of liver lipoprotein lipase mRNA expression might be regulated by an NF-1-like site

K. Schoonjans; B. Staels; P. Devos; J. Szpirer; C. Szpirer et al. 

FEBS letters. 1993. Vol. 329, num. 1-2, p. 89 – 95. DOI : 10.1016/0014-5793(93)80200-E.

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Acyl-CoA synthetase mRNA expression is controlled by fibric-acid derivatives, feeding and liver proliferation

K. Schoonjans; B. Staels; P. Grimaldi; J. Auwerx 

European journal of biochemistry / FEBS. 1993. Vol. 216, num. 2, p. 615 – 22. DOI : 10.1111/j.1432-1033.1993.tb18181.x.

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1992

Reviews

Lipoprotein lipase: recent contributions from molecular biology

J. Auwerx; P. Leroy; K. Schoonjans 

Critical reviews in clinical laboratory sciences. 1992. Vol. 29, num. 3-4, p. 243 – 68. DOI : 10.3109/10408369209114602.

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1991

Reviews

New insights into apolipoprotein B and low density lipoprotein physiology; implications for atherosclerosis

J. Auwerx; K. Schoonjans 

Acta clinica Belgica. 1991. Vol. 46, num. 6, p. 355 – 358. DOI : 10.1080/17843286.1991.11718190.

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