Since the beginning of his career, he has worked on ion channels, synaptic plasticity and focused on neural microcircuitry, applying a broad range of anatomical, physiological, biophysical and molecular techniques, and pioneering the multi-neuron patch-clamp approach. His best-known discoveries are the principles of Spike Timing Dependent Plasticity (STDP), Redistribution of Synaptic Efficacy (RSE), and Long-Term Microcircuit Plasticity (LTMP). He has also worked intensively with theoretical neuroscientists to develop the concept of “liquid computing”, a novel technique for handling real time continuous input to recurrent neural networks. He has also been active in autism research, a field in which he has co-developed the “Intense World Theory of Autism”.
In 2005 Henry Markram founded the Blue Brain Project with the aim to build and simulate biologically founded brain circuits.