The Laboratory for the Neural Basis of Brain States (LNBBS) is part of EPFL Blue Brain Project, a Swiss national brain research initiative that applies advanced neuroinformatics, data analytics, high-performance computing infrastructure and simulation-based approaches to the challenge of digitally reconstructing and simulating the mouse brain.

The LNBBS is directed by Prof. Sean Hill and based at the Campus Biotech in Geneva, Switzerland. The laboratory focuses on understanding cortical and thalamocortical structure and function and the relationship to states of the brain including wakefulness, sleep and anesthesia. The group employs biophysically-detailed computational models and large-scale simulations to investigate the cellular and synaptic mechanisms underlying brain states in health and disease.

Professor Hill is primarily based in Toronto where he is the inaugural Director of the Krembil Centre for Neuroinformatics at the Centre for Addiction and Mental Health (CAMH). He is also a Director at the EPFL Blue Brain Project where he founded the Neuroinformatics team, which provides the informatics infrastructure to organize, search, access and analyze heterogeneous neuroscience data including multi-scale brain atlases, machine learning, machine vision, data and text mining, data analysis and data-driven ontologies.

Dr. Sean Hill is the inaugural Director of the Krembil Centre for Neuroinformatics at the Centre for Addiction and Mental Health (CAMH) in Toronto, Canada and Professor of Psychiatry at the University of Toronto. He obtained his Ph.D. in Computational Neuroscience at the University of Lausanne, Switzerland.

The Krembil Centre for Neuroinformatics (krembilneuroinformatics.ca) is transforming our understanding of mental health by organizing, integrating, analyzing, visualizing and modelling data across all levels of the brain —from genes to circuits to behaviour. Employing state-of-the-art data science, artificial intelligence and multi-scale modelling approaches, the centre aims to accelerate the data-driven definition of mental health, predict patient trajectories and improve clinical care.

Under Dr. Hill’s leadership, the Krembil Centre for Neuroinformatics applies state-of-the-art data science, machine learning and multi-scale computational modeling to accelerate the diagnosis, prediction and treatment of brain disorders.