Deplancke lab – Laboratory of Systems Biology and Genetics

©EPFL, Deplancke's lab

The central research focus of the Laboratory of Systems Biology and Genetics (LSBG) is to understand genome organization, regulation, and variation and is broadly partitioned according to three major research pillars:


In the “Adipo” pillar, we are characterizing the regulatory mechanisms driving mesenchymal stromal cell heterogeneity and function in adipose biology and other metabolically relevant processes.


In the “Geno” pillar, we are examining how variation in the regulatory code affects molecular and organismal diversity.


In the “Techo” pillar, we are developing novel microfluidic, high-throughput sequencing, single cell omic, and computational approaches, which are used to address biological questions in the other two pillars.


Latest news


Presentation of Prof. Bart Deplancke with laudation by Prof. Didier Trono at the Cloëtta Prize Ceremony in Zurich.


A warm welcome to two new PhD students who have recently joined our lab: Jose Antonio Vasquez Porto Viso and Antoni Gralak.


We thank Dr. Wanze Chen and Dr. Marjan Biocanin for their precious collaboration with our lab for the past few years, and we wish them all the best for their bright scientific careers ahead!


Congratulations to Prof. Bart Deplancke for being awarded the eminent 2021 Cloëtta Prize!


Alithea Genomics wins CHF 150,000 from Venture Kick to advance their BRB-seq kit offering and continue to expand the throughput and cost-efficiency of RNA-seq. Congratulations!

Our creations / innovations / inventions


Catalyze4life’s mission is to support translational projects and to educate to innovate

Junior European Drosophilia Investigators (JEDI)

The JEDIs are early career scientists working on Drosophila melanogaster in Europe.


Head of laboratory: Bart Deplancke
Office Number: SV 3823
Administration: Joanna Rusnok
Office Number: SV 3515