Deplancke lab – Laboratory of Systems Biology and Genetics
The central research focus of the Laboratory of Systems Biology and Genetics (LSBG) is to understand genome organization, regulation, and variation and is broadly partitioned according to three major research pillars:
In the “Adipo” pillar, we are characterizing the regulatory mechanisms driving mesenchymal stromal cell heterogeneity and function in adipose biology and other metabolically relevant processes.
In the “Geno” pillar, we are examining how variation in the regulatory code affects molecular and organismal diversity.
In the “Techo” pillar, we are developing novel microfluidic, high-throughput sequencing, single cell omic, and computational approaches, which are used to address biological questions in the other two pillars.
Bioengineers in Deplancke’s group have found a way to radically increase the efficiency of single-cell RNA-sequencing, a powerful tool that can “read” the genetic profile of an individual cell. Published in Nature Methods, the method is dubbed “DisCo” for “deterministic, mRNA-capture bead and cell co-encapsulation dropleting system”.
Presentation of Prof. Bart Deplancke with laudation by Prof. Didier Trono at the Cloëtta Prize Ceremony in Zurich.
A warm welcome to two new PhD students who have recently joined our lab: Jose Antonio Vasquez Porto Viso and Antoni Gralak.
We thank Dr. Wanze Chen and Dr. Marjan Biocanin for their precious collaboration with our lab for the past few years, and we wish them all the best for their bright scientific careers ahead!