2023
Journal Articles
Computational design of dynamic receptor—peptide signaling complexes applied to chemotaxis
Nature Communications. 2023-05-19. Vol. 14, num. Article number: 2875. DOI : 10.1038/s41467-023-38491-9.Uncovering and engineering the mechanical properties of the adhesion GPCR ADGRG1 GAIN domain
2023-04-06. DOI : 10.1101/2023.04.05.535724.2022
Journal Articles
Computationally designed GPCR quaternary structures bias signaling pathway activation
Nature Communications. 2022-11-11. Vol. 13, num. 1, p. 6826. DOI : 10.1038/s41467-022-34382-7.Computational design of ultrasensitive flexible peptide:receptor signaling complexes for enhanced chemotaxis
bioRxiv. 2022-04-01. DOI : 10.1101/2022.03.30.486413.Reviews
Deep learning approaches for conformational flexibility and switching properties in protein design
Frontiers in Molecular Biosciences. 2022-08-10. Vol. 9, p. 928534. DOI : 10.3389/fmolb.2022.928534.Working Papers
Computational rewiring of allosteric pathways reprograms GPCR selective responses to ligands
2022-03-31
2021
Journal Articles
Computational design of highly signaling active membrane receptors through de novo solvent-mediated allosteric networks
bioRxiv. 2021-10-01. DOI : 10.1101/2021.09.29.462228.Computationally-guided tuning of ligand sensitivity in a GPCR-based sensor
bioRxiv. 2021-09-24. DOI : 10.1101/2021.09.21.461282.Computationally designed GPCR quaternary structures bias signaling pathway activation
bioRxiv. 2021-09-23. DOI : 10.1101/2021.09.23.461493.Conference Papers
Computationally designed GPCR quaternary structures bias signaling pathway activation
2021-10-01. p. 51-51.Theses
Reprogramming G Protein-Coupled Receptor Structure, Function And Signaling By Computational Design
Lausanne, EPFL, 2021.Patents
Method for generating variants of a protein
US2023227534; EP4004925; WO2021018756; EP3772065.
2021.Method for generating variants of a protein
US2023227534; EP4004925; WO2021018756; EP3772065.
2021.