Computational design of dynamic receptor—peptide signaling complexes applied to chemotaxis

R. Jefferson; A. Oggier; A. Füglistaler; N. Camviel; M. Hijazi et al. 

Uncovering and engineering the mechanical properties of the adhesion GPCR ADGRG1 GAIN domain

L. Dumas; M. Marfoglia; B. Yang; M. Hijazi; A. Larabi et al. 

Computationally designed GPCR quaternary structures bias signaling pathway activation

J. S. Paradis; X. Feng; B. Murat; R. E. Jefferson; B. Sokrat et al. 

Computational design of ultrasensitive flexible peptide:receptor signaling complexes for enhanced chemotaxis

R. Jefferson; A. Oggier; A. Fuglistaler; N. Camviel; M. Hijazi et al. 

Deep learning approaches for conformational flexibility and switching properties in protein design

L. S. P. Rudden; M. Hijazi; P. Barth 

Computational rewiring of allosteric pathways reprograms GPCR selective responses to ligands

D. Keri; M. Hijazi; A. Oggier; P. Barth 

Computational design of highly signaling active membrane receptors through de novo solvent-mediated allosteric networks

-Y. Chen; J. Lai; J. Wang; A. Russell; K. Conners et al. 

Computationally-guided tuning of ligand sensitivity in a GPCR-based sensor

D. Keri; R. B. Cola; Z. Kagiampaki; P. Tommaso; P. Barth 

Computationally designed GPCR quaternary structures bias signaling pathway activation

J. S. Paradis; X. Feng; B. Murat; R. Jefferson; M. Szpakowska et al. 

Computationally designed GPCR quaternary structures bias signaling pathway activation

R. Jefferson; X. Feng; P. Barth; J. Paradis; M. Bouvier et al. 

Reprogramming G Protein-Coupled Receptor Structure, Function And Signaling By Computational Design

Method for generating variants of a protein

P. Barth 

Method for generating variants of a protein

P. Barth 

Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane

J. Yin; K-Y. M. Chen; M. J. Clark; M. Hijazi; P. Kumari et al. 

Macromolecular modeling and design in Rosetta: recent methods and frameworks

J. K. Leman; B. D. Weitzner; S. M. Lewis; J. Adolf-Bryfogle; N. Alam et al. 

Computational design of G Protein-Coupled Receptor allosteric signal transductions

K-Y. M. Chen; D. Keri; P. Barth 

An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function

L. Wang; K. Pang; K. Han; C. J. Adamski; W. Wang et al. 

Reprogramming G protein coupled receptor structure and function

D. Keri; P. Barth 

Computational design of orthogonal membrane receptor-effector switches for rewiring signaling pathways

M. Young; T. Dahoun; B. Sokrat; C. Arber; K. M. Chen et al. 

Computational design of GPCR structure, stability and function

P. Barth 

Reprogramming cellular functions with engineered membrane proteins

C. Arber; M. Young; P. Barth 

Computational design of ligand-binding membrane receptors with high selectivity

X. Feng; J. Ambia; K-Y. M. Chen; M. Young; P. Barth 

Enhancing Structure Prediction and Design of Soluble and Membrane Proteins with Explicit Solvent-Protein Interactions

J. K. Lai; J. Ambia; Y. Wang; P. Barth 

Introduction of a polar core into the de novo designed protein Top7

B. Basanta; K. K. Chan; P. Barth; T. King; T. R. Sosnick et al. 

Toward high-resolution computational design of the structure and function of helical membrane proteins

P. Barth; A. Senes 

A topological and conformational stability alphabet for multipass membrane proteins

X. Feng; P. Barth 

Evolutionary-guided de novo structure prediction of self-associated transmembrane helical proteins with near-atomic accuracy

Y. Wang; P. Barth 

Survivin-specific T cell receptor targets tumor but not T cells

C. Arber; X. Feng; H. Abhyankar; E. Romero; M-F. Wu et al. 

Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges

I. Kufareva; V. Katritch; R. Stevens; R. Abagyan 

High-Resolution Modeling of Transmembrane Helical Protein Structures from Distant Homologues

A. Schlessinger; K-Y. M. Chen; J. Sun; J. S. Salvo; D. Baker et al. 

Novel Conserved Genotypes Correspond to Antibiotic Resistance Phenotypes of E. coli Clinical Isolates

W. van Schaik; M. C. Swick; M. A. Evangelista; T. J. Bodine; J. R. Easton-Marks et al. 

Naturally evolved G protein-coupled receptors adopt metastable conformations

K-Y. M. Chen; F. Zhou; B. G. Fryszczyn; P. Barth 

Status of GPCR Modeling and Docking as Reflected by Community-wide GPCR Dock 2010 Assessment

I. Kufareva; M. Rueda; V. Katritch; R. Stevens; R. Abagyan 

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008

M. Michino; E. Abola; C. L. Brooks; J. S. Dixon; J. Moult et al. 

The Structure of a Receptor with Two Associating Transmembrane Domains on the Cell Surface: Integrin αIIbβ3

J. Zhu; B-H. Luo; P. Barth; J. Schonbrun; D. Baker et al. 

Prediction of membrane protein structures with complex topologies using limited constraints

P. Barth; B. Wallner; D. Baker 

Targeting Metastable Coiled-Coil Domains by Computational Design

P. Barth; A. Schoeffler; T. Alber 

Closing In on the Resting State of the Shaker K+ Channel

M. M. Pathak; V. Yarov-Yarovoy; G. Agarwal; B. Roux; P. Barth et al. 

Toward high-resolution prediction and design of transmembrane helical protein structures

P. Barth; J. Schonbrun; D. Baker 

Modulating membrane protein stability and association by design

P. Barth