2025
Journal Articles
Computational design of highly signalling-active membrane receptors through solvent-mediated allosteric networks
Nature Chemistry. 2025. DOI : 10.1038/s41557-024-01719-2.Reviews
Functional dynamics of G protein-coupled receptors reveal new routes for drug discovery
Nature Reviews Drug Discovery. 2025. DOI : 10.1038/s41573-024-01083-3.Theses
Molecular characterization of an adhesion GPCR signal transduction using Graph-neural networks
Lausanne, EPFL, 2025.2024
Journal Articles
Ca2+-dependent lipid preferences shape synaptotagmin-1 C2A and C2B dynamics: Insights from experiments and simulations
STRUCTURE. 2024. Vol. 32, num. 10. DOI : 10.1016/j.str.2024.07.017.Inducible CXCL12/CXCR4–dependent extramedullary hematopoietic niches in the adrenal gland
Blood. 2024. Vol. 144, num. 9, p. 964 – 976. DOI : 10.1182/blood.2023020875.Unravelling the components of diffuse scattering using deep learning
Iucrj. 2024. Vol. 11, p. 34 – 44. DOI : 10.1107/S2052252523009521.Antibodies expand the scope of angiotensin receptor pharmacology
Nature Chemical Biology. 2024. DOI : 10.1038/s41589-024-01620-6.Theses
Boosting CAR T-cell therapy through G-protein signal rewiring
Lausanne, EPFL, 2024.From Sequence to Dynamics to Function: Computational Design of Allostery and Ligand Selectivity in G-Protein Coupled Receptors
Lausanne, EPFL, 2024.Working Papers
AlloPool: An Adaptive Graph Neural Network for Dynamic Allosteric Network Prediction in Protein Systems
2024
2023
Journal Articles
Computational design of dynamic receptor—peptide signaling complexes applied to chemotaxis
Nature Communications. 2023. Vol. 14, num. Article number: 2875. DOI : 10.1038/s41467-023-38491-9.Uncovering and engineering the mechanical properties of the adhesion GPCR ADGRG1 GAIN domain
2023. DOI : 10.1101/2023.04.05.535724.Conference Papers
Designed Tumor Microenvironment Responsive Biosensors Enhance Chimeric Antigen Receptor T Cell Therapy for Cancer
2023. p. 79 – 79.2022
Journal Articles
Computationally designed GPCR quaternary structures bias signaling pathway activation
Nature Communications. 2022. Vol. 13, num. 1, p. 6826. DOI : 10.1038/s41467-022-34382-7.Computational design of ultrasensitive flexible peptide:receptor signaling complexes for enhanced chemotaxis
bioRxiv. 2022. DOI : 10.1101/2022.03.30.486413.Reviews
Deep learning approaches for conformational flexibility and switching properties in protein design
Frontiers in Molecular Biosciences. 2022. Vol. 9, p. 928534. DOI : 10.3389/fmolb.2022.928534.Working Papers
Computational rewiring of allosteric pathways reprograms GPCR selective responses to ligands
2022
2021
Journal Articles
Computational design of highly signaling active membrane receptors through de novo solvent-mediated allosteric networks
bioRxiv. 2021. DOI : 10.1101/2021.09.29.462228.Computationally-guided tuning of ligand sensitivity in a GPCR-based sensor
bioRxiv. 2021. DOI : 10.1101/2021.09.21.461282.Computationally designed GPCR quaternary structures bias signaling pathway activation
bioRxiv. 2021. DOI : 10.1101/2021.09.23.461493.Conference Papers
Computationally designed GPCR quaternary structures bias signaling pathway activation
2021. p. 51 – 51.Theses
Reprogramming G Protein-Coupled Receptor Structure, Function And Signaling By Computational Design
Lausanne, EPFL, 2021.Patents
Method for generating variants of a protein
US2023227534; EP4004925; WO2021018756; EP3772065.
2021.Method for generating variants of a protein
US2023227534; EP4004925; WO2021018756; EP3772065.
2021.