EDCB Published theses

It is our pleasure to present the theses undertaken in the frame of the EPFL PhD Program in Computational and Quantitative Biology.

2026

Interrogating spinal cord injury pathophysiology from a single-cell perspective

Y. Y. Teo / G. Courtine; J. Squair (Dir.)  

Lausanne, EPFL, 2026. 

Structure-based Design of Biomolecular Interactions with Geometric Deep Learning

A. Schneuing / B. E. Ferreira De Sousa Correia; M. Bronstein (Dir.)  

Lausanne, EPFL, 2026. 

Generative structure-based design of synthetically accessible small molecules

I. Igashov / B. E. Ferreira De Sousa Correia; M. Bronstein (Dir.)  

Lausanne, EPFL, 2026. 

2025

Revealing and exploiting coevolution through protein language models

D. Sgarbossa / A-F. R. Bitbol (Dir.)  

Lausanne, EPFL, 2025. 

Learning the language of the genome: AI- and data-driven decoding of genetic variants and disease mechanisms

A. Saadat Varnosfaderanii / J. Fellay (Dir.)  

Lausanne, EPFL, 2025. 

Protein Organisation at Different Scales: Amyloid Disaggregation, Chaperone Networks and Engineered Allostery

D. Cois / P. De Los Rios (Dir.)  

Lausanne, EPFL, 2025. 

Dynamics and Coordination of Protein Synthesis and Protein Decay in Mammalian Cells

B. J. C. A. H. Martin / D. M. Suter (Dir.)  

Lausanne, EPFL, 2025. 

Leveraging social media data and large language models for understanding public health behaviours in the context of infectious diseases and vaccination

L. Espinosa Montalbán / M. Salathé (Dir.)  

Lausanne, EPFL, 2025. 

The Regulation of Transcription Factors Binding Site Occupancies by Their Concentrations

R. Mizeret / D. M. Suter (Dir.)  

Lausanne, EPFL, 2025. 

SPAD Image Sensors with Embedded Intelligence

Y. Lin / E. Charbon; C. Bruschini (Dir.)  

Lausanne, EPFL, 2025. 

Mapping Brain Morphology with Micro-CT and Topological Data Analysis: From Drosophila to General Applications

S. S. Bourgeat / B. McCabe; A. M. Jaksic (Dir.)  

Lausanne, EPFL, 2025. 

Investigation of the bone marrow niche in clonal hematopoiesis and myelodysplastic syndrome

M. Kholmatov / B. Deplancke; J. Zaugg (Dir.)  

Lausanne, EPFL, 2025. 

Light-directed evolution of dynamic biological systems

V. Gligorovski / S. J. Rahi (Dir.)  

Lausanne, EPFL, 2025. 

Computational approaches for spatialomics data: construction, integration and analysis of biomolecular atlases

H. H. E. Schede / G. D’Angelo; G. La Manno (Dir.)  

Lausanne, EPFL, 2025. 

Transcription Factor Target Search on Chromatin via Electrostatic Interactions

S. Sakong / D. Suter; B. Fierz (Dir.)  

Lausanne, EPFL, 2025. 

Computational design of complex protein folds and soluble analogs of membrane proteins

C. A. Goverde / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2025. 

Leveraging chromatin modules to explore the impact of regulatory variation on disease

O. Pushkarev / B. Deplancke (Dir.)  

Lausanne, EPFL, 2025. 

Non-equilibrium control of biomolecular condensates

A. Shelest / P. De Los Rios (Dir.)  

Lausanne, EPFL, 2025. 

2024

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

A. R. Lederer / G. La Manno (Dir.)  

Lausanne, EPFL, 2024. 

Study of disease-associated proteins using integrative structural biology: the case of GOLPH3 and PREPL

A. Theodoropoulou / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2024.