EDBB PhD Theses

It is our pleasure to present the theses undertaken in the frame of the EPFL PhD Program in Biotechnology & Bioengineering.

2019

Label-free plasmonic biosensors for real-time live cell analysis

X. Li / H. Altug (Dir.)  

Lausanne: EPFL, 2019. DOI : 10.5075/epfl-thesis-9594.

Engineering Dynamic Hydrogels For In Vitro Organoid Culture

D. L. P. Blondel / M. Lütolf (Dir.)  

Lausanne: EPFL, 2019. DOI : 10.5075/epfl-thesis-7455.

Bioengineering human bone marrow models to elucidate the triggers of the stem cell niche

Q. Vallmajó Martín / M. Lütolf; M. Ehrbar (Dir.)  

Lausanne: EPFL, 2019. DOI : 10.5075/epfl-thesis-9543.

Characterization of Coenzyme Q Biosynthesis Proteins through Integrative Modeling at the Protein-Membrane Interface

D. Aydin / M. Dal Peraro (Dir.)  

Lausanne: EPFL, 2019. DOI : 10.5075/epfl-thesis-9641.

Anti-angiogenic immunotherapy for lung cancer

E. Kadioglu / M. De Palma (Dir.)  

Lausanne: EPFL, 2019. DOI : 10.5075/epfl-thesis-9561.

2D nanopores: fabrication, energy harvesting and field-effect sensing

M. Graf / A. Radenovic (Dir.)  

Lausanne: EPFL, 2019. DOI : 10.5075/epfl-thesis-9516.

Metabolic and microenvironmental strategies to accelerate hematopoietic recovery post-aplasia

V. Ledebur de Antas de Campos / O. M. Naveiras Torres-Quiroga (Dir.)  

Lausanne: EPFL, 2019. DOI : 10.5075/epfl-thesis-9395.

Microchannel-based technologies for nerve interfacing

S. Gribi / S. Lacour (Dir.)  

Lausanne: EPFL, 2019. DOI : 10.5075/epfl-thesis-9425.

Optical projection tomography for whole organ imaging

D. Nguyen / T. Lasser; D. N. A. Van De Ville (Dir.)  

Lausanne: EPFL, 2019. DOI : 10.5075/epfl-thesis-9094.

Soft multimodal neural interfaces for unravelling sensory neurological circuits

F. P. G. Michoud / S. Lacour (Dir.)  

Lausanne: EPFL, 2019. DOI : 10.5075/epfl-thesis-9046.

Integrated microfluidic tools for the characterization of protein/DNA interactions in vitro and in vivo

R. Dainese / B. Deplancke (Dir.)  

Lausanne: EPFL, 2019. DOI : 10.5075/epfl-thesis-9233.

Tailoring the Mechanical Properties of Tissue Engineering Scaffolds made from Decellularized Cartilage

J. Antons / D. Pioletti; L. A. Laurent-Applegate (Dir.)  

Lausanne: EPFL, 2019. DOI : 10.5075/epfl-thesis-9059.

Tissue-specific circadian transcriptional regulation

J. Yeung / F. Naef (Dir.)  

Lausanne: EPFL, 2019. DOI : 10.5075/epfl-thesis-8893.

2018

In vitro fate mapping of stem cell development at the single cell level

V. Trachsel / M. Lütolf (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-9030.

Genetic determinants of healthy human immune variance: from humoral response to microbiome diversity

P. Scepanovic / J. Fellay; B. Deplancke (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-8955.

The phenotypic impact of naturally occurring genetic and molecular mitochondrial variation in a Drosophila Genetic Reference Population

R. P. J. Bevers / B. Deplancke (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-9015.

Circadian clock- and feeding-dependent regulation of translation initiation and elongation in the liver

C. A. Gobet / F. Naef; K. Sakamoto (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-8900.

Quantitative single cell dynamics of signaling and transcriptional response in mammalian cells

O. Tidin / D. M. Suter; F. Naef (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-8629.

Development of microfluidic tools and methods for the biochemical characterization of scFv and Cas9 affinity reagents and their applications in molecular detection

E. E. Petrova / S. Maerkl (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-8614.

More Medicines for Tuberculosis: Fuelling Drug Discovery against Mycobacterium tuberculosis

S-Y. C. Foo / S. Cole (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-8906.

Computational and Statistical analyses of Molecular Evolution and Demography using Large-scale Sequencing Data

A. Kapopoulou / B. Deplancke; J. D. Jensen (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-8748.

Advancing immunotherapy for HPV-related cancers: Improving therapeutic vaccination approaches and understanding the immunosuppressive role of myeloid cells

G. Galliverti / M. Swartz; D. Hanahan (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-8697.

Quantitative analysis of gene expression and transcriptional memory in mouse embryonic stem cells

A. Mandic / D. M. Suter (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-8610.

Mid-Infrared plasmonic nanoantennas for ultrasensitive detection of proteins and their secondary structure

D. Etezadi / H. Altug (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-8569.

New roles of the lymphatic endothelium in modulating adaptive immunity: implications for immune tolerance and cancer immunotherapy

L. C. F. Potin / M. Swartz; D. Hanahan (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-8817.

Novel tools to dissect stem cell metabolism at single cell level

G. Nikitin / M. Lütolf; A. Meibom (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-8441.

What is the role of fish intestine as environment-organism barrier? Mechanistic investigations using fish intestinal cells on a chip

C. Drieschner / P. Renaud; K. Schirmer (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-8708.

Constrained optimization applied to multiscale integrative modeling

G. E. Tamo / M. Dal Peraro (Dir.)  

EPFL, 2018. DOI : 10.5075/epfl-thesis-8630.

Mitochondrial stress signalling and its impacts on physiology

A. J. L. Mottis / J. Auwerx (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-8433.

Likelihood-free Inference of Population Genetic Parameters from Time-Sampled Genetic Data

H. Shim / F. G. van der Goot Grunberg (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-7605.

Single-cell division and killing dynamics of bacteria exposed to isocratic and time-dependent concentrations of antibiotic

K. E. Schneider / J. McKinney; N. Dhar (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-8585.

Quantitative analysis of SOX2 and OCT4 expression in pluripotency and differentiation

D. Strebinger / D. M. Suter (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-8301.

Modeling and analysis of parts and devices of genetic regulation

Y. Berset / V. Hatzimanikatis; J. R. van der Meer (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-8081.

Introducing tolerance to foreign and partly foreign proteins by erythrocyte binding and artificial glycosylations

K. L. Brünggel / M. Lütolf; J. A. Hubbell (Dir.)  

EPFL, 2018. DOI : 10.5075/epfl-thesis-8190.

Ultra high magnetic field for glial contribution into brain metabolism studied by MR spectroscopy and CEST methods for molecular imaging of glycogen

E. M. C. Vinckenbosch / R. Gruetter (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-8125.

Electronic dura mater soft, multimodal neural interfaces

A. E. Hirsch / S. Lacour (Dir.)  

Lausanne: EPFL, 2018. DOI : 10.5075/epfl-thesis-8112.

2017

Fighting preterm birth with novel surgical tools and biomaterials engineering

Y. R. Devaud / M. Lütolf; M. Ehrbar (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-8359.

Evaluation of oxidation-sensitive polymersomes as vaccine nanocarriers to enhance humoral responses against arenavirus envelope glycoproteins

C. Galan Navarro / M. Dal Peraro; M. Swartz (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-8193.

Cell lineage tracing in human tissues using somatic mitochondrial mutations

P. Refinetti / S. Morgenthaler; P. O. Ekstrom (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7643.

Microfluidic platforms for high-throughput mammalian cell printing, transfection, and dosage-dependent studies

K. P. Woodruff / S. Maerkl (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7889.

Gene regulatory dynamics underlying brown fat cell differentiation

R. N. Pradhan / B. Deplancke (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7797.

Computational methods and modeling of cellular function for the optimization of protein production and the study of cellular disease states

J. R. Pinto Vieira / V. Hatzimanikatis (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7865.

AAV based gene therapy for rare diseases

C. C. Rochat / P. Aebischer; B. Schneider (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7888.

Role of ACMSD in regulation of NAD+ metabolism and mitochondrial function

E. Katsyuba / J. Auwerx (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7664.

A Microfluidic Brain Interface for In Vivo Recording of Neurochemical Activity

G. C. Y. Petitpierre / P. Renaud (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7816.

The therapeutic role of NAD+ modulation in fatty liver disease

K. L. Gariani / J. Auwerx (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7668.

Deciphering the subcapsular epithelial cells in human fetal and postnatal thymus

D. S. E. Hemon / Y. Barrandon (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7832.

Exploring the potency of normal and pathological human thymic epithelial cells

T. M. C. Arlabosse / Y. Barrandon (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-6788.

Inferring the age and strength of mutations evolving under positive selection

N. L. Ormond / J. D. Jensen (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7500.

Selective electrical and optical neuromodulation of the central nervous system with conformable microfabricated implants

A. A. Guex / S. Lacour (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7628.

A Microfluidic Platform Enables Large-Scale Single-Cell Screening to Identify Genes Involved in Bacterial Persistence

A. Verpoorte / J. McKinney; S. Maerkl (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7641.

Nanocapillaries combined with optical tweezers as a single molecule technique for studying DNA-protein complexes

R. Bulushev / A. Radenovic (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7608.

Elucidating the role of lymphatic vessels within the tumor microenvironment of breast cancer

I. M. van Mier / M. Swartz; M. De Palma (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7522.

Lipid membrane characterization with second harmonic scattering

C. U. Lütgebaucks / S. Roke (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7626.

Human and eco-toxicological impacts of organometallic halide perovskites

R. I. Benmessaoud / L. Forró; H. Lashuel (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7595.

Investigating the Biological Mechanisms underlying the Initiation of Autoimmunity against Beta Cell Antigens in Type 1 Diabetes

C. Cianciaruso / J. A. Hubbell; S. Baekkeskov Hanahan (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7426.

Microfluidic and Electrokinetic Manipulation of Single Cells

S. Kilchenmann / C. Guiducci (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7403.

Group Decisions Influence Emergence and Regulation of Leaders during Collective Migration of Epithelial Cells

M. Vishwakarma / J. A. Hubbell; J. Spatz (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7392.

The role of the polyglutamine and N-terminal domains in regulating the aggregation and structural properties of Huntingtin Exon 1

S. Vieweg / H. Lashuel (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7374.

Novel systems biology approaches for design and analysis of palmitoylation networks reveal its regulatory effects on protein stability, activity and localization

T. Dallavilla / V. Hatzimanikatis; F. G. van der Goot Grunberg (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7383.

In vitro modeling of complex microenvironmental regulation of stem cells

Y. Tabata / M. Lütolf (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7349.

Advanced technologies to control stem-cell based organogenesis

N. Brandenberg / M. Lütolf (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7461.

Regulation of Endoplasmic Reticulum Architecture by Protein S-Palmitoylation

P. A. Sandoz / F. G. van der Goot Grunberg (Dir.)  

Lausanne: EPFL, 2017. DOI : 10.5075/epfl-thesis-7429.

2016

Mechanisms of tolerance induction by erythrocyte-targeted antigens

A. J. Grimm / J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-7327.

Deciphering the Role of LRH-1 in Liver Intermediary Metabolism and Cancer

P. Xu / K. Schoonjans (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-7369.

Metabolic control of muscle and muscle stem cell function

H. Zhang / J. Auwerx (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-7169.

Novel interventions to recover the regenerative capacity of aged skeletal muscle by targeting the interactions in the stem cell niche

L. Lukjanenko / J. Feige; J. Auwerx (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-7144.

Stem cell niche engineering through photopatterning and microfluidics

L. Kolb / M. Lütolf (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-7316.

Mitochondrial unfolded protein response, its molecular mechanism and physiological impact

V. Jovaisaite / J. Auwerx (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-7352.

In vivo mechanical loading combined with cell therapy in a bone tissue engineering scaffold

T. C. Hausherr / D. Pioletti (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-7076.

Microwell and impedance-based approaches to isolate single cells for life sciences

G. Muller / Y. Barrandon; P. Renaud (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-7088.

Engineering Lymphangiogenesis

M. A. Fankhauser / M. Swartz (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-7047.

Instrumented shoes for daily activity monitoring in healthy and at risk populations

C. Moufawad El Achkar / K. Aminian (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-7149.

Mechanical and Functional Study of Cell Physiology at the Nanoscale

P. D. Odermatt / G. Fantner (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-6999.

Tunable and cell-responsive 3D poly(ethylene glycol) microenvironments for the development of tissue models

S. E. Metzger / J. A. Hubbell; M. Ehrbar (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-7155.

Therapeutic Proteins Engineered for Super-Affinity to the Extracellular Matrix in Regenerative Medicine

P. S. M. Briquez / J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-7103.

Quantitative Single-Cell Analysis of Host-Pathogen Interactions

M. J-H. Delincé / J. McKinney (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-7019.

Unraveling the KRAB/KAP1 control of transposable elements in pluripotent and somatic cells

G. Ecco / D. Trono; P. Turelli (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-7020.

Role of microRNAs in tumor-associated macrophages

C. M. Baer / M. De Palma (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-6955.

From the early steps of whisker formation to its evolutionary disappearance: the (curious) case of Prdm1 and its regulation

P. G. Manti / Y. Barrandon (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-6984.

Protrusion-retraction switches and traction forces in spontaneous cell polarization

A. C. Bornert / A. Verkhovsky (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-7006.

Allosteric regulation and targeting of Abl SH2-kinase interface and other cytoplasmic tyrosine kinases

A. J. Lamontanara / O. Hantschel (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-6987.

New immunomodulatory roles of lymphatic endothelium and implications for immunotherapy

E. Vokali / M. Swartz (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-6967.

Host and pathogen genomics of severe pediatric infections

S. Asgari / J. Fellay (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-6656.

BCI based on Neural Correlates of Anticipatory Behavior during Driving

Z. Khaliliardali / J. d. R. Millán Ruiz (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-6910.

Towards brain-on-a-chip

Y. Ren / P. Renaud (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-6854.

Bioengineering approaches in immunotherapy

M. Damo / J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-6909.

Nanoscopy in nonlinear scanning fluorescence imaging systems

G. P. J. Laporte / D. Psaltis (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-6905.

Protein engineering approaches for direct antigen targeting in CD8+ T cell inducing vaccines

V. Panagiotou / J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-6864.

Microdevices for Locomotion in Complex Biological Fluids

T. Qiu / J. A. Hubbell; P. Fischer (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-6941.

Integrating Gene Synthesis and MITOMI for Rapid Protein Engineering

M. C. Blackburn / S. Maerkl (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-6796.

Engineering nanoparticle-based vaccines: Implications for the quality of humoral and cellular immunity

M. Rincón-Restrepo / M. Swartz; S. Hirosue (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-6848.

Engineering the Extra Domain A of fibronectin as a vaccine adjuvant and study of its role in tissue regeneration

Z. Julier / J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2016. DOI : 10.5075/epfl-thesis-6804.

2015

Transposable elements and their KRAB/KAP1 controllers broadly regulate transcription in adult human cells

F. Marzetta / D. Trono; P. Turelli (Dir.)  

Lausanne: EPFL, 2015. DOI : 10.5075/epfl-thesis-6842.

Connectivity Analysis of Brain States and Applications in Brain-Computer Interfaces

H. Zhang / J. d. R. Millán Ruiz (Dir.)  

Lausanne: EPFL, 2015. DOI : 10.5075/epfl-thesis-6779.

Interactions of Peripheral Nerve Cells with Soft Micropillar Interfaces

C. X. Paulou / S. Lacour (Dir.)  

Lausanne: EPFL, 2015. DOI : 10.5075/epfl-thesis-6705.

Analytical Methods, Correlative Microscopy and Software Tools for Quantitative Single Molecule Localization Microscopy

A. Shivanandan / A. Radenovic; I. Sbalzarini (Dir.)  

Lausanne: EPFL, 2015. DOI : 10.5075/epfl-thesis-6726.

Reconstruction and systems analysis of metabolism in apicomplexan parasites Toxoplasma gondii and Plasmodium falciparum

S. Tymoshenko / V. Hatzimanikatis; D. Soldati-Favre (Dir.)  

Lausanne: EPFL, 2015. DOI : 10.5075/epfl-thesis-6692.

Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson's Disease

M-B. Fares / H. Lashuel (Dir.)  

Lausanne: EPFL, 2015. DOI : 10.5075/epfl-thesis-6679.

Deciphering Metabolic Regulation of Hematopoietic Stem Cell Fate

M. Girotra / M. Lütolf (Dir.)  

Lausanne: EPFL, 2015. DOI : 10.5075/epfl-thesis-6676.

Implementation and Characterization of Dynamic Genetic Networks in Vitro

H. M. Niederholtmeyer / S. Maerkl (Dir.)  

Lausanne: EPFL, 2015. DOI : 10.5075/epfl-thesis-6617.

Tissue engineering for prenatal applications

A-S. J. Kiveliö / J. A. Hubbell; M. Ehrbar (Dir.)  

Lausanne: EPFL, 2015. DOI : 10.5075/epfl-thesis-6591.

Bio-engineered collagen-fibrin scaffolds for enhancing urological tissue regeneration

E. Vardar / J. A. Hubbell; P. Frey (Dir.)  

Lausanne: EPFL, 2015. DOI : 10.5075/epfl-thesis-6619.

Modeling and Engineering Proteins Thermostability

H. Pezeshgi Modarres / M. Dal Peraro (Dir.)  

Lausanne: EPFL, 2015. DOI : 10.5075/epfl-thesis-6637.

Study of transposon-mediated cell pool and cell line generation in CHO cells

S. Balasubramanian / F. M. Wurm; D. Hacker (Dir.)  

Lausanne: EPFL, 2015. DOI : 10.5075/epfl-thesis-6563.

Functional Perturbation of the Gab2 Multiprotein Complex by High-affinity SH2-binding Monobodies in Chronic Myelogenous Leukemia

E. B. Gencer Akçok / O. Hantschel (Dir.)  

Lausanne: EPFL, 2015. DOI : 10.5075/epfl-thesis-6538.

Superresolution Reconstruction for Magnetic Resonance Spectroscopic Imaging Exploiting Low-Rank Spatio-Spectral Structure

J. A. Kasten / D. Van De Ville; F. Lazeyras (Dir.)  

Lausanne: EPFL, 2015. DOI : 10.5075/epfl-thesis-6546.

Quantification of low molecular weight drugs

A. Ferretti / C. Guiducci (Dir.)  

Lausanne: EPFL, 2015. DOI : 10.5075/epfl-thesis-6480.

Microfluidic engineering of artificial stem cell niches

S. Allazetta / M. Lütolf (Dir.)  

Lausanne: EPFL, 2015. DOI : 10.5075/epfl-thesis-6528.

Quantitative single-cell analysis of S. cerevisiae using a microfluidic live-cell imaging platform

J. Becker / F. Naef; S. Maerkl (Dir.)  

Lausanne: EPFL, 2015. DOI : 10.5075/epfl-thesis-6519.

Bioengineering approaches to emulate the stem cell niche

S. Höhnel / M. Lütolf (Dir.)  

Lausanne: EPFL, 2015. DOI : 10.5075/epfl-thesis-6502.

2014

A Systems Approach to Identify Genetic and Environmental Regulators of Metabolism

E. G. Williams / J. Auwerx (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6486.

Novel non-invasive techniques for hemodynamic monitoring

O. Vardoulis / N. Stergiopulos (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6446.

Development of plasmid-based expression technology for rapid and sustained production of recombinant proteins in insect cells

X. Shen / F. M. Wurm; D. Hacker (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6435.

Reversible attachment of Cell-Penetrating Peptides for the efficient delivery of α-synuclein to HeLa cells and primary cortical neurons

C. Desobry / H. Lashuel (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6412.

Modeling of transcription mechanisms in mammals from kinetic measurements in single cells

B. Zoller / F. Naef (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6414.

Label-free Analytics by Transmission Localized-SPR and its Application to Small Molecules Monitoring in Serum

G. Cappi / C. Guiducci; L. Benini (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6454.

Genetic analysis of the decaprenyl-phospho-D-arabinofuranose pathway in Mycobacterium tuberculosis

G. S. Kolly / S. Cole (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6352.

Automated long-term single cell analysis of Schizosaccharomyces pombe on a microfluidic microchemostat array

J-B. Nobs / S. Maerkl (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6196.

The Engineering of a Scalable Disposable Orbitally Shaken Bioreactor System for Animal Cell Cultivation and Therapeutic Protein Production

D. T. Monteil Jr / F. M. Wurm; D. Hacker (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6423.

Development of a Bisphosphonate Delivering Hydrogel for the Augmentation of Impaired Peri-Implant Bone

U. Kettenberger / D. Pioletti (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6370.

A New Noninvasively Adjustable Glaucoma Drainage Device

A. Villamarin / N. Stergiopulos (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6295.

Subject-specific computational fluid dynamics modelling and measurement of cerebrospinal fluid motion in the cervical spine

T. Yiallourou / N. Stergiopulos; B. A. Martin (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6293.

An integrative genomics approach toward deciphering the regulatory logic of phase-specific circadian transcription in the mouse liver

I. Krier / B. Deplancke; J. Rougemont (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6283.

New Tools for Hydrogel-Based 3D Bioprinting

A. Negro / M. Lütolf (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6313.

Dissecting the DNA binding principles of transcription factor monomers and heterodimers

A. Isakova / B. Deplancke (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6230.

Direct Somatic Cell Reprogramming in Synthetic 3D Microenvironments

Y. Okawa / M. Lütolf (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6267.

Engineering adjuvants for prophylactic and therapeutic subunit vaccines

A. de Titta / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6224.

Dynamic brain networks explored by structure-revealing methods

N. Leonardi / D. Van De Ville (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6274.

Tissue Engineering Bone by Matrix-Assisted MSC Recruitment

P. S. Lienemann / M. Lütolf; M. Ehrbar (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6124.

A systems approach to elucidate the genetic architecture of molecular phenotypes

S. M. Waszak / B. Deplancke (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6179.

Engineering lymphangiogenesis

E. Güç / M. Swartz (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6241.

Active Transport Mechanisms by Lymphatic Endothelium and their Modulation by Inflammatory Mediators

V. Triacca / M. Swartz (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6193.

Engineering the lymphatic microenvironment for investigating tumor invasion, immune cell traficking and parasite infection under relevant biomechanical conditions

M. Pisano / M. Swartz (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6173.

In vitro Fate Mapping of Single Hematopoietic Stem Cells

A. Roch / M. Lütolf (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6132.

Pharmacological and biochemical assessment of γ-secretase-mediated APP processing involved in Alzheimer's disease

M. Dimitrov / P. Fraering (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6071.

Thermal gradients on a chip for the local stimulation of biological systems

S. Delasoie-Baranek / P. Renaud (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6058.

Experimental and theoretical studies on the effects of smooth muscle on the mechanical response and remodeling of arteries

A. Agianniotis / N. Stergiopulos (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-5793.

The Effectual Hitchhiker

J. K. Herren / B. Lemaître (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6079.

From Genes to Organisms

T. Schaffter / D. Floreano; M. Affolter (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6081.

The regulatory circuit of natural competence for transformation in the human pathogen Vibrio cholerae

M. Lo Scrudato / M. Blokesch (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6078.

Structure-function analysis of the EspR virulence regulator of Mycobacterium tuberculosis

B. Blasco / S. Cole (Dir.)  

Lausanne: EPFL, 2014. DOI : 10.5075/epfl-thesis-6000.

2013

Systematic Analysis of Yeast Gene Expression by Synthetic Promoter Libraries

A. S. Rajkumar / S. Maerkl (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-6002.

Dissipation as variable in cartilage mechanobiology

P. Abdel-Sayed / D. Pioletti (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5998.

Targeting and Modulating Tumor-Associated Sites with Novel Nanoparticle-Based Immunotherapies

L. Jeanbart / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-6021.

Metabolic modeling and experimental studies on carbon and energy metabolism of Mycobacterium tuberculosis

M. E. Özdemir / J. McKinney; V. Hatzimanikatis (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5970.

Multiscale simulations of protein dynamics

E. Spiga / M. Dal Peraro (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5841.

Development and application of experimental tools to elucidate the gene regulatory network underlying adipogenesis

C. Delattre-Gubelmann / B. Deplancke (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5718.

The Phosphate Specific Transport (Pst) System in Fast- and Slow-Growing Mycobacteria

C. De Piano / J. McKinney (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5885.

Identification of genetic determinants and pharmacological modulators of mitochondrial function

P. Andreux / J. Auwerx (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5795.

Engineering nanoparticle vaccines

S. Raghunathan / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5792.

Epiphyseal Chondro-Progenitor Cell Therapy For Articular Cartilage Regeneration

S. E. Darwiche / D. Pioletti; L. A. Laurent-Applegate (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5870.

Structure and function of proteins involved in attachment and piercing of the bacterial cell envelope

L. Sycheva / P. Leiman (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5820.

Control of calcification in a biphasic osteochondral construct and enhancing interface integration

J. Hollenstein / D. Pioletti; R. L-Y. Sah (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5823.

Temperature impacts human epidermal stem cell behaviour through thermoTRPs and mTOR signalling

J. A. Mosig Rodriguez / Y. Barrandon (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5766.

Molecular Modeling of Membrane Embedded Proteins

T. Lemmin / M. Dal Peraro (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5695.

Discovery and functional characterisation of structural genomic variation in a natural population

A. Massouras / B. Deplancke (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5751.

Role of the bile acid membrane receptor TGR5 in macrophages and metabolism

M. Nomura / J. Auwerx; K. Schoonjans (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5609.

Systems Biology of 3D Stem Cell-Niche Interactions

A. Ranga / M. Lutolf (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5685.

Computational Studies on Cellular Bioenergetics

K. C. Soh / V. Hatzimanikatis (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5560.

Flexible Micro/Nanofabricated Systems for Medical Devices and Implants

W. Hasenkamp Carreira / P. Renaud (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5512.

A microfluidic live-cell imaging platform to study large collections of microbial genotypes

N. Dénervaud / S. Maerkl; F. Naef (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5593.

Development of Novel Nanoparticle-Based Vaccines and Immunotherapies

M. Ballester / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5633.

A Simple High Yielding Transient Gene Expression System for CHO Cells

Y. Rajendra / F. M. Wurm; D. Hacker (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5572.

The Use of Valproic Acid in Transient Gene Expression with HEK-293E Cells

D. Kiseljak / F. M. Wurm (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5498.

Generating microarrays for protein interaction studies using microfluidic devices

S. Rockel / S. Maerkl (Dir.)  

Lausanne: EPFL, 2013. DOI : 10.5075/epfl-thesis-5592.

2012

Single-Cell Analysis of Mycobacterial Persistence Using Microfabricated Tools

M. Elitas / J. McKinney; S. Maerkl (Dir.)  

Lausanne: EPFL, 2012. DOI : 10.5075/epfl-thesis-5621.

Toxicity study of nanostructures

L. Horváth / L. Forró; B. Schwaller (Dir.)  

Lausanne: EPFL, 2012. DOI : 10.5075/epfl-thesis-5571.

Nanopore sensing of single molecules application to RNAP-DNA complexes, fabrication of graphene-nanopore devices and translocation algorithm analysis

C. Raillon / A. Radenovic; N. Hernandez (Dir.)  

Lausanne: EPFL, 2012. DOI : 10.5075/epfl-thesis-5570.

Hydrogel Microfluidics to Control Stem Cell Fate

S. Cosson / M. Lutolf (Dir.)  

Lausanne: EPFL, 2012. DOI : 10.5075/epfl-thesis-5558.

Genomics and transcriptomics of the Mycobacterium tuberculosis complex

S. Uplekar / S. Cole; J. Rougemont (Dir.)  

Lausanne: EPFL, 2012. DOI : 10.5075/epfl-thesis-5550.

Dissecting Gene Regulatory Networks Using Targeted Quantitative Proteomics

J. Simicevic / B. Deplancke (Dir.)  

Lausanne: EPFL, 2012. DOI : 10.5075/epfl-thesis-5482.

Molecular and Functional Characterization of Clonogenic Human Thymic Epithelial Cells

M. Maggioni / Y. Barrandon (Dir.)  

Lausanne: EPFL, 2012. DOI : 10.5075/epfl-thesis-5393.

Immune Engineering Via Differential Antigen Carriers and Co-Stimulatory Molecules

J. Eby / J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2012. DOI : 10.5075/epfl-thesis-5487.

Culture and Characterization of Human and Porcine Urothelial Progenitor Cells

H. M. Larsson / J. A. Hubbell; P. Frey (Dir.)  

Lausanne: EPFL, 2012. DOI : 10.5075/epfl-thesis-5481.

Elucidating the role of post-translational modifications of alpha-synuclein using semisynthesis

M. Hejjaoui / H. Lashuel (Dir.)  

Lausanne: EPFL, 2012. DOI : 10.5075/epfl-thesis-5494.

Improving Immunogenicity of Subunit Vaccines Using Nanocarrier Systems

A. Stano / J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2012. DOI : 10.5075/epfl-thesis-5463.

KRAB/KAP1 Regulation of Embryonic Stem Cell Pluripotent Self-renewal

A. Corsinotti / D. Trono (Dir.)  

Lausanne: EPFL, 2012. DOI : 10.5075/epfl-thesis-5436.

Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

F. Zagari / F. Wurm; M. Jordan (Dir.)  

Lausanne: EPFL, 2012. DOI : 10.5075/epfl-thesis-5420.

Early Fate Choice Determines in vivo Engraftment and in vitro Behavior of Epidermal Stem Cells

F. Gorostidi / Y. Barrandon (Dir.)  

Lausanne: EPFL, 2012. DOI : 10.5075/epfl-thesis-5406.

Molecular Modeling of Bacterial Nanomachineries

M. T. Degiacomi / M. Dal Peraro (Dir.)  

Lausanne: EPFL, 2012. DOI : 10.5075/epfl-thesis-5404.

Photopatterning of Synthetic Hydrogels

K. Mosiewicz / M. Lutolf (Dir.)  

Lausanne: EPFL, 2012. DOI : 10.5075/epfl-thesis-5349.

Structural Studies and Protein Engineering of Human O6-Alkylguanine-DNA Alkyltransferase

B. Mollwitz / K. Johnsson (Dir.)  

Lausanne: EPFL, 2012. DOI : 10.5075/epfl-thesis-5343.

Microtechnologies to Map the Fate of Single Stem Cells and their Progeny

S. Kobel / M. Lutolf; P. Renaud (Dir.)  

Lausanne: EPFL, 2012. DOI : 10.5075/epfl-thesis-5322.

Therapeutic Immunomodulation of the Lymphoid-like Tumor Environment Using Nanoparticulate Formulations

I. Kourtis / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2012. DOI : 10.5075/epfl-thesis-5294.

2011

New/Surface-Modified Biocompatible Polymer for ICD Lead Insulation

R. B. Pisarek / J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2011. DOI : 10.5075/epfl-thesis-5209.

Assessment of Body Motion and Muscle Weakness

R. L. Ganea / K. Aminian (Dir.)  

Lausanne: EPFL, 2011. DOI : 10.5075/epfl-thesis-5188.

In vitro lymphatic endothelial morphogenesis

C. Yong Pullin / M. Swartz (Dir.)  

Lausanne: EPFL, 2011. DOI : 10.5075/epfl-thesis-3898.

On the Precision of Circadian Oscillators

T. D'Eysmond / F. Naef (Dir.)  

Lausanne: EPFL, 2011. DOI : 10.5075/epfl-thesis-5157.

The Role of LEKTI in the Fate Determination of Keratinocyte Stem Cells

A. W. Amici / Y. Barrandon (Dir.)  

Lausanne: EPFL, 2011. DOI : 10.5075/epfl-thesis-5151.

OrbShake Bioreactors for Mammalian Cell Cultures

S. Tissot / F. Wurm (Dir.)  

Lausanne: EPFL, 2011. DOI : 10.5075/epfl-thesis-5135.

In Vivo Studies on the Control of Gene Expression and Protein Degradation

K. Bojkowska / K. Johnsson; D. Trono (Dir.)  

Lausanne: EPFL, 2011. DOI : 10.5075/epfl-thesis-5119.

Hydrogels for Urinary Tract Tissue Engineering

L. A. Micol / J. A. Hubbell; P. Frey (Dir.)  

Lausanne: EPFL, 2011. DOI : 10.5075/epfl-thesis-5115.

Engineering Erythrocyte Affinity for Improved Pharmacokinetics and Immune Tolerogenesis

S. Kontos / J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2011. DOI : 10.5075/epfl-thesis-5075.

Biofunctional Scaffold Design for Soft Tissue Regeneration

K. Lorentz / J. A. Hubbell; P. Frey (Dir.)  

Lausanne: EPFL, 2011. DOI : 10.5075/epfl-thesis-5071.

Pressure and Flow Wave Propagation in Patient-Specific Models of the Arterial Tree

P. Reymond / N. Stergiopulos (Dir.)  

Lausanne: EPFL, 2011. DOI : 10.5075/epfl-thesis-5029.

Studies on KRAB/KAP1-Mediated Transcriptional Repression

A. C. Groner / D. Trono (Dir.)  

Lausanne: EPFL, 2011. DOI : 10.5075/epfl-thesis-4972.

Engineering of Signaling Microenvironments with Fibronectin Domains to Enhance Tissue Regeneration

M. Martino / J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2011. DOI : 10.5075/epfl-thesis-4971.

Identification and Functional Response of "Interstitial Cells of Cajal"-like Cells from Rat Mesenteric Artery

A. Formey de Saint Louvent / J-J. Meister; J-L. Bény (Dir.)  

Lausanne: EPFL, 2011. DOI : 10.5075/epfl-thesis-4966.

Cellular Responses to Bacterial Pore-Forming Toxins

R. M. Gonzalez / F. G. v. d. Goot Grunberg (Dir.)  

Lausanne: EPFL, 2011. DOI : 10.5075/epfl-thesis-4965.

Force Transmission in Migrating Cells

M. Fournier / A. Verkhovski (Dir.)  

Lausanne: EPFL, 2011. DOI : 10.5075/epfl-thesis-4936.

Folding and Structure of the Pore Forming Toxin Aerolysin

M. I. Iacovache / F. G. v. d. Goot Grunberg (Dir.)  

Lausanne: EPFL, 2011. DOI : 10.5075/epfl-thesis-4925.

Molecular Mechanisms Underlying Hyaline Fibromatosis Syndrome

J. Deuquet Ariosa / F. G. v. d. Goot Grunberg (Dir.)  

Lausanne: EPFL, 2011. DOI : 10.5075/epfl-thesis-4909.

2010

Ambulatory Assessment of Foot Kinematics and Kinetics

H. Rouhani / K. Aminian (Dir.)  

Lausanne: EPFL, 2010. DOI : 10.5075/epfl-thesis-4878.

Lentiviral Vector-Mediated Gene Delivery for the Generation of Chinese Hamster Ovary Cell Lines with Improved Productivity and Stability

A. Oberbek / F. Wurm; D. Hacker (Dir.)  

Lausanne: EPFL, 2010. DOI : 10.5075/epfl-thesis-4834.

Dendritic cell chemotaxis in 3D

U. Haessler / M. Swartz (Dir.)  

Lausanne: EPFL, 2010. DOI : 10.5075/epfl-thesis-4833.

Transient Gene Expression in HEK-293E Cells for Recombinant Protein Production

S. Nallet / F. Wurm (Dir.)  

Lausanne: EPFL, 2010. DOI : 10.5075/epfl-thesis-4815.

The Interplay between Cytidine Deaminases, HIV and Domesticated Genetic Parasites

Y. Bulliard / D. Trono (Dir.)  

Lausanne: EPFL, 2010. DOI : 10.5075/epfl-thesis-4759.

Biomechanics of Vascular Wall

R. Saitta-Rezakhaniha / N. Stergiopulos (Dir.)  

Lausanne: EPFL, 2010. DOI : 10.5075/epfl-thesis-4712.

Genomic Context and KRAB/KAP1-mediated Transcriptional Repression

S. Meylan / D. Trono (Dir.)  

Lausanne: EPFL, 2010. DOI : 10.5075/epfl-thesis-4678.

Biophysical Regulation of Lymphatic Vessel Function

D. Miteva / M. Swartz (Dir.)  

Lausanne: EPFL, 2010. DOI : 10.5075/epfl-thesis-4666.

Small Molecule Based Approaches to Inhibit Macrophage Migration Inhibitory Factor (MIF) Activities and Elucidate its Role in Health and Disease

H. Ouertatani-Sakouhi / H. Lashuel (Dir.)  

Lausanne: EPFL, 2010. DOI : 10.5075/epfl-thesis-4633.

Elucidating the Role of Quaternary Structure in Modulating Macrophage Migration Inhibitory Factor (MIF) Functions

F. El Turk / H. Lashuel (Dir.)  

Lausanne: EPFL, 2010. DOI : 10.5075/epfl-thesis-4632.

Innate Barriers to Genome Invasion

P. Maillard / D. Trono (Dir.)  

Lausanne: EPFL, 2010. DOI : 10.5075/epfl-thesis-4630.

Arterial remodeling using a constituent-based approach

A. Tsamis / N. Stergiopulos (Dir.)  

Lausanne: EPFL, 2010. DOI : 10.5075/epfl-thesis-4588.

Identification of genetic insulator elements to increase the safety of viral gene therapy vectors

A. Gaussin / J. A. Hubbell; N. Mermod (Dir.)  

Lausanne: EPFL, 2010. DOI : 10.5075/epfl-thesis-4584.

Rat bladder muscle regeneration induced by local delivery of an engineered insulin-like growth factor 1 in fibrin gels

L. Yang / J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2010. DOI : 10.5075/epfl-thesis-4413.

2009

Differential effects of reduced cyclic stretch and perturbed shear stress within the arterial wall

T. Thacher / N. Stergiopulos; R. F. d. Silva (Dir.)  

Lausanne: EPFL, 2009. DOI : 10.5075/epfl-thesis-4571.

Protein-binding microarray technology and ChIP-sequencing for the identification of novel targets of the human tumor suppressor AP2[alpha]

J. Kerschgens / J. A. Hubbell; N. Mermod (Dir.)  

Lausanne: EPFL, 2009. DOI : 10.5075/epfl-thesis-4535.

Peptide ligands for targeting and retention of nanoparticles and protein therapeutics in articular cartilage

D. A. Rothenfluh / J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2009. DOI : 10.5075/epfl-thesis-4534.

Immunoisolated cell implants for intracerebral delivery of anti-Aß single chain Fv antibodies in the APP23 Alzheimer's mouse model

O. Marroquin Belaunzaran / P. Aebischer (Dir.)  

Lausanne: EPFL, 2009. DOI : 10.5075/epfl-thesis-4464.

Orbitally shaken bioreactors for mammalian cell culture

X. Zhang / F. Wurm (Dir.)  

Lausanne: EPFL, 2009. DOI : 10.5075/epfl-thesis-4492.

Studies on scaffold design for tissue engineering applications

E-M. Engelhardt / F. Wurm; P. Frey (Dir.)  

Lausanne: EPFL, 2009. DOI : 10.5075/epfl-thesis-4445.

Fetal cells for intervertebral disc regeneration

A. Quintin / D. Pioletti; L. A. Laurent-Applegate (Dir.)  

Lausanne: EPFL, 2009. DOI : 10.5075/epfl-thesis-4439.

The role of TIF1 gamma during adult murine hematopoiesis

K. Shakhbazov / F. Radtke; A. Trumpp (Dir.)  

Lausanne: EPFL, 2009. DOI : 10.5075/epfl-thesis-4415.

Transient recombinant protein expression in mammalian cells

S. Wulhfard / F. Wurm (Dir.)  

Lausanne: EPFL, 2009. DOI : 10.5075/epfl-thesis-4393.

Tissue engineering of the bladder

C. Adelöw / J. A. Hubbell; P. Frey (Dir.)  

Lausanne: EPFL, 2009. DOI : 10.5075/epfl-thesis-4385.

Stem cell-based cardiovascular tissue engineering

T. Krähenbühl / J. A. Hubbell; R. S. Langer (Dir.)  

Lausanne: EPFL, 2009. DOI : 10.5075/epfl-thesis-4384.

Investigation of novel calcium-related events as suspected contributors to neurodegeneration

N. Rudinskiy / R. Luthi-Carter (Dir.)  

Lausanne: EPFL, 2009. DOI : 10.5075/epfl-thesis-4377.

The tissue reaction to neuroprostheses

A. Mercanzini / P. Renaud (Dir.)  

Lausanne: EPFL, 2009. DOI : 10.5075/epfl-thesis-4339.

Studies on lentiviral-mediated transgenesis

M-O. Sauvain / D. Trono (Dir.)  

Lausanne: EPFL, 2009. DOI : 10.5075/epfl-thesis-4281.

The interplay between the VEGF-C/VEGFR-3 axis and CCL21/CCR7 axis in tumor cell invasion

A. Issa / M. Swartz (Dir.)  

Lausanne: EPFL, 2009. DOI : 10.5075/epfl-thesis-4217.

2008

Development of an in vitro microenvironment for maturing oocytes

J. E. Ihm / J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2008. DOI : 10.5075/epfl-thesis-4237.

Role and mechanism of transient receptor potential (TRP) channels in gustatory and chemesthetic sensations associated with dietary molecules

C. Riera / H. Vogel (Dir.)  

Lausanne: EPFL, 2008. DOI : 10.5075/epfl-thesis-4212.

Tissue engineering complex and mechanically active microenvironments for studies in asthma and cancer

A. A. Tomei / M. Swartz (Dir.)  

Lausanne: EPFL, 2008. DOI : 10.5075/epfl-thesis-4202.

Novel applications of poly(ethylene glycol)-bl-poly(propylene sulfide) block copolymers

C. O'Neil / J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2008. DOI : 10.5075/epfl-thesis-4200.

Exploiting immunofunctional nanoparticles as vaccines and synthetic pathogens

S. T. Reddy / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2008. DOI : 10.5075/epfl-thesis-4198.

Development of high-titer transient gene expression processes for manufacturing recombinant proteins

G. Backliwal / F. Wurm (Dir.)  

Lausanne: EPFL, 2008. DOI : 10.5075/epfl-thesis-4174.

Prevention of micromotion-related periprosthetic bone loss using local release of bisphosphonate

V. Stadelmann / D. Pioletti (Dir.)  

Lausanne: EPFL, 2008. DOI : 10.5075/epfl-thesis-4157.

A novel cell culture approach for tissue engineering based on surface expansion

H. Majd / B. Hinz (Dir.)  

Lausanne: EPFL, 2008. DOI : 10.5075/epfl-thesis-4149.

Accelerating the development time of recombinant mammalian cell lines producing high titers of protein therapeutics

S. Chenuet / F. Wurm (Dir.)  

Lausanne: EPFL, 2008. DOI : 10.5075/epfl-thesis-4128.

Mechanical orchestration of tissue remodeling

P-J. Wipff / B. Hinz (Dir.)  

Lausanne: EPFL, 2008. DOI : 10.5075/epfl-thesis-4109.

Polymeric carriers for therapeutic agents

Y. S. Jo / J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2008. DOI : 10.5075/epfl-thesis-4107.

Molecular and mechanical regulators of lymphatic biology

J. M. Rutkowski / M. Swartz (Dir.)  

Lausanne: EPFL, 2008. DOI : 10.5075/epfl-thesis-4096.

Vascular physiology

S. Roy / N. Stergiopulos (Dir.)  

Lausanne: EPFL, 2008. DOI : 10.5075/epfl-thesis-4063.

Effects of base-pair sequence, nicks and gaps on DNA minicircle shapes

A. Amzallag / J. H. Maddocks (Dir.)  

Lausanne: EPFL, 2008. DOI : 10.5075/epfl-thesis-3995.

2007

Polynucleotide cytidine deaminases, innate immunity and hepatitis B infection

S. Jost / D. Trono (Dir.)  

Lausanne: EPFL, 2007. DOI : 10.5075/epfl-thesis-3975.

Bioreactor processes based on disposable materials for the production of recombinant proteins from mammalian cells

M. Stettler / F. Wurm (Dir.)  

Lausanne: EPFL, 2007. DOI : 10.5075/epfl-thesis-3947.

Effects of dynamic environments on extracellular morphogen gradients

M. E. Fleury / M. Swartz (Dir.)  

Lausanne: EPFL, 2007. DOI : 10.5075/epfl-thesis-3832.

2005

Development of a novel drug delivery system based on polymeric, thermoresponsive, hydrogel nanoparticles

D. Misirlis / J. A. Hubbell (Dir.)  

Lausanne: EPFL, 2005. DOI : 10.5075/epfl-thesis-3362.