During embryogenesis, the control of cell differentiation in space and time defines the architecture of multicellular organisms. A multitude of biochemical and physical processes converge on the regulation of gene expression, which is the ultimate determinant of cell identity. Our laboratory studies the regulation of cell identity with quantitative, time-resolved approaches that span the whole gene expression flow – from transcription factor binding to protein degradation. We have a strong core in molecular/cell biology, as well as computational and biophysical expertise within our group and through close collaborations. We combine genome editing with various imaging modalities to quantify transcription factor motions, mRNA production, protein synthesis and degradation in single live cells. We also take advantage of high throughput genomics technologies such as ChIP-seq, CUT&RUN and ATAC-seq combined with quantitative analysis approaches. We use this toolbox to study both physiological and pathological regulation of cell identity with embryonic stem cells and cancer cells as our main model systems.
Prospective Post-doctoral researchers, PhD and Master students are encouraged to apply by directly writing do [email protected]
We are located in the AI building – see directions using this link (the SV building is next to the AI building)